PT87716A - Process for preparing cycloalkylamides of (8-beta)-1-alkyl-6-(substituted) ergolines - Google Patents

Process for preparing cycloalkylamides of (8-beta)-1-alkyl-6-(substituted) ergolines

Info

Publication number
PT87716A
PT87716A PT87716A PT8771688A PT87716A PT 87716 A PT87716 A PT 87716A PT 87716 A PT87716 A PT 87716A PT 8771688 A PT8771688 A PT 8771688A PT 87716 A PT87716 A PT 87716A
Authority
PT
Portugal
Prior art keywords
alkyl
beta
substituted
cycloalkylamides
ergolines
Prior art date
Application number
PT87716A
Other languages
English (en)
Other versions
PT87716B (pt
Inventor
Mark Mortensen Foreman
William Lee Garbrecht
Gifford Purnell Marzoni
Kathleen Rose Whitten
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of PT87716A publication Critical patent/PT87716A/pt
Publication of PT87716B publication Critical patent/PT87716B/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C07D457/04—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 8
    • C07D457/06—Lysergic acid amides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Vascular Medicine (AREA)
  • Obesity (AREA)
  • Child & Adolescent Psychology (AREA)
  • Anesthesiology (AREA)
  • Nutrition Science (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
PT87716A 1987-06-15 1988-06-14 Processo para a preparacao de cicloalquilamidas de (8 beta)-1-alquil-6-(substituidas)ergolinas PT87716B (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US6228587A 1987-06-15 1987-06-15

Publications (2)

Publication Number Publication Date
PT87716A true PT87716A (pt) 1988-07-01
PT87716B PT87716B (pt) 1992-10-30

Family

ID=22041482

Family Applications (1)

Application Number Title Priority Date Filing Date
PT87716A PT87716B (pt) 1987-06-15 1988-06-14 Processo para a preparacao de cicloalquilamidas de (8 beta)-1-alquil-6-(substituidas)ergolinas

Country Status (22)

Country Link
EP (1) EP0296748B1 (pt)
JP (1) JP2653835B2 (pt)
KR (1) KR960010454B1 (pt)
CN (1) CN1019451B (pt)
AT (1) ATE87921T1 (pt)
AU (1) AU613641B2 (pt)
CA (1) CA1339661C (pt)
DE (1) DE3880022T2 (pt)
DK (1) DK322588A (pt)
EG (1) EG18586A (pt)
ES (1) ES2054806T3 (pt)
HK (1) HK77693A (pt)
HU (2) HU203344B (pt)
IE (1) IE61884B1 (pt)
IL (1) IL86725A (pt)
MX (1) MX11866A (pt)
NZ (1) NZ225022A (pt)
PH (1) PH24309A (pt)
PT (1) PT87716B (pt)
SU (1) SU1597103A3 (pt)
UA (1) UA6022A1 (pt)
ZA (1) ZA884222B (pt)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4902691A (en) * 1988-12-19 1990-02-20 Eli Lilly And Company Heteroalkylamides of (8-β)-1-alkyl-6-(substituted)ergolines useful for blocking 5HT2 receptors
IT1232692B (it) * 1989-08-04 1992-03-04 Poli Ind Chimica Spa Derivati ergolinici con attivita' dopaminergica
US5043341A (en) * 1990-04-11 1991-08-27 Eli Lilly And Company N-(2-hydroxycyclopentyl)-1-isopropyl-6-methylergoline-8-carboxamides
US5141944A (en) * 1990-04-11 1992-08-25 Eli Lilly And Company N-(2-hydroxycyclopentyl)-1-isopropyl-6-methylergoline-8-carboxamides
JPH11503757A (ja) * 1995-04-18 1999-03-30 イーライ・リリー・アンド・カンパニー ５−ｈｔ▲下７▼レセプターにおいて生理学的および病理学的機能を生じるエルゴリン化合物の使用方法
US5880134A (en) * 1996-03-20 1999-03-09 Eli Lilly And Company Method for using ergoline compounds to effect physiological and pathological functions at the 5-HT7 receptor
US6175692B1 (en) 1998-05-26 2001-01-16 Canon Kabushiki Kaisha Focus detecting device, distance measuring device, and optical apparatus for adjusting focus
WO2011079313A1 (en) 2009-12-23 2011-06-30 Map Pharmaceuticals, Inc. Novel ergoline analogs
CN102775402B (zh) * 2011-05-13 2015-08-26 上海现代制药股份有限公司 一种制备二氢麦角酸的中间体及其制备方法
CN103827113A (zh) 2011-06-23 2014-05-28 Map药物公司 新型氟麦角碱类似物
CA2859173A1 (en) 2011-12-19 2013-06-27 Map Pharmaceuticals, Inc. Novel iso-ergoline derivatives
AU2012355983A1 (en) 2011-12-21 2015-01-22 Map Pharmaceuticals, Inc. Novel neuromodulatory compounds
US9012640B2 (en) 2012-06-22 2015-04-21 Map Pharmaceuticals, Inc. Cabergoline derivatives

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH386441A (de) * 1961-02-17 1965-01-15 Sandoz Ag Verfahren zur Herstellung von am Indolstickstoff substituierten Derivaten der Lysergsäure-Reihe
GB982737A (en) * 1961-05-08 1965-02-10 Westminster Bank Ltd Improvements in or relating to lysergic acid compounds
GB996062A (en) * 1961-07-13 1965-06-23 Westminster Bank Ltd Improvements in or relating to lysergic acid compounds

Also Published As

Publication number Publication date
SU1597103A3 (ru) 1990-09-30
JPS6416781A (en) 1989-01-20
IL86725A0 (en) 1988-11-30
EP0296748A1 (en) 1988-12-28
CN1030586A (zh) 1989-01-25
AU1765288A (en) 1988-12-15
HU203344B (en) 1991-07-29
ATE87921T1 (de) 1993-04-15
ES2054806T3 (es) 1994-08-16
DK322588D0 (da) 1988-06-14
ZA884222B (en) 1990-02-28
CN1019451B (zh) 1992-12-16
UA6022A1 (uk) 1994-12-29
CA1339661C (en) 1998-02-10
DE3880022T2 (de) 1993-08-19
EG18586A (en) 1993-08-30
KR890000482A (ko) 1989-03-14
KR960010454B1 (ko) 1996-08-01
IE61884B1 (en) 1994-11-30
AU613641B2 (en) 1991-08-08
IL86725A (en) 1993-01-14
HU211235A9 (en) 1995-11-28
HUT47271A (en) 1989-02-28
NZ225022A (en) 1990-07-26
JP2653835B2 (ja) 1997-09-17
IE881788L (en) 1988-12-15
PT87716B (pt) 1992-10-30
PH24309A (en) 1990-05-29
DE3880022D1 (de) 1993-05-13
MX11866A (es) 1993-12-01
HK77693A (en) 1993-08-13
EP0296748B1 (en) 1993-04-07
DK322588A (da) 1989-02-01

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Legal Events

Date Code Title Description
FG3A Patent granted, date of granting

Effective date: 19920421

MM3A Annulment or lapse

Free format text: LAPSE DUE TO NON-PAYMENT OF FEES

Effective date: 20011031