ES8308330A1 - "procedimiento para la preparacion de compuestos heterociclicos". - Google Patents

"procedimiento para la preparacion de compuestos heterociclicos".

Info

Publication number
ES8308330A1
ES8308330A1 ES515413A ES515413A ES8308330A1 ES 8308330 A1 ES8308330 A1 ES 8308330A1 ES 515413 A ES515413 A ES 515413A ES 515413 A ES515413 A ES 515413A ES 8308330 A1 ES8308330 A1 ES 8308330A1
Authority
ES
Spain
Prior art keywords
carbon atoms
alkyl
phenyl
hydrogen
alkoxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES515413A
Other languages
English (en)
Other versions
ES515413A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim GmbH
Original Assignee
Boehringer Ingelheim GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim GmbH filed Critical Boehringer Ingelheim GmbH
Publication of ES8308330A1 publication Critical patent/ES8308330A1/es
Publication of ES515413A0 publication Critical patent/ES515413A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Lubricants (AREA)
  • Gyroscopes (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE COMPUESTOS HETEROCICLICOS Y DE SUS SALES DE ADICION DE ACIDOS, DE FORMULA (I), EN LA QUE X ES OXIGENO, AZUFRE O METILENO; LA LINEA DE TRAZOS INDICA ENLACE DOBLE O SENCILLO; Y R<1, R<2, R<3, R<4, R<5 Y R<6 PUEDEN SER VARIOS TIPOS DE RADICALES. CONSISTE EN EL CIERRE DE ANILLO MEDIANTE REACCION INTRAMOLECULAR DE UNA DIAMINA DE FORMULA (II), EN LA QUE TODOS LOS SIMBOLOS TIENEN EL MISMO SIGNIFICADO QUE EN LA FORMULA (I), CON UN HALOGENURO DE CIANOGENO; SEGUIDA DE LA EVENTUAL REACCION CON UN COMPUESTO DE FORMULA R<5-X, EN LA QUE X ES HALOGENO O SULFONILOXILO Y R<5 ES EL MISMO QUE EN LA FORMULA (I), EN UN DISOLVENTE POLAR Y EN PRESENCIA DE UNA BASE. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS POR SU EFECTO ANTIALERGICO, ANTIHISTAMINERGICO Y ANTISEROTOMINERGICO Y POR INHIBIR LA AGREGACION DE LAS PLAQUETAS.
ES515413A 1981-09-02 1982-09-01 "procedimiento para la preparacion de compuestos heterociclicos". Granted ES515413A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19813134672 DE3134672A1 (de) 1981-09-02 1981-09-02 Heterocyclische verbindungen, ihre herstellung und verwendung

Publications (2)

Publication Number Publication Date
ES8308330A1 true ES8308330A1 (es) 1983-08-16
ES515413A0 ES515413A0 (es) 1983-08-16

Family

ID=6140652

Family Applications (3)

Application Number Title Priority Date Filing Date
ES515413A Granted ES515413A0 (es) 1981-09-02 1982-09-01 "procedimiento para la preparacion de compuestos heterociclicos".
ES521605A Expired ES8405018A1 (es) 1981-09-02 1983-04-19 Procedimiento para la preparacion de compuestos heterociclicos.
ES521604A Granted ES521604A0 (es) 1981-09-02 1983-04-19 Procedimiento para la preparacion de compuestos heterociclicos.

Family Applications After (2)

Application Number Title Priority Date Filing Date
ES521605A Expired ES8405018A1 (es) 1981-09-02 1983-04-19 Procedimiento para la preparacion de compuestos heterociclicos.
ES521604A Granted ES521604A0 (es) 1981-09-02 1983-04-19 Procedimiento para la preparacion de compuestos heterociclicos.

Country Status (26)

Country Link
US (1) US4503060A (es)
EP (1) EP0073506B1 (es)
JP (1) JPS5846089A (es)
KR (1) KR880001988B1 (es)
AT (1) ATE18049T1 (es)
AU (1) AU550340B2 (es)
CA (1) CA1169858A (es)
CS (1) CS236680B2 (es)
DD (1) DD204255A5 (es)
DE (2) DE3134672A1 (es)
DK (1) DK160047C (es)
ES (3) ES515413A0 (es)
FI (1) FI76089C (es)
GB (1) GB2108112B (es)
GR (1) GR77274B (es)
HU (1) HU185110B (es)
IE (1) IE54261B1 (es)
IL (1) IL66694A0 (es)
NO (1) NO160445C (es)
NZ (1) NZ201780A (es)
PH (1) PH19377A (es)
PL (1) PL135812B1 (es)
PT (1) PT75494B (es)
SU (1) SU1155158A3 (es)
YU (1) YU43089B (es)
ZA (1) ZA826380B (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020091850A1 (en) 1992-10-23 2002-07-11 Cybex Corporation System and method for remote monitoring and operation of personal computers
ES2162907T3 (es) * 1993-11-22 2002-01-16 Merck & Co Inc 3-acilaminobenzacepinas.
US5658901A (en) * 1994-08-18 1997-08-19 Merck & Co., Inc. 2,3-dihydro-1-(2,2,2,-trifluoroethyl)-2-oxo-5-phenyl-1H-1,4-benzodiazepines
US5478934A (en) * 1994-11-23 1995-12-26 Yuan; Jun Certain 1-substituted aminomethyl imidazole and pyrrole derivatives: novel dopamine receptor subtype specific ligands
WO1996040656A1 (en) * 1995-06-07 1996-12-19 Merck & Co., Inc. Novel n-(2,4-dioxo-2,3,4,5-tetrahydro-1h-1,5-benzodiazepin-3yl)-3-amides
US5700797A (en) * 1995-06-07 1997-12-23 Merck & Co, Inc. N-(2,4-dioxo-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-3-yl)-3-amides
US5631251A (en) * 1995-06-07 1997-05-20 Merck & Co., Inc. 5-cyclopropyl-1,4 benzodiazepine-2-ones
US5726171A (en) * 1995-06-07 1998-03-10 Merck & Co Inc N-(1-alkyl-5-phenyl-2,3,4,5-tetrahydro-1H-benzo B! 1,4!diazepin-3yl)-acetamides
US5691331A (en) * 1995-06-07 1997-11-25 Merck & Co., Inc. N-(2,4-Dioxo-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-3yl) -3- amides
ES2594655T3 (es) * 2006-03-31 2016-12-21 Vistakon Pharmaceuticals, Llc Tratamiento de alergias oculares

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE789410A (fr) * 1971-10-05 1973-01-15 Akzo Nv Nieuwe imidazolidine derivaten
NL7202963A (es) * 1972-03-07 1973-09-11
NL7414038A (nl) * 1974-10-28 1976-05-03 Akzo Nv Nieuwe tetracyclische pyrrolidino derivaten.
DE3008944A1 (de) * 1980-03-08 1981-09-24 C.H. Boehringer Sohn, 6507 Ingelheim Dibenzimidazoazepine, ihre herstellung und verwendung

Also Published As

Publication number Publication date
ES521605A0 (es) 1984-05-16
CA1169858A (en) 1984-06-26
KR840001577A (ko) 1984-05-07
GB2108112B (en) 1985-01-09
EP0073506B1 (de) 1986-02-19
KR880001988B1 (ko) 1988-10-10
ES8405017A1 (es) 1984-05-16
YU43089B (en) 1989-02-28
PT75494A (en) 1982-10-01
AU8792682A (en) 1984-03-08
DK391182A (da) 1983-03-03
FI76089C (fi) 1988-09-09
PL238090A1 (en) 1984-01-02
IL66694A0 (en) 1982-12-31
FI823001L (fi) 1983-03-03
PT75494B (en) 1986-04-17
DK160047C (da) 1991-06-10
DE3269187D1 (en) 1986-03-27
HU185110B (en) 1984-12-28
FI823001A0 (fi) 1982-08-31
NZ201780A (en) 1986-01-24
PL135812B1 (en) 1985-12-31
DK160047B (da) 1991-01-21
ES8405018A1 (es) 1984-05-16
NO160445B (no) 1989-01-09
AU550340B2 (en) 1986-03-20
NO160445C (no) 1989-04-19
CS236680B2 (en) 1985-05-15
EP0073506A1 (de) 1983-03-09
ZA826380B (en) 1984-05-30
ES515413A0 (es) 1983-08-16
US4503060A (en) 1985-03-05
PH19377A (en) 1986-04-02
NO822948L (no) 1983-03-03
GR77274B (es) 1984-09-11
ATE18049T1 (de) 1986-03-15
SU1155158A3 (ru) 1985-05-07
YU196082A (en) 1984-12-31
DD204255A5 (de) 1983-11-23
DE3134672A1 (de) 1983-03-17
FI76089B (fi) 1988-05-31
ES521604A0 (es) 1984-05-16
IE54261B1 (en) 1989-08-02
JPH0380795B2 (es) 1991-12-26
GB2108112A (en) 1983-05-11
JPS5846089A (ja) 1983-03-17
IE822131L (en) 1983-03-02

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970203