ES8301962A1 - Un procedimiento para la produccion de un derivado de carboslivilo. - Google Patents

Un procedimiento para la produccion de un derivado de carboslivilo.

Info

Publication number
ES8301962A1
ES8301962A1 ES500137A ES500137A ES8301962A1 ES 8301962 A1 ES8301962 A1 ES 8301962A1 ES 500137 A ES500137 A ES 500137A ES 500137 A ES500137 A ES 500137A ES 8301962 A1 ES8301962 A1 ES 8301962A1
Authority
ES
Spain
Prior art keywords
group
image
formula
same
pharmaceutical composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES500137A
Other languages
English (en)
Other versions
ES500137A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Otsuka Pharmaceutical Co Ltd
Original Assignee
Otsuka Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP2880580A external-priority patent/JPS56125370A/ja
Priority claimed from JP11502280A external-priority patent/JPS5738772A/ja
Application filed by Otsuka Pharmaceutical Co Ltd filed Critical Otsuka Pharmaceutical Co Ltd
Publication of ES8301962A1 publication Critical patent/ES8301962A1/es
Publication of ES500137A0 publication Critical patent/ES500137A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DE CARBOSTIRILO DE FORMULA (I), EN LA QUE B ES UN GRUPO ALQUILENO INFERIOR; R , A Y Z PUEDEN SER VARIOS TIPOS DE RADICALES; A VALE 0 O 1; Y LA LINEA DISCONTINUA INDICA UN ENLACE DOBLE O SENCILLO. CONSISTE EN LA REACCION DE SUSTITUCION ENTRE UN COMPUESTO DE FORMULA (II), EN LA QUE TODOS LOS SIMBOLOS TIENEN EL MISMO SIGNIFICADO QUE EN LA FORMULA (I) Y X ES UN HALOGENO O UN DERIVADO DE SULFONILOXI, CON UN COMPUESTO DE FORMULA (III), EN LA QUE Z ES EL MISMO QUE EN LA FORMULA (I). LA REACCION SE LLEVA A CABO SIN DISOLVENTE O EN UN DISOLVENTE INERTE, EN PRESENCIA DE UNA BASE COMO AGENTE ACEPTOR DE ACIDO, A UNA TEMPERATURA ENTRE LA AMBIENTE Y 200<025>C. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS COMO AGENTES ANTIHISTAMINICOS Y COMO CONTROLADORES DEL SISTEMA NERVIOSO CENTRAL.
ES500137A 1980-03-06 1981-03-05 Un procedimiento para la produccion de un derivado de carboslivilo. Granted ES500137A0 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2880580A JPS56125370A (en) 1980-03-06 1980-03-06 Carbostyril derivative
JP11502280A JPS5738772A (en) 1980-08-20 1980-08-20 Carbostyril derivative

Publications (2)

Publication Number Publication Date
ES8301962A1 true ES8301962A1 (es) 1982-11-01
ES500137A0 ES500137A0 (es) 1982-11-01

Family

ID=26366952

Family Applications (4)

Application Number Title Priority Date Filing Date
ES500137A Granted ES500137A0 (es) 1980-03-06 1981-03-05 Un procedimiento para la produccion de un derivado de carboslivilo.
ES509659A Expired ES8306141A1 (es) 1980-03-06 1982-02-16 Un procedimiento para la produccion de un derivado de carbostirilo
ES509658A Granted ES509658A0 (es) 1980-03-06 1982-02-16 Un procedimiento para la produccion de un derivado de carbostirilo
ES518667A Granted ES518667A0 (es) 1980-03-06 1982-12-29 Un procedimiento para la produccion de un derivado de carbostirilo.

Family Applications After (3)

Application Number Title Priority Date Filing Date
ES509659A Expired ES8306141A1 (es) 1980-03-06 1982-02-16 Un procedimiento para la produccion de un derivado de carbostirilo
ES509658A Granted ES509658A0 (es) 1980-03-06 1982-02-16 Un procedimiento para la produccion de un derivado de carbostirilo
ES518667A Granted ES518667A0 (es) 1980-03-06 1982-12-29 Un procedimiento para la produccion de un derivado de carbostirilo.

Country Status (21)

Country Link
US (4) US4567187A (es)
AT (1) AT381307B (es)
AU (1) AU523005B2 (es)
BE (1) BE887800A (es)
CA (1) CA1155119A (es)
CH (1) CH647775A5 (es)
DE (2) DE3107601A1 (es)
DK (1) DK155282C (es)
ES (4) ES500137A0 (es)
FI (1) FI76323C (es)
FR (1) FR2477542A1 (es)
GB (1) GB2071094B (es)
IT (1) IT1144315B (es)
MX (1) MX6980E (es)
NL (1) NL184364C (es)
NO (1) NO159531C (es)
PH (1) PH17194A (es)
PT (1) PT72622B (es)
RU (1) RU1779249C (es)
SE (1) SE447255B (es)
SU (1) SU1367857A3 (es)

Families Citing this family (57)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PH17194A (en) * 1980-03-06 1984-06-19 Otsuka Pharma Co Ltd Novel carbostyril derivatives,and pharmaceutical composition containing the same
FI77852C (fi) * 1981-02-17 1989-05-10 Otsuka Pharma Co Ltd Foerfarande foer framstaellning av nya, saosom hjaertmediciner anvaendbara substituerade amid- och (maettad heterocykel)karbonylkarbostyrilderivat.
AU532361B2 (en) * 1981-09-01 1983-09-29 Otsuka Pharmaceutical Co., Ltd. Carbostyril derivatives
FI80022C (fi) * 1982-07-05 1990-04-10 Otsuka Pharma Co Ltd Foerfarande foer framstaellning av ett nytt, terapeutiskt anvaendbart karbostyrilderivat.
CH655110A5 (de) * 1982-09-03 1986-03-27 Otsuka Pharma Co Ltd Carbostyrilderivate, verfahren zu deren herstellung und arzneimittel, welche diese enthalten.
DE3434271A1 (de) * 1984-09-19 1986-03-20 Beiersdorf Ag, 2000 Hamburg Substituierte 3,4-dihydro-chinolin-2(1h)-one verfahren zu ihrer herstellung und ihre verwendung sowie diese verbindungen enthaltende zubereitungen
DE3509131A1 (de) * 1985-03-14 1986-09-18 Fa. Carl Zeiss, 7920 Heidenheim Verfahren zur justierten montage der optischen bauteile eines optischen geraetes
US4704390A (en) * 1986-02-13 1987-11-03 Warner-Lambert Company Phenyl and heterocyclic tetrahydropyridyl alkoxy-benzheterocyclic compounds as antipsychotic agents
DK167187A (da) * 1986-04-02 1987-10-03 Otsuka Pharma Co Ltd Carbostyrilderivater og salte deraf, fremgangsmaade til fremstilling af saadanne forbindelser og laegemiddel indeholdende disse
KR940000785B1 (ko) * 1986-04-02 1994-01-31 오오쓰까세이야꾸 가부시끼가이샤 카르보스티릴 유도체 및 그의 염의 제조 방법
US4792561A (en) * 1986-05-29 1988-12-20 Syntex (U.S.A.) Inc. Carbostyril derivatives as combined thromboxane synthetase and cyclic-AMP phosphodiesterase inhibitors
JPH0696555B2 (ja) * 1986-07-31 1994-11-30 大塚製薬株式会社 カルボスチリル誘導体
DE3784401T2 (de) * 1986-07-31 1993-08-12 Otsuka Pharma Co Ltd Karbostyril-derivate und ihre salze, verfahren zu ihrer herstellung und diese enthaltende kardiotonische zusammensetzung.
DE3802030A1 (de) * 1988-01-25 1989-07-27 Hoechst Ag Makroporoese, asymmetrische, hydrophile membran aus polyaramid
FR2640266B2 (fr) * 1988-07-12 1992-07-10 Synthelabo Derives de (hydroxy-1 piperidinyl-2 alkyl) indolones-2, quinoleinones-2, benzo(b)azepinones-2 et benzimidazolones-2, leur preparation et leur application en therapeutique
FR2634206B1 (fr) * 1988-07-12 1992-05-15 Synthelabo Derives de (hydroxy-1 piperidinyl-2 alkyl) indolones-2 et quinoleinones-2, leur preparation et leur application en therapeutique
FR2637591B1 (fr) * 1988-10-11 1992-10-23 Synthelabo Derives de quinoleinone, leur preparation et leur application en therapeutique
US5006528A (en) * 1988-10-31 1991-04-09 Otsuka Pharmaceutical Co., Ltd. Carbostyril derivatives
BR9106432A (pt) * 1990-05-10 1993-05-04 Pfizer Indolona neuroprotetora e derivados correlatos
FR2668149B1 (fr) * 1990-10-18 1994-09-23 Synthelabo Le 1-(3,4-dihydro-2-oxo-1h-quinolein-6-yl)-2-[4-(2-phenyl-ethyl)piperidin-1-yl]ethanol, sa preparation et son application en therapeutique.
US5147881A (en) * 1990-11-14 1992-09-15 Pfizer Inc 4-(1,2-benzisoxazolyl)piperidine antipsychotic agents
US5166367A (en) * 1991-06-21 1992-11-24 American Home Products Corporation Antipsychotic benzodioxan derivatives
US5189171A (en) * 1991-06-21 1993-02-23 American Home Products Corporation Antipsychotic benzodioxan derivatives
AU655840B2 (en) * 1991-07-17 1995-01-12 Pfizer Inc. 2-(4-hydroxypiperidino)-1-alkanol derivatives as antiischemic agents
US6255322B1 (en) 1992-06-19 2001-07-03 Pfizer Inc. 2-(4-hydroxypiperidino)-1-alkanol derivatives as antiischemic agents
CA2136999C (en) * 1993-04-07 2004-05-11 Takafumi Fujioka Peripheral vasodilating agent containing piperidine derivative as active ingredient
EP0709384B1 (de) * 1994-10-31 1998-12-23 MERCK PATENT GmbH Benzylpiperidinderivate mit hoher Affinität zu Bindungsstellen von Aminosäure-Rezeptoren
ZA9610738B (en) 1995-12-22 1997-06-24 Warner Lambert Co Subtype selective nmda receptor ligands and the use thereof
ZA9610745B (en) * 1995-12-22 1997-06-24 Warner Lambert Co 4-Subsituted piperidine analogs and their use as subtype selective nmda receptor antagonists
ZA9610741B (en) 1995-12-22 1997-06-24 Warner Lambert Co 4-Substituted piperidine analogs and their use as subtype selective nmda receptor antagonists
ZA9610736B (en) 1995-12-22 1997-06-27 Warner Lambert Co 2-Substituted piperidine analogs and their use as subtypeselective nmda receptor antagonists
DE19812331A1 (de) * 1998-03-20 1999-09-23 Merck Patent Gmbh Piperidinderivate
FR2823749B1 (fr) 2001-04-20 2004-02-20 Sanofi Synthelabo Phenyl- et pyridyl-piperidines, procede pour leur preparation et compositions pharmaceutiques les contenant
MY129350A (en) * 2001-04-25 2007-03-30 Bristol Myers Squibb Co Aripiprazole oral solution
DE10210779A1 (de) * 2002-03-12 2003-10-09 Merck Patent Gmbh Cyclische Amide
WO2003076401A1 (en) 2002-03-13 2003-09-18 Janssen Pharmaceutica N.V. Sulfonylamino-derivatives as novel inhibitors of histone deacetylase
KR20040090979A (ko) 2002-03-13 2004-10-27 얀센 파마슈티카 엔.브이. 히스톤 데아세틸레이즈의 신규한 억제제
KR20040093692A (ko) * 2002-03-13 2004-11-08 얀센 파마슈티카 엔.브이. 히스톤 디아세틸라제의 신규한 저해제로서의 피페라지닐-,피페리디닐- 및 모르폴리닐-유도체
CA2476067C (en) * 2002-03-13 2011-09-20 Janssen Pharmaceutica N.V. Carbonylamino-derivatives as novel inhibitors of histone deacetylase
MY142362A (en) * 2004-01-29 2010-11-30 Otsuka Pharma Co Ltd Pharmaceutical composition for promoting angiogenesis
UA86066C2 (ru) * 2004-07-28 2009-03-25 Янссен Фармацевтика Н.В. Производные замещенного пропенилпиперазина как ингибиторы гистондеацетилазы
WO2006010750A1 (en) 2004-07-28 2006-02-02 Janssen Pharmaceutica N.V. Substituted indolyl alkyl amino derivatives as novel inhibitors of histone deacetylase
DK1776358T3 (da) * 2004-07-28 2009-09-07 Janssen Pharmaceutica Nv Substituerede propenylpiperazinderivater som nye inhibitorer af histondeacetylase
TWI320783B (en) 2005-04-14 2010-02-21 Otsuka Pharma Co Ltd Heterocyclic compound
ES2553178T3 (es) 2005-05-18 2015-12-04 Janssen Pharmaceutica N.V. Derivados sustituidos de aminopropenil piperidina o morfolina como nuevos inhibidores de histona deacetilasa
EP1981875B1 (en) * 2006-01-19 2014-04-16 Janssen Pharmaceutica N.V. Substituted indolyl-alkyl-amino-derivatives as inhibitors of histone deacetylase
US8101616B2 (en) * 2006-01-19 2012-01-24 Janssen Pharmaceutica N.V. Pyridine and pyrimidine derivatives as inhibitors of histone deacetylase
ES2327972T3 (es) * 2006-01-19 2009-11-05 Janssen Pharmaceutica, N.V. Derivados de aminofenil como nuevos inhibidores de histona deacetilasa.
DK1979326T3 (da) 2006-01-19 2013-01-07 Janssen Pharmaceutica Nv Pyridin- og pyrimidinderivater som inhibitorer af histondeacetylase
EP2520567A3 (en) * 2006-02-23 2012-12-12 Shionogi & Co., Ltd. Nitrogen-containing heterocycle derivatives substituted with cyclic group
WO2009034029A2 (de) * 2007-09-07 2009-03-19 Boehringer Ingelheim International Gmbh 1-substituierte 4 -heterocyclylpiperidine als cgrp antagonisten
JP5337259B2 (ja) 2009-02-26 2013-11-06 レビバ ファーマシューティカルズ，インコーポレーテッド アリールピペラジン誘導体の組成物、合成および利用方法
WO2013169964A1 (en) * 2012-05-09 2013-11-14 Sunovion Pharmaceuticals Inc. Heteroaryl compounds and methods of use thereof
CN106608875A (zh) 2015-10-26 2017-05-03 江苏恩华药业股份有限公司 一种稠和杂环类衍生物合成及其应用
CN108031471A (zh) * 2017-10-27 2018-05-15 苏州盖德精细材料有限公司 一种静电纺丝制备的负载型纳米纤维催化剂及其在3,5-二羟基甲苯制备中的应用
CN114409680B (zh) * 2018-01-19 2023-11-21 上海怡立舍生物技术有限公司 Ppar激动剂及其应用
CN116554127A (zh) * 2022-01-28 2023-08-08 成都麻沸散医药科技有限公司 哌嗪取代苯酚类衍生物及其用途

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3629266A (en) * 1969-03-03 1971-12-21 Miles Lab (phenyl piperidino alkyl)3 4-dihydrocarbostyrils
US3910924A (en) * 1972-04-13 1975-10-07 Otsuka Pharma Co Ltd 3,4-Dihydrocarbostyril derivatives and a process for preparing the same
JPS5239035B2 (es) * 1972-12-14 1977-10-03
US4068076A (en) * 1972-12-29 1978-01-10 Otsuka Pharmaceutical Co., Ltd. 5-(1-Hydroxy-2-(heterocyclic amino))ethyl-8-hydroxy-3,4-dihydrocarbostyril derivatives
US4022784A (en) * 1974-01-31 1977-05-10 Otsuka Pharmaceutical Company Limited 5-[1-Hydroxy-2-(substituted-amino)]alkyl-8-substituted-carbostyril and -3,4-dihydrocarbostyril derivatives
US4026897A (en) * 1974-01-31 1977-05-31 Otsuka Pharmaceutical Company 5-[1-Hydroxy-2-(substituted-amino)]alkyl-8-hydroxycarbostyril derivatives
JPS5310986B2 (es) * 1974-02-05 1978-04-18
JPS5310989B2 (es) * 1974-04-25 1978-04-18
US3994901A (en) * 1974-06-13 1976-11-30 Otsuka Pharmaceutical Company Limited 5-[1-Hydroxy-2-(substituted-amino)]alkyl-8-hydroxy-3,4-dihydrocarbostyril derivatives
US4145542A (en) * 1974-06-13 1979-03-20 Otsuka Pharmaceutical Co., Ltd. 5- 1-Hydroxy-2-(heterocyclic-amino)!alkyl-8-hydroxy-3,4-dihydrocarbostyril derivatives
JPS5112516A (es) * 1974-07-21 1976-01-31 Toyoda Automatic Loom Works
JPS5112515A (ja) * 1974-07-23 1976-01-31 Nikkari Kk Tankijonpansochiniokeru seidoseigyosochi
JPS5116478A (ja) * 1974-07-30 1976-02-09 Omron Tateisi Electronics Co Rodenshadanki
JPS51125291A (en) * 1974-12-07 1976-11-01 Otsuka Pharmaceut Co Ltd A process for preparing novel carbostyryl derivatives
JPS51118772A (en) * 1975-04-09 1976-10-18 Otsuka Pharmaceut Co Ltd Method for preparing carbostyryl derivatives
JPS51118771A (en) * 1975-04-09 1976-10-18 Otsuka Pharmaceut Co Ltd Method for preparing carbostyryl derivatives
FR2336674A1 (fr) * 1975-12-24 1977-07-22 Kronenbourg Brasseries Appareil pour la mesure automatique du temps de resorption de la mousse, en particulier d'une boisson gazeuse, notamment la biere
US3994900A (en) * 1976-01-23 1976-11-30 E. R. Squibb & Sons, Inc. 6-(Or 8)-[[(substituted amino)alkyl]oxy(or thio)]-3,4-dihydro-4-phenyl-2(1H)-quinolinones
US4210753A (en) * 1976-03-17 1980-07-01 Otsuka Pharmaceutical Co., Ltd. Carbostyril compounds
GB1574665A (en) * 1976-05-08 1980-09-10 Otsuka Pharma Co Ltd 3,4-dihydrocarbostyril derivatives and process for preparing the same
JPS6026797B2 (ja) * 1976-07-12 1985-06-25 大塚製薬株式会社 新規なカルボスチリル誘導体
JPS609713B2 (ja) * 1976-10-08 1985-03-12 大塚製薬株式会社 カルボスチリル誘導体
JPS5416478A (en) * 1977-07-08 1979-02-07 Otsuka Pharmaceut Co Ltd 3,4-dihydrocarbostyril herivative
JPS54130587A (en) * 1978-03-30 1979-10-09 Otsuka Pharmaceut Co Ltd Carbostyryl derivative
DE2960178D1 (en) * 1978-06-06 1981-04-09 Hoechst Ag New substituted phenylpiperazine derivatives, pharmaceutical compositions containing them and process for their preparation
DE2827566A1 (de) * 1978-06-23 1980-01-10 Boehringer Mannheim Gmbh 1,2-dihydro-chinolin-2-on-derivate und verfahren zu ihrer herstellung
JPS5527158A (en) * 1978-08-16 1980-02-27 Otsuka Pharmaceut Co Ltd 5-oxo-3,4,5,6,7,8-hexahydrocarbostyril derivative
JPS5583749A (en) * 1978-12-19 1980-06-24 Yoshitomi Pharmaceut Ind Ltd Quinolone derivative
JPS5589221A (en) * 1978-12-28 1980-07-05 Otsuka Pharmaceut Co Ltd Antihistaminic agent
JPS5589222A (en) * 1978-12-28 1980-07-05 Otsuka Pharmaceut Co Ltd Antihistaminic agent
PH17194A (en) * 1980-03-06 1984-06-19 Otsuka Pharma Co Ltd Novel carbostyril derivatives,and pharmaceutical composition containing the same
FI77852C (fi) * 1981-02-17 1989-05-10 Otsuka Pharma Co Ltd Foerfarande foer framstaellning av nya, saosom hjaertmediciner anvaendbara substituerade amid- och (maettad heterocykel)karbonylkarbostyrilderivat.
AU532361B2 (en) * 1981-09-01 1983-09-29 Otsuka Pharmaceutical Co., Ltd. Carbostyril derivatives

Also Published As

Publication number Publication date
FI76323C (fi) 1988-10-10
ES8305356A1 (es) 1983-04-01
IT8167311A0 (it) 1981-03-05
GB2071094B (en) 1984-09-26
DK155282B (da) 1989-03-20
FI810669L (fi) 1981-09-07
FR2477542B1 (es) 1983-09-09
RU1779249C (ru) 1992-11-30
DK99781A (da) 1981-09-07
ES509659A0 (es) 1983-05-01
US4460593A (en) 1984-07-17
FR2477542A1 (fr) 1981-09-11
US4455422A (en) 1984-06-19
NL8101099A (nl) 1981-10-01
DE3107601A1 (de) 1982-02-04
ES8405782A1 (es) 1984-06-16
ES518667A0 (es) 1984-06-16
ES500137A0 (es) 1982-11-01
CH647775A5 (de) 1985-02-15
DE3152880C2 (es) 1990-03-22
SE8101409L (sv) 1981-09-07
NO159531C (no) 1989-01-11
GB2071094A (en) 1981-09-16
PT72622B (en) 1982-06-15
PT72622A (en) 1981-04-01
NL184364C (nl) 1989-07-03
BE887800A (fr) 1981-09-07
PH17194A (en) 1984-06-19
ES8306141A1 (es) 1983-05-01
NO810765L (no) 1981-09-07
CA1155119A (en) 1983-10-11
NL184364B (nl) 1989-02-01
SE447255B (sv) 1986-11-03
DK155282C (da) 1989-08-07
ATA98481A (de) 1986-02-15
AT381307B (de) 1986-09-25
NO159531B (no) 1988-10-03
AU6797381A (en) 1981-09-10
DE3107601C2 (es) 1989-07-20
SU1367857A3 (ru) 1988-01-15
FI76323B (fi) 1988-06-30
IT1144315B (it) 1986-10-29
MX6980E (es) 1987-01-19
US4567187A (en) 1986-01-28
US4619932A (en) 1986-10-28
AU523005B2 (en) 1982-07-08
ES509658A0 (es) 1983-04-01

Similar Documents

Publication Publication Date Title
ES8305356A1 (es) Un procedimiento para la produccion de un derivado de carbostirilo
ES483311A1 (es) Un procedimiento para preparar derivados de prolina
ES8103743A1 (es) Un metodo para la preparacion de derivados de ftalimidina
ES8603242A1 (es) Procedimiento para la obtencion de un derivado de nitrometi-leno
ES8400422A1 (es) &#34;procedimiento de preparacion de eteres triciclicos, asi como de sus sales de adicion con un acido mineral u organico terapeuticamente compatible&#34;.
ES486991A1 (es) Un procedimiento para la preparacion de un derivado de car- boestirilo
IL104024A (en) 4-pyrimidinyl and pyridinyl derivatives of indol-3-yl- alkyl piperazines and antimigraine pharmaceutical compositions containing them
DE3069408D1 (en) 5-oxo- and 5-thioxoproline derivatives, process for their production and pharmaceutical compositions containing them
ES481729A1 (es) Procedimiento para la preparacion de derivados de 1,2-dihi- droquinolein-2-onas.
ES8200679A1 (es) Un procedimiento para la preparacion de derivados de carboestirilo.
ES482472A1 (es) Procedimiento para la preparacion de isoquinoleinas.
DE69031913D1 (de) Antivirale mittel
MY100115A (en) Nitrogen containing heterocyclic compounds, and their production and use.
IL75273A (en) Cephalosporin derivatives,process for their preparation and pharmaceutical compositions containing them
ES2019163A6 (es) Procedimiento para preparar derivados de imidazol.
ES8301224A1 (es) Procedimiento para la preparacion de nuevas 5,10-dihidro -11h-dibenzo b,e 1,4 diazepin-11-onas, sustituidas en posi- cion 5
ES8800122A1 (es) Un procedimiento para la preparacion de derivados de indeno y naftaleno.
ES8701156A1 (es) Un procedimiento para producir un derivado de 2-(3,5-dial- quil-4-hidroxifenil)indol
ES8702433A1 (es) Un procedimiento para la preparacion de un compuesto heterociclico sustituido con peptidos.
ES8203867A1 (es) Procedimiento para la obtencion de derivados de benzotiazol
ES463424A1 (es) Procedimiento de preparacion de lactamas sustituidas en n.
ES8202818A1 (es) Un procedimiento para preparar derivados de tetrazolilcuma- rina
ES8300688A1 (es) Un procedimiento para preparar amidas de ciclopentanona
ES8504159A1 (es) Un procedimiento para la preparacion de nuevos derivados de 1,2,5,-tidiazol.
ES8400743A1 (es) &#34;procedimiento para la preparacion de compuestos de 1-fenilindazol-3-ona&#34;.

Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20010201