ES8301224A1 - Procedimiento para la preparacion de nuevas 5,10-dihidro -11h-dibenzo b,e 1,4 diazepin-11-onas, sustituidas en posi- cion 5 - Google Patents

Procedimiento para la preparacion de nuevas 5,10-dihidro -11h-dibenzo b,e 1,4 diazepin-11-onas, sustituidas en posi- cion 5

Info

Publication number
ES8301224A1
ES8301224A1 ES504206A ES504206A ES8301224A1 ES 8301224 A1 ES8301224 A1 ES 8301224A1 ES 504206 A ES504206 A ES 504206A ES 504206 A ES504206 A ES 504206A ES 8301224 A1 ES8301224 A1 ES 8301224A1
Authority
ES
Spain
Prior art keywords
piperidino
subsituted
diazepin
dibenzo
dihydro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES504206A
Other languages
English (en)
Other versions
ES504206A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Pharma GmbH and Co KG
Original Assignee
Dr Karl Thomae GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dr Karl Thomae GmbH filed Critical Dr Karl Thomae GmbH
Publication of ES8301224A1 publication Critical patent/ES8301224A1/es
Publication of ES504206A0 publication Critical patent/ES504206A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/38—[b, e]- or [b, f]-condensed with six-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Photoreceptors In Electrophotography (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE 5,10-DIHIDRO-11H-DIBENZO<014>B,E<015><014>1,4<015>DIAZOPIN-11-ONAS, SUSTITUIDOS EN POSICION 5. SE HACE REACCIONAR UN COMPUESTO DE FORMULA (I) DONDE R ES UN ATOMO DE HIDROGENO O UN GRUPO METILO O ETILO, R ES UN ATOMO DE HIDROGENO O CLORO, R ES UN ATOMO DE HIDROGENO O CLORO Y Z ES UN GRUPO <024>CH <024>CH <024>HAL O <024>CH=CH , SIENDO HAL UN ATOMO DE HALOGENO, CON UNA AMINA DE FORMULA (II) DONDE R ES UN GRUPO PIRROLIDINO, PIPERIDINO, 2-METIL-PIPERIDINO, 2,6-DIMETILPIPERIDINO O MORFOLINO, DANDO UN COMPUESTO DE FORMULA (III) QUE SI SE DESEA SE PUEDE TRANSFORMAR EN SUS SALES MEDIANTE ACIDOS INORGANICOS U ORGANICOS. >SE UTILIZAN COMO INHIBIDORES DE ULCERAS E INHIBIDORES DE SECRECION.
ES504206A 1980-07-24 1981-07-23 Procedimiento para la preparacion de nuevas 5,10-dihidro -11h-dibenzo b,e 1,4 diazepin-11-onas, sustituidas en posi- cion 5 Granted ES504206A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19803028001 DE3028001A1 (de) 1980-07-24 1980-07-24 Neue, in 5-stellung substituierte 5,10-dihydro-11h-dibenzo (b,e)(1,4) diazepin-11-one, verfahren zu ihrer herstellung und diese verbindung enthaltende arzneimittel

Publications (2)

Publication Number Publication Date
ES8301224A1 true ES8301224A1 (es) 1982-11-16
ES504206A0 ES504206A0 (es) 1982-11-16

Family

ID=6107969

Family Applications (1)

Application Number Title Priority Date Filing Date
ES504206A Granted ES504206A0 (es) 1980-07-24 1981-07-23 Procedimiento para la preparacion de nuevas 5,10-dihidro -11h-dibenzo b,e 1,4 diazepin-11-onas, sustituidas en posi- cion 5

Country Status (21)

Country Link
US (1) US4377576A (es)
EP (1) EP0044989B1 (es)
JP (1) JPS5756470A (es)
AT (1) ATE3548T1 (es)
AU (1) AU543677B2 (es)
CA (1) CA1154763A (es)
DD (1) DD202023A5 (es)
DE (2) DE3028001A1 (es)
DK (1) DK326481A (es)
ES (1) ES504206A0 (es)
FI (1) FI67697C (es)
GB (1) GB2081264B (es)
GR (1) GR75281B (es)
HU (1) HU187340B (es)
IL (1) IL63381A0 (es)
NO (1) NO812529L (es)
NZ (1) NZ197809A (es)
PH (1) PH16815A (es)
PT (1) PT73402B (es)
YU (1) YU182581A (es)
ZA (1) ZA815043B (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3204157A1 (de) * 1982-02-06 1983-08-11 Dr. Karl Thomae Gmbh, 7950 Biberach Substituierte dibenzodiazepinone, verfahren zu ihrer herstellung und sie enthaltende arzneimittel
DE3204158A1 (de) * 1982-02-06 1983-08-11 Dr. Karl Thomae Gmbh, 7950 Biberach "substituierte dibenzodiazepinone, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel"
DE3204403A1 (de) 1982-02-09 1983-08-11 Dr. Karl Thomae Gmbh, 7950 Biberach Neue pyridobenzodiazepinone, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
IT1212742B (it) * 1983-05-17 1989-11-30 Dompe Farmaceutici Spa Derivati dibenzo [1,4]diazepinonici pirido [1,4] benzodiazepinonici,pirido [1,5] benzodiazepinonici e loro attivita' farmacologica
IT1212743B (it) * 1983-05-17 1989-11-30 Dompe Farmaceutici Spa Sali quaternari di derivati di benzo[ 1,4 ]diazepinonici,pirido [1,4]benzodiazepinonici,prido [1,5]benzodiazepinonici e loro atti vita' farmacologica
DD236731B3 (de) * 1983-10-19 1992-12-10 Dresden Arzneimittel Verfahren zur herstellung von neuen in 5-stellung substituierten 5,10-dihydro-11h-dibenzo|b,e¨|1,4¨diazepin-11-onen
DE3409237A1 (de) * 1984-03-14 1985-09-19 Dr. Karl Thomae Gmbh, 7950 Biberach Kondensierte diazepinone, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
DE3531682A1 (de) * 1985-09-05 1987-03-12 Thomae Gmbh Dr K (+)-6-chlor-5,10-dihydro-5-((1-methyl-4- piperidinyl)acetyl)-11h-dibenzo(b,e)(1,4) diazepin-11-on, seine isolierung und verwendung als arzneimittel
DE3643666A1 (de) * 1986-12-20 1988-06-30 Thomae Gmbh Dr K Neue kondensierte diazepinone, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
DD293582A5 (de) * 1989-07-31 1991-09-05 Arzneimittelwerk Dresden,De Neue 5-(omega-aminoacyl)-5,10-dihydro-11h-dibenzo/b,e//1,4/-diazepin-11-one, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
US6277592B1 (en) 1996-07-31 2001-08-21 Purina Mills, Inc. Porcine leptin protein, nucleic acid sequences coding therefor and uses thereof
US6297027B1 (en) 1996-07-31 2001-10-02 Purina Mills, Inc. Bovine leptin protein, nucleic acid sequences coding therefor and uses thereof
WO2007056388A2 (en) * 2005-11-07 2007-05-18 The General Hospital Corporation Compositions and methods for modulating poly (adp-ribose) polymerase activity

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1795176C3 (de) * 1968-08-20 1974-10-24 Dr. Karl Thomae Gmbh, 7950 Biberach hT-substituierte 5-Aminoacetyl-5,10-dihydro-l lH-dibenzo eckige Klammer auf b,e eckige Klammer zu eckige Klammer auf 1,4 eckige Klammer zu diazepin-11one und Verfahren zu ihrer Herstellung
DE1931487C3 (de) * 1969-06-20 1975-12-18 Dr. Karl Thomae Gmbh, 7950 Biberach In 5-Stellung substituierte 5,10-Dihydro-11H-dibenzo eckige Klammer auf b,e eckige Klammer zu eckige Klammer auf 1,4 eckige Klammer zu diazepin-11 -one und Verfahren zu ihrer Herstellung
FI49509C (fi) * 1968-08-20 1975-07-10 Thomae Gmbh Dr K Menetelmä farmakologisesti vaikuttavien 5-asemaan substituoitujen 5,10 -dihydro-11H-dibentso/b,e//1,4/deatsepiini-11-onien ja niiden suolojen valmistamiseksi.

Also Published As

Publication number Publication date
GB2081264B (en) 1984-01-25
GB2081264A (en) 1982-02-17
EP0044989A1 (de) 1982-02-03
PT73402B (de) 1983-06-15
YU182581A (en) 1984-02-29
AU543677B2 (en) 1985-04-26
ZA815043B (en) 1983-03-30
NZ197809A (en) 1983-06-14
IL63381A0 (en) 1981-10-30
FI67697C (fi) 1985-05-10
HU187340B (en) 1985-12-28
DE3160360D1 (en) 1983-07-07
EP0044989B1 (de) 1983-05-25
ATE3548T1 (de) 1983-06-15
JPS5756470A (en) 1982-04-05
PT73402A (de) 1981-08-01
DD202023A5 (de) 1983-08-24
NO812529L (no) 1982-01-25
PH16815A (en) 1984-03-06
ES504206A0 (es) 1982-11-16
GR75281B (es) 1984-07-13
AU7337081A (en) 1982-01-28
US4377576A (en) 1983-03-22
DK326481A (da) 1982-01-25
FI812321L (fi) 1982-01-25
CA1154763A (en) 1983-10-04
FI67697B (fi) 1985-01-31
DE3028001A1 (de) 1982-02-18

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20000601