DK270983A - 1-aryloxy-2,3,4,5-tetrahydro-3-benzazepiner, en fremgangsmaade til fremstilling deraf og deres anvendelse - Google Patents

1-aryloxy-2,3,4,5-tetrahydro-3-benzazepiner, en fremgangsmaade til fremstilling deraf og deres anvendelse Download PDF

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Publication number
DK270983A
DK270983A DK270983A DK270983A DK270983A DK 270983 A DK270983 A DK 270983A DK 270983 A DK270983 A DK 270983A DK 270983 A DK270983 A DK 270983A DK 270983 A DK270983 A DK 270983A
Authority
DK
Denmark
Prior art keywords
sub
hydrogen
lower alkyl
benzazepines
tetrahydro
Prior art date
Application number
DK270983A
Other languages
Danish (da)
English (en)
Other versions
DK270983D0 (da
Inventor
Richard Charles Effland
Joseph Thomas Klein
Larry Davis
Original Assignee
Hoechst Roussel Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Roussel Pharma filed Critical Hoechst Roussel Pharma
Publication of DK270983D0 publication Critical patent/DK270983D0/da
Publication of DK270983A publication Critical patent/DK270983A/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
DK270983A 1982-06-14 1983-06-13 1-aryloxy-2,3,4,5-tetrahydro-3-benzazepiner, en fremgangsmaade til fremstilling deraf og deres anvendelse DK270983A (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/387,916 US4988690A (en) 1982-06-14 1982-06-14 1-aryloxy-2,3,4,5-tetrahydro-3-benzazepines and anti-depressant use thereof

Publications (2)

Publication Number Publication Date
DK270983D0 DK270983D0 (da) 1983-06-13
DK270983A true DK270983A (da) 1983-12-15

Family

ID=23531838

Family Applications (1)

Application Number Title Priority Date Filing Date
DK270983A DK270983A (da) 1982-06-14 1983-06-13 1-aryloxy-2,3,4,5-tetrahydro-3-benzazepiner, en fremgangsmaade til fremstilling deraf og deres anvendelse

Country Status (17)

Country Link
US (1) US4988690A (de)
EP (1) EP0096838B1 (de)
JP (1) JPS595165A (de)
KR (1) KR900001214B1 (de)
AT (1) ATE26263T1 (de)
AU (1) AU570920B2 (de)
CA (1) CA1214460A (de)
DE (1) DE3370621D1 (de)
DK (1) DK270983A (de)
ES (1) ES8503666A1 (de)
FI (1) FI78473C (de)
GR (1) GR78291B (de)
HU (1) HU190902B (de)
IE (1) IE55404B1 (de)
IL (1) IL68964A (de)
PT (1) PT76864B (de)
ZA (1) ZA834309B (de)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5015639A (en) * 1987-03-27 1991-05-14 Schering Corporation Substituted benzazepines, their preparation and pharmaceutical compositions containing them
ZA882080B (en) * 1987-03-27 1989-04-26 Schering Corp Substituted benzazepines,their preparation and pharmaceutical compositions containing them
CA1327795C (en) * 1987-08-14 1994-03-15 Jules Freedman Antidepressants which are aryloxy inadanamines
US5202319A (en) * 1991-09-23 1993-04-13 Hoechst-Roussel Pharmaceuticals Inc. Substituted 3-amino-2,3,4,5-tetrahydro-1-aryloxy-3-benzazepines
US5639482A (en) * 1993-11-10 1997-06-17 Crary; Ely J. Composition for control and prevention of diabetic retinopathy
WO2002044144A2 (en) * 2000-11-30 2002-06-06 Advanced Research And Technology Institute, Inc. Nucleophilic approach for preparing radiolabeled imaging agents and associated compounds
US6953787B2 (en) 2002-04-12 2005-10-11 Arena Pharmaceuticals, Inc. 5HT2C receptor modulators
AU2004267016B2 (en) * 2003-06-17 2011-11-24 Arena Pharmaceuticals, Inc. Benzazepine derivatives useful for the treatment of 5HT2C receptor associated diseases
US7704993B2 (en) * 2003-06-17 2010-04-27 Arena Pharmaceuticals, Inc. Benzazepine derivatives and methods of prophylaxis or treatment of 5ht2c receptor associated diseases
US20080009478A1 (en) * 2003-10-22 2008-01-10 Arena Pharmaceuticals, Inc. Benzazepine Derivatives and Methods of Prophylaxis or Treatment of 5Ht2c Receptor Associated Diseases
US20070275949A1 (en) * 2003-10-22 2007-11-29 Arena Pharmaceuticals, Inc. Benzazepine Derivatives and Methods of Prophylaxis or Treatment of 5Ht2C Receptor Associated Diseases
PL1838677T3 (pl) 2004-12-21 2010-02-26 Arena Pharm Inc Krystaliczne postacie agonisty chlorowodorku (R)-8-chloro-1-metylo-2,3,4,5-tetrahydro-1H-3-benzazepiny
CN102627607A (zh) 2004-12-23 2012-08-08 艾尼纳制药公司 5HT2c受体调节剂组合物和使用方法
CN101466684B (zh) 2006-04-03 2012-06-20 艾尼纳制药公司 8-氯-1-甲基-2,3,4,5-四氢-1h-3-苯并氮杂卓的制备工艺和其相关中间体
WO2008070111A2 (en) * 2006-12-05 2008-06-12 Arena Pharmaceuticals, Inc. Processes for preparing (r)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1h-3-benzazepine and intermediates thereof
CA2685861A1 (en) * 2007-05-10 2008-11-20 Amr Technology, Inc. Aryloxy-and heteroaryloxy-substituted tetrahydrobenzazepines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin
JP5491421B2 (ja) 2008-03-04 2014-05-14 アリーナ ファーマシューティカルズ， インコーポレイテッド ５−ｈｔ２ｃアゴニストである（ｒ）−８−クロロ−１−メチル−２，３，４，５−テトラヒドロ−１ｈ−３−ベンゾアゼピンに関連する中間体の調製のためのプロセス
EP2443080A2 (de) 2009-06-18 2012-04-25 Arena Pharmaceuticals, Inc. Verfahren zur herstellung von 5-ht2c-rezeptoragonisten
KR20130112848A (ko) 2010-06-02 2013-10-14 아레나 파마슈티칼스, 인크. 5-ｈｔ2ｃ 수용체 아고니스트의 제조 방법
KR20130138770A (ko) 2010-09-01 2013-12-19 아레나 파마슈티칼스, 인크. 광학적으로 활성 산을 갖는 로르카세린의 염
AU2011296003B2 (en) 2010-09-01 2015-11-12 Arena Pharmaceuticals, Inc. Modified-release dosage forms of 5-HT2C agonist useful for weight management
JP2013536859A (ja) 2010-09-01 2013-09-26 アリーナ ファーマシューティカルズ， インコーポレイテッド ５−ｈｔ２ｃアゴニストの非吸湿性塩
SG10201506896RA (en) 2010-09-01 2015-10-29 Arena Pharm Inc Administration of lorcaserin to individuals with renal impairment
KR20190128001A (ko) 2012-10-09 2019-11-13 에자이 알앤드디 매니지먼트 가부시키가이샤 체중 관리 방법

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5233687A (en) * 1975-09-11 1977-03-14 Shionogi & Co Ltd Process for preparation of 1,5-dihydro-2h-1,4-benzodiazepine-2-on deri vatives
JPS5481290A (en) * 1977-11-17 1979-06-28 Smithkline Corp Benzazepin compound

Also Published As

Publication number Publication date
IE831384L (en) 1983-12-14
HU190902B (en) 1986-12-28
EP0096838A1 (de) 1983-12-28
DK270983D0 (da) 1983-06-13
US4988690A (en) 1991-01-29
AU1576483A (en) 1983-12-22
JPH0365342B2 (de) 1991-10-11
IL68964A0 (en) 1983-10-31
FI832092A0 (fi) 1983-06-10
ES523191A0 (es) 1985-03-01
FI78473C (fi) 1989-08-10
KR900001214B1 (ko) 1990-02-28
ZA834309B (en) 1984-03-28
GR78291B (de) 1984-09-26
IL68964A (en) 1988-03-31
FI832092L (fi) 1983-12-15
KR840005103A (ko) 1984-11-03
DE3370621D1 (en) 1987-05-07
FI78473B (fi) 1989-04-28
AU570920B2 (en) 1988-03-31
IE55404B1 (en) 1990-09-12
CA1214460A (en) 1986-11-25
PT76864B (en) 1986-02-27
ES8503666A1 (es) 1985-03-01
EP0096838B1 (de) 1987-04-01
PT76864A (en) 1983-07-01
JPS595165A (ja) 1984-01-12
ATE26263T1 (de) 1987-04-15

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