ES8203840A1 - Un procedimiento para la preparacion de nuevos derivados de piperidina - Google Patents

Un procedimiento para la preparacion de nuevos derivados de piperidina

Info

Publication number
ES8203840A1
ES8203840A1 ES499716A ES499716A ES8203840A1 ES 8203840 A1 ES8203840 A1 ES 8203840A1 ES 499716 A ES499716 A ES 499716A ES 499716 A ES499716 A ES 499716A ES 8203840 A1 ES8203840 A1 ES 8203840A1
Authority
ES
Spain
Prior art keywords
derivatives
formula
preparing
processes
pharmaceutical compositions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES499716A
Other languages
English (en)
Other versions
ES499716A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
John Wyeth and Brother Ltd
Original Assignee
John Wyeth and Brother Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by John Wyeth and Brother Ltd filed Critical John Wyeth and Brother Ltd
Publication of ES8203840A1 publication Critical patent/ES8203840A1/es
Publication of ES499716A0 publication Critical patent/ES499716A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56—Nitrogen atoms
    • C07D211/58—Nitrogen atoms attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DE PIPERIDINA Y DE SUS SALES DE ADICION DE ACIDO Y DE AMONIO CUATERNARIAS, DE FORMULA (I), EN LA QUE R1, R2, R3 Y R9 SON HIDROGENO O ALQUILO INFERIOR; X ES = O, = S O = NH; Y ES - O- O UN ENLACE DIRECTO; Z ES -CO- O -CH2-; N VALE 0 O 1; RR Y R PUEDEN SER VARIOS TIPOS DE RADICALES, Y LA LINEA DE TRAZOS REPRESENTA UN ENLACE OPCIONAL. CONSISTE EN LA REACCION DE UN COMPUESTO DE FORMULA (II) CON UN COMPUESTO DE FORMULA ARR12, EN LAS QUE R11 ES HIDROGENO O UN RADICAL DE FORMULA HAL-CHR9-(CHR2)N-, SIENDO HAL UN ATOMO DE HALOGENO, R12 PUEDE SER OH O UN RADICAL DE FORMULA -Y-CHR9-(CHR2)N-W1, SIENDO W1 UN GRUPO PARTIENTE, Y TODOS LOS DEMAS SIMBOLOS TIENEN EL MISMO SIGNIFICADO QUE EN LA FORMULA (I). CUANDO W1 ES OH, LA REACCION SE LLEVA A CABO EN PRESENCIA DE UN CATALIZADOR DE NIQUEL.
ES499716A 1980-03-01 1981-02-23 Un procedimiento para la preparacion de nuevos derivados de piperidina Granted ES499716A0 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB8007048 1980-03-01
GB8027435 1980-08-22

Publications (2)

Publication Number Publication Date
ES8203840A1 true ES8203840A1 (es) 1982-05-01
ES499716A0 ES499716A0 (es) 1982-05-01

Family

ID=26274662

Family Applications (4)

Application Number Title Priority Date Filing Date
ES499716A Granted ES499716A0 (es) 1980-03-01 1981-02-23 Un procedimiento para la preparacion de nuevos derivados de piperidina
ES509163A Expired ES8302656A1 (es) 1980-03-01 1982-01-29 "un procedimiento para la preparacion de nuevos derivados de piperidina"
ES509165A Granted ES509165A0 (es) 1980-03-01 1982-01-29 "un procedimiento para la preparacion de nuevos derivados de piperidina"
ES509164A Granted ES509164A0 (es) 1980-03-01 1982-01-29 "un procedimiento para la preparacion de nuevos derivados de piperidina"

Family Applications After (3)

Application Number Title Priority Date Filing Date
ES509163A Expired ES8302656A1 (es) 1980-03-01 1982-01-29 "un procedimiento para la preparacion de nuevos derivados de piperidina"
ES509165A Granted ES509165A0 (es) 1980-03-01 1982-01-29 "un procedimiento para la preparacion de nuevos derivados de piperidina"
ES509164A Granted ES509164A0 (es) 1980-03-01 1982-01-29 "un procedimiento para la preparacion de nuevos derivados de piperidina"

Country Status (20)

Country Link
US (2) US4426387A (es)
EP (1) EP0035374B1 (es)
KR (4) KR850000630B1 (es)
AU (1) AU542950B2 (es)
CA (1) CA1173037A (es)
DE (1) DE3168564D1 (es)
DK (1) DK164546C (es)
EG (1) EG16004A (es)
ES (4) ES499716A0 (es)
FI (1) FI77231C (es)
GR (1) GR73576B (es)
HU (1) HU187768B (es)
IE (1) IE52014B1 (es)
IL (1) IL62200A (es)
NO (1) NO156864C (es)
NZ (1) NZ196324A (es)
PH (1) PH17019A (es)
PL (4) PL129174B1 (es)
PT (1) PT72562B (es)
YU (4) YU47381A (es)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8528235D0 (en) * 1985-11-15 1985-12-18 Wyeth John & Brother Ltd Heterocyclic compounds
US4508722A (en) * 1981-05-18 1985-04-02 Eli Lilly And Company 1-Benzoyl-3-(arylpyridyl)urea compounds
ATE27152T1 (de) * 1982-04-07 1987-05-15 Ici Plc Chinolin-derivate.
EP0093521B1 (en) * 1982-05-04 1988-08-24 Imperial Chemical Industries Plc Quinoline derivatives
FR2527205A1 (fr) * 1982-05-18 1983-11-25 Bouchara Emile Nouvelles phenyloxoalcoyl piperidines, leurs procedes d'obtention et les compositions pharmaceutiques en renfermant
DE3381799D1 (de) * 1983-09-19 1990-09-13 Bouchara Sa Substituierte, piperidinoguanidine, verfahren zu ihrer herstellung, und diese enthaltende pharmazeutische zusammensetzungen.
US4569933A (en) * 1984-04-13 1986-02-11 Cornu Pierre Jean Antihypertensive substituted derivatives of 2,5-diamino 1,4-diazole
GB8528234D0 (en) * 1985-11-15 1985-12-18 Wyeth John & Brother Ltd Heterocyclic compounds
US5312840A (en) * 1986-07-10 1994-05-17 State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education Substituted guanidines having high binding to the sigma receptor and the use thereof
US5385946A (en) * 1986-07-10 1995-01-31 State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University And The University Of Oregon Method for treating hypertension with disubstituted granidine compounds
US4709094A (en) * 1986-07-10 1987-11-24 State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University And The University Of Oregon Sigma brain receptor ligands and their use
EP0343307A1 (en) * 1988-05-26 1989-11-29 Fabrica Espanola De Productos Quimicos Y Farmaceuticos, S.A. 4-Piperidinealkanamine derivatives
GR1000662B (el) * 1988-07-01 1992-09-25 Janssen Pharmaceutica Nv Μεθοδος παρασκευης cis-ν-(3-μεθοξυ-4-πιπεριδινυλο)βενζαμιδιων.
US5262568A (en) * 1990-03-02 1993-11-16 State Of Oregon Tri- and tetra-substituted guanidines and their use as excitatory amino acid antagonists
DE69133065T2 (de) 1990-03-02 2003-02-27 Oregon State Tri- und tetra-substituierte guanidine und deren verwendung als antagonisten von exzitatorischen aminosäuren
FR2662162B1 (fr) * 1990-05-18 1995-01-20 Adir Nouveaux derives de l'amino piperidine, de l'amino pyrrolidine et de l'amino perhydroazepine, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent.
WO1991018868A1 (en) * 1990-05-25 1991-12-12 STATE OF OREGON, acting by and through the OREGON STATE BOARD OF HIGHER EDUCATION, acting for and onbehalf of the OREGON HEALTH SCIENCES UNIVERSITY Substituted guanidines having high binding to the sigma receptor and the use thereof
US5847006A (en) * 1991-02-08 1998-12-08 Cambridge Neuroscience, Inc. Therapeutic guanidines
US5741661A (en) * 1991-02-08 1998-04-21 Cambridge Neuroscience, Inc. Substituted guanidines and derivatives thereof as modulators of neurotransmitter release and novel methodology for identifying neurotransmitter release blockers
ATE288262T1 (de) * 1991-02-08 2005-02-15 Scion Pharmaceuticals Inc Substituierte guanidine und derivate hiervon als modulatoren der freisetzung von neurotransmittern und neue methode zur identifizierung von inhibitoren der neurotransmitter-freisetzung
FR2690158B1 (fr) * 1992-04-17 1994-07-22 Sanofi Elf Nouveau derive arylpiperidinique, procede pour sa preparation et compositions pharmaceutiques le contenant.
WO1994027591A1 (en) * 1993-05-27 1994-12-08 Cambridge Neuroscience, Inc. Therapeutic substituted guanidines
US5739135A (en) * 1993-09-03 1998-04-14 Bristol-Myers Squibb Company Inhibitors of microsomal triglyceride transfer protein and method
CA2177081A1 (en) * 1993-11-23 1995-06-01 Graham J. Durant Therapeutic substituted guanidines
US7351743B1 (en) 1994-02-03 2008-04-01 Wyeth Therapeutic guanidines
EP0751767A4 (en) 1994-02-03 1997-12-10 Cambridge Neuroscience Inc GUANIDINE FOR THERAPEUTIC USE
US6787569B1 (en) 1994-02-03 2004-09-07 Cambridge Neuroscience, Inc. Therapeutic guanidines
US6143791A (en) * 1994-02-03 2000-11-07 Cambridge Neuroscience, Inc. Therapeutic guanidines
US6025355A (en) 1997-05-19 2000-02-15 Cambridge Neuroscience, Inc. Pharmaceutically active compounds and methods of use
US6242198B1 (en) 1996-07-25 2001-06-05 Cambridge Neuroscience, Inc. Methods of treatment of eye trauma and disorders
US6756389B2 (en) 1996-08-09 2004-06-29 Cambridge Neuroscience, Inc. Pharmaceutically active compounds and methods of use
DE19824470A1 (de) * 1998-05-30 1999-12-02 Boehringer Ingelheim Pharma Neue Neurokininantagonisten, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende pharmazeutische Zusammensetzungen

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3072663A (en) * 1961-09-25 1963-01-08 Warner Lambert Pharmaceutical Polyalkyl substituted-4-guanidopiperidines
US3161637A (en) * 1961-10-10 1964-12-15 Res Lab Dr C Janssen N V 1-(gamma-aroyl-propyl)-4-(nu-arylcarbonyl amino) piperidines and related compounds
US3171838A (en) * 1961-10-10 1965-03-02 Res Lab Dr C Janssen N V Aroylalkyl and hydroxyaralkyl derivatives of 4-(n-arylalkanamido)-piperidines and related compounds
GB1411782A (en) * 1972-02-24 1975-10-29 Wyeth John & Brother Ltd Piperidine derivatives
GB1411783A (en) * 1972-02-24 1975-10-29 Wyeth John & Brother Ltd Piperidine derivatives
US3910930A (en) * 1973-01-04 1975-10-07 Janssen Pharmaceutica Nv 1-{55 1-{8 2-(1,4-Benzodioxan-2-yl)-2-hydroxyethyl{9 -4-piperidyl{56 -2-benzimidazolinones
US4177279A (en) * 1973-10-10 1979-12-04 John Wyeth & Brother Ltd. 1-[(3-Indolyl)-alkyl]-piperidyl ureas and hypotensive compositions
GB1459506A (en) * 1974-02-18 1976-12-22 Wyeth John & Brother Ltd Piperidine derivatives
JPS5152176A (es) * 1974-10-12 1976-05-08 Yoshitomi Pharmaceutical
AU500990B2 (en) * 1975-07-25 1979-06-07 John Wyeth & Brother Limited Piperidine derivatives
JPS6039680B2 (ja) * 1975-12-22 1985-09-06 日本化薬株式会社 ３‐（メチルメルカプト）プロピルアミノブレオマイシンの製造法
JPS5285174A (en) * 1976-01-05 1977-07-15 Yoshitomi Pharmaceut Ind Ltd Novel urea or thiourea derivatives
GB1582239A (en) * 1976-12-11 1981-01-07 Wyeth John & Brother Ltd Piperidin-4-yl ureas and thioureas
GB1561023A (en) * 1977-04-22 1980-02-13 Beecham Group Ltd 2-methoxy - 5 - chloro aniline derivatives
IN148482B (es) * 1977-06-03 1981-03-07 Pfizer
EP0000485A1 (de) * 1977-07-08 1979-02-07 Ciba-Geigy Ag Piperidino-propanole, ihre Herstellung und pharmazeutische Präparate die diese enthalten
US4281132A (en) * 1977-10-29 1981-07-28 John Wyeth & Brother Limited Piperidino ureas and thioureas
GB1586817A (en) * 1977-12-01 1981-03-25 Wyeth John & Brother Ltd Indole derivatives
US4169202A (en) * 1978-06-05 1979-09-25 American Home Products Corporation Process for preparing 4,5-dihydro-4-oxofuran-2-carboxylic acid derivatives
GB2034305B (en) * 1978-10-24 1982-12-22 Wyeth John & Brother Ltd Preparation of piperidine derivatives

Also Published As

Publication number Publication date
PL234317A1 (es) 1982-08-16
YU97483A (en) 1983-10-31
YU47381A (en) 1983-10-31
EG16004A (en) 1986-12-30
KR850002008A (ko) 1985-04-10
NO156864B (no) 1987-08-31
PH17019A (en) 1984-05-11
ES509163A0 (es) 1983-02-01
KR850002009A (ko) 1985-04-10
IL62200A0 (en) 1981-03-31
PL234316A1 (en) 1983-11-07
AU542950B2 (en) 1985-03-28
HU187768B (en) 1986-02-28
KR830005140A (ko) 1983-08-03
PL128409B1 (en) 1984-01-31
IE810392L (en) 1981-09-01
FI77231C (fi) 1989-02-10
EP0035374A2 (en) 1981-09-09
FI810587L (fi) 1981-09-02
NO810610L (no) 1981-09-02
PT72562A (en) 1981-03-01
PT72562B (en) 1982-06-20
KR850000631B1 (ko) 1985-05-06
ES8302658A1 (es) 1983-02-01
DE3168564D1 (en) 1985-03-14
KR850002007A (ko) 1985-05-06
ES8302657A1 (es) 1983-02-01
FI77231B (fi) 1988-10-31
NZ196324A (en) 1983-09-02
CA1173037A (en) 1984-08-21
PL135545B1 (en) 1985-11-30
ES509164A0 (es) 1983-02-01
EP0035374B1 (en) 1985-01-30
PL234318A1 (es) 1982-08-16
AU6761481A (en) 1981-09-10
DK164546C (da) 1992-11-30
ES509165A0 (es) 1983-02-01
PL129174B1 (en) 1984-04-30
KR850000630B1 (ko) 1985-05-06
PL229830A1 (es) 1982-11-22
ES499716A0 (es) 1982-05-01
US4563466A (en) 1986-01-07
GR73576B (es) 1984-03-20
DK87881A (da) 1981-09-02
EP0035374A3 (en) 1981-11-11
IL62200A (en) 1984-09-30
IE52014B1 (en) 1987-05-27
KR850001063B1 (ko) 1985-07-25
US4426387A (en) 1984-01-17
DK164546B (da) 1992-07-13
YU97383A (en) 1983-10-31
ES8302656A1 (es) 1983-02-01
NO156864C (no) 1987-12-09
YU97583A (en) 1983-10-31
KR850001035B1 (ko) 1985-07-19
PL128510B1 (en) 1984-02-29

Similar Documents

Publication Publication Date Title
ES8203840A1 (es) Un procedimiento para la preparacion de nuevos derivados de piperidina
ES482134A1 (es) Un procedimiento para preparar derivados de 1-(3-mercapto- 2-metilpropanoil)-prolil-aminoacido.
DE3363244D1 (en) Compounds, process for their preparation and their use as pharmaceutical preparations
DE3069408D1 (en) 5-oxo- and 5-thioxoproline derivatives, process for their production and pharmaceutical compositions containing them
ES8304096A1 (es) "procedimiento para la preparacion de nuevas piriimidinonas".
ES8203883A1 (es) Un procedimiento para la preparacion de derivados de imida- zol
ES8504706A1 (es) Un procedimiento para la preparacion de un derivado del indol.
ES435458A1 (es) Un procedimiento para la preparacion de sales metalicas de beta-alaninas n, n-disustituidas.
MY100115A (en) Nitrogen containing heterocyclic compounds, and their production and use.
KR850000755B1 (en) Process for preparing 3,1-benzoxazin-2-ones and acid addition salts thereof
ES466366A1 (es) Un procedimiento para preparar derivados de metasulfonamido-benzamida.
CH612431A5 (en) Process for the preparation of novel indole derivatives
DE2965377D1 (en) 6-amino substituted n-pyrrolyl-3-pyridazine amines, their preparation, and pharmaceutically antihypertensive compositions containing them
JPS57134485A (en) Trisubstituted pyrimidopyrimidine
ES8306374A1 (es) "procedimiento para la preparacion de nuevos derivados de acidos 4-fenoxialcarboxilicos sustituidos con radicales haterociclicos".
HUT58270A (en) Process for producing amine derivatives and pharmaceutical compositions containing them
ES8607235A1 (es) "4-(nitrofenil)-tetrahidropiridinas,procedimiento para su obtencion y su empleo como medicamento"
ES464013A1 (es) Procedimiento para preparar derivados sustituidos de orto- fenilendiamina.
ATE30718T1 (de) Herstellung von 1-benzyl azetidin-3-ol und von dem entsprechenden halid acid.
GB888664A (en) Improvements in or relating to acylamidophenol derivatives
ES8801652A1 (es) Un procedimiento para la preparacion de un derivado de tiazolidina.
ES8704459A1 (es) Procedimiento para la obtencion de acemetacina.
GB1109502A (en) Substituted n-benzyl-ethylenediamines
ES435832A1 (es) Un procedimiento para la preparacion de un agente regulador del crecimiento de las plantas.
ES8200661A1 (es) Un procedimiento para la preparacion de nuevos derivados de dihidropiridina

Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20020225