ES8701156A1 - Un procedimiento para producir un derivado de 2-(3,5-dial- quil-4-hidroxifenil)indol - Google Patents

Un procedimiento para producir un derivado de 2-(3,5-dial- quil-4-hidroxifenil)indol

Info

Publication number
ES8701156A1
ES8701156A1 ES546602A ES546602A ES8701156A1 ES 8701156 A1 ES8701156 A1 ES 8701156A1 ES 546602 A ES546602 A ES 546602A ES 546602 A ES546602 A ES 546602A ES 8701156 A1 ES8701156 A1 ES 8701156A1
Authority
ES
Spain
Prior art keywords
group
lower alkyl
alkyl group
hydrogen atom
carbon atoms
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES546602A
Other languages
English (en)
Other versions
ES546602A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aska Pharmaceutical Co Ltd
Original Assignee
Teikoku Hormone Manufacturing Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teikoku Hormone Manufacturing Co Ltd filed Critical Teikoku Hormone Manufacturing Co Ltd
Publication of ES546602A0 publication Critical patent/ES546602A0/es
Publication of ES8701156A1 publication Critical patent/ES8701156A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12—Radicals substituted by oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

PROCEDIMIENTO PARA PRODUCIR DERIVADOS DE 2-(2,5-DIALQUIL-4-HIDROXI-FENIL) INDOL, REPRESENTADOS POR LA FORMULA (I) Y SUS SALES Y UTILIZACION TERAPEUTICA DE TODOS ELLOS. LOS DERIVADOS PUEDEN OBTENERSE DE ACUERDO CON EL METODO DE SINTESIS DE INDOLES DE FISCHER, PARTIENDO DE DERIVADOS DE FENILHIDRAZINA, EN UN DISOLVENTE ADECUADO (ALCOHOLES, ETERES O MEZCLA DE AL MENOS DOS DE ESTOS), A TEMPERATURA COMPRENDIDA ENTRE LA AMBIENTE Y LA DE REFLUJO DE LA MEZCLA DE REACCION. LA REACCION EN ESTAS CONDICIONES, TARDA EN EFECTUARSE DE UNOS MINUTOS A 5 HORAS. LOS COMPUESTOS REPRESENTADOS POR LA FORMULA (I) SON INHIBIDORES ESPECIFICOS DE LA LIPOXIGENASA.
ES546602A 1984-08-31 1985-08-30 Un procedimiento para producir un derivado de 2-(3,5-dial- quil-4-hidroxifenil)indol Expired ES8701156A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP59180656A JPS6160648A (ja) 1984-08-31 1984-08-31 ２−（３，５−ジアルキル−４−ヒドロキシフエニル）インド−ル誘導体

Publications (2)

Publication Number Publication Date
ES546602A0 ES546602A0 (es) 1986-11-16
ES8701156A1 true ES8701156A1 (es) 1986-11-16

Family

ID=16087012

Family Applications (1)

Application Number Title Priority Date Filing Date
ES546602A Expired ES8701156A1 (es) 1984-08-31 1985-08-30 Un procedimiento para producir un derivado de 2-(3,5-dial- quil-4-hidroxifenil)indol

Country Status (11)

Country Link
US (1) US4695581A (es)
EP (1) EP0173279B1 (es)
JP (1) JPS6160648A (es)
KR (1) KR900006428B1 (es)
AT (1) ATE45730T1 (es)
AU (1) AU575197B2 (es)
CA (1) CA1247626A (es)
DE (1) DE3572480D1 (es)
ES (1) ES8701156A1 (es)
IN (1) IN162048B (es)
NZ (1) NZ213222A (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5428052A (en) * 1984-09-19 1995-06-27 Centre Internationale De Recherches Dermatologiques (C.I.R.D.) Aromatic heterocyclic derivatives and their therapeutic and cosmetic use
US4868183A (en) * 1986-07-21 1989-09-19 Otsuka Pharmaceutical Factory, Inc. N-pyrazinyl substituted P-aminophenols
US4906563A (en) * 1987-12-28 1990-03-06 Idetek, Inc. Detection of skatole for meat quality
US4910216A (en) * 1988-02-25 1990-03-20 Teikoku Hormone Mfg. Co., Ltd. 2-(3,5-dimethyl-4-hydroxyphenyl)indole derivatives
JPH0764841B2 (ja) * 1990-10-03 1995-07-12 ファイザー製薬株式会社 インドール誘導体およびその用途
ITTO20040125A1 (it) * 2004-03-01 2004-06-01 Rotta Research Lab Nuove amidine eterocicliche inibitrici la produzione di ossido d'azoto (no) ad attivita' antinfiammatoria ed analgesica
WO2007054446A1 (en) * 2005-11-09 2007-05-18 Ciba Holding Inc. Photolatent systems
CN101801965B (zh) * 2007-08-17 2014-07-30 株式会社Lg生命科学 作为细胞坏死抑制剂的吲哚化合物
US20100291533A1 (en) * 2008-01-04 2010-11-18 Soon Ha Kim Indole and indazole derivatives having a cell-, tissue- and organ-preserving effect
WO2019046467A1 (en) 2017-08-29 2019-03-07 Rutgers, The State University Of New Jersey INDAZOLES THERAPEUTIC
US11660677B2 (en) * 2018-05-30 2023-05-30 Amera-Seiki Direct, Llc Tooling assemblies for lathe machines, CNC threading lathes, and methods of milling threads in tubular workpieces

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4024155A (en) * 1974-06-05 1977-05-17 Labaz 2-(3'-Methoxy-4'-hydroxy-phenol)-indole
US4543360A (en) * 1981-09-10 1985-09-24 Degussa Aktiengesellschaft 2-(Hydroxy-phenyl)-indoles and process for their production
JPS58162573A (ja) * 1982-03-19 1983-09-27 Teikoku Hormone Mfg Co Ltd １−置換−２−フエニルインド−ル誘導体
JPS60130567A (ja) * 1983-12-19 1985-07-12 Teikoku Hormone Mfg Co Ltd ３−置換−２−フエニルインド−ル誘導体

Also Published As

Publication number Publication date
JPS6160648A (ja) 1986-03-28
KR900006428B1 (ko) 1990-08-31
ATE45730T1 (de) 1989-09-15
CA1247626A (en) 1988-12-28
AU575197B2 (en) 1988-07-21
EP0173279A1 (en) 1986-03-05
DE3572480D1 (de) 1989-09-28
IN162048B (es) 1988-03-19
JPH0466232B2 (es) 1992-10-22
US4695581A (en) 1987-09-22
AU4682985A (en) 1986-03-06
EP0173279B1 (en) 1989-08-23
NZ213222A (en) 1989-03-29
KR870002069A (ko) 1987-03-28
ES546602A0 (es) 1986-11-16

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19971001