ZA823532B - 9-(1,3-dihydroxy-2-propoxymethyl)-guanine as antiviral agent - Google Patents

9-(1,3-dihydroxy-2-propoxymethyl)-guanine as antiviral agent

Info

Publication number
ZA823532B
ZA823532B ZA823532A ZA823532A ZA823532B ZA 823532 B ZA823532 B ZA 823532B ZA 823532 A ZA823532 A ZA 823532A ZA 823532 A ZA823532 A ZA 823532A ZA 823532 B ZA823532 B ZA 823532B
Authority
ZA
South Africa
Prior art keywords
propoxymethyl
guanine
dihydroxy
antiviral agent
antiviral
Prior art date
Application number
ZA823532A
Other languages
English (en)
Inventor
Julian P Verheyden
John C Martin
Original Assignee
Syntex Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23017790&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ZA823532(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Syntex Inc filed Critical Syntex Inc
Publication of ZA823532B publication Critical patent/ZA823532B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
ZA823532A 1981-05-21 1982-05-21 9-(1,3-dihydroxy-2-propoxymethyl)-guanine as antiviral agent ZA823532B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06267210 US4355032B2 (en) 1981-05-21 1981-05-21 9-(1,3-dihydroxy-2-propoxymethyl)guanine as antiviral agent

Publications (1)

Publication Number Publication Date
ZA823532B true ZA823532B (en) 1983-03-30

Family

ID=23017790

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA823532A ZA823532B (en) 1981-05-21 1982-05-21 9-(1,3-dihydroxy-2-propoxymethyl)-guanine as antiviral agent

Country Status (33)

Country Link
US (1) US4355032B2 (da)
EP (1) EP0066208B1 (da)
JP (2) JPS57203086A (da)
KR (1) KR890004663B1 (da)
AR (1) AR244227A1 (da)
AT (1) ATE15899T1 (da)
AU (1) AU572086B2 (da)
BR (1) BR8202931A (da)
CA (3) CA1305139C (da)
CS (4) CS235043B2 (da)
DD (2) DD213218A5 (da)
DE (1) DE3266644D1 (da)
DK (2) DK150304C (da)
ES (7) ES512414A0 (da)
FI (1) FI73682C (da)
GR (1) GR76459B (da)
HK (1) HK67088A (da)
HU (2) HU188000B (da)
IE (1) IE53731B1 (da)
IL (1) IL65836A (da)
IN (1) IN156469B (da)
LU (1) LU88334I2 (da)
MY (1) MY8700793A (da)
NL (2) NL930022I1 (da)
NO (2) NO161740C (da)
NZ (1) NZ200691A (da)
PH (1) PH17975A (da)
PL (4) PL136004B1 (da)
PT (1) PT74934B (da)
RO (2) RO84860B (da)
SG (1) SG81687G (da)
SU (1) SU1176841A3 (da)
ZA (1) ZA823532B (da)

Families Citing this family (73)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4347360A (en) * 1980-09-16 1982-08-31 Ens Bio Logicals Inc. Ring open nucleoside analogues
US5157120A (en) * 1980-09-16 1992-10-20 Syntex (U.S.A.) Inc. Guanine derivatives
US4508898A (en) * 1980-09-16 1985-04-02 Ogilvie Kelvin K Antiviral triazine compounds
US4423050A (en) * 1981-05-21 1983-12-27 Syntex (U.S.A.) Inc. 9-(1,3-Dihydroxy-2-propoxymethyl)guanine as antiviral agent
US4507305A (en) * 1981-05-21 1985-03-26 Syntex (U.S.A.) Inc. 9-(1,3-Dihydroxy-2-propoxymethyl)guanine as antiviral agent
ES8403128A1 (es) * 1981-08-11 1983-10-01 Wellcome Found "un procedimiento para preparar derivados de purina".
NZ201662A (en) * 1981-08-26 1986-07-11 Merck & Co Inc 9-(1,3-(and 2,3)-dihydroxy-1-(and 2)-propoxy-methyl)guanine derivatives and methods for their preparation
JPS58135885A (ja) * 1982-02-01 1983-08-12 シンテツクス（ユ−・エス・エイ）インコ−ポレイテツド 置換されたプリン、その製造方法およびそれからなる抗ウイルス剤
US5250535A (en) * 1982-02-01 1993-10-05 Syntex Inc. Substituted 9-(1 or 3-monoacyloxy or 1,3-diacyloxy-2-propoxymethyl) purines as antiviral agent
US4902678A (en) * 1982-02-12 1990-02-20 Syntex (U.S.A.) Inc. Anti-viral compositions
US4609662A (en) * 1982-10-14 1986-09-02 Burroughs Wellcome Co. Method for using purine derivatives
US4462986A (en) * 1982-11-04 1984-07-31 Ens Bio Logicals, Inc. Synergistic anti-herpes compositions
US4814335A (en) * 1982-12-30 1989-03-21 Biomeasure, Incorporated Antiviral compounds
US4461757A (en) * 1983-02-23 1984-07-24 Ens Bio Logicals Inc. Dimethylaminomethylenated anti-herpes compounds
US5047533A (en) * 1983-05-24 1991-09-10 Sri International Acyclic purine phosphonate nucleotide analogs
US4880820A (en) * 1983-06-24 1989-11-14 Merck & Co., Inc. Guanine derivatives
GB8320308D0 (en) * 1983-07-28 1983-09-01 Wellcome Found Antiviral combinations
US4897479A (en) * 1983-09-30 1990-01-30 Merck & Co., Inc. Arylsulfonyloxy purine intermediates
EP0138683A3 (en) * 1983-09-30 1988-01-20 Merck & Co. Inc. Purine derivatives, their application in anti-viral compositions
US4806642A (en) * 1984-10-05 1989-02-21 Warner-Lambert Company Purine derivatives
IE842642L (en) * 1983-10-31 1985-04-30 Harvard College Purine Derivatives
IL73682A (en) * 1983-12-20 1991-08-16 Medivir Ab Antiviral pharmaceutical compositions containing 9-hydroxy aliphatic derivatives of guanine,some new such derivatives and process for their preparation
US4621140A (en) * 1984-02-23 1986-11-04 Syntex (U.S.A.) Inc. Process for preparing 2,6-substituted-9-(1,3-dihydroxy-2-propoxymethyl)-purines and certain derivatives
US4579849A (en) * 1984-04-06 1986-04-01 Merck & Co., Inc. N-alkylguanine acyclonucleosides as antiviral agents
EP0190123A1 (en) * 1984-07-20 1986-08-13 GAUNTT, Charles, O. Immunoregulatory and anti-viral compound
HUT39145A (en) * 1984-12-12 1986-08-28 Syntex Inc Process for preparing alkoxy-methyl-ether and alkoxy-methyl ester derivatives
SE8406538D0 (sv) 1984-12-21 1984-12-21 Astra Laekemedel Ab Novel derivatives of purine
US4642346A (en) * 1985-06-24 1987-02-10 Syntex (U.S.A.) Inc. Anhydrous crystalline 9-(1,3-dihydroxy-2-propoxymethyl)guanine
US4863927A (en) * 1987-05-11 1989-09-05 Merck & Co., Inc. 1-(2-hydroxymethyl)cycloalkylmethyl)-5-substituted uracils
DE68922903T2 (de) * 1988-12-19 1995-11-23 Wellcome Found Antivirale Pyrimidin- und Purinverbindungen, Verfahren zu ihrer Herstellung und sie enthaltende pharmazeutische Präparate.
US5068119A (en) * 1990-09-28 1991-11-26 Nabisco Brands, Inc. Acid-hydrolyzable ester derivatives as low calorie fat mimetics
GB2260319B (en) 1991-10-07 1995-12-06 Norsk Hydro As Acyl derivatives of nucleosides and nucleoside analogues having anti-viral activity
DK0705264T3 (da) * 1993-06-23 1999-10-18 Merrell Pharma Inc Carbo-acyliske nukleosidderivater som antivirale og antineoplastiske midler
US5856481A (en) * 1994-07-28 1999-01-05 Syntex (U.S.A.) Inc. 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl)methoxy-1,3-propanediol derivative
US5543414A (en) * 1994-07-28 1996-08-06 Syntex (Usa) Inc. Achiral amino acid acyl esters of ganciclovir and its derivatives
US5565565A (en) * 1994-08-04 1996-10-15 Syntex (U.S.A.) Inc. Preparation of N-9 substituted guanine compounds
US5627185A (en) * 1994-11-23 1997-05-06 Gosselin; Gilles Acyclovir derivatives as antiviral agents
US5840763A (en) * 1994-12-12 1998-11-24 Smithkline Beecham Plc Treatment of a latent infection of herpes viruses
DE19536164A1 (de) * 1995-09-28 1997-04-03 Boehringer Ingelheim Kg Verbessertes Verfahren zur Herstellung von 9-[(2-Hyroxyethoxy)methyl]guanin (Acyclovir)
US5700936A (en) * 1996-01-26 1997-12-23 Syntex (U.S.A.) Inc. Process for preparing a 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl) methoxy-1,3-propanediol valinate
US6040446A (en) 1996-01-26 2000-03-21 Syntex (U.S.A.) Inc. Process for preparing a 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl) methoxy-1,3-propanediol derivative
US5756736A (en) * 1996-01-26 1998-05-26 Syntex (U.S.A.) Inc. Process for preparing a 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl)methoxy-1,3-propanediol derivative
US5840890A (en) * 1996-01-26 1998-11-24 Syntex (U.S.A.) Inc. Process for preparing a 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl)methoxy-1,3-propanediol derivative
IN179493B (da) * 1996-02-22 1997-10-11 Lupin Laboraties Ltd
EP0976751A1 (en) * 1996-04-09 2000-02-02 Lupin Laboratories Limited A process for the isomerisation of an N-7 isomer into an N-9 isomer useful in the synthesis of acyclic nucleosides
US5852208A (en) * 1996-08-30 1998-12-22 Dixie Chemical Company, Inc. Method of producing compounds containing acyloxyalkoxy groups from alcohols
CN1091445C (zh) * 1999-12-29 2002-09-25 湖北省医药工业研究院 抗病毒药物中间体、它们的制备及应用
IL163666A0 (en) 2002-02-22 2005-12-18 New River Pharmaceuticals Inc Active agent delivery systems and methods for protecting and administering active agents
WO2004037263A1 (en) * 2002-10-22 2004-05-06 Ranbaxy Laboratories Limited Pharmaceutical compositions of ganciclovir
EP1565470A2 (en) * 2002-10-31 2005-08-24 Ranbaxy Laboratories Limited Process for the preparation of ganciclovir
US7078524B2 (en) * 2002-11-22 2006-07-18 Ranbaxy Laboratories Limited Process for the synthesis of ganciclovir
ATE398455T1 (de) * 2003-01-14 2008-07-15 Gilead Sciences Inc Zusammensetzungen und verfahren zur antiviralen kombinationstherapie
ITMI20031202A1 (it) * 2003-06-13 2004-12-14 Lyogen Ltd Forma di cristallina del ganciclovir
US20070129385A1 (en) * 2003-08-28 2007-06-07 Sharma Mukesh K Amorphous valganciclovir hydrochloride
JP4746866B2 (ja) * 2004-11-19 2011-08-10 Ｔｃｍ株式会社 キャリッジ用ガタ抑制装置
TWI375560B (en) * 2005-06-13 2012-11-01 Gilead Sciences Inc Composition comprising dry granulated emtricitabine and tenofovir df and method for making the same
TWI471145B (zh) 2005-06-13 2015-02-01 Bristol Myers Squibb & Gilead Sciences Llc 單一式藥學劑量型
EP2085397A1 (en) 2008-01-21 2009-08-05 Esteve Quimica, S.A. Crystalline form of abacavir
WO2009120358A1 (en) * 2008-03-27 2009-10-01 Nektar Therapeutics Oligomer-nitrogenous base conjugates
US8173621B2 (en) 2008-06-11 2012-05-08 Gilead Pharmasset Llc Nucleoside cyclicphosphates
CL2009002207A1 (es) 2008-12-23 2011-02-18 Gilead Pharmasset Llc Compuestos derivados de 3-hidroxi-5-(9h-purin-9-il)tetrahidrofuran-2-il, inhibidor de la replicacion de arn viral dependiente de arn; composicion farmaceutica; uso para el tratamiento de hepatitis c.
WO2010075517A2 (en) * 2008-12-23 2010-07-01 Pharmasset, Inc. Nucleoside analogs
SG172363A1 (en) 2008-12-23 2011-07-28 Pharmasset Inc Synthesis of purine nucleosides
CN101851239B (zh) * 2009-04-03 2012-11-28 上海益威实业有限公司 一种更昔洛韦的回收方法
AP3515A (en) 2010-03-31 2016-01-11 Gilead Pharmasset Llc Nucleoside phosphoramidates
US9550803B2 (en) * 2011-05-06 2017-01-24 University Of Southern California Method to improve antiviral activity of nucleotide analogue drugs
CN102627643B (zh) * 2012-04-10 2014-01-08 常州康丽制药有限公司 更昔洛韦的精制方法
US9227990B2 (en) 2012-10-29 2016-01-05 Cipla Limited Antiviral phosphonate analogues and process for preparation thereof
US9505775B2 (en) * 2012-11-03 2016-11-29 Boehringer Ingelheim International Gmbh Inhibitors of cytomegalovirus
CN103059023B (zh) * 2012-12-31 2015-09-30 浙江车头制药股份有限公司 一种制备更昔洛韦晶型ⅱ的方法
US9486530B1 (en) 2013-08-30 2016-11-08 Exela Pharma Sciences, LLC Ganciclovir compositions and related methods
US20230218644A1 (en) 2020-04-16 2023-07-13 Som Innovation Biotech, S.A. Compounds for use in the treatment of viral infections by respiratory syndrome-related coronavirus
CN113476413B (zh) * 2021-08-09 2022-06-28 海南海灵化学制药有限公司 一种注射用更昔洛韦钠冻干粉的制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1523865A (en) * 1974-09-02 1978-09-06 Wellcome Found Purine compunds and salts thereof
US4199574A (en) * 1974-09-02 1980-04-22 Burroughs Wellcome Co. Methods and compositions for treating viral infections and guanine acyclic nucleosides
US4060616A (en) * 1976-03-01 1977-11-29 Burroughs Wellcome Co. Purine derivatives with repeating unit
US4221910A (en) * 1978-09-15 1980-09-09 Newport Pharmaceuticals International, Inc. 9-(Hydroxy alkyl)purines
US4347360A (en) * 1980-09-16 1982-08-31 Ens Bio Logicals Inc. Ring open nucleoside analogues
AU7938482A (en) * 1980-12-22 1982-07-20 Astra Lakemedel Aktiebolag Novel derivatives of guanine
ES8403128A1 (es) * 1981-08-11 1983-10-01 Wellcome Found "un procedimiento para preparar derivados de purina".

Also Published As

Publication number Publication date
IE53731B1 (en) 1989-02-01
HU186514B (en) 1985-08-28
HU188000B (en) 1986-03-28
US4355032B2 (en) 1990-10-30
ES8507549A1 (es) 1985-09-16
DK227782A (da) 1982-11-22
CA1305140C (en) 1992-07-14
KR890004663B1 (ko) 1989-11-24
NL930022I1 (nl) 1993-05-03
ES8404355A1 (es) 1984-05-01
ES8606869A1 (es) 1986-05-16
DE3266644D1 (en) 1985-11-07
CS235018B2 (en) 1985-04-16
PT74934A (en) 1982-06-01
RO84860B (ro) 1984-10-30
JPS57203086A (en) 1982-12-13
ES8500276A1 (es) 1984-11-01
ES8505681A1 (es) 1985-06-16
ES533821A0 (es) 1985-06-16
DK504183A (da) 1983-11-03
GR76459B (da) 1984-08-10
NO161740B (no) 1989-06-12
NO1994005I1 (no) 1994-07-29
ES529383A0 (es) 1986-05-16
BR8202931A (pt) 1983-05-03
RO84860A (ro) 1984-09-29
MY8700793A (en) 1987-12-31
JPH0529399B2 (da) 1993-04-30
SG81687G (en) 1989-07-07
PL136637B1 (en) 1986-03-31
FI73682B (fi) 1987-07-31
AU572086B2 (en) 1988-05-05
ATE15899T1 (de) 1985-10-15
EP0066208A1 (en) 1982-12-08
PL242101A1 (en) 1984-07-16
JPH04217983A (ja) 1992-08-07
JPH046195B2 (da) 1992-02-05
ES8701496A1 (es) 1987-01-01
US4355032B1 (da) 1983-06-14
AR244227A1 (es) 1993-10-29
RO87387B (ro) 1985-08-31
PL246770A1 (en) 1984-08-27
PL236521A1 (en) 1984-01-02
US4355032A (en) 1982-10-19
PL242100A1 (en) 1984-04-24
PH17975A (en) 1985-02-22
DD203052A5 (de) 1983-10-12
NL930139I1 (nl) 1993-11-01
CA1305139C (en) 1992-07-14
NL930139I2 (nl) 1997-07-01
PL136579B1 (en) 1986-02-28
SU1176841A3 (ru) 1985-08-30
DK149001B (da) 1985-12-16
ES8601204A1 (es) 1985-11-16
ES512414A0 (es) 1984-05-01
ES529384A0 (es) 1987-01-01
AU8389282A (en) 1982-11-25
PL136004B1 (en) 1986-01-31
DK150304C (da) 1988-01-04
DK149001C (da) 1988-11-28
CS235044B2 (en) 1985-04-16
IL65836A0 (en) 1982-08-31
NO821676L (no) 1982-11-22
IL65836A (en) 1991-04-15
CS235043B2 (en) 1985-04-16
DK504183D0 (da) 1983-11-03
RO87387A (ro) 1985-08-31
ES520849A0 (es) 1984-11-01
FI73682C (fi) 1987-11-09
NO161740C (no) 1989-09-20
ES524899A0 (es) 1985-09-16
LU88334I2 (fr) 1994-09-09
CA1305141C (en) 1992-07-14
HK67088A (en) 1988-09-02
CS235042B2 (en) 1985-04-16
DD213218A5 (de) 1984-09-05
IE821210L (en) 1982-11-21
PT74934B (en) 1984-05-08
NZ200691A (en) 1986-11-12
KR830010112A (ko) 1983-12-26
IN156469B (da) 1985-08-10
PL136332B1 (en) 1986-02-28
FI821794A0 (fi) 1982-05-20
ES524900A0 (es) 1985-11-16
DK150304B (da) 1987-02-02
EP0066208B1 (en) 1985-10-02

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