ES483311A1 - Un procedimiento para preparar derivados de prolina - Google Patents

Un procedimiento para preparar derivados de prolina

Info

Publication number
ES483311A1
ES483311A1 ES483311A ES483311A ES483311A1 ES 483311 A1 ES483311 A1 ES 483311A1 ES 483311 A ES483311 A ES 483311A ES 483311 A ES483311 A ES 483311A ES 483311 A1 ES483311 A1 ES 483311A1
Authority
ES
Spain
Prior art keywords
phenyl
lower alkyl
hydrogen
image
substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES483311A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ER Squibb and Sons LLC
Original Assignee
ER Squibb and Sons LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ER Squibb and Sons LLC filed Critical ER Squibb and Sons LLC
Publication of ES483311A1 publication Critical patent/ES483311A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/12—Oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C327/00—Thiocarboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pyrrole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)

Abstract

La invención se refiere a las éter y tioéter mercaptoacil prolinas que tienen composiciones que contienen tales compuestos, y a un método para usar tales compuestos como agentes antihipertensores. La expresión alcohilo inferior cuando se usa para definir los símbolos R, R1, R2 y R3 significa radicales de hidrocarburo de cadena recta o ramificada que tienen hasta siete carbonos, por ejemplo metilo, etilo, propilo, isopropilo, butilo, isobutilo, terc-butilo, pentilo, isopentilo, etc. Los grupos alcohilo inferior preferidos son de hasta cuatro átomos de carbono, siendo los más preferidos metilo y etilo.
ES483311A 1978-08-11 1979-08-10 Un procedimiento para preparar derivados de prolina Expired ES483311A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US93288378A 1978-08-11 1978-08-11
KR1019790002731A KR830002450B1 (ko) 1978-08-11 1979-08-10 치환 프로린의 메르캅토아실 유도체의 제조방법

Publications (1)

Publication Number Publication Date
ES483311A1 true ES483311A1 (es) 1980-04-16

Family

ID=26626596

Family Applications (1)

Application Number Title Priority Date Filing Date
ES483311A Expired ES483311A1 (es) 1978-08-11 1979-08-10 Un procedimiento para preparar derivados de prolina

Country Status (30)

Country Link
JP (2) JPS5527199A (es)
KR (1) KR830002450B1 (es)
AR (1) AR229081A1 (es)
AT (1) AT379589B (es)
AU (1) AU530690B2 (es)
BE (1) BE878191A (es)
CA (1) CA1144930A (es)
CH (1) CH642064A5 (es)
CS (1) CS228118B2 (es)
DD (1) DD145749A5 (es)
DE (1) DE2932021C2 (es)
DK (1) DK154553C (es)
ES (1) ES483311A1 (es)
FI (1) FI69834C (es)
FR (1) FR2435469A1 (es)
GB (1) GB2028327B (es)
GR (1) GR72420B (es)
IE (1) IE48802B1 (es)
IN (1) IN152712B (es)
IT (1) IT1117782B (es)
LU (2) LU81593A1 (es)
NL (2) NL193374C (es)
NZ (1) NZ191036A (es)
PH (1) PH15030A (es)
PT (1) PT70049A (es)
RO (1) RO78870B (es)
SE (1) SE447477B (es)
SU (1) SU1066460A3 (es)
YU (1) YU41876B (es)
ZA (1) ZA793633B (es)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4483861A (en) * 1978-10-31 1984-11-20 Santen Pharmaceutical Co., Ltd. Antihypertensive sulfur-containing compounds
CA1132985A (en) * 1978-12-22 1982-10-05 John Krapcho Ketal and thioketal derivatives of mercaptoacyl prolines
US4347371A (en) * 1978-12-30 1982-08-31 Santen Pharmaceutical Co., Ltd. Disulfide compounds
US4234489A (en) * 1979-06-25 1980-11-18 E. R. Squibb & Sons, Inc. Pyroglutamic acid derivatives and analogs
US4288368A (en) * 1979-07-30 1981-09-08 E. R. Squibb & Sons, Inc. Dithioacylproline derivatives
US4291040A (en) * 1979-10-22 1981-09-22 E. R. Squibb & Sons, Inc. Mercaptoacyl derivatives of 4-disubstituted prolines and 4-substituted dehydroprolines
US4692458A (en) * 1980-03-05 1987-09-08 University Of Miami Anti-hypertensive agents
AU542211B2 (en) * 1980-03-07 1985-02-14 Gruppo Lepetit S.P.A. Mercaptocycloalkyl carbonyl prolines
SE431331B (sv) * 1980-03-21 1984-01-30 Squibb & Sons Inc Nya terapeutiskt aktiva svavelinnehallande n-acylerade derivat av 4-oxo-l-prolin
US4284624A (en) 1980-05-02 1981-08-18 E. R. Squibb & Sons, Inc. Mixed disulfides
US4578474A (en) * 1980-06-23 1986-03-25 E. R. Squibb & Sons, Inc. Imido, amido and amino derivatives of mercaptoacyl prolines and pipecolic acids
US4390695A (en) * 1980-06-23 1983-06-28 E. R. Squibb & Sons, Inc. Imido, amido and amino derivatives of mercaptoacyl prolines and pipecolic acids
US4316905A (en) * 1980-07-01 1982-02-23 E. R. Squibb & Sons, Inc. Mercaptoacyl derivatives of various 4-substituted prolines
US4332726A (en) * 1980-08-25 1982-06-01 E. R. Squibb & Sons, Inc. Purification of mercaptoacyl amino acids
US4307110A (en) * 1980-09-12 1981-12-22 E. R. Squibb & Sons, Inc. Mercaptoacyl derivatives of 3-substituted proline derivatives
US4311705A (en) * 1980-10-06 1982-01-19 E. R. Squibb & Sons, Inc. Carboxyalkanoyl and hydroxycarbamoylalkanoyl derivatives of substituted prolines
US4312809A (en) 1980-10-31 1982-01-26 E. R. Squibb & Sons, Inc. Lactam derivatives of mercaptoacylamino acids
US4462943A (en) * 1980-11-24 1984-07-31 E. R. Squibb & Sons, Inc. Carboxyalkyl amino acid derivatives of various substituted prolines
US4337201A (en) * 1980-12-04 1982-06-29 E. R. Squibb & Sons, Inc. Phosphinylalkanoyl substituted prolines
US4384123A (en) * 1980-12-04 1983-05-17 E. R. Squibb & Sons, Inc. Phosphinylalkanoyl substituted prolines
US4416831A (en) 1981-04-27 1983-11-22 E. R. Squibb & Sons, Inc. Amino and substituted amino phosphinylalkanoyl compounds
US4374131A (en) 1981-04-27 1983-02-15 E. R. Squibb & Sons, Inc. Amino and substituted amino phosphinyl-alkanoyl compounds
US4416833A (en) 1981-05-04 1983-11-22 E. R. Squibb & Sons, Inc. Substituted carbonyl phosphinyl-alkanoyl compounds
US4381297A (en) 1981-05-04 1983-04-26 E. R. Squibb & Sons, Inc. Substituted carbonyl phosphinyl-alkanoyl compounds
US4497953A (en) * 1981-06-01 1985-02-05 E. R. Squibb & Sons, Inc. Imido, amido and amino derivatives of mercaptoacyl prolines and pipecolic acids
US4377701A (en) * 1981-09-21 1983-03-22 E. R. Squibb & Sons, Inc. 4-Methylene-1-[[(alranoyl or arylcarbonyl)mercapto]acyl]proline and pipecolic acid
US4555506A (en) * 1981-12-24 1985-11-26 E. R. Squibb & Sons, Inc. Phosphorus containing compounds and use as hypotensives
US4452791A (en) * 1982-03-15 1984-06-05 E. R. Squibb & Sons, Inc. Aminoalkyl and related substituted phosphinic acid angiotensin converting enzyme inhibitors
US4560680A (en) * 1982-03-15 1985-12-24 E. R. Squibb & Sons, Inc. Aminoalkyl and related substituted phosphinic acid angiotensin converting enzyme inhibitors
US4703043A (en) * 1982-06-23 1987-10-27 E. R. Squibb & Sons, Inc. Phosphonyl hydroxyacyl amino acid derivatives as antihypertensive
US4616005A (en) * 1982-06-23 1986-10-07 E. R. Squibb & Sons, Inc. Phosphonyl hydroxyacyl amino acid derivatives as antihypertensives
US4452790A (en) * 1982-06-23 1984-06-05 E. R. Squibb & Sons, Inc. Phosphonyl hydroxyacyl amino acid derivatives as antihypertensives
US4567166A (en) * 1982-07-14 1986-01-28 E. R. Squibb & Sons, Inc. Amino and substituted amino phosphinylalkanoyl compounds useful for treating hypertension
EP0187037A3 (en) * 1984-12-21 1988-03-23 Takeda Chemical Industries, Ltd. Piperidine derivatives, their production and use
AU632596B2 (en) * 1989-08-21 1993-01-07 E.R. Squibb & Sons, Inc. Phosphonate substituted amino or imino acids useful as antihypertensives
JPH05344844A (ja) * 1992-06-12 1993-12-27 Suzumo Kiko Kk 焼おむすびせんべいの製造方法
EP0640594A1 (en) 1993-08-23 1995-03-01 Fujirebio Inc. Hydantoin derivative as metalloprotease inhibitor
US5435286A (en) * 1994-05-02 1995-07-25 Cummins Engine Company, Inc. Ball link assembly for vehicle engine drive trains
US7659305B2 (en) 2002-10-31 2010-02-09 Pfizer Inc. Therapeutic proline derivatives
GB0225379D0 (en) * 2002-10-31 2002-12-11 Pfizer Ltd Therapeutic proline derivatives
WO2006038119A1 (en) * 2004-10-08 2006-04-13 Warner-Lambert Company Llc Stereoselective synthesis of n-protected alkoxy prolines
GB0715626D0 (en) 2007-08-10 2007-09-19 Generics Uk Ltd Crystalline form of zofenopril calcium
US8853421B2 (en) 2008-02-27 2014-10-07 Generics [Uk] Limited Crystalline forms of zofenopril calcium
AU2009219892B2 (en) * 2008-02-27 2014-08-07 Generics [Uk] Limited Novel crystalline forms
SI23949A (sl) 2011-12-19 2013-06-28 Silverstone Pharma Nove kristalne soli zofenoprila, postopek za njihovo dobivanje in njihova uporaba v terapiji

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2340092A2 (fr) * 1976-02-09 1977-09-02 Roussel Uclaf Nouveaux derives de l'acide 3-quinoleine carboxylique, leur procede de preparation et leur application comme medicament
AU509899B2 (en) * 1976-02-13 1980-05-29 E.R. Squibb & Sons, Inc. Proline derivatives and related compounds
US4116962A (en) * 1976-12-03 1978-09-26 E. R. Squibb & Sons, Inc. Pyrrolidine and piperidine-2-carboxylic acid derivatives
US4113715A (en) * 1977-01-17 1978-09-12 E. R. Squibb & Sons, Inc. Amino acid derivatives
US4108886A (en) * 1977-03-11 1978-08-22 E. R. Squibb & Sons, Inc. Thiopropanoylamino acid derivatives
PH15381A (en) * 1978-02-21 1982-12-17 Squibb & Sons Inc Halogen substituted mercaptoacylamino acids
US4154934A (en) * 1978-08-11 1979-05-15 E. R. Squibb & Sons, Inc. Mercaptoacylamino derivatives of heterocyclic carboxylic acids

Also Published As

Publication number Publication date
NL7906120A (nl) 1980-02-13
FR2435469B1 (es) 1983-02-11
GB2028327B (en) 1982-11-24
DE2932021C2 (de) 1994-05-19
ATA541679A (de) 1985-06-15
JPH01287069A (ja) 1989-11-17
IE791544L (en) 1980-02-11
AU530690B2 (en) 1983-07-28
CH642064A5 (de) 1984-03-30
DE2932021A1 (de) 1980-02-21
NZ191036A (en) 1984-05-31
RO78870A (ro) 1982-07-06
CA1144930A (en) 1983-04-19
NL990024I1 (nl) 1999-11-01
AU4919079A (en) 1980-02-14
SE7906722L (sv) 1980-02-12
NL193374C (nl) 1999-08-03
LU90403I2 (fr) 2000-07-07
SU1066460A3 (ru) 1984-01-07
BE878191A (fr) 1980-02-11
AT379589B (de) 1986-01-27
IT1117782B (it) 1986-02-24
FI69834B (fi) 1985-12-31
IT7949954A0 (it) 1979-08-03
FR2435469A1 (fr) 1980-04-04
DK154553C (da) 1989-04-17
NL990024I2 (nl) 1999-11-01
YU192379A (en) 1983-02-28
DK335879A (da) 1980-02-12
PH15030A (en) 1982-05-13
KR830002450B1 (ko) 1983-10-26
JPS5527199A (en) 1980-02-27
SE447477B (sv) 1986-11-17
CS228118B2 (en) 1984-05-14
AR229081A1 (es) 1983-06-15
ZA793633B (en) 1980-07-30
LU81593A1 (fr) 1979-12-07
DK154553B (da) 1988-11-28
IN152712B (es) 1984-03-17
YU41876B (en) 1988-02-29
KR830001269A (ko) 1983-04-29
RO78870B (ro) 1985-01-30
FI69834C (fi) 1986-05-26
IE48802B1 (en) 1985-05-15
GB2028327A (en) 1980-03-05
DD145749A5 (de) 1981-01-07
FI792498A (fi) 1980-02-12
GR72420B (es) 1983-11-03
NL193374B (nl) 1999-04-01
PT70049A (en) 1979-09-01
JPH0134987B2 (es) 1989-07-21

Similar Documents

Publication Publication Date Title
ES483311A1 (es) Un procedimiento para preparar derivados de prolina
ZA803251B (en) Pyroglutamic acid derivatives and analogs
ES8405782A1 (es) Un procedimiento para la produccion de un derivado de carbostirilo.
SE7908727L (sv) Fosfinylalkanoylproliner
NO893481D0 (no) Fremgangsmaate for fremstilling av alfa,alfa-disubstituerte n-cykloalkylalkylbenzylaminer.
MY100115A (en) Nitrogen containing heterocyclic compounds, and their production and use.
SE8503415L (sv) Nya isoindolinylalkylpiperaziner och farmaceutiska kompositioner innehallande desamma
DE3362504D1 (en) 1-carboxyalkanoylindoline-2-carboxylic-acid esters, their preparation, pharmaceutical compositions containing them, and their therapeutic use
ZA816259B (en) 2-(1,4-benzodioxan-2-ylalkyl)imidazoles useful as antidepressants
ATE76405T1 (de) 2-trifluormethyl-benzimidazole.
ATE92470T1 (de) Carboxyalkyl-ether von 2-amino-7-hydroxytetralin.
ES477878A1 (es) Un procedimiento para preparar mercaptoacilaminoacidos sustituidos con halogeno.
IL62608A (en) 6h-1,2,4,6-thiatriazine-1,1-dioxides,their manufacture and their use as herbicides
ES8200100A1 (es) Procedimiento para la obtencion de un 1,1-dioxido de 6h-1,2,4,6-tiatriazina
NO169176C (no) Tyroninderivater, og deres fremstillig og anvendelse
ES451484A1 (es) Procedimiento para la obtencion de derivados de n-(1, 2, 4- triacin-5, on-4-il)oliuna.
ES8800220A1 (es) Procedimiento para la produccion de 8-alfa-acilamino-ergolinas.
GB1504016A (en) Fungicidal agents
ES480391A1 (es) Un procedimiento para la preparacion de derivados de difeni-lamina.
IL67360A0 (en) Alpha-azolylglycols and their use as fungicides
DE3360427D1 (en) Organosilyl compounds and their use as fungicides
ES8203355A1 (es) Un procedimiento para la preparacion de nuevas oxazolinas
GR79583B (es)
IL76155A0 (en) Benzoylurea derivatives,their preparation and pesticidal compositions containing them

Legal Events

Date Code Title Description
PC1A Transfer granted