GB1411782A - Piperidine derivatives - Google Patents

Piperidine derivatives

Info

Publication number
GB1411782A
GB1411782A GB848872A GB848872A GB1411782A GB 1411782 A GB1411782 A GB 1411782A GB 848872 A GB848872 A GB 848872A GB 848872 A GB848872 A GB 848872A GB 1411782 A GB1411782 A GB 1411782A
Authority
GB
United Kingdom
Prior art keywords
alkyl
formula
piperidine derivatives
compounds
cycloalkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB848872A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
John Wyeth and Brother Ltd
Original Assignee
John Wyeth and Brother Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by John Wyeth and Brother Ltd filed Critical John Wyeth and Brother Ltd
Priority to GB848872A priority Critical patent/GB1411782A/en
Publication of GB1411782A publication Critical patent/GB1411782A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56—Nitrogen atoms
    • C07D211/58—Nitrogen atoms attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

1411782 Piperidine derivatives JOHN WYETH & BRO Ltd 22 Feb 1973 [24 Feb 1972] 8488/72 Heading C2C The invention comprises piperidine derivatives of the formula wherein 2 is COR, where R is C 1-6 alkyl, C 3-6 cycloalkyl, C 1-6 alkoxy, di(C 1-6 alkyl)amino, 1- pyrrolidinyl, morpholino or piperidino, R<SP>1</SP> is C 1-6 alkyl or C 3-6 cycloalkyl, R<SP>2</SP> is H, OH, C 1-6 alkyl, C 1-6 alkoxy or C 3-6 cycloalkyl, R<SP>3</SP> is H or C 1-6 alkyl, W is an optionally substituted phenyl radical, and A is C 1-4 alkylene, and the acid addition and quaternary ammonium salts thereof. The compounds are prepared either by acylating the corresponding compounds of the above formula in which Z is H, or by reacting compounds of the formula with compounds of the formula [W]-A-Y or [W]-A-OH, when Y is for example, halogen or tosyl, N-(3-Methyl-4-piperidyl)propionanilide is obtained by the hydrogenolysis of N-(1- benzyl-3-methyl-4-piperidyl) propionanilide. Pharmaceutical compositions, suitable for oral or parenteral administration, contain the above piperidine derivatives or the acid addition or quaternary ammonium salt thereof and pharmaceutically acceptable carriers.
GB848872A 1972-02-24 1972-02-24 Piperidine derivatives Expired GB1411782A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB848872A GB1411782A (en) 1972-02-24 1972-02-24 Piperidine derivatives

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB848872A GB1411782A (en) 1972-02-24 1972-02-24 Piperidine derivatives

Publications (1)

Publication Number Publication Date
GB1411782A true GB1411782A (en) 1975-10-29

Family

ID=9853419

Family Applications (1)

Application Number Title Priority Date Filing Date
GB848872A Expired GB1411782A (en) 1972-02-24 1972-02-24 Piperidine derivatives

Country Status (1)

Country Link
GB (1) GB1411782A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0035374A2 (en) * 1980-03-01 1981-09-09 JOHN WYETH &amp; BROTHER LIMITED Piperidyl - urea, - thiourea and - guanidine derivatives, and intermediates therefor, processes for preparing them and pharmaceutical compositions containing the derivatives
WO2005123679A3 (en) * 2004-06-18 2006-03-02 Neurosearch As Alkyl substituted piperidine derivatives and their use as monoamine neurotransmitter re-uptake inhibitors

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0035374A2 (en) * 1980-03-01 1981-09-09 JOHN WYETH &amp; BROTHER LIMITED Piperidyl - urea, - thiourea and - guanidine derivatives, and intermediates therefor, processes for preparing them and pharmaceutical compositions containing the derivatives
EP0035374A3 (en) * 1980-03-01 1981-11-11 John Wyeth & Brother Limited Piperidyl - urea, - thiourea and - guanidine derivatives, and intermediates therefor, processes for preparing them and pharmaceutical compositions containing the derivatives
WO2005123679A3 (en) * 2004-06-18 2006-03-02 Neurosearch As Alkyl substituted piperidine derivatives and their use as monoamine neurotransmitter re-uptake inhibitors
US7547788B2 (en) 2004-06-18 2009-06-16 Neurosearch A/S Alkyl substituted piperidine derivatives and their use as monoamine neurotransmitter re-uptake inhibitors
US7915419B2 (en) 2004-06-18 2011-03-29 Neurosearch A/S Alkyl substituted piperidine derivatives and their use as monoamine neurotransmitter re-uptake inhibitors

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Legal Events

Date Code Title Description
PS Patent sealed
746 Register noted 'licences of right' (sect. 46/1977)
PCNP Patent ceased through non-payment of renewal fee