DE69929362D1 - verwendung von 1,4-benzothiazepinen zur Herstellung eines Medikaments ZUR BEHANDLUNG DER VORHOF-FIBRILLATION - Google Patents
verwendung von 1,4-benzothiazepinen zur Herstellung eines Medikaments ZUR BEHANDLUNG DER VORHOF-FIBRILLATIONInfo
- Publication number
- DE69929362D1 DE69929362D1 DE69929362T DE69929362T DE69929362D1 DE 69929362 D1 DE69929362 D1 DE 69929362D1 DE 69929362 T DE69929362 T DE 69929362T DE 69929362 T DE69929362 T DE 69929362T DE 69929362 D1 DE69929362 D1 DE 69929362D1
- Authority
- DE
- Germany
- Prior art keywords
- atrial fibrillation
- group
- treatment
- lower alkoxy
- benzothiazepines
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 206010003658 Atrial Fibrillation Diseases 0.000 title abstract 4
- 239000003814 drug Substances 0.000 title abstract 2
- KYVHGCKMVJDCNV-UHFFFAOYSA-N 1,4-benzothiazepine Chemical class S1C=CN=CC2=CC=CC=C12 KYVHGCKMVJDCNV-UHFFFAOYSA-N 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical group O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Veterinary Medicine (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP37333298 | 1998-12-28 | ||
| JP37333298 | 1998-12-28 | ||
| PCT/JP1999/007359 WO2000038688A1 (fr) | 1998-12-28 | 1999-12-27 | Compositions medicamenteuses utilisees dans le traitement de la fibrillation auriculaire |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69929362D1 true DE69929362D1 (de) | 2006-03-30 |
| DE69929362T2 DE69929362T2 (de) | 2006-09-28 |
Family
ID=18501984
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69929362T Expired - Lifetime DE69929362T2 (de) | 1998-12-28 | 1999-12-27 | verwendung von 1,4-benzothiazepinen zur Herstellung eines Medikaments ZUR BEHANDLUNG DER VORHOF-FIBRILLATION |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US6506745B1 (de) |
| EP (1) | EP1147772B1 (de) |
| AT (1) | ATE314852T1 (de) |
| CA (1) | CA2357038C (de) |
| DE (1) | DE69929362T2 (de) |
| WO (1) | WO2000038688A1 (de) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000038688A1 (fr) | 1998-12-28 | 2000-07-06 | Japan Tobacco Inc. | Compositions medicamenteuses utilisees dans le traitement de la fibrillation auriculaire |
| US8022058B2 (en) | 2000-05-10 | 2011-09-20 | The Trustees Of Columbia University In The City Of New York | Agents for preventing and treating disorders involving modulation of the RyR receptors |
| US6489125B1 (en) * | 2000-05-10 | 2002-12-03 | The Trustees Of Columbia University In The City Of New York | Methods for identifying chemical compounds that inhibit dissociation of FKBP12.6 binding protein from type 2 ryanodine receptor |
| US20060293266A1 (en) * | 2000-05-10 | 2006-12-28 | The Trustees Of Columbia | Phosphodiesterase 4D in the ryanodine receptor complex protects against heart failure |
| US7879840B2 (en) * | 2005-08-25 | 2011-02-01 | The Trustees Of Columbia University In The City Of New York | Agents for preventing and treating disorders involving modulation of the RyR receptors |
| US7393652B2 (en) * | 2000-05-10 | 2008-07-01 | The Trustees Of Columbia University In The City Of New York | Methods for identifying a chemical compound that directly enhances binding of FKBP12.6 to PKA-phosphorylated type 2 ryanodine receptor (RyR2) |
| US7718644B2 (en) * | 2004-01-22 | 2010-05-18 | The Trustees Of Columbia University In The City Of New York | Anti-arrhythmic and heart failure drugs that target the leak in the ryanodine receptor (RyR2) and uses thereof |
| US20040048780A1 (en) * | 2000-05-10 | 2004-03-11 | The Trustees Of Columbia University In The City Of New York | Method for treating and preventing cardiac arrhythmia |
| US20040229781A1 (en) * | 2000-05-10 | 2004-11-18 | Marks Andrew Robert | Compounds and methods for treating and preventing exercise-induced cardiac arrhythmias |
| US7544678B2 (en) * | 2002-11-05 | 2009-06-09 | The Trustees Of Columbia University In The City Of New York | Anti-arrythmic and heart failure drugs that target the leak in the ryanodine receptor (RyR2) |
| WO2004080283A2 (en) | 2003-03-07 | 2004-09-23 | The Trustees Of Columbia University, In The City Of New York | Type 1 ryanodine receptor-based methods |
| US8710045B2 (en) * | 2004-01-22 | 2014-04-29 | The Trustees Of Columbia University In The City Of New York | Agents for preventing and treating disorders involving modulation of the ryanodine receptors |
| US7704990B2 (en) | 2005-08-25 | 2010-04-27 | The Trustees Of Columbia University In The City Of New York | Agents for preventing and treating disorders involving modulation of the RyR receptors |
| EP3176164B1 (de) | 2014-07-30 | 2019-08-21 | Aetas Pharma Co. Ltd. | Optisches isomer von 1,4-benzothiazepin-1-oxidderivat und damit hergestellte pharmazeutische zusammensetzung |
| WO2019117116A1 (ja) | 2017-12-11 | 2019-06-20 | 株式会社アエタスファルマ | １，４－ベンゾチアゼピン－１－オキシド誘導体の光学異性体を含む腎機能障害の改善薬 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8707121D0 (en) * | 1987-03-25 | 1987-04-29 | Pfizer Ltd | Antiarrhythmic agents |
| JPH0749807B2 (ja) | 1987-05-15 | 1995-05-31 | 清隆 滝本 | 埋込式固形潤滑剤 |
| US5082847A (en) * | 1990-07-18 | 1992-01-21 | Syntex (U.S.A.) Inc. | Carbostyril compounds connected via an oxyalkyl group with a piperidine ring and having pharmaceutical utility |
| JP2703408B2 (ja) * | 1990-12-28 | 1998-01-26 | 麒麟麦酒株式会社 | １，４‐ベンゾチアゼピン誘導体 |
| JPH0565721A (ja) | 1991-09-05 | 1993-03-19 | Iseki & Co Ltd | 操作レバーの制御パターン切替装置 |
| WO2000038688A1 (fr) | 1998-12-28 | 2000-07-06 | Japan Tobacco Inc. | Compositions medicamenteuses utilisees dans le traitement de la fibrillation auriculaire |
-
1999
- 1999-12-27 WO PCT/JP1999/007359 patent/WO2000038688A1/ja active IP Right Grant
- 1999-12-27 DE DE69929362T patent/DE69929362T2/de not_active Expired - Lifetime
- 1999-12-27 CA CA002357038A patent/CA2357038C/en not_active Expired - Fee Related
- 1999-12-27 AT AT99961438T patent/ATE314852T1/de active
- 1999-12-27 US US09/869,428 patent/US6506745B1/en not_active Expired - Fee Related
- 1999-12-27 EP EP99961438A patent/EP1147772B1/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| EP1147772A4 (de) | 2002-07-10 |
| ATE314852T1 (de) | 2006-02-15 |
| DE69929362T2 (de) | 2006-09-28 |
| CA2357038C (en) | 2008-10-21 |
| WO2000038688A1 (fr) | 2000-07-06 |
| US6506745B1 (en) | 2003-01-14 |
| EP1147772A1 (de) | 2001-10-24 |
| CA2357038A1 (en) | 2000-07-06 |
| EP1147772B1 (de) | 2006-01-04 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE69929362D1 (de) | verwendung von 1,4-benzothiazepinen zur Herstellung eines Medikaments ZUR BEHANDLUNG DER VORHOF-FIBRILLATION | |
| DE60119894D1 (de) | Piperidinverbindungen und diese enthaltenden medikamente | |
| FI894566A (fi) | Substituerade benzazepiner, deras framstaellning och dessa innehaollande farmaceutiska blandningar. | |
| RS20060146A (en) | Malonamide derivatives blocking the activity of gama-secretase | |
| EP1092435A4 (de) | Antidiabetische medikamente | |
| ATE268752T1 (de) | Aralkyl-1,2-diaminen mit calcimimetischer wirkung und verfahren zu ihrer herstellung | |
| DE69326395T2 (de) | Spirooxathiolan-quinuclidin-Derivat zur Behandlung des Sjögren-Syndroms | |
| ATE102482T1 (de) | Verwendung von 1,4-disubstituierten-piperidinyl- verbindungen zur herstellung eines arzneimittels zur behandlung von schlaflosigkeit. | |
| DE69400723T2 (de) | Verwendung von Pyridoxal-Derivaten zur Herstellung eines Arzneimittels zur Behandlung des Katarakts | |
| DE69426855T2 (de) | Verwendung von 2-phenyl-3-aroylbenzothiophen Derivaten zur Herstellung eines Medikaments zur Hemmung des Knorpelabbaus | |
| DE69707372T2 (de) | Verwendung eines Phosphorsäurediesters zur Herstellung eines Arzneimittels zur Behandlung von Akne | |
| DE59607208D1 (de) | Verwendung eines Natrium- oder Lysiniumsalzes von Crotonsäureamidderivaten zur Herstellung eines Arzneimittels zur Behandlung von Krebserkrankungen | |
| DE60216239T8 (de) | Verwendung von Cyclohexenon-Derivaten zur Herstellung eines Arzneimittels zur Behandlung von Dysurie | |
| DE69518706T2 (de) | Verwendung von Diphenylethanderivaten zur Herstellung eines Arzneimittels zur Behandlung von Glaukom | |
| DE69828197D1 (de) | Amidderivate zur behandlung neurodegenerativer erkrankungen der netzhaut | |
| DE602004019778D1 (de) | Verwendung von 2-amino-1,3-propandiolderivaten zur herstellung eines medikaments zur behandlung von bestimmten schmerzen | |
| DE60123528D1 (de) | Verwendung eines Mittels zur Verbesserung der Astrozytenfunktion zur Behandlung von Parkinsons Krankheit | |
| DE69924741D1 (de) | Verwendung einer zusammensetzung zur herstellung eines arzneimittels zur vorbeugung und behandlung von parodontitis | |
| FI952203A (fi) | Sykloheksaanijohdannaiset, menetelmä niiden valmistamiseksi ja yhdisteiden käyttö sairauksien hoitamiseksi | |
| DE3587252T2 (de) | Keten-s,s,-acetalderivate, verfahren zu ihrer herstellung und methode zur heilung von mykose unter verwendung dieser derivate. | |
| ATE265854T1 (de) | Azasteroidverbindung zur behandlung oder vorbeugung von prostatakrebs | |
| ATE130003T1 (de) | Benzopyranderivate und verfahren zu deren herstellung. | |
| DE69208502D1 (de) | Alphamethylen-5-Thiazoloessigsäurederivate, Zwischenprodukte und Verfahren zur Herstellung, ihre Anwendung als Fongizide und diese enthaltende Zusammensetzungen | |
| DE69532963D1 (de) | Verwendung von 4-acylaminopyridin derivaten zur Herstellung eines Medikaments für die Behandlung von zerebrovaskulären Erkrankungen | |
| DE69424677D1 (de) | Präparat zur behandlung der drogenabhängigkeit |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition |