GB1261004A - Ketones derived from -1-(2-hydroxyethyl)-piperazine - Google Patents

Ketones derived from -1-(2-hydroxyethyl)-piperazine

Info

Publication number
GB1261004A
GB1261004A GB211070A GB211070A GB1261004A GB 1261004 A GB1261004 A GB 1261004A GB 211070 A GB211070 A GB 211070A GB 211070 A GB211070 A GB 211070A GB 1261004 A GB1261004 A GB 1261004A
Authority
GB
United Kingdom
Prior art keywords
pharmaceutically acceptable
formula
piperazine
ketones
hydroxyethyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB211070A
Inventor
Claude Louis Clement Carron
Bernard Philippe Bucher
Maurice Claude Ernest Carron
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Robert & Carriere Lab
Original Assignee
Robert & Carriere Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Robert & Carriere Lab filed Critical Robert & Carriere Lab
Publication of GB1261004A publication Critical patent/GB1261004A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/10—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms
    • C07D295/104—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/108—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

1,261,004. Hydroxyethylpiperazinylalkyl 4- fluorophenyl ketones. SOC ANON DES LABORATOIRES ROBERT ET CARRIERE. 15 Jan., 1970 [16 Jan., 1969], No. 2110/70. Heading C2C. Novel ketones of the general formula in which n is 2 or 3, and their pharmaceutically acceptable acid addition salts, are obtained by reacting 1-(2-hydroxyethyl)-piperazine with a (4-fluorophenyl) ketone of the formula in which X denotes a halogen, e.g. Cl, Br or I, or a -N(alkyl) 2 radical, and n is 2 or 3 when X is halogen and 2 when X is dialkylamino and optionally forming a pharmaceutically acceptable salt. 4<SP>1</SP>-Fluoro-3-dimethylamino-propiophenone hydrochloride is obtained by reacting together pfluoro-acetophenone, trioxymethylene and dimethylamine hydrochloride. Pharmaceutical compositions having neuroleptic and/or analgesic and antiinflammatory action comprise compounds of Formula (I) or pharmaceutically acceptable acid addition salts thereof in association with a pharmaceutical carrier, preferably in forms suitable for oral, rectal or parenteral administration.
GB211070A 1969-01-16 1970-01-15 Ketones derived from -1-(2-hydroxyethyl)-piperazine Expired GB1261004A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR6900630A FR2028047B1 (en) 1969-01-16 1969-01-16

Publications (1)

Publication Number Publication Date
GB1261004A true GB1261004A (en) 1972-01-19

Family

ID=9027881

Family Applications (1)

Application Number Title Priority Date Filing Date
GB211070A Expired GB1261004A (en) 1969-01-16 1970-01-15 Ketones derived from -1-(2-hydroxyethyl)-piperazine

Country Status (5)

Country Link
BE (1) BE743969A (en)
DE (1) DE2001144A1 (en)
ES (1) ES375495A1 (en)
FR (1) FR2028047B1 (en)
GB (1) GB1261004A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006074192A2 (en) * 2005-01-03 2006-07-13 Bionaut Pharmaceuticals, Inc. Treatment of inflammatory disorders

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2145682C3 (en) * 1971-09-13 1975-09-04 Kali-Chemie Ag, 3000 Hannover 1,4-disubstituted piperazine derivatives and their acid addition compounds
FR2206088A1 (en) * 1972-11-14 1974-06-07 Synthelabo Analgesic piperazino butyrophenone ketals - prepd. by reaction of halo butyrophenone ketal with hydroxy alkyl piperazine

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1481001A (en) * 1959-07-01 1967-05-19 Process for the preparation of phenacyl-piperazine derivatives

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006074192A2 (en) * 2005-01-03 2006-07-13 Bionaut Pharmaceuticals, Inc. Treatment of inflammatory disorders
WO2006074192A3 (en) * 2005-01-03 2007-01-11 Bionaut Pharmaceuticals Inc Treatment of inflammatory disorders

Also Published As

Publication number Publication date
ES375495A1 (en) 1972-05-16
DE2001144A1 (en) 1970-07-23
FR2028047A1 (en) 1970-10-09
BE743969A (en) 1970-05-28
FR2028047B1 (en) 1974-10-11

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