NO156864B - Analogifremgangsmaate for fremstilling av terapeutisk aktive piperinderivater. - Google Patents

Analogifremgangsmaate for fremstilling av terapeutisk aktive piperinderivater.

Info

Publication number
NO156864B
NO156864B NO810610A NO810610A NO156864B NO 156864 B NO156864 B NO 156864B NO 810610 A NO810610 A NO 810610A NO 810610 A NO810610 A NO 810610A NO 156864 B NO156864 B NO 156864B
Authority
NO
Norway
Prior art keywords
piperin
derivatives
preparation
therapeutic active
analogy procedure
Prior art date
Application number
NO810610A
Other languages
English (en)
Other versions
NO810610L (no
NO156864C (no
Inventor
John Leheup Archibald
Terence James Ward
Original Assignee
Wyeth John & Brother Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth John & Brother Ltd filed Critical Wyeth John & Brother Ltd
Publication of NO810610L publication Critical patent/NO810610L/no
Publication of NO156864B publication Critical patent/NO156864B/no
Publication of NO156864C publication Critical patent/NO156864C/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56—Nitrogen atoms
    • C07D211/58—Nitrogen atoms attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
NO810610A 1980-03-01 1981-02-23 Analogifremgangsmaate for fremstilling av terapeutisk aktive piperinderivater. NO156864C (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB8007048 1980-03-01
GB8027435 1980-08-22

Publications (3)

Publication Number Publication Date
NO810610L NO810610L (no) 1981-09-02
NO156864B true NO156864B (no) 1987-08-31
NO156864C NO156864C (no) 1987-12-09

Family

ID=26274662

Family Applications (1)

Application Number Title Priority Date Filing Date
NO810610A NO156864C (no) 1980-03-01 1981-02-23 Analogifremgangsmaate for fremstilling av terapeutisk aktive piperinderivater.

Country Status (20)

Country Link
US (2) US4426387A (no)
EP (1) EP0035374B1 (no)
KR (4) KR850000630B1 (no)
AU (1) AU542950B2 (no)
CA (1) CA1173037A (no)
DE (1) DE3168564D1 (no)
DK (1) DK164546C (no)
EG (1) EG16004A (no)
ES (4) ES499716A0 (no)
FI (1) FI77231C (no)
GR (1) GR73576B (no)
HU (1) HU187768B (no)
IE (1) IE52014B1 (no)
IL (1) IL62200A (no)
NO (1) NO156864C (no)
NZ (1) NZ196324A (no)
PH (1) PH17019A (no)
PL (4) PL135545B1 (no)
PT (1) PT72562B (no)
YU (4) YU47381A (no)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8528235D0 (en) * 1985-11-15 1985-12-18 Wyeth John & Brother Ltd Heterocyclic compounds
US4508722A (en) * 1981-05-18 1985-04-02 Eli Lilly And Company 1-Benzoyl-3-(arylpyridyl)urea compounds
EP0091198B1 (en) * 1982-04-07 1987-05-13 Imperial Chemical Industries Plc Quinoline derivatives
DE3377796D1 (en) * 1982-05-04 1988-09-29 Ici Plc Quinoline derivatives
FR2527205A1 (fr) * 1982-05-18 1983-11-25 Bouchara Emile Nouvelles phenyloxoalcoyl piperidines, leurs procedes d'obtention et les compositions pharmaceutiques en renfermant
WO1985001288A1 (fr) * 1983-09-19 1985-03-28 Bouchara, Emile Nouvelles piperidinoguanidines substituees, leur procede de preparation et les compositions pharmaceutiques en renfermant
US4569933A (en) * 1984-04-13 1986-02-11 Cornu Pierre Jean Antihypertensive substituted derivatives of 2,5-diamino 1,4-diazole
GB8528234D0 (en) * 1985-11-15 1985-12-18 Wyeth John & Brother Ltd Heterocyclic compounds
US5312840A (en) * 1986-07-10 1994-05-17 State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education Substituted guanidines having high binding to the sigma receptor and the use thereof
US5385946A (en) * 1986-07-10 1995-01-31 State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University And The University Of Oregon Method for treating hypertension with disubstituted granidine compounds
US4709094A (en) * 1986-07-10 1987-11-24 State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University And The University Of Oregon Sigma brain receptor ligands and their use
EP0343307A1 (en) * 1988-05-26 1989-11-29 Fabrica Espanola De Productos Quimicos Y Farmaceuticos, S.A. 4-Piperidinealkanamine derivatives
GR1000662B (el) * 1988-07-01 1992-09-25 Janssen Pharmaceutica Nv Μεθοδος παρασκευης cis-ν-(3-μεθοξυ-4-πιπεριδινυλο)βενζαμιδιων.
US5262568A (en) * 1990-03-02 1993-11-16 State Of Oregon Tri- and tetra-substituted guanidines and their use as excitatory amino acid antagonists
CA2076664C (en) 1990-03-02 2004-01-13 Eckard Weber Tri- and tetra-substituted guanidines and their use as excitatory amino acid antagonists
FR2662162B1 (fr) * 1990-05-18 1995-01-20 Adir Nouveaux derives de l'amino piperidine, de l'amino pyrrolidine et de l'amino perhydroazepine, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent.
US5574070A (en) * 1990-05-25 1996-11-12 State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University Substituted guanidines having high binding to the sigma receptor and the use thereof
US5741661A (en) * 1991-02-08 1998-04-21 Cambridge Neuroscience, Inc. Substituted guanidines and derivatives thereof as modulators of neurotransmitter release and novel methodology for identifying neurotransmitter release blockers
PT100115B (pt) * 1991-02-08 1999-06-30 Cambridge Neuroscience Inc Guanidinas substituidas e seus derivados uteis como moduladores de libertacao de neurotransmissores e ensaios de rastreio para de bloqueadores de libertacao de neurotransmissores
US5847006A (en) * 1991-02-08 1998-12-08 Cambridge Neuroscience, Inc. Therapeutic guanidines
FR2690158B1 (fr) * 1992-04-17 1994-07-22 Sanofi Elf Nouveau derive arylpiperidinique, procede pour sa preparation et compositions pharmaceutiques le contenant.
ZA943744B (en) * 1993-05-27 1995-04-26 Cambridge Neuroscience Inc Therapeutic substituted guanidines
US5739135A (en) * 1993-09-03 1998-04-14 Bristol-Myers Squibb Company Inhibitors of microsomal triglyceride transfer protein and method
CA2177081A1 (en) * 1993-11-23 1995-06-01 Graham J. Durant Therapeutic substituted guanidines
US7351743B1 (en) 1994-02-03 2008-04-01 Wyeth Therapeutic guanidines
EP0751767A4 (en) 1994-02-03 1997-12-10 Cambridge Neuroscience Inc GUANIDINE FOR THERAPEUTIC USE
US6143791A (en) * 1994-02-03 2000-11-07 Cambridge Neuroscience, Inc. Therapeutic guanidines
US6787569B1 (en) 1994-02-03 2004-09-07 Cambridge Neuroscience, Inc. Therapeutic guanidines
US6025355A (en) 1997-05-19 2000-02-15 Cambridge Neuroscience, Inc. Pharmaceutically active compounds and methods of use
US6242198B1 (en) 1996-07-25 2001-06-05 Cambridge Neuroscience, Inc. Methods of treatment of eye trauma and disorders
US6756389B2 (en) 1996-08-09 2004-06-29 Cambridge Neuroscience, Inc. Pharmaceutically active compounds and methods of use
DE19824470A1 (de) * 1998-05-30 1999-12-02 Boehringer Ingelheim Pharma Neue Neurokininantagonisten, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende pharmazeutische Zusammensetzungen

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3072663A (en) * 1961-09-25 1963-01-08 Warner Lambert Pharmaceutical Polyalkyl substituted-4-guanidopiperidines
US3161637A (en) * 1961-10-10 1964-12-15 Res Lab Dr C Janssen N V 1-(gamma-aroyl-propyl)-4-(nu-arylcarbonyl amino) piperidines and related compounds
US3171838A (en) * 1961-10-10 1965-03-02 Res Lab Dr C Janssen N V Aroylalkyl and hydroxyaralkyl derivatives of 4-(n-arylalkanamido)-piperidines and related compounds
GB1411783A (en) * 1972-02-24 1975-10-29 Wyeth John & Brother Ltd Piperidine derivatives
GB1411782A (en) * 1972-02-24 1975-10-29 Wyeth John & Brother Ltd Piperidine derivatives
US3910930A (en) * 1973-01-04 1975-10-07 Janssen Pharmaceutica Nv 1-{55 1-{8 2-(1,4-Benzodioxan-2-yl)-2-hydroxyethyl{9 -4-piperidyl{56 -2-benzimidazolinones
US4177279A (en) * 1973-10-10 1979-12-04 John Wyeth & Brother Ltd. 1-[(3-Indolyl)-alkyl]-piperidyl ureas and hypotensive compositions
GB1459506A (en) * 1974-02-18 1976-12-22 Wyeth John & Brother Ltd Piperidine derivatives
JPS5152176A (no) 1974-10-12 1976-05-08 Yoshitomi Pharmaceutical
AU500990B2 (en) * 1975-07-25 1979-06-07 John Wyeth & Brother Limited Piperidine derivatives
JPS6039680B2 (ja) * 1975-12-22 1985-09-06 日本化薬株式会社 ３‐（メチルメルカプト）プロピルアミノブレオマイシンの製造法
JPS5285174A (en) * 1976-01-05 1977-07-15 Yoshitomi Pharmaceut Ind Ltd Novel urea or thiourea derivatives
GB1582239A (en) * 1976-12-11 1981-01-07 Wyeth John & Brother Ltd Piperidin-4-yl ureas and thioureas
GB1561023A (en) * 1977-04-22 1980-02-13 Beecham Group Ltd 2-methoxy - 5 - chloro aniline derivatives
IN148482B (no) * 1977-06-03 1981-03-07 Pfizer
EP0000485A1 (de) * 1977-07-08 1979-02-07 Ciba-Geigy Ag Piperidino-propanole, ihre Herstellung und pharmazeutische Präparate die diese enthalten
US4281132A (en) * 1977-10-29 1981-07-28 John Wyeth & Brother Limited Piperidino ureas and thioureas
GB1586817A (en) * 1977-12-01 1981-03-25 Wyeth John & Brother Ltd Indole derivatives
US4169202A (en) * 1978-06-05 1979-09-25 American Home Products Corporation Process for preparing 4,5-dihydro-4-oxofuran-2-carboxylic acid derivatives
GB2034305B (en) * 1978-10-24 1982-12-22 Wyeth John & Brother Ltd Preparation of piperidine derivatives

Also Published As

Publication number Publication date
DK164546B (da) 1992-07-13
ES509165A0 (es) 1983-02-01
EP0035374A3 (en) 1981-11-11
NO810610L (no) 1981-09-02
AU542950B2 (en) 1985-03-28
PL234317A1 (no) 1982-08-16
EP0035374B1 (en) 1985-01-30
US4563466A (en) 1986-01-07
EP0035374A2 (en) 1981-09-09
ES8302657A1 (es) 1983-02-01
PL129174B1 (en) 1984-04-30
YU97383A (en) 1983-10-31
KR850002009A (ko) 1985-04-10
IL62200A0 (en) 1981-03-31
KR850002008A (ko) 1985-04-10
ES8203840A1 (es) 1982-05-01
PL135545B1 (en) 1985-11-30
NO156864C (no) 1987-12-09
GR73576B (no) 1984-03-20
KR850002007A (ko) 1985-05-06
DE3168564D1 (en) 1985-03-14
KR850000630B1 (ko) 1985-05-06
AU6761481A (en) 1981-09-10
PL234318A1 (no) 1982-08-16
PL234316A1 (en) 1983-11-07
PT72562B (en) 1982-06-20
ES499716A0 (es) 1982-05-01
EG16004A (en) 1986-12-30
IE52014B1 (en) 1987-05-27
DK164546C (da) 1992-11-30
FI77231C (fi) 1989-02-10
ES8302658A1 (es) 1983-02-01
NZ196324A (en) 1983-09-02
KR850001035B1 (ko) 1985-07-19
KR850001063B1 (ko) 1985-07-25
KR830005140A (ko) 1983-08-03
KR850000631B1 (ko) 1985-05-06
IE810392L (en) 1981-09-01
FI810587L (fi) 1981-09-02
CA1173037A (en) 1984-08-21
YU47381A (en) 1983-10-31
PL128510B1 (en) 1984-02-29
DK87881A (da) 1981-09-02
ES509164A0 (es) 1983-02-01
IL62200A (en) 1984-09-30
PH17019A (en) 1984-05-11
PL128409B1 (en) 1984-01-31
US4426387A (en) 1984-01-17
PL229830A1 (no) 1982-11-22
PT72562A (en) 1981-03-01
HU187768B (en) 1986-02-28
YU97483A (en) 1983-10-31
ES509163A0 (es) 1983-02-01
ES8302656A1 (es) 1983-02-01
YU97583A (en) 1983-10-31
FI77231B (fi) 1988-10-31

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