NO161740C - Analogifremgangsmaate for fremstilling av terapeutisk aktivt 9-(1,3-dihydroksy-2-propoksymetyl) guanin. - Google Patents

Analogifremgangsmaate for fremstilling av terapeutisk aktivt 9-(1,3-dihydroksy-2-propoksymetyl) guanin.

Info

Publication number
NO161740C
NO161740C NO821676A NO821676A NO161740C NO 161740 C NO161740 C NO 161740C NO 821676 A NO821676 A NO 821676A NO 821676 A NO821676 A NO 821676A NO 161740 C NO161740 C NO 161740C
Authority
NO
Norway
Prior art keywords
propoxymethyl
guanine
dihydroxy
preparation
therapeutic active
Prior art date
Application number
NO821676A
Other languages
English (en)
Norwegian (no)
Other versions
NO161740B (no
NO821676L (no
Inventor
Julien P Verheyden
John C Martin
Original Assignee
Syntex Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23017790&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO161740(C) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Syntex Inc filed Critical Syntex Inc
Publication of NO821676L publication Critical patent/NO821676L/no
Priority to NO874847A priority Critical patent/NO160260C/no
Priority to NO890477A priority patent/NO165026C/no
Priority to NO890476A priority patent/NO165025C/no
Publication of NO161740B publication Critical patent/NO161740B/no
Publication of NO161740C publication Critical patent/NO161740C/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
NO821676A 1981-05-21 1982-05-19 Analogifremgangsmaate for fremstilling av terapeutisk aktivt 9-(1,3-dihydroksy-2-propoksymetyl) guanin. NO161740C (no)

Priority Applications (3)

Application Number Priority Date Filing Date Title
NO874847A NO160260C (no) 1981-05-21 1987-11-20 9-(1,3-dihydroksy-2-propoksymetyl)-guanin-derivater.
NO890477A NO165026C (no) 1981-05-21 1989-02-06 Analogifremgangsmaate for fremstilling av natriumsaltet 9-(1,2-dihydroksy-2-propoksymetyl)guanin.
NO890476A NO165025C (no) 1981-05-21 1989-02-06 Analogifremgangsmaate for fremstilling av natriumsaltet 9-(1,3-dihydroksy-2-propoksymetyl)guanin.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06267210 US4355032B2 (en) 1981-05-21 1981-05-21 9-(1,3-dihydroxy-2-propoxymethyl)guanine as antiviral agent

Publications (3)

Publication Number Publication Date
NO821676L NO821676L (no) 1982-11-22
NO161740B NO161740B (no) 1989-06-12
NO161740C true NO161740C (no) 1989-09-20

Family

ID=23017790

Family Applications (2)

Application Number Title Priority Date Filing Date
NO821676A NO161740C (no) 1981-05-21 1982-05-19 Analogifremgangsmaate for fremstilling av terapeutisk aktivt 9-(1,3-dihydroksy-2-propoksymetyl) guanin.
NO1994005C NO1994005I1 (no) 1981-05-21 1994-07-29 Ganciclovir

Family Applications After (1)

Application Number Title Priority Date Filing Date
NO1994005C NO1994005I1 (no) 1981-05-21 1994-07-29 Ganciclovir

Country Status (33)

Country Link
US (1) US4355032B2 (da)
EP (1) EP0066208B1 (da)
JP (2) JPS57203086A (da)
KR (1) KR890004663B1 (da)
AR (1) AR244227A1 (da)
AT (1) ATE15899T1 (da)
AU (1) AU572086B2 (da)
BR (1) BR8202931A (da)
CA (3) CA1305139C (da)
CS (4) CS235042B2 (da)
DD (2) DD203052A5 (da)
DE (1) DE3266644D1 (da)
DK (2) DK150304C (da)
ES (7) ES8404355A1 (da)
FI (1) FI73682C (da)
GR (1) GR76459B (da)
HK (1) HK67088A (da)
HU (2) HU186514B (da)
IE (1) IE53731B1 (da)
IL (1) IL65836A (da)
IN (1) IN156469B (da)
LU (1) LU88334I2 (da)
MY (1) MY8700793A (da)
NL (2) NL930022I1 (da)
NO (2) NO161740C (da)
NZ (1) NZ200691A (da)
PH (1) PH17975A (da)
PL (4) PL136004B1 (da)
PT (1) PT74934B (da)
RO (2) RO87387B (da)
SG (1) SG81687G (da)
SU (1) SU1176841A3 (da)
ZA (1) ZA823532B (da)

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US4508898A (en) * 1980-09-16 1985-04-02 Ogilvie Kelvin K Antiviral triazine compounds
US4347360A (en) * 1980-09-16 1982-08-31 Ens Bio Logicals Inc. Ring open nucleoside analogues
US4507305A (en) * 1981-05-21 1985-03-26 Syntex (U.S.A.) Inc. 9-(1,3-Dihydroxy-2-propoxymethyl)guanine as antiviral agent
US4423050A (en) * 1981-05-21 1983-12-27 Syntex (U.S.A.) Inc. 9-(1,3-Dihydroxy-2-propoxymethyl)guanine as antiviral agent
GB2104070B (en) * 1981-08-11 1985-08-14 Wellcome Found Purines
NZ201662A (en) * 1981-08-26 1986-07-11 Merck & Co Inc 9-(1,3-(and 2,3)-dihydroxy-1-(and 2)-propoxy-methyl)guanine derivatives and methods for their preparation
IE830186L (en) * 1982-02-01 1983-08-01 Syntex Inc Purines
US5250535A (en) * 1982-02-01 1993-10-05 Syntex Inc. Substituted 9-(1 or 3-monoacyloxy or 1,3-diacyloxy-2-propoxymethyl) purines as antiviral agent
US4902678A (en) * 1982-02-12 1990-02-20 Syntex (U.S.A.) Inc. Anti-viral compositions
US4609662A (en) * 1982-10-14 1986-09-02 Burroughs Wellcome Co. Method for using purine derivatives
US4462986A (en) * 1982-11-04 1984-07-31 Ens Bio Logicals, Inc. Synergistic anti-herpes compositions
US4814335A (en) * 1982-12-30 1989-03-21 Biomeasure, Incorporated Antiviral compounds
US4461757A (en) * 1983-02-23 1984-07-24 Ens Bio Logicals Inc. Dimethylaminomethylenated anti-herpes compounds
US5047533A (en) * 1983-05-24 1991-09-10 Sri International Acyclic purine phosphonate nucleotide analogs
US4880820A (en) * 1983-06-24 1989-11-14 Merck & Co., Inc. Guanine derivatives
GB8320308D0 (en) * 1983-07-28 1983-09-01 Wellcome Found Antiviral combinations
US4897479A (en) * 1983-09-30 1990-01-30 Merck & Co., Inc. Arylsulfonyloxy purine intermediates
EP0138683A3 (en) * 1983-09-30 1988-01-20 Merck & Co. Inc. Purine derivatives, their application in anti-viral compositions
IE842642L (en) * 1983-10-31 1985-04-30 Harvard College Purine Derivatives
US4806642A (en) * 1984-10-05 1989-02-21 Warner-Lambert Company Purine derivatives
IL73682A (en) * 1983-12-20 1991-08-16 Medivir Ab Antiviral pharmaceutical compositions containing 9-hydroxy aliphatic derivatives of guanine,some new such derivatives and process for their preparation
US4621140A (en) * 1984-02-23 1986-11-04 Syntex (U.S.A.) Inc. Process for preparing 2,6-substituted-9-(1,3-dihydroxy-2-propoxymethyl)-purines and certain derivatives
US4579849A (en) * 1984-04-06 1986-04-01 Merck & Co., Inc. N-alkylguanine acyclonucleosides as antiviral agents
EP0190123A1 (en) * 1984-07-20 1986-08-13 GAUNTT, Charles, O. Immunoregulatory and anti-viral compound
DE3583858D1 (de) * 1984-12-12 1991-09-26 Syntex Inc Derivate von alcoxymethylaether und alcoxymethylester.
SE8406538D0 (sv) 1984-12-21 1984-12-21 Astra Laekemedel Ab Novel derivatives of purine
US4642346A (en) * 1985-06-24 1987-02-10 Syntex (U.S.A.) Inc. Anhydrous crystalline 9-(1,3-dihydroxy-2-propoxymethyl)guanine
US4863927A (en) * 1987-05-11 1989-09-05 Merck & Co., Inc. 1-(2-hydroxymethyl)cycloalkylmethyl)-5-substituted uracils
DE68922903T2 (de) * 1988-12-19 1995-11-23 Wellcome Found Antivirale Pyrimidin- und Purinverbindungen, Verfahren zu ihrer Herstellung und sie enthaltende pharmazeutische Präparate.
US5068119A (en) * 1990-09-28 1991-11-26 Nabisco Brands, Inc. Acid-hydrolyzable ester derivatives as low calorie fat mimetics
GB2260319B (en) 1991-10-07 1995-12-06 Norsk Hydro As Acyl derivatives of nucleosides and nucleoside analogues having anti-viral activity
CA2165419C (en) * 1993-06-23 1999-03-02 Jeffrey S. Sabol Carbo-acyclic nucleoside derivatives as antiviral and antineoplastic agents
US5840891A (en) * 1994-07-28 1998-11-24 Syntex (U.S.A.) Inc. 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl) methoxy-1,3-propanediol derivative
US5543414A (en) * 1994-07-28 1996-08-06 Syntex (Usa) Inc. Achiral amino acid acyl esters of ganciclovir and its derivatives
US5565565A (en) 1994-08-04 1996-10-15 Syntex (U.S.A.) Inc. Preparation of N-9 substituted guanine compounds
US5627185A (en) * 1994-11-23 1997-05-06 Gosselin; Gilles Acyclovir derivatives as antiviral agents
US5840763A (en) * 1994-12-12 1998-11-24 Smithkline Beecham Plc Treatment of a latent infection of herpes viruses
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US5756736A (en) * 1996-01-26 1998-05-26 Syntex (U.S.A.) Inc. Process for preparing a 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl)methoxy-1,3-propanediol derivative
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IN179493B (da) * 1996-02-22 1997-10-11 Lupin Laboraties Ltd
EP0976751A1 (en) * 1996-04-09 2000-02-02 Lupin Laboratories Limited A process for the isomerisation of an N-7 isomer into an N-9 isomer useful in the synthesis of acyclic nucleosides
US5852208A (en) * 1996-08-30 1998-12-22 Dixie Chemical Company, Inc. Method of producing compounds containing acyloxyalkoxy groups from alcohols
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GB1523865A (en) * 1974-09-02 1978-09-06 Wellcome Found Purine compunds and salts thereof
US4199574A (en) * 1974-09-02 1980-04-22 Burroughs Wellcome Co. Methods and compositions for treating viral infections and guanine acyclic nucleosides
US4060616A (en) * 1976-03-01 1977-11-29 Burroughs Wellcome Co. Purine derivatives with repeating unit
US4221910A (en) * 1978-09-15 1980-09-09 Newport Pharmaceuticals International, Inc. 9-(Hydroxy alkyl)purines
US4347360A (en) * 1980-09-16 1982-08-31 Ens Bio Logicals Inc. Ring open nucleoside analogues
AU7938482A (en) * 1980-12-22 1982-07-20 Astra Lakemedel Aktiebolag Novel derivatives of guanine
GB2104070B (en) * 1981-08-11 1985-08-14 Wellcome Found Purines

Also Published As

Publication number Publication date
SG81687G (en) 1989-07-07
ES8601204A1 (es) 1985-11-16
US4355032B2 (en) 1990-10-30
US4355032B1 (da) 1983-06-14
CS235042B2 (en) 1985-04-16
US4355032A (en) 1982-10-19
DK504183D0 (da) 1983-11-03
EP0066208A1 (en) 1982-12-08
IL65836A0 (en) 1982-08-31
ES8500276A1 (es) 1984-11-01
ES8701496A1 (es) 1987-01-01
PT74934A (en) 1982-06-01
CS235043B2 (en) 1985-04-16
NL930139I2 (nl) 1997-07-01
DK149001C (da) 1988-11-28
ES512414A0 (es) 1984-05-01
DK227782A (da) 1982-11-22
DD213218A5 (de) 1984-09-05
PL242101A1 (en) 1984-07-16
PH17975A (en) 1985-02-22
CS235044B2 (en) 1985-04-16
ATE15899T1 (de) 1985-10-15
PL136004B1 (en) 1986-01-31
ES8404355A1 (es) 1984-05-01
SU1176841A3 (ru) 1985-08-30
HK67088A (en) 1988-09-02
ES520849A0 (es) 1984-11-01
NL930139I1 (nl) 1993-11-01
NL930022I1 (nl) 1993-05-03
DE3266644D1 (en) 1985-11-07
ES8505681A1 (es) 1985-06-16
DK504183A (da) 1983-11-03
PT74934B (en) 1984-05-08
RO87387A (ro) 1985-08-31
ES529384A0 (es) 1987-01-01
HU188000B (en) 1986-03-28
ES8606869A1 (es) 1986-05-16
RO84860A (ro) 1984-09-29
PL136332B1 (en) 1986-02-28
DK150304C (da) 1988-01-04
IE821210L (en) 1982-11-21
FI73682C (fi) 1987-11-09
AU8389282A (en) 1982-11-25
JPH0529399B2 (da) 1993-04-30
DD203052A5 (de) 1983-10-12
PL236521A1 (en) 1984-01-02
PL136579B1 (en) 1986-02-28
IN156469B (da) 1985-08-10
ES524899A0 (es) 1985-09-16
MY8700793A (en) 1987-12-31
BR8202931A (pt) 1983-05-03
NO1994005I1 (no) 1994-07-29
CA1305139C (en) 1992-07-14
ES8507549A1 (es) 1985-09-16
KR890004663B1 (ko) 1989-11-24
ES524900A0 (es) 1985-11-16
RO87387B (ro) 1985-08-31
NO161740B (no) 1989-06-12
ES529383A0 (es) 1986-05-16
LU88334I2 (fr) 1994-09-09
PL246770A1 (en) 1984-08-27
IL65836A (en) 1991-04-15
AR244227A1 (es) 1993-10-29
DK150304B (da) 1987-02-02
EP0066208B1 (en) 1985-10-02
JPH046195B2 (da) 1992-02-05
PL242100A1 (en) 1984-04-24
CA1305141C (en) 1992-07-14
IE53731B1 (en) 1989-02-01
NO821676L (no) 1982-11-22
FI73682B (fi) 1987-07-31
RO84860B (ro) 1984-10-30
KR830010112A (ko) 1983-12-26
GR76459B (da) 1984-08-10
JPS57203086A (en) 1982-12-13
FI821794A0 (fi) 1982-05-20
PL136637B1 (en) 1986-03-31
AU572086B2 (en) 1988-05-05
DK149001B (da) 1985-12-16
ES533821A0 (es) 1985-06-16
JPH04217983A (ja) 1992-08-07
HU186514B (en) 1985-08-28
ZA823532B (en) 1983-03-30
NZ200691A (en) 1986-11-12
CA1305140C (en) 1992-07-14
CS235018B2 (en) 1985-04-16

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