DK504183A - Guaninderivater og fremgangsmaade til fremstilling deraf - Google Patents

Guaninderivater og fremgangsmaade til fremstilling deraf Download PDF

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Publication number
DK504183A
DK504183A DK504183A DK504183A DK504183A DK 504183 A DK504183 A DK 504183A DK 504183 A DK504183 A DK 504183A DK 504183 A DK504183 A DK 504183A DK 504183 A DK504183 A DK 504183A
Authority
DK
Denmark
Prior art keywords
compound
general formula
preparing
salts
guanine
Prior art date
Application number
DK504183A
Other languages
English (en)
Other versions
DK149001B (da
DK504183D0 (da
DK149001C (da
Inventor
Julien P Verheyden
John C Martin
Original Assignee
Syntex Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23017790&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK504183(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Syntex Inc filed Critical Syntex Inc
Publication of DK504183A publication Critical patent/DK504183A/da
Publication of DK504183D0 publication Critical patent/DK504183D0/da
Publication of DK149001B publication Critical patent/DK149001B/da
Application granted granted Critical
Publication of DK149001C publication Critical patent/DK149001C/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
DK504183A 1981-05-21 1983-11-03 9-substituerede n2-acylguaniner eller syreadditionssalte eller uorganiske metalsalte deraf DK149001C (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US26721081 1981-05-21
US06267210 US4355032B2 (en) 1981-05-21 1981-05-21 9-(1,3-dihydroxy-2-propoxymethyl)guanine as antiviral agent
DK227782 1982-05-19
DK227782A DK150304C (da) 1981-05-21 1982-05-19 Analogifremgangsmaade til fremstilling af 9-(1,3-dihydroxy-2-propoxymethyl)guanin eller farmaceutisk acceptable salte deraf

Publications (4)

Publication Number Publication Date
DK504183A true DK504183A (da) 1983-11-03
DK504183D0 DK504183D0 (da) 1983-11-03
DK149001B DK149001B (da) 1985-12-16
DK149001C DK149001C (da) 1988-11-28

Family

ID=23017790

Family Applications (2)

Application Number Title Priority Date Filing Date
DK227782A DK150304C (da) 1981-05-21 1982-05-19 Analogifremgangsmaade til fremstilling af 9-(1,3-dihydroxy-2-propoxymethyl)guanin eller farmaceutisk acceptable salte deraf
DK504183A DK149001C (da) 1981-05-21 1983-11-03 9-substituerede n2-acylguaniner eller syreadditionssalte eller uorganiske metalsalte deraf

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK227782A DK150304C (da) 1981-05-21 1982-05-19 Analogifremgangsmaade til fremstilling af 9-(1,3-dihydroxy-2-propoxymethyl)guanin eller farmaceutisk acceptable salte deraf

Country Status (33)

Country Link
US (1) US4355032B2 (da)
EP (1) EP0066208B1 (da)
JP (2) JPS57203086A (da)
KR (1) KR890004663B1 (da)
AR (1) AR244227A1 (da)
AT (1) ATE15899T1 (da)
AU (1) AU572086B2 (da)
BR (1) BR8202931A (da)
CA (3) CA1305141C (da)
CS (4) CS235043B2 (da)
DD (2) DD213218A5 (da)
DE (1) DE3266644D1 (da)
DK (2) DK150304C (da)
ES (7) ES512414A0 (da)
FI (1) FI73682C (da)
GR (1) GR76459B (da)
HK (1) HK67088A (da)
HU (2) HU186514B (da)
IE (1) IE53731B1 (da)
IL (1) IL65836A (da)
IN (1) IN156469B (da)
LU (1) LU88334I2 (da)
MY (1) MY8700793A (da)
NL (2) NL930022I1 (da)
NO (2) NO161740C (da)
NZ (1) NZ200691A (da)
PH (1) PH17975A (da)
PL (4) PL136579B1 (da)
PT (1) PT74934B (da)
RO (2) RO84860B (da)
SG (1) SG81687G (da)
SU (1) SU1176841A3 (da)
ZA (1) ZA823532B (da)

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US4347360A (en) * 1980-09-16 1982-08-31 Ens Bio Logicals Inc. Ring open nucleoside analogues
US4507305A (en) * 1981-05-21 1985-03-26 Syntex (U.S.A.) Inc. 9-(1,3-Dihydroxy-2-propoxymethyl)guanine as antiviral agent
US4423050A (en) * 1981-05-21 1983-12-27 Syntex (U.S.A.) Inc. 9-(1,3-Dihydroxy-2-propoxymethyl)guanine as antiviral agent
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NZ201662A (en) * 1981-08-26 1986-07-11 Merck & Co Inc 9-(1,3-(and 2,3)-dihydroxy-1-(and 2)-propoxy-methyl)guanine derivatives and methods for their preparation
SU1537138A3 (ru) * 1982-02-01 1990-01-15 Синтекс (Ю.С.А.) Инк (Фирма) Способ получени производных пуринов или их солей
US5250535A (en) * 1982-02-01 1993-10-05 Syntex Inc. Substituted 9-(1 or 3-monoacyloxy or 1,3-diacyloxy-2-propoxymethyl) purines as antiviral agent
US4902678A (en) * 1982-02-12 1990-02-20 Syntex (U.S.A.) Inc. Anti-viral compositions
US4609662A (en) * 1982-10-14 1986-09-02 Burroughs Wellcome Co. Method for using purine derivatives
US4462986A (en) * 1982-11-04 1984-07-31 Ens Bio Logicals, Inc. Synergistic anti-herpes compositions
US4814335A (en) * 1982-12-30 1989-03-21 Biomeasure, Incorporated Antiviral compounds
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US5047533A (en) * 1983-05-24 1991-09-10 Sri International Acyclic purine phosphonate nucleotide analogs
US4880820A (en) * 1983-06-24 1989-11-14 Merck & Co., Inc. Guanine derivatives
GB8320308D0 (en) * 1983-07-28 1983-09-01 Wellcome Found Antiviral combinations
EP0138683A3 (en) * 1983-09-30 1988-01-20 Merck & Co. Inc. Purine derivatives, their application in anti-viral compositions
US4897479A (en) * 1983-09-30 1990-01-30 Merck & Co., Inc. Arylsulfonyloxy purine intermediates
US4806642A (en) * 1984-10-05 1989-02-21 Warner-Lambert Company Purine derivatives
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SE8406538D0 (sv) 1984-12-21 1984-12-21 Astra Laekemedel Ab Novel derivatives of purine
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US5068119A (en) * 1990-09-28 1991-11-26 Nabisco Brands, Inc. Acid-hydrolyzable ester derivatives as low calorie fat mimetics
GB2260319B (en) 1991-10-07 1995-12-06 Norsk Hydro As Acyl derivatives of nucleosides and nucleoside analogues having anti-viral activity
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US5543414A (en) * 1994-07-28 1996-08-06 Syntex (Usa) Inc. Achiral amino acid acyl esters of ganciclovir and its derivatives
US6083953A (en) * 1994-07-28 2000-07-04 Syntex (U.S.A.) Inc. 2- (2-amino-1,6-dihydro-6-oxo-purin-9-yl) methoxy-1,3- propanediol derivative
US5565565A (en) 1994-08-04 1996-10-15 Syntex (U.S.A.) Inc. Preparation of N-9 substituted guanine compounds
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US4347360A (en) * 1980-09-16 1982-08-31 Ens Bio Logicals Inc. Ring open nucleoside analogues
AU7938482A (en) * 1980-12-22 1982-07-20 Astra Lakemedel Aktiebolag Novel derivatives of guanine
GB2104070B (en) * 1981-08-11 1985-08-14 Wellcome Found Purines

Also Published As

Publication number Publication date
DK149001B (da) 1985-12-16
ZA823532B (en) 1983-03-30
US4355032B1 (da) 1983-06-14
SU1176841A3 (ru) 1985-08-30
DK150304B (da) 1987-02-02
EP0066208B1 (en) 1985-10-02
ES8505681A1 (es) 1985-06-16
NL930139I2 (nl) 1997-07-01
RO84860B (ro) 1984-10-30
NL930139I1 (nl) 1993-11-01
PL136637B1 (en) 1986-03-31
ES8701496A1 (es) 1987-01-01
ES8507549A1 (es) 1985-09-16
ES524900A0 (es) 1985-11-16
ES8404355A1 (es) 1984-05-01
LU88334I2 (fr) 1994-09-09
ES8606869A1 (es) 1986-05-16
DD203052A5 (de) 1983-10-12
ES512414A0 (es) 1984-05-01
PH17975A (en) 1985-02-22
CS235044B2 (en) 1985-04-16
ES529383A0 (es) 1986-05-16
AU8389282A (en) 1982-11-25
JPH046195B2 (da) 1992-02-05
IE821210L (en) 1982-11-21
FI73682B (fi) 1987-07-31
KR890004663B1 (ko) 1989-11-24
NZ200691A (en) 1986-11-12
US4355032A (en) 1982-10-19
DK150304C (da) 1988-01-04
RO87387B (ro) 1985-08-31
HK67088A (en) 1988-09-02
NL930022I1 (nl) 1993-05-03
GR76459B (da) 1984-08-10
PL246770A1 (en) 1984-08-27
ES8601204A1 (es) 1985-11-16
ES533821A0 (es) 1985-06-16
PL136332B1 (en) 1986-02-28
NO161740C (no) 1989-09-20
RO87387A (ro) 1985-08-31
MY8700793A (en) 1987-12-31
PL242100A1 (en) 1984-04-24
AR244227A1 (es) 1993-10-29
PT74934B (en) 1984-05-08
CS235018B2 (en) 1985-04-16
BR8202931A (pt) 1983-05-03
PL236521A1 (en) 1984-01-02
ATE15899T1 (de) 1985-10-15
CS235042B2 (en) 1985-04-16
JPH0529399B2 (da) 1993-04-30
DD213218A5 (de) 1984-09-05
IN156469B (da) 1985-08-10
RO84860A (ro) 1984-09-29
DK504183D0 (da) 1983-11-03
SG81687G (en) 1989-07-07
HU188000B (en) 1986-03-28
IE53731B1 (en) 1989-02-01
ES8500276A1 (es) 1984-11-01
NO1994005I1 (no) 1994-07-29
CA1305139C (en) 1992-07-14
EP0066208A1 (en) 1982-12-08
DK149001C (da) 1988-11-28
FI821794A0 (fi) 1982-05-20
PT74934A (en) 1982-06-01
KR830010112A (ko) 1983-12-26
ES520849A0 (es) 1984-11-01
US4355032B2 (en) 1990-10-30
IL65836A (en) 1991-04-15
JPS57203086A (en) 1982-12-13
HU186514B (en) 1985-08-28
ES524899A0 (es) 1985-09-16
PL136004B1 (en) 1986-01-31
CA1305140C (en) 1992-07-14
FI73682C (fi) 1987-11-09
DK227782A (da) 1982-11-22
IL65836A0 (en) 1982-08-31
PL242101A1 (en) 1984-07-16
JPH04217983A (ja) 1992-08-07
CS235043B2 (en) 1985-04-16
NO821676L (no) 1982-11-22
DE3266644D1 (en) 1985-11-07
CA1305141C (en) 1992-07-14
NO161740B (no) 1989-06-12
PL136579B1 (en) 1986-02-28
ES529384A0 (es) 1987-01-01
AU572086B2 (en) 1988-05-05

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