ATE26263T1 - 1-aryloxy-2,3,4,5-tetrahydro-3-benzazepine, verfahren zur herstellung derselben und ihre verwendung als heilmittel. - Google Patents

1-aryloxy-2,3,4,5-tetrahydro-3-benzazepine, verfahren zur herstellung derselben und ihre verwendung als heilmittel.

Info

Publication number
ATE26263T1
ATE26263T1 AT83105610T AT83105610T ATE26263T1 AT E26263 T1 ATE26263 T1 AT E26263T1 AT 83105610 T AT83105610 T AT 83105610T AT 83105610 T AT83105610 T AT 83105610T AT E26263 T1 ATE26263 T1 AT E26263T1
Authority
AT
Austria
Prior art keywords
sub
hydrogen
lower alkyl
same
tetrahydro
Prior art date
Application number
AT83105610T
Other languages
English (en)
Inventor
Richard Charles Effland
Joseph Thomas Klein
Larry Davis
Original Assignee
Hoechst Roussel Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Roussel Pharma filed Critical Hoechst Roussel Pharma
Application granted granted Critical
Publication of ATE26263T1 publication Critical patent/ATE26263T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
AT83105610T 1982-06-14 1983-06-08 1-aryloxy-2,3,4,5-tetrahydro-3-benzazepine, verfahren zur herstellung derselben und ihre verwendung als heilmittel. ATE26263T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/387,916 US4988690A (en) 1982-06-14 1982-06-14 1-aryloxy-2,3,4,5-tetrahydro-3-benzazepines and anti-depressant use thereof
EP83105610A EP0096838B1 (de) 1982-06-14 1983-06-08 1-Aryloxy-2,3,4,5-tetrahydro-3-benzazepine, Verfahren zur Herstellung derselben und ihre Verwendung als Heilmittel

Publications (1)

Publication Number Publication Date
ATE26263T1 true ATE26263T1 (de) 1987-04-15

Family

ID=23531838

Family Applications (1)

Application Number Title Priority Date Filing Date
AT83105610T ATE26263T1 (de) 1982-06-14 1983-06-08 1-aryloxy-2,3,4,5-tetrahydro-3-benzazepine, verfahren zur herstellung derselben und ihre verwendung als heilmittel.

Country Status (17)

Country Link
US (1) US4988690A (de)
EP (1) EP0096838B1 (de)
JP (1) JPS595165A (de)
KR (1) KR900001214B1 (de)
AT (1) ATE26263T1 (de)
AU (1) AU570920B2 (de)
CA (1) CA1214460A (de)
DE (1) DE3370621D1 (de)
DK (1) DK270983A (de)
ES (1) ES523191A0 (de)
FI (1) FI78473C (de)
GR (1) GR78291B (de)
HU (1) HU190902B (de)
IE (1) IE55404B1 (de)
IL (1) IL68964A (de)
PT (1) PT76864B (de)
ZA (1) ZA834309B (de)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5015639A (en) * 1987-03-27 1991-05-14 Schering Corporation Substituted benzazepines, their preparation and pharmaceutical compositions containing them
ZA882080B (en) * 1987-03-27 1989-04-26 Schering Corp Substituted benzazepines,their preparation and pharmaceutical compositions containing them
CA1327795C (en) * 1987-08-14 1994-03-15 Jules Freedman Antidepressants which are aryloxy inadanamines
US5202319A (en) * 1991-09-23 1993-04-13 Hoechst-Roussel Pharmaceuticals Inc. Substituted 3-amino-2,3,4,5-tetrahydro-1-aryloxy-3-benzazepines
US5639482A (en) * 1993-11-10 1997-06-17 Crary; Ely J. Composition for control and prevention of diabetic retinopathy
US7115766B2 (en) * 2000-11-30 2006-10-03 Indiana University Research & Technology Corp. Nucleophilic approach for preparing radiolabeled imaging agents and associated compounds
US6953787B2 (en) * 2002-04-12 2005-10-11 Arena Pharmaceuticals, Inc. 5HT2C receptor modulators
EP2332921B1 (de) * 2003-06-17 2016-03-02 Arena Pharmaceuticals, Inc. 8-Chloro-1 -methyl-2,3,4,5-tetrahydro-1 H-3benzazapine Hydrochlorid
CA2888392A1 (en) * 2003-06-17 2005-03-03 Arena Pharmaceuticals, Inc. Processes for preparing 3-benzazepines
US20070275949A1 (en) * 2003-10-22 2007-11-29 Arena Pharmaceuticals, Inc. Benzazepine Derivatives and Methods of Prophylaxis or Treatment of 5Ht2C Receptor Associated Diseases
WO2005042491A1 (en) * 2003-10-22 2005-05-12 Arena Pharmaceuticals, Inc. Benzazepine derivatives and methods of prophylaxis or treatment of 5ht2c receptor associated diseases
EA201200954A1 (ru) 2004-12-21 2013-05-30 Арена Фармасьютикалз, Инк. Способ получения полугидрата гидрохлорида (r)-8-хлор-1-метил-2,3,4,5-тетрагидро-1н-3-бензазепина, фармацевтическая композиция на его основе и его применение
RS50997B (sr) 2004-12-23 2010-10-31 Arena Pharmaceuticals Inc. Kompozicije 5ht2c receptor modulatora i postupci njihove upotrebe
EP2001852A2 (de) 2006-04-03 2008-12-17 Arena Pharmaceuticals, Inc. Verfahren zur herstellung von 8-chlor-1-methyl-2,3,4,5-tetrahydro-1h-3-benzazepin und entsprechenden zwischenprodukten
JP5404414B2 (ja) * 2006-12-05 2014-01-29 アリーナ ファーマシューティカルズ， インコーポレイテッド （ｒ）−８−クロロ−１−メチル−２，３，４，５−テトラヒドロ−１ｈ−３−ベンゾアゼピンおよびその中間体を調製するための方法
BRPI0811200A8 (pt) * 2007-05-10 2015-09-22 Bristol Myers Squibb Co Tetra-hidrobenzapinas arilóxi- e heteroarilóxi-substituídas e uso das mesmas para bloquear percepção de norepinefrina, dopamina, e serotonina
US8822727B2 (en) 2008-03-04 2014-09-02 Arena Pharmaceuticals, Inc. Processes for the preparation of intermediates related to the 5-HT2C agonist (R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine
EP2443080A2 (de) 2009-06-18 2012-04-25 Arena Pharmaceuticals, Inc. Verfahren zur herstellung von 5-ht2c-rezeptoragonisten
US9045431B2 (en) 2010-06-02 2015-06-02 Arena Pharmaceuticals, Inc. Processes for the preparation of 5-HT2C receptor agonists
CN103189053A (zh) 2010-09-01 2013-07-03 艾尼纳制药公司 用于体重控制的5-ht2c激动剂的调节释放剂型
JP2013539470A (ja) 2010-09-01 2013-10-24 アリーナ ファーマシューティカルズ， インコーポレイテッド ロルカセリンと光学活性な酸との塩
SG10201506865WA (en) 2010-09-01 2015-10-29 Arena Pharm Inc Non-hygroscopic salts of 5-ht2c agonists
AU2011296015B2 (en) 2010-09-01 2015-11-12 Arena Pharmaceuticals, Inc. Administration of lorcaserin to individuals with renal impairment
UY34436A (es) 2012-10-09 2014-07-31 Arena Pharm Inc Metodo de control del peso

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5233687A (en) * 1975-09-11 1977-03-14 Shionogi & Co Ltd Process for preparation of 1,5-dihydro-2h-1,4-benzodiazepine-2-on deri vatives
JPS5481290A (en) * 1977-11-17 1979-06-28 Smithkline Corp Benzazepin compound

Also Published As

Publication number Publication date
GR78291B (de) 1984-09-26
PT76864A (en) 1983-07-01
EP0096838A1 (de) 1983-12-28
JPS595165A (ja) 1984-01-12
IL68964A0 (en) 1983-10-31
CA1214460A (en) 1986-11-25
KR900001214B1 (ko) 1990-02-28
ES8503666A1 (es) 1985-03-01
AU570920B2 (en) 1988-03-31
HU190902B (en) 1986-12-28
DE3370621D1 (en) 1987-05-07
KR840005103A (ko) 1984-11-03
ZA834309B (en) 1984-03-28
US4988690A (en) 1991-01-29
IE55404B1 (en) 1990-09-12
IE831384L (en) 1983-12-14
EP0096838B1 (de) 1987-04-01
FI78473B (fi) 1989-04-28
DK270983D0 (da) 1983-06-13
AU1576483A (en) 1983-12-22
JPH0365342B2 (de) 1991-10-11
DK270983A (da) 1983-12-15
ES523191A0 (es) 1985-03-01
IL68964A (en) 1988-03-31
FI832092A0 (fi) 1983-06-10
PT76864B (en) 1986-02-27
FI78473C (fi) 1989-08-10
FI832092L (fi) 1983-12-15

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Legal Events

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UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee