DE3370621D1 - 1-aryloxy-2,3,4,5-tetrahydro-3-benzazepines, a process for preparing the same and their use as medicaments - Google Patents
1-aryloxy-2,3,4,5-tetrahydro-3-benzazepines, a process for preparing the same and their use as medicamentsInfo
- Publication number
- DE3370621D1 DE3370621D1 DE8383105610T DE3370621T DE3370621D1 DE 3370621 D1 DE3370621 D1 DE 3370621D1 DE 8383105610 T DE8383105610 T DE 8383105610T DE 3370621 T DE3370621 T DE 3370621T DE 3370621 D1 DE3370621 D1 DE 3370621D1
- Authority
- DE
- Germany
- Prior art keywords
- sub
- hydrogen
- lower alkyl
- same
- benzazepines
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/16—Benzazepines; Hydrogenated benzazepines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US06/387,916 US4988690A (en) | 1982-06-14 | 1982-06-14 | 1-aryloxy-2,3,4,5-tetrahydro-3-benzazepines and anti-depressant use thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
DE3370621D1 true DE3370621D1 (en) | 1987-05-07 |
Family
ID=23531838
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE8383105610T Expired DE3370621D1 (en) | 1982-06-14 | 1983-06-08 | 1-aryloxy-2,3,4,5-tetrahydro-3-benzazepines, a process for preparing the same and their use as medicaments |
Country Status (17)
Country | Link |
---|---|
US (1) | US4988690A (de) |
EP (1) | EP0096838B1 (de) |
JP (1) | JPS595165A (de) |
KR (1) | KR900001214B1 (de) |
AT (1) | ATE26263T1 (de) |
AU (1) | AU570920B2 (de) |
CA (1) | CA1214460A (de) |
DE (1) | DE3370621D1 (de) |
DK (1) | DK270983A (de) |
ES (1) | ES8503666A1 (de) |
FI (1) | FI78473C (de) |
GR (1) | GR78291B (de) |
HU (1) | HU190902B (de) |
IE (1) | IE55404B1 (de) |
IL (1) | IL68964A (de) |
PT (1) | PT76864B (de) |
ZA (1) | ZA834309B (de) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ZA882080B (en) * | 1987-03-27 | 1989-04-26 | Schering Corp | Substituted benzazepines,their preparation and pharmaceutical compositions containing them |
US5015639A (en) * | 1987-03-27 | 1991-05-14 | Schering Corporation | Substituted benzazepines, their preparation and pharmaceutical compositions containing them |
CA1327795C (en) * | 1987-08-14 | 1994-03-15 | Jules Freedman | Antidepressants which are aryloxy inadanamines |
US5202319A (en) * | 1991-09-23 | 1993-04-13 | Hoechst-Roussel Pharmaceuticals Inc. | Substituted 3-amino-2,3,4,5-tetrahydro-1-aryloxy-3-benzazepines |
US5639482A (en) * | 1993-11-10 | 1997-06-17 | Crary; Ely J. | Composition for control and prevention of diabetic retinopathy |
AU2002228725A1 (en) * | 2000-11-30 | 2002-06-11 | Advanced Research And Technology Institute, Inc. | Nucleophilic approach for preparing radiolabeled imaging agents and associated compounds |
US6953787B2 (en) * | 2002-04-12 | 2005-10-11 | Arena Pharmaceuticals, Inc. | 5HT2C receptor modulators |
EP2189448B1 (de) | 2003-06-17 | 2014-01-29 | Arena Pharmaceuticals, Inc. | Prozesse zur Trennung von 3-Benzazepin-Razematen |
NZ578503A (en) * | 2003-06-17 | 2011-02-25 | Arena Pharm Inc | Benzazepine derivatives useful for the treatment of 5HT2C receptor associated diseases |
US20070275949A1 (en) * | 2003-10-22 | 2007-11-29 | Arena Pharmaceuticals, Inc. | Benzazepine Derivatives and Methods of Prophylaxis or Treatment of 5Ht2C Receptor Associated Diseases |
WO2005042491A1 (en) * | 2003-10-22 | 2005-05-12 | Arena Pharmaceuticals, Inc. | Benzazepine derivatives and methods of prophylaxis or treatment of 5ht2c receptor associated diseases |
EP1838677B1 (de) | 2004-12-21 | 2009-09-09 | Arena Pharmaceuticals, Inc. | Kristalline formen von (r)-8-chlor-1-methyl-2,3,4,5-tetrahydro-1h-3-benzazepinhydrochlorid |
CA2588941A1 (en) * | 2004-12-23 | 2006-07-06 | Arena Pharmaceuticals, Inc. | 5ht2c receptor modulator compositions and methods of use |
CN101466684B (zh) | 2006-04-03 | 2012-06-20 | 艾尼纳制药公司 | 8-氯-1-甲基-2,3,4,5-四氢-1h-3-苯并氮杂卓的制备工艺和其相关中间体 |
CA2670285A1 (en) * | 2006-12-05 | 2008-06-12 | Arena Pharmaceuticals, Inc. | Processes for preparing (r)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1h-3-benzazepine and intermediates thereof |
CN101686982A (zh) | 2007-05-10 | 2010-03-31 | Amr科技公司 | 芳氧基和杂芳氧基取代的四氢苯并氮杂及其阻断去甲肾上腺素、多巴胺和5-羟色胺重摄取的用途 |
CN102015591B (zh) | 2008-03-04 | 2014-01-29 | 艾尼纳制药公司 | 制备与5-ht2c激动剂(r)-8-氯-1-甲基-2,3,4,5-四氢-1h-3-苯并氮杂卓相关的中间体的方法 |
US8952197B2 (en) | 2009-06-18 | 2015-02-10 | Arena Pharmaceuticals, Inc. | Processes for the preparation of 5-HT2C receptor agonists |
WO2011153206A1 (en) | 2010-06-02 | 2011-12-08 | Arena Pharmaceuticals, Inc. | Processes for the preparation of 5-ht2c receptor agonists |
KR20140091458A (ko) | 2010-09-01 | 2014-07-21 | 아레나 파마슈티칼스, 인크. | 신장 손상을 갖는 개체에 대한 로카세린의 투여 |
CN103189359A (zh) | 2010-09-01 | 2013-07-03 | 艾尼纳制药公司 | 5-ht2c激动剂的光学活性酸盐 |
AU2011296003B2 (en) | 2010-09-01 | 2015-11-12 | Arena Pharmaceuticals, Inc. | Modified-release dosage forms of 5-HT2C agonist useful for weight management |
KR20130101524A (ko) | 2010-09-01 | 2013-09-13 | 아레나 파마슈티칼스, 인크. | 5-ht2c 아고니스트의 비-흡습성 염 |
CA2886875A1 (en) | 2012-10-09 | 2014-04-17 | Arena Pharmaceuticals, Inc. | Method of weight management |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5233687A (en) * | 1975-09-11 | 1977-03-14 | Shionogi & Co Ltd | Process for preparation of 1,5-dihydro-2h-1,4-benzodiazepine-2-on deri vatives |
JPS5481290A (en) * | 1977-11-17 | 1979-06-28 | Smithkline Corp | Benzazepin compound |
-
1982
- 1982-06-14 US US06/387,916 patent/US4988690A/en not_active Expired - Fee Related
-
1983
- 1983-06-08 DE DE8383105610T patent/DE3370621D1/de not_active Expired
- 1983-06-08 AT AT83105610T patent/ATE26263T1/de not_active IP Right Cessation
- 1983-06-08 EP EP83105610A patent/EP0096838B1/de not_active Expired
- 1983-06-10 FI FI832092A patent/FI78473C/fi not_active IP Right Cessation
- 1983-06-11 KR KR1019830002597A patent/KR900001214B1/ko active IP Right Grant
- 1983-06-13 CA CA000430280A patent/CA1214460A/en not_active Expired
- 1983-06-13 JP JP58104343A patent/JPS595165A/ja active Granted
- 1983-06-13 ES ES523191A patent/ES8503666A1/es not_active Expired
- 1983-06-13 HU HU832096A patent/HU190902B/hu not_active IP Right Cessation
- 1983-06-13 IE IE1384/83A patent/IE55404B1/en unknown
- 1983-06-13 IL IL68964A patent/IL68964A/xx unknown
- 1983-06-13 GR GR71648A patent/GR78291B/el unknown
- 1983-06-13 DK DK270983A patent/DK270983A/da not_active Application Discontinuation
- 1983-06-13 ZA ZA834309A patent/ZA834309B/xx unknown
- 1983-06-14 AU AU15764/83A patent/AU570920B2/en not_active Ceased
- 1983-06-14 PT PT76864A patent/PT76864B/pt unknown
Also Published As
Publication number | Publication date |
---|---|
PT76864A (en) | 1983-07-01 |
ES523191A0 (es) | 1985-03-01 |
DK270983D0 (da) | 1983-06-13 |
FI78473C (fi) | 1989-08-10 |
ATE26263T1 (de) | 1987-04-15 |
FI832092L (fi) | 1983-12-15 |
HU190902B (en) | 1986-12-28 |
PT76864B (en) | 1986-02-27 |
GR78291B (de) | 1984-09-26 |
DK270983A (da) | 1983-12-15 |
AU570920B2 (en) | 1988-03-31 |
JPS595165A (ja) | 1984-01-12 |
IL68964A (en) | 1988-03-31 |
EP0096838A1 (de) | 1983-12-28 |
ZA834309B (en) | 1984-03-28 |
IE831384L (en) | 1983-12-14 |
FI832092A0 (fi) | 1983-06-10 |
CA1214460A (en) | 1986-11-25 |
FI78473B (fi) | 1989-04-28 |
JPH0365342B2 (de) | 1991-10-11 |
KR900001214B1 (ko) | 1990-02-28 |
US4988690A (en) | 1991-01-29 |
KR840005103A (ko) | 1984-11-03 |
EP0096838B1 (de) | 1987-04-01 |
ES8503666A1 (es) | 1985-03-01 |
IE55404B1 (en) | 1990-09-12 |
AU1576483A (en) | 1983-12-22 |
IL68964A0 (en) | 1983-10-31 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |