ES8207156A1 - Procedimiento para la preparacion de nuevas pirimidinonas . - Google Patents

Procedimiento para la preparacion de nuevas pirimidinonas .

Info

Publication number
ES8207156A1
ES8207156A1 ES507761A ES507761A ES8207156A1 ES 8207156 A1 ES8207156 A1 ES 8207156A1 ES 507761 A ES507761 A ES 507761A ES 507761 A ES507761 A ES 507761A ES 8207156 A1 ES8207156 A1 ES 8207156A1
Authority
ES
Spain
Prior art keywords
carbon atoms
hydrogen
alkoxy
alkylene
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES507761A
Other languages
English (en)
Other versions
ES507761A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Pharma GmbH and Co KG
Original Assignee
Dr Karl Thomae GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19803046871 external-priority patent/DE3046871A1/de
Priority claimed from DE19813115447 external-priority patent/DE3115447A1/de
Application filed by Dr Karl Thomae GmbH filed Critical Dr Karl Thomae GmbH
Publication of ES507761A0 publication Critical patent/ES507761A0/es
Publication of ES8207156A1 publication Critical patent/ES8207156A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C07D213/82—Amides; Imides in position 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/88—Oxygen atoms
    • C07D239/91—Oxygen atoms with aryl or aralkyl radicals attached in position 2 or 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
    • C07D265/12—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
    • C07D265/14—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D265/20—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with hetero atoms directly attached in position 4
    • C07D265/22—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

PROCEDIMIENTO DE OBTENCION DE PIRIMIDINONAS. CONSISTE EN HACER REACCIONAR UN DERIVADO PROPOXIGENILICO CON UNA AMINA A UNA T UN COMPUESTO DE FORMULA GENERAL (I),EMPERATURA COMPRENDIDA ENTRE 50 Y 200 GRADOS CENTIGRADOS Y EN PRESENCIA DE UN AGENTE FIJADOR DE ACIDOS. SE OBTIENE EL COMPUESTO DE FORMULA GENERAL (I) QUE OPCIONALMENTE SE TRANSFORMA EN UNA SAL POR ADICION DE ACIDOS. A Y B, CONJUNTAMENTE CON LOS DOS ATOMOS DE CARBONOS SITUADOS ENTRE ELLOS, SIGNIFICAN UN ANILLO PIRIDINA O UN ANILLO FENILO QUE PUEDE ESTAR SUSTITUIDO.
ES507761A 1980-12-12 1981-12-07 Procedimiento para la preparacion de nuevas pirimidinonas . Expired ES8207156A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19803046871 DE3046871A1 (de) 1980-12-12 1980-12-12 Neue chinazolinone, ihre herstellung und ihre verwendung als arzneimittel
DE19813115447 DE3115447A1 (de) 1981-04-16 1981-04-16 Neue pyrimidinone, ihre herstellung und ihre verwendung als arzneimittel

Publications (2)

Publication Number Publication Date
ES507761A0 ES507761A0 (es) 1982-09-01
ES8207156A1 true ES8207156A1 (es) 1982-09-01

Family

ID=25789685

Family Applications (2)

Application Number Title Priority Date Filing Date
ES507761A Expired ES8207156A1 (es) 1980-12-12 1981-12-07 Procedimiento para la preparacion de nuevas pirimidinonas .
ES82511835A Expired ES8304096A1 (es) 1980-12-12 1982-04-30 "procedimiento para la preparacion de nuevas piriimidinonas".

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES82511835A Expired ES8304096A1 (es) 1980-12-12 1982-04-30 "procedimiento para la preparacion de nuevas piriimidinonas".

Country Status (22)

Country Link
US (1) US4379788A (es)
EP (1) EP0054132B1 (es)
AR (1) AR227567A1 (es)
AU (1) AU543568B2 (es)
CA (1) CA1217767A (es)
CS (1) CS227024B2 (es)
DD (1) DD208151A5 (es)
DE (1) DE3166627D1 (es)
DK (1) DK525481A (es)
ES (2) ES8207156A1 (es)
FI (1) FI813971L (es)
GB (1) GB2090249B (es)
GR (1) GR76952B (es)
HU (1) HU187384B (es)
IL (1) IL64504A (es)
MY (1) MY8700562A (es)
NO (1) NO814239L (es)
NZ (1) NZ199254A (es)
PH (1) PH18930A (es)
PL (1) PL135330B1 (es)
PT (1) PT74116B (es)
SU (1) SU1056900A3 (es)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4460589A (en) * 1980-10-03 1984-07-17 The Upjohn Company Process for treating hypertension
US4379778A (en) * 1980-10-10 1983-04-12 Air Products And Chemicals, Inc. Hydrogen peroxide synthesis
DE3428476A1 (de) * 1984-08-02 1986-02-13 Basf Ag, 6700 Ludwigshafen 4h-pyrido(2,3-d)(1,3)oxazin-4-on-derivate, verfahren zu ihrer herstellung und ihre verwendung zur bekaempfung unerwuenschten pflanzenwuchses
DE3631294A1 (de) * 1986-09-13 1988-03-24 Thomae Gmbh Dr K Neue synergistische kombination bestehend aus einem phosphodiesterase-hemmer und einem thromboxan-a(pfeil abwaerts)2(pfeil abwaerts)-antagonisten und deren verwendung bzw. herstellung
US5037980A (en) * 1988-04-18 1991-08-06 American Cyanamid Company Phenyl imidazo[1,2-a]pyrimidines
GB8928346D0 (en) * 1989-12-15 1990-02-21 Smith Kline French Lab Chemical compounds
GB9126260D0 (en) * 1991-12-11 1992-02-12 Pfizer Ltd Therapeutic agents
GB9404485D0 (en) 1994-03-09 1994-04-20 Cancer Res Campaign Tech Benzamide analogues
EP2295436A1 (de) * 1997-11-12 2011-03-16 Bayer Schering Pharma AG 2-Phenyl-substituierte Imidazotriazinone als Phosphodiesterase V Inhibitoren
WO2000029389A1 (fr) * 1998-11-18 2000-05-25 Elena Alexandrovna Izaxon 6-(3-carboxymethylphenyl)-amino-uracyle ayant une action biologique
US20040102324A1 (en) 2002-02-28 2004-05-27 Annis Gary David Heterocyclic diamide invertebrate pest control agents
US6642244B2 (en) 2001-03-16 2003-11-04 Bristol-Myers Squibb Co. Pyrazolopyridopyrimidine inhibitors of cGMP phosphodiesterase
CN1518447A (zh) * 2001-04-23 2004-08-04 �������Ǵ�ѧר������� 作为抗血管生成剂的新的苯邻二甲酰亚胺模拟物的合成和评估
PL363679A1 (en) * 2001-05-09 2004-11-29 Bayer Healthcare Ag Novel use of 2-phenyl-substituted imidazotriazinones
DE10232113A1 (de) 2002-07-16 2004-01-29 Bayer Ag Vardenafil Hydrochlorid Trihydrat enthaltende Arzneimittel
WO2005065183A2 (en) * 2003-12-19 2005-07-21 Merck & Co., Inc. Mitotic kinesin inhibitors
SE0401342D0 (sv) * 2004-05-25 2004-05-25 Astrazeneca Ab Therapeutic compounds
SE0401345D0 (sv) * 2004-05-25 2004-05-25 Astrazeneca Ab Therapeutic compounds: Pyridine as scaffold
EP1757594A4 (en) * 2004-05-31 2007-12-12 Banyu Pharma Co Ltd quinazoline derivative
DE102005001989A1 (de) * 2005-01-15 2006-07-20 Bayer Healthcare Ag Intravenöse Formulierungen von PDE-Inhibitoren
DE102005009241A1 (de) * 2005-03-01 2006-09-07 Bayer Healthcare Ag Arzneiformen mit kontrollierter Bioverfügbarkeit
DE102005009240A1 (de) * 2005-03-01 2006-09-07 Bayer Healthcare Ag Arzneiformen mit verbesserten pharmakokinetischen Eigenschaften
EP1931797A2 (en) * 2005-09-29 2008-06-18 Bayer HealthCare AG Pde inhibitors and combinations thereof for the treatment of urological disorders
AU2007303846B2 (en) * 2006-10-04 2011-03-10 Pfizer Products Inc. Pyrido[4,3-d]pyrimidin-4(3H)-one derivatives as calcium receptor antagonists
KR20100029762A (ko) * 2007-06-13 2010-03-17 바이엘 쉐링 파마 악티엔게젤샤프트 청력 장애 치료용 ｐｄｅ 억제제
CN101531638B (zh) * 2008-03-13 2011-12-28 中国科学院广州生物医药与健康研究院 用作雌激素相关受体调节剂的化合物及其应用
CN102098918A (zh) * 2008-05-13 2011-06-15 帕纳德制药公司 用于治疗癌症和神经退行性疾病的生物活性化合物
CN101628913B (zh) 2008-07-18 2013-01-23 中国科学院广州生物医药与健康研究院 用作雌激素相关受体调节剂的化合物及其应用
WO2014048532A1 (en) * 2012-09-26 2014-04-03 Merck Patent Gmbh Quinazolinone derivatives as parp inhibitors

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3265697A (en) * 1964-09-04 1966-08-09 Shulton Inc 2-p-dialkylaminoalkoxyphenyl-2, 3-dihydro-4 (1h)-quinazolinones and their derivatives
DE1939109A1 (de) * 1968-08-31 1970-03-05 Troponwerke Dinklage & Co 2-Methyl-3-[2-(2-diaethylaminoaethoxy)-phenyl]-chinazolinon-(4) und Verfahren zu seiner Herstellung
US3862191A (en) * 1972-09-27 1975-01-21 Pfizer Pyrido{8 2,3-d{9 pyrimidin-4(3H)-one

Also Published As

Publication number Publication date
DK525481A (da) 1982-06-13
CA1217767A (en) 1987-02-10
ES511835A0 (es) 1983-02-16
GB2090249A (en) 1982-07-07
PT74116A (de) 1982-01-01
DE3166627D1 (en) 1984-11-15
NO814239L (no) 1982-06-14
NZ199254A (en) 1985-02-28
GB2090249B (en) 1984-08-22
CS227024B2 (en) 1984-04-16
MY8700562A (en) 1987-12-31
PT74116B (de) 1983-12-19
ES8304096A1 (es) 1983-02-16
FI813971L (fi) 1982-06-13
IL64504A (en) 1985-02-28
PH18930A (en) 1985-11-11
AU7847381A (en) 1982-06-17
EP0054132B1 (de) 1984-10-10
IL64504A0 (en) 1982-03-31
PL135330B1 (en) 1985-10-31
HU187384B (en) 1985-12-28
ES507761A0 (es) 1982-09-01
GR76952B (es) 1984-09-04
PL234175A1 (es) 1982-08-16
SU1056900A3 (ru) 1983-11-23
AR227567A1 (es) 1982-11-15
AU543568B2 (en) 1985-04-26
DD208151A5 (de) 1984-03-28
US4379788A (en) 1983-04-12
EP0054132A1 (de) 1982-06-23

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