ATE26263T1 - 1-aryloxy-2,3,4,5-tetrahydro-3-benzazepine, verfahren zur herstellung derselben und ihre verwendung als heilmittel. - Google Patents

1-aryloxy-2,3,4,5-tetrahydro-3-benzazepine, verfahren zur herstellung derselben und ihre verwendung als heilmittel.

Info

Publication number
ATE26263T1
ATE26263T1 AT83105610T AT83105610T ATE26263T1 AT E26263 T1 ATE26263 T1 AT E26263T1 AT 83105610 T AT83105610 T AT 83105610T AT 83105610 T AT83105610 T AT 83105610T AT E26263 T1 ATE26263 T1 AT E26263T1
Authority
AT
Austria
Prior art keywords
sub
hydrogen
lower alkyl
same
tetrahydro
Prior art date
Application number
AT83105610T
Other languages
English (en)
Inventor
Richard Charles Effland
Joseph Thomas Klein
Larry Davis
Original Assignee
Hoechst Roussel Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Roussel Pharma filed Critical Hoechst Roussel Pharma
Application granted granted Critical
Publication of ATE26263T1 publication Critical patent/ATE26263T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
AT83105610T 1982-06-14 1983-06-08 1-aryloxy-2,3,4,5-tetrahydro-3-benzazepine, verfahren zur herstellung derselben und ihre verwendung als heilmittel. ATE26263T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/387,916 US4988690A (en) 1982-06-14 1982-06-14 1-aryloxy-2,3,4,5-tetrahydro-3-benzazepines and anti-depressant use thereof
EP83105610A EP0096838B1 (de) 1982-06-14 1983-06-08 1-Aryloxy-2,3,4,5-tetrahydro-3-benzazepine, Verfahren zur Herstellung derselben und ihre Verwendung als Heilmittel

Publications (1)

Publication Number Publication Date
ATE26263T1 true ATE26263T1 (de) 1987-04-15

Family

ID=23531838

Family Applications (1)

Application Number Title Priority Date Filing Date
AT83105610T ATE26263T1 (de) 1982-06-14 1983-06-08 1-aryloxy-2,3,4,5-tetrahydro-3-benzazepine, verfahren zur herstellung derselben und ihre verwendung als heilmittel.

Country Status (17)

Country Link
US (1) US4988690A (de)
EP (1) EP0096838B1 (de)
JP (1) JPS595165A (de)
KR (1) KR900001214B1 (de)
AT (1) ATE26263T1 (de)
AU (1) AU570920B2 (de)
CA (1) CA1214460A (de)
DE (1) DE3370621D1 (de)
DK (1) DK270983A (de)
ES (1) ES8503666A1 (de)
FI (1) FI78473C (de)
GR (1) GR78291B (de)
HU (1) HU190902B (de)
IE (1) IE55404B1 (de)
IL (1) IL68964A (de)
PT (1) PT76864B (de)
ZA (1) ZA834309B (de)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PH27337A (en) * 1987-03-27 1993-06-08 Schering Corp Substituted benzazepines their preparation and pharmaceutical compositions containing them
US5015639A (en) * 1987-03-27 1991-05-14 Schering Corporation Substituted benzazepines, their preparation and pharmaceutical compositions containing them
ZA885824B (en) * 1987-08-14 1989-04-26 Merrell Dow Pharma Novel antidepressants
US5202319A (en) * 1991-09-23 1993-04-13 Hoechst-Roussel Pharmaceuticals Inc. Substituted 3-amino-2,3,4,5-tetrahydro-1-aryloxy-3-benzazepines
US5639482A (en) * 1993-11-10 1997-06-17 Crary; Ely J. Composition for control and prevention of diabetic retinopathy
US7115766B2 (en) * 2000-11-30 2006-10-03 Indiana University Research & Technology Corp. Nucleophilic approach for preparing radiolabeled imaging agents and associated compounds
US6953787B2 (en) 2002-04-12 2005-10-11 Arena Pharmaceuticals, Inc. 5HT2C receptor modulators
WO2005019179A2 (en) * 2003-06-17 2005-03-03 Arena Pharmaceuticals, Inc. Benzazepine derivatives useful for the treatment of 5ht2c receptor associated diseases
NZ578503A (en) * 2003-06-17 2011-02-25 Arena Pharm Inc Benzazepine derivatives useful for the treatment of 5HT2C receptor associated diseases
WO2005042490A1 (en) * 2003-10-22 2005-05-12 Arena Pharmaceuticals, Inc. Benzazepine derivatives and methods of prophylaxis or treatment of 5ht2c receptor associated diseases
US20080009478A1 (en) * 2003-10-22 2008-01-10 Arena Pharmaceuticals, Inc. Benzazepine Derivatives and Methods of Prophylaxis or Treatment of 5Ht2c Receptor Associated Diseases
WO2006069363A2 (en) 2004-12-21 2006-06-29 Arena Pharmaceuticals, Inc. Crystalline forms of (r)-8-chloro-1-methyl- 2,3,4,5-tetrahydro-1h-3-benzazepine hydrochloride
DK1833473T3 (da) * 2004-12-23 2010-01-11 Arena Pharm Inc 5HT2C-Receptormodulator-sammensætninger og metoder for anvendelse
EP2001852A2 (de) 2006-04-03 2008-12-17 Arena Pharmaceuticals, Inc. Verfahren zur herstellung von 8-chlor-1-methyl-2,3,4,5-tetrahydro-1h-3-benzazepin und entsprechenden zwischenprodukten
EP2099743B1 (de) * 2006-12-05 2014-08-27 Arena Pharmaceuticals, Inc. Verfahren zur herstellung von (r)-8-chlor-1-methyl-2,3,4,5-tetrahydro-1h-3-benzazepin und zwischenprodukten davon
US8987252B2 (en) * 2007-05-10 2015-03-24 Albany Molecular Research, Inc. Aryloxy- and heteroaryloxy-substituted tetrahydrobenzazepines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin
JP5491421B2 (ja) 2008-03-04 2014-05-14 アリーナ ファーマシューティカルズ， インコーポレイテッド ５−ｈｔ２ｃアゴニストである（ｒ）−８−クロロ−１−メチル−２，３，４，５−テトラヒドロ−１ｈ−３−ベンゾアゼピンに関連する中間体の調製のためのプロセス
WO2010148207A2 (en) 2009-06-18 2010-12-23 Arena Pharmaceuticals, Inc. Processes for the preparation of 5-ht2c receptor agonists
WO2011153206A1 (en) 2010-06-02 2011-12-08 Arena Pharmaceuticals, Inc. Processes for the preparation of 5-ht2c receptor agonists
CA2808909A1 (en) 2010-09-01 2012-03-08 Arena Pharmaceuticals, Inc. Salts of lorcaserin with optically active acids
KR20140091458A (ko) 2010-09-01 2014-07-21 아레나 파마슈티칼스, 인크. 신장 손상을 갖는 개체에 대한 로카세린의 투여
CN107669687A (zh) 2010-09-01 2018-02-09 艾尼纳制药公司 用于体重控制的5‑ht2c激动剂的调节释放剂型
CN103189360A (zh) 2010-09-01 2013-07-03 艾尼纳制药公司 5-ht2c激动剂的非吸湿性盐
JP2015534563A (ja) 2012-10-09 2015-12-03 アリーナ ファーマシューティカルズ， インコーポレイテッド 体重管理の方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5233687A (en) * 1975-09-11 1977-03-14 Shionogi & Co Ltd Process for preparation of 1,5-dihydro-2h-1,4-benzodiazepine-2-on deri vatives
JPS5481290A (en) * 1977-11-17 1979-06-28 Smithkline Corp Benzazepin compound

Also Published As

Publication number Publication date
JPS595165A (ja) 1984-01-12
KR900001214B1 (ko) 1990-02-28
FI832092L (fi) 1983-12-15
IL68964A (en) 1988-03-31
KR840005103A (ko) 1984-11-03
FI832092A0 (fi) 1983-06-10
IE831384L (en) 1983-12-14
JPH0365342B2 (de) 1991-10-11
US4988690A (en) 1991-01-29
FI78473C (fi) 1989-08-10
AU570920B2 (en) 1988-03-31
GR78291B (de) 1984-09-26
IL68964A0 (en) 1983-10-31
FI78473B (fi) 1989-04-28
ES523191A0 (es) 1985-03-01
HU190902B (en) 1986-12-28
PT76864A (en) 1983-07-01
AU1576483A (en) 1983-12-22
PT76864B (en) 1986-02-27
IE55404B1 (en) 1990-09-12
DK270983D0 (da) 1983-06-13
ES8503666A1 (es) 1985-03-01
DE3370621D1 (en) 1987-05-07
EP0096838B1 (de) 1987-04-01
ZA834309B (en) 1984-03-28
EP0096838A1 (de) 1983-12-28
CA1214460A (en) 1986-11-25
DK270983A (da) 1983-12-15

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Legal Events

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UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee