ATE102482T1 - Verwendung von 1,4-disubstituierten-piperidinyl- verbindungen zur herstellung eines arzneimittels zur behandlung von schlaflosigkeit. - Google Patents
Verwendung von 1,4-disubstituierten-piperidinyl- verbindungen zur herstellung eines arzneimittels zur behandlung von schlaflosigkeit.Info
- Publication number
- ATE102482T1 ATE102482T1 AT88400131T AT88400131T ATE102482T1 AT E102482 T1 ATE102482 T1 AT E102482T1 AT 88400131 T AT88400131 T AT 88400131T AT 88400131 T AT88400131 T AT 88400131T AT E102482 T1 ATE102482 T1 AT E102482T1
- Authority
- AT
- Austria
- Prior art keywords
- insomnia
- treatment
- medication
- manufacture
- piperidinyl compounds
- Prior art date
Links
- -1 1,4-DISUBSTITUTED PIPERIDINYL COMPOUNDS Chemical class 0.000 title abstract 3
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 title abstract 2
- 206010022437 insomnia Diseases 0.000 title abstract 2
- 229940079593 drug Drugs 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F02—COMBUSTION ENGINES; HOT-GAS OR COMBUSTION-PRODUCT ENGINE PLANTS
- F02D—CONTROLLING COMBUSTION ENGINES
- F02D45/00—Electrical control not provided for in groups F02D41/00 - F02D43/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Neurosurgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Anesthesiology (AREA)
- Combustion & Propulsion (AREA)
- Mechanical Engineering (AREA)
- General Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP88400131A EP0325063B1 (de) | 1988-01-21 | 1988-01-21 | Verwendung von 1,4-disubstituierten-Piperidinyl-Verbindungen zur Herstellung eines Arzneimittels zur Behandlung von Schlaflosigkeit |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE102482T1 true ATE102482T1 (de) | 1994-03-15 |
Family
ID=8200343
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT88400131T ATE102482T1 (de) | 1988-01-21 | 1988-01-21 | Verwendung von 1,4-disubstituierten-piperidinyl- verbindungen zur herstellung eines arzneimittels zur behandlung von schlaflosigkeit. |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US4908369A (de) |
| EP (1) | EP0325063B1 (de) |
| JP (1) | JP2852933B2 (de) |
| KR (1) | KR890011596A (de) |
| AT (1) | ATE102482T1 (de) |
| AU (1) | AU610972B2 (de) |
| DE (1) | DE3888340T2 (de) |
| DK (1) | DK26289A (de) |
| IE (1) | IE62992B1 (de) |
| ZA (1) | ZA89389B (de) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1991018602A1 (en) * | 1990-06-01 | 1991-12-12 | Merrell Dow Pharmaceuticals Inc. | (+)-α-(2,3-DIMETHOXYPHENYL)-1-[2-(4-FLUOROPHENYL)ETHYL]-4-PIPERIDINEMETHANOL |
| US6004980A (en) * | 1990-06-01 | 1999-12-21 | Merrell Pharmaceuticals, Inc. | (+)-α-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanol |
| EP0796619A1 (de) * | 1996-03-21 | 1997-09-24 | Merrell Pharmaceuticals Inc. | Verwendung von (+)-alpha-(2,3-dimethoxyphenyl)-1-(2-(4-Fluorophenyl)ethyl)-4-Piperidinmethanol zur Behandlung von Depressionen und bipolaren Erkrankungen |
| US6028083A (en) * | 1997-07-25 | 2000-02-22 | Hoechst Marion Roussel, Inc. | Esters of (+)-α-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl) ethyl]-4-piperidinemethanol |
| US20050261341A1 (en) * | 1998-03-13 | 2005-11-24 | Aventis Pharmaceuticals Inc. | Novel processes for the preparation of (R)-alpha-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanol |
| US6713627B2 (en) * | 1998-03-13 | 2004-03-30 | Aventis Pharmaceuticals Inc. | Processes for the preparation of (R)-α-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanol |
| HRP20010140A2 (en) * | 1998-08-28 | 2002-02-28 | Aventis Pharma Inc | THE USE OF R(+)-<F128M>a<F255D>-(2,3-DIMETHOXYPHENYL)-1-[2-(4-FLUOROPHENYL)ETHYL]-4-PIPERIDINEMETHANOL FOR THE TREATMENT OF SLEEP DISORDERS |
| US6277864B1 (en) * | 1998-08-28 | 2001-08-21 | Aventis Pharmaceuticals Inc. | Use of R- +)-α-(2,3-dimethoxyphenyl-1-[2-(4-fluorophenyl) ethyl]-4-piperidinemethanol for the treatment of sleep disorders |
| US6939879B2 (en) * | 1998-08-28 | 2005-09-06 | Aventis Pharmaceuticals Inc. | Use of R (+)-α-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanol for the treatment of substance induced insomnia |
| US6465490B1 (en) | 1999-07-16 | 2002-10-15 | Aventis Pharmaceuticals Inc. | Sulfuric acid mono-[3({1-[2-(4-fluoro-phenyl)-ethyl]-piperidin-4-yl}-hydroxy-methyl)-2-methoxy-phenyl]ester |
| NZ521576A (en) * | 2000-02-29 | 2005-06-24 | Mitsubishi Pharma Corp | Novel cyclic amide derivatives |
| US20020099076A1 (en) * | 2000-05-25 | 2002-07-25 | Richard Scheyer D. | Use of (+)-a-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl) ethyl]-4-piperidinemethanol or its prodrug in the treatment of symptoms of dementia and dopamine induced psychosis |
| US20050261278A1 (en) * | 2004-05-21 | 2005-11-24 | Weiner David M | Selective serotonin receptor inverse agonists as therapeutics for disease |
| WO2012012542A1 (en) * | 2010-07-20 | 2012-01-26 | Cyrenaic Pharmaceuticals, Inc. | Methods of use of cyclic amide derivatives to treat schizophrenia |
| IL301320B2 (en) | 2014-12-02 | 2024-11-01 | Minerva Neurosciences Inc | Compositions comprising 2-((1-(2(4-fluorophenyl)-2-oxoethyl)piperidin-4-yl)methyl)isoindolin-1-one for treating schizophrenia |
| JP2020525436A (ja) | 2017-06-21 | 2020-08-27 | ミネルバ・ニューロサイエンシズ・インコーポレイテッド | 胃耐性制御放出経口剤形 |
| EP3840835A1 (de) | 2018-08-21 | 2021-06-30 | Minerva Neurosciences, Inc. | Verwendung von roluperidon zur behandlung von negativen symptomen und störungen, zur erhöhung der neuroplastizität und zur förderung der neuroprotektion |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1280421C (en) * | 1985-07-02 | 1991-02-19 | Albert A. Carr | 1,4-disubstituted piperidinyl derivatives |
-
1988
- 1988-01-21 AT AT88400131T patent/ATE102482T1/de active
- 1988-01-21 DE DE3888340T patent/DE3888340T2/de not_active Expired - Fee Related
- 1988-01-21 EP EP88400131A patent/EP0325063B1/de not_active Expired - Lifetime
-
1989
- 1989-01-17 JP JP1006077A patent/JP2852933B2/ja not_active Expired - Lifetime
- 1989-01-17 ZA ZA89389A patent/ZA89389B/xx unknown
- 1989-01-19 US US07/299,913 patent/US4908369A/en not_active Expired - Lifetime
- 1989-01-20 IE IE17789A patent/IE62992B1/en not_active IP Right Cessation
- 1989-01-20 KR KR1019890000598A patent/KR890011596A/ko not_active Ceased
- 1989-01-20 AU AU28686/89A patent/AU610972B2/en not_active Ceased
- 1989-01-20 DK DK026289A patent/DK26289A/da not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| US4908369A (en) | 1990-03-13 |
| EP0325063A1 (de) | 1989-07-26 |
| IE890177L (en) | 1989-07-21 |
| IE62992B1 (en) | 1995-03-08 |
| DK26289D0 (da) | 1989-01-20 |
| JP2852933B2 (ja) | 1999-02-03 |
| KR890011596A (ko) | 1989-08-21 |
| DK26289A (da) | 1989-07-22 |
| JPH01279832A (ja) | 1989-11-10 |
| EP0325063B1 (de) | 1994-03-09 |
| DE3888340T2 (de) | 1994-06-30 |
| AU2868689A (en) | 1989-07-27 |
| ZA89389B (en) | 1989-10-25 |
| DE3888340D1 (de) | 1994-04-14 |
| AU610972B2 (en) | 1991-05-30 |
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