BE887800A - Derives de carbostyrile, leurs procedes de preparation et leur application en therapeutique - Google Patents

Derives de carbostyrile, leurs procedes de preparation et leur application en therapeutique

Info

Publication number
BE887800A
BE887800A BE0/204016A BE204016A BE887800A BE 887800 A BE887800 A BE 887800A BE 0/204016 A BE0/204016 A BE 0/204016A BE 204016 A BE204016 A BE 204016A BE 887800 A BE887800 A BE 887800A
Authority
BE
Belgium
Prior art keywords
preparation methods
therapeutic application
carbostyrile
derivatives
carbostyrile derivatives
Prior art date
Application number
BE0/204016A
Other languages
English (en)
Original Assignee
Otsuka Pharma Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP2880580A external-priority patent/JPS56125370A/ja
Priority claimed from JP11502280A external-priority patent/JPS5738772A/ja
Application filed by Otsuka Pharma Co Ltd filed Critical Otsuka Pharma Co Ltd
Publication of BE887800A publication Critical patent/BE887800A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
BE0/204016A 1980-03-06 1981-03-05 Derives de carbostyrile, leurs procedes de preparation et leur application en therapeutique BE887800A (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2880580A JPS56125370A (en) 1980-03-06 1980-03-06 Carbostyril derivative
JP11502280A JPS5738772A (en) 1980-08-20 1980-08-20 Carbostyril derivative

Publications (1)

Publication Number Publication Date
BE887800A true BE887800A (fr) 1981-09-07

Family

ID=26366952

Family Applications (1)

Application Number Title Priority Date Filing Date
BE0/204016A BE887800A (fr) 1980-03-06 1981-03-05 Derives de carbostyrile, leurs procedes de preparation et leur application en therapeutique

Country Status (21)

Country Link
US (4) US4460593A (fr)
AT (1) AT381307B (fr)
AU (1) AU523005B2 (fr)
BE (1) BE887800A (fr)
CA (1) CA1155119A (fr)
CH (1) CH647775A5 (fr)
DE (2) DE3152880C2 (fr)
DK (1) DK155282C (fr)
ES (4) ES500137A0 (fr)
FI (1) FI76323C (fr)
FR (1) FR2477542A1 (fr)
GB (1) GB2071094B (fr)
IT (1) IT1144315B (fr)
MX (1) MX6980E (fr)
NL (1) NL184364C (fr)
NO (1) NO159531C (fr)
PH (1) PH17194A (fr)
PT (1) PT72622B (fr)
RU (1) RU1779249C (fr)
SE (1) SE447255B (fr)
SU (1) SU1367857A3 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3204892A1 (de) * 1981-02-17 1982-09-23 Otsuka Pharmaceutical Co. Ltd., Tokyo Carbostyrilderivate, verfahren zu deren herstellung und kardiotonische zusammensetzungen, welche diese enthalten

Families Citing this family (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PH17194A (en) * 1980-03-06 1984-06-19 Otsuka Pharma Co Ltd Novel carbostyril derivatives,and pharmaceutical composition containing the same
AU532361B2 (en) * 1981-09-01 1983-09-29 Otsuka Pharmaceutical Co., Ltd. Carbostyril derivatives
US4578381A (en) * 1982-07-05 1986-03-25 Otsuka Pharmaceutical Co., Ltd. Carbostyril derivatives
CH655110A5 (de) * 1982-09-03 1986-03-27 Otsuka Pharma Co Ltd Carbostyrilderivate, verfahren zu deren herstellung und arzneimittel, welche diese enthalten.
DE3434271A1 (de) * 1984-09-19 1986-03-20 Beiersdorf Ag, 2000 Hamburg Substituierte 3,4-dihydro-chinolin-2(1h)-one verfahren zu ihrer herstellung und ihre verwendung sowie diese verbindungen enthaltende zubereitungen
DE3509131A1 (de) * 1985-03-14 1986-09-18 Fa. Carl Zeiss, 7920 Heidenheim Verfahren zur justierten montage der optischen bauteile eines optischen geraetes
US4704390A (en) * 1986-02-13 1987-11-03 Warner-Lambert Company Phenyl and heterocyclic tetrahydropyridyl alkoxy-benzheterocyclic compounds as antipsychotic agents
DK167187A (da) 1986-04-02 1987-10-03 Otsuka Pharma Co Ltd Carbostyrilderivater og salte deraf, fremgangsmaade til fremstilling af saadanne forbindelser og laegemiddel indeholdende disse
KR940000785B1 (ko) * 1986-04-02 1994-01-31 오오쓰까세이야꾸 가부시끼가이샤 카르보스티릴 유도체 및 그의 염의 제조 방법
US4792561A (en) * 1986-05-29 1988-12-20 Syntex (U.S.A.) Inc. Carbostyril derivatives as combined thromboxane synthetase and cyclic-AMP phosphodiesterase inhibitors
ES2053480T3 (es) * 1986-07-31 1994-08-01 Otsuka Pharma Co Ltd Un procedimiento para preparar un derivado de carboestirilo.
JPH0696555B2 (ja) * 1986-07-31 1994-11-30 大塚製薬株式会社 カルボスチリル誘導体
DE3802030A1 (de) * 1988-01-25 1989-07-27 Hoechst Ag Makroporoese, asymmetrische, hydrophile membran aus polyaramid
FR2634206B1 (fr) * 1988-07-12 1992-05-15 Synthelabo Derives de (hydroxy-1 piperidinyl-2 alkyl) indolones-2 et quinoleinones-2, leur preparation et leur application en therapeutique
FR2640266B2 (fr) * 1988-07-12 1992-07-10 Synthelabo Derives de (hydroxy-1 piperidinyl-2 alkyl) indolones-2, quinoleinones-2, benzo(b)azepinones-2 et benzimidazolones-2, leur preparation et leur application en therapeutique
FR2637591B1 (fr) * 1988-10-11 1992-10-23 Synthelabo Derives de quinoleinone, leur preparation et leur application en therapeutique
US5006528A (en) * 1988-10-31 1991-04-09 Otsuka Pharmaceutical Co., Ltd. Carbostyril derivatives
DE69132141T2 (de) * 1990-05-10 2000-09-21 Pfizer Inc., New York Neuroprotective indolone und verwandte derivate
FR2668149B1 (fr) * 1990-10-18 1994-09-23 Synthelabo Le 1-(3,4-dihydro-2-oxo-1h-quinolein-6-yl)-2-[4-(2-phenyl-ethyl)piperidin-1-yl]ethanol, sa preparation et son application en therapeutique.
US5147881A (en) * 1990-11-14 1992-09-15 Pfizer Inc 4-(1,2-benzisoxazolyl)piperidine antipsychotic agents
US5189171A (en) * 1991-06-21 1993-02-23 American Home Products Corporation Antipsychotic benzodioxan derivatives
US5166367A (en) * 1991-06-21 1992-11-24 American Home Products Corporation Antipsychotic benzodioxan derivatives
CA2113568A1 (fr) * 1991-07-17 1993-02-04 Willard Mckowan Welch Jr. Derives du 2-(4-hydroxypiperidino)-1-alcanol comme agents anti-ischemique
US6255322B1 (en) 1992-06-19 2001-07-03 Pfizer Inc. 2-(4-hydroxypiperidino)-1-alkanol derivatives as antiischemic agents
PT650476E (pt) * 1993-04-07 2002-11-29 Otsuka Pharma Co Ltd Agente vasodilatador periferico que contem derivados n-acilados de 4-amino-piperidina como ingredientes activos
ES2128629T3 (es) * 1994-10-31 1999-05-16 Merck Patent Gmbh Derivados de bencilpiperidina con afinidad elevada a puntos de enlace de receptores de aminoacidos.
ZA9610736B (en) * 1995-12-22 1997-06-27 Warner Lambert Co 2-Substituted piperidine analogs and their use as subtypeselective nmda receptor antagonists
ZA9610741B (en) 1995-12-22 1997-06-24 Warner Lambert Co 4-Substituted piperidine analogs and their use as subtype selective nmda receptor antagonists
ZA9610738B (en) 1995-12-22 1997-06-24 Warner Lambert Co Subtype selective nmda receptor ligands and the use thereof
ZA9610745B (en) * 1995-12-22 1997-06-24 Warner Lambert Co 4-Subsituted piperidine analogs and their use as subtype selective nmda receptor antagonists
DE19812331A1 (de) 1998-03-20 1999-09-23 Merck Patent Gmbh Piperidinderivate
FR2823749B1 (fr) 2001-04-20 2004-02-20 Sanofi Synthelabo Phenyl- et pyridyl-piperidines, procede pour leur preparation et compositions pharmaceutiques les contenant
MY129350A (en) * 2001-04-25 2007-03-30 Bristol Myers Squibb Co Aripiprazole oral solution
DE10210779A1 (de) * 2002-03-12 2003-10-09 Merck Patent Gmbh Cyclische Amide
EA007270B1 (ru) * 2002-03-13 2006-08-25 Янссен Фармацевтика Н.В. Пиперазинил-, пиперидинил- и морфолинилпроизводные как новые ингибиторы гистондеацетилазы
JP4725945B2 (ja) 2002-03-13 2011-07-13 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ ヒストンデアセチラーゼの新規な阻害剤としてのスルホニルアミノ誘導体
PL212089B1 (pl) 2002-03-13 2012-08-31 Janssen Pharmaceutica Nv Związki heterocykliczne jako inhibitory deacetylazy histonowej, kompozycja farmaceutyczna je zawierająca, ich zastosowanie, sposób wytwarzania, sposób wykrywania lub identyfikacji HDAC oraz kompozycja
OA12789A (en) * 2002-03-13 2006-07-10 Janssen Pharmaceutica Nv Carbonylamino-derivatives as novel inhibitors of histone deacetylase.
MY142362A (en) * 2004-01-29 2010-11-30 Otsuka Pharma Co Ltd Pharmaceutical composition for promoting angiogenesis
DE602005014646D1 (de) * 2004-07-28 2009-07-09 Janssen Pharmaceutica Nv Substituierte propenylpiperazinderivate als neue inhibitoren von histondeacetylase
RS51189B (sr) * 2004-07-28 2010-10-31 Janssen Pharmaceutica N.V. Supstituisani derivati propenil piperazina kao novi inhibitori histonske deacetilaze
BRPI0512676B8 (pt) * 2004-07-28 2021-05-25 Janssen Pharmaceutica Nv derivados de indolil alquil amina substituídos como inibidores de histona desacetilase, composição farmacêutica que os compreende, seus processos de preparação e uso
TWI320783B (en) 2005-04-14 2010-02-21 Otsuka Pharma Co Ltd Heterocyclic compound
DK1885710T3 (en) 2005-05-18 2015-11-23 Janssen Pharmaceutica Nv SUBSTITUTED AMINOPROPENYLPIPERIDINE OR MORPHOLINE DERIVATIVES AS UNKNOWN INHIBITORS OF HISTONDEACETYLASE
ATE432272T1 (de) * 2006-01-19 2009-06-15 Janssen Pharmaceutica Nv Aminophenylderivate als neue inhibitoren von histondeacetylase
JP5137848B2 (ja) * 2006-01-19 2013-02-06 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ ヒストンデアセチラーゼのインヒビターとしてのピリジン及びピリミジン誘導体
CA2630717C (fr) 2006-01-19 2015-02-24 Janssen Pharmaceutica N.V. Derives de pyridine et de pyrimidine en tant qu'inhibiteurs d'histone desacetylase
EP1981875B1 (fr) * 2006-01-19 2014-04-16 Janssen Pharmaceutica N.V. Dérivés substitués d'indolyl-alkyl-amine en tant qu'inhibiteurs de l'histone désacétylase
EP1988077A4 (fr) * 2006-02-23 2009-09-02 Shionogi & Co Derives heterocycliques azotes substitues par des groupes cycliques
WO2009034029A2 (fr) * 2007-09-07 2009-03-19 Boehringer Ingelheim International Gmbh Nouveaux composés
NZ595263A (en) 2009-02-26 2013-06-28 Compositions, synthesis, and methods of utilizing arylpiperazine derivatives
WO2013169964A1 (fr) * 2012-05-09 2013-11-14 Sunovion Pharmaceuticals Inc. Composés hétéroaryles et leurs procédés d'utilisation
CN106608875A (zh) 2015-10-26 2017-05-03 江苏恩华药业股份有限公司 一种稠和杂环类衍生物合成及其应用
CN108031471A (zh) * 2017-10-27 2018-05-15 苏州盖德精细材料有限公司 一种静电纺丝制备的负载型纳米纤维催化剂及其在3,5-二羟基甲苯制备中的应用
CN108250058B (zh) * 2018-01-19 2022-02-11 上海怡立舍生物技术有限公司 Ppar激动剂及其在治疗老年痴呆及其他疾病中的用途
CN116554127A (zh) * 2022-01-28 2023-08-08 成都麻沸散医药科技有限公司 哌嗪取代苯酚类衍生物及其用途

Family Cites Families (33)

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US3629266A (en) * 1969-03-03 1971-12-21 Miles Lab (phenyl piperidino alkyl)3 4-dihydrocarbostyrils
US3910924A (en) * 1972-04-13 1975-10-07 Otsuka Pharma Co Ltd 3,4-Dihydrocarbostyril derivatives and a process for preparing the same
JPS5239035B2 (fr) * 1972-12-14 1977-10-03
US4068076A (en) * 1972-12-29 1978-01-10 Otsuka Pharmaceutical Co., Ltd. 5-(1-Hydroxy-2-(heterocyclic amino))ethyl-8-hydroxy-3,4-dihydrocarbostyril derivatives
US4026897A (en) * 1974-01-31 1977-05-31 Otsuka Pharmaceutical Company 5-[1-Hydroxy-2-(substituted-amino)]alkyl-8-hydroxycarbostyril derivatives
US4022784A (en) * 1974-01-31 1977-05-10 Otsuka Pharmaceutical Company Limited 5-[1-Hydroxy-2-(substituted-amino)]alkyl-8-substituted-carbostyril and -3,4-dihydrocarbostyril derivatives
JPS5310986B2 (fr) * 1974-02-05 1978-04-18
JPS5310989B2 (fr) * 1974-04-25 1978-04-18
US3994901A (en) * 1974-06-13 1976-11-30 Otsuka Pharmaceutical Company Limited 5-[1-Hydroxy-2-(substituted-amino)]alkyl-8-hydroxy-3,4-dihydrocarbostyril derivatives
US4145542A (en) * 1974-06-13 1979-03-20 Otsuka Pharmaceutical Co., Ltd. 5- 1-Hydroxy-2-(heterocyclic-amino)!alkyl-8-hydroxy-3,4-dihydrocarbostyril derivatives
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JPS6026797B2 (ja) * 1976-07-12 1985-06-25 大塚製薬株式会社 新規なカルボスチリル誘導体
JPS609713B2 (ja) * 1976-10-08 1985-03-12 大塚製薬株式会社 カルボスチリル誘導体
JPS5416478A (en) * 1977-07-08 1979-02-07 Otsuka Pharmaceut Co Ltd 3,4-dihydrocarbostyril herivative
JPS54130587A (en) 1978-03-30 1979-10-09 Otsuka Pharmaceut Co Ltd Carbostyryl derivative
DE2960178D1 (en) * 1978-06-06 1981-04-09 Hoechst Ag New substituted phenylpiperazine derivatives, pharmaceutical compositions containing them and process for their preparation
DE2827566A1 (de) * 1978-06-23 1980-01-10 Boehringer Mannheim Gmbh 1,2-dihydro-chinolin-2-on-derivate und verfahren zu ihrer herstellung
JPS5527158A (en) * 1978-08-16 1980-02-27 Otsuka Pharmaceut Co Ltd 5-oxo-3,4,5,6,7,8-hexahydrocarbostyril derivative
JPS5583749A (en) * 1978-12-19 1980-06-24 Yoshitomi Pharmaceut Ind Ltd Quinolone derivative
JPS5589221A (en) * 1978-12-28 1980-07-05 Otsuka Pharmaceut Co Ltd Antihistaminic agent
JPS5589222A (en) * 1978-12-28 1980-07-05 Otsuka Pharmaceut Co Ltd Antihistaminic agent
PH17194A (en) * 1980-03-06 1984-06-19 Otsuka Pharma Co Ltd Novel carbostyril derivatives,and pharmaceutical composition containing the same
FI77852C (fi) * 1981-02-17 1989-05-10 Otsuka Pharma Co Ltd Foerfarande foer framstaellning av nya, saosom hjaertmediciner anvaendbara substituerade amid- och (maettad heterocykel)karbonylkarbostyrilderivat.
AU532361B2 (en) * 1981-09-01 1983-09-29 Otsuka Pharmaceutical Co., Ltd. Carbostyril derivatives

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3204892A1 (de) * 1981-02-17 1982-09-23 Otsuka Pharmaceutical Co. Ltd., Tokyo Carbostyrilderivate, verfahren zu deren herstellung und kardiotonische zusammensetzungen, welche diese enthalten

Also Published As

Publication number Publication date
PT72622B (en) 1982-06-15
RU1779249C (ru) 1992-11-30
ES8305356A1 (es) 1983-04-01
ES8301962A1 (es) 1982-11-01
SU1367857A3 (ru) 1988-01-15
AT381307B (de) 1986-09-25
DK155282C (da) 1989-08-07
FI810669L (fi) 1981-09-07
SE8101409L (sv) 1981-09-07
NO159531C (no) 1989-01-11
MX6980E (es) 1987-01-19
DE3107601C2 (fr) 1989-07-20
IT1144315B (it) 1986-10-29
FI76323C (fi) 1988-10-10
CH647775A5 (de) 1985-02-15
ES500137A0 (es) 1982-11-01
SE447255B (sv) 1986-11-03
AU6797381A (en) 1981-09-10
NO159531B (no) 1988-10-03
ATA98481A (de) 1986-02-15
CA1155119A (fr) 1983-10-11
AU523005B2 (en) 1982-07-08
US4455422A (en) 1984-06-19
DE3107601A1 (de) 1982-02-04
NL8101099A (nl) 1981-10-01
FR2477542A1 (fr) 1981-09-11
ES8405782A1 (es) 1984-06-16
GB2071094A (en) 1981-09-16
IT8167311A0 (it) 1981-03-05
ES8306141A1 (es) 1983-05-01
FR2477542B1 (fr) 1983-09-09
US4619932A (en) 1986-10-28
US4460593A (en) 1984-07-17
PT72622A (en) 1981-04-01
FI76323B (fi) 1988-06-30
DK155282B (da) 1989-03-20
DK99781A (da) 1981-09-07
NL184364B (nl) 1989-02-01
ES518667A0 (es) 1984-06-16
DE3152880C2 (fr) 1990-03-22
ES509659A0 (es) 1983-05-01
NL184364C (nl) 1989-07-03
PH17194A (en) 1984-06-19
GB2071094B (en) 1984-09-26
NO810765L (no) 1981-09-07
US4567187A (en) 1986-01-28
ES509658A0 (es) 1983-04-01

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Legal Events

Date Code Title Description
RE Patent lapsed

Owner name: OTSUKA PHARMACEUTICAL CO. LTD

Effective date: 19930331