ES8704459A1 - Procedimiento para la obtencion de acemetacina. - Google Patents

Procedimiento para la obtencion de acemetacina.

Info

Publication number
ES8704459A1
ES8704459A1 ES549429A ES549429A ES8704459A1 ES 8704459 A1 ES8704459 A1 ES 8704459A1 ES 549429 A ES549429 A ES 549429A ES 549429 A ES549429 A ES 549429A ES 8704459 A1 ES8704459 A1 ES 8704459A1
Authority
ES
Spain
Prior art keywords
indole derivatives
lower alkyl
formula
different
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES549429A
Other languages
English (en)
Other versions
ES549429A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG filed Critical Bayer AG
Publication of ES549429A0 publication Critical patent/ES549429A0/es
Publication of ES8704459A1 publication Critical patent/ES8704459A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/26—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an acyl radical attached to the ring nitrogen atom
    • C07D209/28—1-(4-Chlorobenzoyl)-2-methyl-indolyl-3-acetic acid, substituted in position 5 by an oxygen or nitrogen atom; Esters thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Rheumatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE ACEMETACINA. COMPRENDE LA REACCION DE SALES DEL ACIDO INDOLCARBOXILICO, DE FORMULA (I), CON UN HALOGENOACETATO DE ALQUILO DE FORMULA (II), EN LAS QUE X REPRESENTA HIDROGENO, AMONIO O FOSFONIO, R6 ES HALOGENO Y R1-R5 PUEDEN SER VARIOS RADICALES, EN UN DISOLVENTE INERTE, EN PRESENCIA DE UNA BASE, A UNA TEMPERATURA COMPRENDIDA ENTRE C30JC Y 110JC; SEGUIDA DEL TRATAMIENTO DEL INDOLDERIVADO ASI OBTENIDO CON UN O-COMPLEJO DE FOSFINA-PALADIO Y DE UN NUCLEOFILO, A UNA TEMPERATURA ENTRE 10 Y 150JC, PARA FORMAR ACEMETACINA. LA ACEMETACINA TIENE APLICACIONES FARMACOLOGICAS PARA EL TRATAMIENTO DE INFLAMACIONES Y REUMATISMO Y COMO ANTIFLOGISTICO.
ES549429A 1984-12-01 1985-11-29 Procedimiento para la obtencion de acemetacina. Expired ES8704459A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19843443993 DE3443993A1 (de) 1984-12-01 1984-12-01 Verfahren zur herstellung von neuen indolderivaten und deren verwendung

Publications (2)

Publication Number Publication Date
ES549429A0 ES549429A0 (es) 1987-04-01
ES8704459A1 true ES8704459A1 (es) 1987-04-01

Family

ID=6251738

Family Applications (1)

Application Number Title Priority Date Filing Date
ES549429A Expired ES8704459A1 (es) 1984-12-01 1985-11-29 Procedimiento para la obtencion de acemetacina.

Country Status (5)

Country Link
US (1) US4658039A (es)
EP (1) EP0184058A3 (es)
JP (1) JPS61134372A (es)
DE (1) DE3443993A1 (es)
ES (1) ES8704459A1 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4788282A (en) * 1985-06-07 1988-11-29 Bristol-Myers Company Deprotection of allylic esters and ethers
MY118354A (en) 1995-05-01 2004-10-30 Scarista Ltd 1,3-propane diol derivatives as bioactive compounds
WO1996034858A1 (en) * 1995-05-01 1996-11-07 Scotia Holdings Plc Nicotinic acid esters and pharmaceutical compositions containing them
USRE40546E1 (en) * 1996-05-01 2008-10-21 Scarista, Ltd. 1,3-Propane diol esters and ethers and methods for their use in drug delivery

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH653326A5 (de) * 1981-12-28 1985-12-31 Siegfried Ag Verfahren zur herstellung eines indolderivates.
DE3206887A1 (de) * 1982-02-26 1983-09-15 Troponwerke GmbH & Co KG, 5000 Köln Verfahren zur herstellung von 1-(4-chlorbenzoyl)-5-methoxy-2-methyl-3-indolacetoxyessigsaeure
JPS59204172A (ja) * 1983-04-28 1984-11-19 Kowa Co アセメタシンの製造法
JPS60112760A (ja) * 1983-11-18 1985-06-19 Green Cross Corp:The インド−ル酢酸誘導体及びその脂肪乳剤

Also Published As

Publication number Publication date
US4658039A (en) 1987-04-14
ES549429A0 (es) 1987-04-01
DE3443993A1 (de) 1986-06-05
JPS61134372A (ja) 1986-06-21
EP0184058A3 (de) 1988-02-24
EP0184058A2 (de) 1986-06-11

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