NO913391L - Fremgangsmaate for fremstilling av nye hetrazepinoide syreamider. - Google Patents

Fremgangsmaate for fremstilling av nye hetrazepinoide syreamider.

Info

Publication number
NO913391L
NO913391L NO91913391A NO913391A NO913391L NO 913391 L NO913391 L NO 913391L NO 91913391 A NO91913391 A NO 91913391A NO 913391 A NO913391 A NO 913391A NO 913391 L NO913391 L NO 913391L
Authority
NO
Norway
Prior art keywords
hetrazepinoid
preparation
acidamids
procedure
new
Prior art date
Application number
NO91913391A
Other languages
English (en)
Other versions
NO913391D0 (no
Inventor
Karl-Heinz Weber
Werner Stransky
Ulrike Kuefner-Muehl
Hubert Heuer
Franz Birke
Wolf-Dietrich Bechtel
Original Assignee
Boehringer Ingelheim Kg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Kg filed Critical Boehringer Ingelheim Kg
Publication of NO913391D0 publication Critical patent/NO913391D0/no
Publication of NO913391L publication Critical patent/NO913391L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Pulmonology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Vascular Medicine (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

Det beskrives fremgangsmåte for fremstilling av nye hetrazepinoide syreamider med den generelle formel I. hvor R( R, R, R, R, R' 5 og X er som definert i krav 1.Forbindelsene kan inngå i legemidler med PAF-antagonist-virkning.
NO91913391A 1990-08-30 1991-08-29 Fremgangsmaate for fremstilling av nye hetrazepinoide syreamider. NO913391L (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4027470A DE4027470A1 (de) 1990-08-30 1990-08-30 Neue hetrazepinoide amide

Publications (2)

Publication Number Publication Date
NO913391D0 NO913391D0 (no) 1991-08-29
NO913391L true NO913391L (no) 1992-03-02

Family

ID=6413254

Family Applications (1)

Application Number Title Priority Date Filing Date
NO91913391A NO913391L (no) 1990-08-30 1991-08-29 Fremgangsmaate for fremstilling av nye hetrazepinoide syreamider.

Country Status (17)

Country Link
US (1) US5698552A (no)
EP (1) EP0475204A3 (no)
JP (1) JPH04261181A (no)
KR (1) KR920004394A (no)
AU (1) AU8346291A (no)
CA (1) CA2050268A1 (no)
CS (1) CS265391A3 (no)
DE (1) DE4027470A1 (no)
FI (1) FI914071A (no)
HU (1) HU912821D0 (no)
IE (1) IE913043A1 (no)
IL (1) IL99325A0 (no)
MX (1) MX9100845A (no)
NO (1) NO913391L (no)
PL (1) PL291562A1 (no)
PT (1) PT98816B (no)
ZA (1) ZA916902B (no)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0656004A1 (en) * 1992-08-20 1995-06-07 Cytomed, Inc. Dual functional anti-inflammatory and immunosuppressive agents
US5821924A (en) * 1992-09-04 1998-10-13 Elonex I.P. Holdings, Ltd. Computer peripherals low-power-consumption standby system
US5389952A (en) * 1992-12-02 1995-02-14 Cordata Inc. Low-power-consumption monitor standby system
US5302590A (en) * 1992-12-18 1994-04-12 Hoffmann-La Roche Inc. Compounds useful as dual antagonists of platelet activating factor and leukotriene D4
ATE227727T1 (de) * 1996-09-13 2002-11-15 Mitsubishi Pharma Corp Thienotriazolodiazepinverbindungen und ihre medizinischen anwendungen
AR084070A1 (es) 2010-12-02 2013-04-17 Constellation Pharmaceuticals Inc Inhibidores del bromodominio y usos de los mismos
WO2012075456A1 (en) 2010-12-02 2012-06-07 Constellation Pharmaceuticals Bromodomain inhibitors and uses thereof
US9422292B2 (en) 2011-05-04 2016-08-23 Constellation Pharmaceuticals, Inc. Bromodomain inhibitors and uses thereof
EP2721031B1 (en) 2011-06-17 2016-01-20 Constellation Pharmaceuticals, Inc. Bromodomain inhibitors and uses thereof
TWI602820B (zh) 2012-06-06 2017-10-21 星宿藥物公司 溴域抑制劑及其用途
WO2013184878A1 (en) 2012-06-06 2013-12-12 Constellation Pharmaceuticals, Inc. Benzo [b] isoxazoloazepine bromodomain inhibitors and uses thereof
HUE043441T2 (hu) 2014-06-20 2019-08-28 Constellation Pharmaceuticals Inc 2-((4S)-6-(4-klórfenil)-l-metil-4H-benzo[c]izoxazolo[4,5-e]azepin-4-il)acetamid kristályos formái

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3435973A1 (de) * 1984-10-01 1986-04-10 Boehringer Ingelheim KG, 6507 Ingelheim Diazepine enthaltende pharmazeutische zusammensetzungen mit paf-antagonistischer wirkung
DE3502392A1 (de) * 1985-01-25 1986-07-31 Boehringer Ingelheim KG, 6507 Ingelheim Neue thieno-triazolo-1,4-diazepino-2- carbonsaeureamide, verfahren zu ihrer herstellung und pharmazeutische zusammensetzungen
EP0230942B1 (de) * 1986-01-21 1992-04-29 Boehringer Ingelheim Kg Thieno-1,4-diazepine
PH30676A (en) * 1986-07-22 1997-09-16 Boehringer Ingelhein Kg Hetrazepine compounds which have useful pharmaceutical utility
CA1324863C (en) * 1988-01-30 1993-11-30 Minoru Moriwaki Thienotriazolodiazepine compounds and pharmaceutical uses thereof
FI95708C (fi) * 1988-10-31 1996-03-11 Eisai Co Ltd Analogiamenetelmä 1,4-diatsepiinijohdannaisen ja sen farmaseuttisesti sopivan suolan valmistamiseksi
EP0368175A1 (de) * 1988-11-06 1990-05-16 Boehringer Ingelheim Kg 3S,7S-3-(Morpholinocarbonyl)-5-(2-chlorphenyl)-7,10-dimethyl-3,4-dihydro-2H,7H-cyclopenta[4,5]thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin.
DE3909012A1 (de) * 1989-03-18 1990-09-20 Boehringer Ingelheim Kg Verbessertes verfahren zur herstellung von enantiomerenreinen hetrazepinen
GB8907256D0 (en) * 1989-03-31 1989-05-17 Rech Et D Applic Scient Scras New derivatives of hetrazepine as anti-asthmatic anti-allergic and gastro-intestinal protectors
YU133090A (sh) * 1989-07-12 1993-10-20 Boehringer Ingelheim Kg. Novi heteroazepini s paf-antaganostičnim učinkom in postopek za njihovo pripravo
DE4010528A1 (de) * 1990-04-02 1991-10-17 Boehringer Ingelheim Kg Praeparativ chromatographisches trennverfahren zur herstellung enantiomerenreiner hetrazepine

Also Published As

Publication number Publication date
ZA916902B (en) 1992-04-29
IL99325A0 (en) 1992-07-15
MX9100845A (es) 1992-04-01
NO913391D0 (no) 1991-08-29
HUT62007A (en) 1993-03-29
IE913043A1 (en) 1992-03-11
AU8346291A (en) 1992-03-05
CS265391A3 (en) 1992-03-18
PT98816A (pt) 1992-07-31
KR920004394A (ko) 1992-03-27
CA2050268A1 (en) 1992-03-01
PT98816B (pt) 1999-01-29
JPH04261181A (ja) 1992-09-17
EP0475204A3 (en) 1992-05-13
DE4027470A1 (de) 1992-03-05
FI914071A0 (fi) 1991-08-29
US5698552A (en) 1997-12-16
EP0475204A2 (de) 1992-03-18
PL291562A1 (en) 1992-10-05
HU912821D0 (en) 1993-03-29
FI914071A (fi) 1992-03-01

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