ES8104247A1 - Procedimiento para la preparacion de 3-alcoxi-6-alquiliden- hidracionopiridacina - Google Patents
Procedimiento para la preparacion de 3-alcoxi-6-alquiliden- hidracionopiridacinaInfo
- Publication number
- ES8104247A1 ES8104247A1 ES490620A ES490620A ES8104247A1 ES 8104247 A1 ES8104247 A1 ES 8104247A1 ES 490620 A ES490620 A ES 490620A ES 490620 A ES490620 A ES 490620A ES 8104247 A1 ES8104247 A1 ES 8104247A1
- Authority
- ES
- Spain
- Prior art keywords
- isopropylidenehydrazino
- pyridazines
- prop
- oxy
- hydroxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D237/22—Nitrogen and oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
PROCEDIMIENTO PARA LA PREPARACION DE 3-ALCOXI-6-ALQUILINDENHIDRACIONOPIRIDACINA, DE FORMULA GENERAL (I), Y LAS SALES ATOXICAS CORRESPONDIENTES, ACEPTABLES FARMACETICAMENTE, DONDE R1, R Y R2 SON DISTINTOS TIPOS DE RADICALES. SE OBTIENE HACIENDO REACCIONAR 3,6-DICLOROPIRIDACINA CON ISOPROPILENGLICEROL EN PRESENCIA DE UNA BASE FUERTE Y A UNA TEMPERATURA COMPRENDIDA ENTRE 30 Y 80GC EN MEDIO DE UN DISOLVENTE APROTICO APOLAR. EL COMPUESTO QUE SE OBTIENE SE TRATA CON HIDRACINA Y CON UN DERIVADO CARBOXILICO, EN UN DISOLVENTE APROTICO Y A UNA TEMPERATURA DE 60-90GC. POSTERIORMENTE SE ACIDIFICA Y SE TRATA CON UN DIOL A UNA TEMPERATURA DE 60-110GC Y EN UN PASO SUCESIVO SE PONE EN CONTACTO CON UN HALURO DE ALQUILSILILO Y FINALMENTE CON UNA AMINA EN PRESENCIA DE HIDROXIDO ALCALINO, CON LO CUAL SE OBTIENE EL 3-ALCOXI-6-ALQUILIDENHIDRACIONOPIRIDACINA. ESTE COMPUESTO PRESENTA ACTIVIDAD ANTIHIPERTENSIVA. *FORMULA*
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT22035/79A IT1165040B (it) | 1979-04-23 | 1979-04-23 | Alcossialchilidenidrazinopiridazione e procedimento per la loro preparazione |
Publications (2)
Publication Number | Publication Date |
---|---|
ES490620A0 ES490620A0 (es) | 1981-04-16 |
ES8104247A1 true ES8104247A1 (es) | 1981-04-16 |
Family
ID=11190502
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES490620A Expired ES8104247A1 (es) | 1979-04-23 | 1980-04-16 | Procedimiento para la preparacion de 3-alcoxi-6-alquiliden- hidracionopiridacina |
Country Status (15)
Country | Link |
---|---|
US (1) | US4324788A (es) |
EP (1) | EP0018016B1 (es) |
JP (1) | JPS55143976A (es) |
AR (1) | AR223521A1 (es) |
AT (1) | ATE4423T1 (es) |
CA (1) | CA1132982A (es) |
DE (1) | DE3064520D1 (es) |
DK (1) | DK147887C (es) |
ES (1) | ES8104247A1 (es) |
IL (1) | IL59882A (es) |
IT (1) | IT1165040B (es) |
MX (1) | MX6327E (es) |
NO (1) | NO158737C (es) |
PT (1) | PT71126B (es) |
YU (1) | YU42505B (es) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4711887A (en) * | 1982-04-23 | 1987-12-08 | Imperial Chemical Industries Plc | Hydrazinopyridazine compounds |
US4599333A (en) * | 1982-06-14 | 1986-07-08 | Teikoku Hormone Mfg. Co., Ltd. | Hydrazinopyridazine compound, process for production thereof, and use thereof as medicament |
DE3277694D1 (en) * | 1982-06-23 | 1987-12-23 | Teikoku Hormone Mfg Co Ltd | Hydrazinopyridazine compound, process for production thereof, and use thereof as medicament |
US4517188A (en) * | 1983-05-09 | 1985-05-14 | Mead Johnson & Company | 1-Pyrimidinyloxy-3-hetaryl-alkylamino-2-propanols |
US5082939A (en) * | 1987-01-08 | 1992-01-21 | I.S.F. Societa Per Azioni | Pyridazine derivatives |
IT1208003B (it) * | 1987-01-08 | 1989-06-01 | Isf Spa | Procedimento per preparare derivati alcossi alchiliden, idrazino, piridazinici. |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1054107B (it) | 1970-12-15 | 1981-11-10 | Isf Spa | Nuove 3,idrazinopiridazine 6,sostituite ad attivita antiiperten siva e loro preparazione |
AR207133A1 (es) * | 1973-02-20 | 1976-09-15 | Ciba Geigy Ag | Procedimiento para la elaboracion de derivados de 1-piridiloxi 1-pirimidiniloxi y 1-piraziniloxi-2-hidroxi-3-amino-propano |
US4115575A (en) * | 1973-02-20 | 1978-09-19 | Ciba-Geigy Corporation | 2-(3-Amino-2-hydroxy-propoxy)-pyrazines |
CH591448A5 (es) * | 1974-05-14 | 1977-09-15 | Ciba Geigy Ag | |
GB1527712A (en) | 1974-06-18 | 1978-10-11 | Smith Kline French Lab | Hydrazinopyridazines |
US4082843A (en) * | 1975-11-26 | 1978-04-04 | Smith Kline & French Laboratories Limited | 3-(3-(3-Substituted amino-2-hydroxypropoxy)phenyl)-6-hydrazino pyridazines and their use as vasodilators and β-adrenergic blocking agents |
BE836633A (fr) | 1975-12-15 | 1976-06-15 | Phenylhydrazinopyridazines |
-
1979
- 1979-04-23 IT IT22035/79A patent/IT1165040B/it active
-
1980
- 1980-04-16 ES ES490620A patent/ES8104247A1/es not_active Expired
- 1980-04-18 IL IL59882A patent/IL59882A/xx unknown
- 1980-04-18 AR AR280728A patent/AR223521A1/es active
- 1980-04-21 CA CA350,232A patent/CA1132982A/en not_active Expired
- 1980-04-21 US US06/142,457 patent/US4324788A/en not_active Expired - Lifetime
- 1980-04-21 YU YU1085/80A patent/YU42505B/xx unknown
- 1980-04-21 DK DK169280A patent/DK147887C/da not_active IP Right Cessation
- 1980-04-22 PT PT71126A patent/PT71126B/pt unknown
- 1980-04-22 NO NO801162A patent/NO158737C/no unknown
- 1980-04-22 JP JP5409680A patent/JPS55143976A/ja active Granted
- 1980-04-22 MX MX808767U patent/MX6327E/es unknown
- 1980-04-23 DE DE8080102190T patent/DE3064520D1/de not_active Expired
- 1980-04-23 AT AT80102190T patent/ATE4423T1/de not_active IP Right Cessation
- 1980-04-23 EP EP80102190A patent/EP0018016B1/de not_active Expired
Also Published As
Publication number | Publication date |
---|---|
ES490620A0 (es) | 1981-04-16 |
DK169280A (da) | 1980-10-24 |
MX6327E (es) | 1985-04-10 |
NO158737B (no) | 1988-07-18 |
NO801162L (no) | 1980-10-24 |
ATE4423T1 (de) | 1983-08-15 |
DK147887C (da) | 1985-08-19 |
PT71126B (en) | 1981-08-07 |
IL59882A0 (en) | 1980-06-30 |
US4324788A (en) | 1982-04-13 |
CA1132982A (en) | 1982-10-05 |
PT71126A (en) | 1980-05-01 |
YU108580A (en) | 1983-02-28 |
IT1165040B (it) | 1987-04-22 |
AR223521A1 (es) | 1981-08-31 |
EP0018016A1 (de) | 1980-10-29 |
IL59882A (en) | 1984-06-29 |
NO158737C (no) | 1988-10-26 |
EP0018016B1 (de) | 1983-08-10 |
DK147887B (da) | 1985-01-02 |
JPS6254305B2 (es) | 1987-11-13 |
JPS55143976A (en) | 1980-11-10 |
DE3064520D1 (en) | 1983-09-15 |
YU42505B (en) | 1988-10-31 |
IT7922035A0 (it) | 1979-04-23 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD1A | Patent lapsed |
Effective date: 19970203 |