GB996062A - Improvements in or relating to lysergic acid compounds - Google Patents

Improvements in or relating to lysergic acid compounds

Info

Publication number
GB996062A
GB996062A GB2547661A GB2547661A GB996062A GB 996062 A GB996062 A GB 996062A GB 2547661 A GB2547661 A GB 2547661A GB 2547661 A GB2547661 A GB 2547661A GB 996062 A GB996062 A GB 996062A
Authority
GB
United Kingdom
Prior art keywords
radical
carbon atoms
compounds
hal
alkali metal
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB2547661A
Inventor
Albert Hofmann
Franz Troxler
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
WESTMINSTER BANK Ltd
Original Assignee
WESTMINSTER BANK Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by WESTMINSTER BANK Ltd filed Critical WESTMINSTER BANK Ltd
Priority to GB2547661A priority Critical patent/GB996062A/en
Publication of GB996062A publication Critical patent/GB996062A/en
Expired legal-status Critical Current

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Abstract

The invention comprises compounds of the general formula <FORM:0996062/C2/1> (in which R1 is a mono- or dialkylamino radical of which the alkyl portions contain from 1 to 4 carbon atoms, a hydroxy alkylamino radical containing from 1 to 7 carbon atoms, or an aralkylamino radical having from 7 to 13 carbons, or a cycloalkylamino radical having 5 or 6 carbon atoms, or the piperidino radical, or a tripeptide radical of the water-insoluble ergot alkaloids; R2 is an alkyl radical containing from 1 to 4 carbon atoms, an aralkyl radical containing from 7 to 13 carbon atoms or an alkenyl radical having 2 to 4 carbon atoms; xy signifies the radical <FORM:0996062/C2/2> <FORM:0996062/C2/3> and their acid addition salts, and a method for their preparation by reacting a compound of the formula <FORM:0996062/C2/4> in liquid ammonia with an alkali metal amide and treating the resulting alkali metal salt with a halogen compound R2-hal, and if desired, salifying the product with an organic or inorganic acid (hal = bromine or iodine). The compounds and processes of the parent Specification and Specification 854,569 are disclaimed. The compounds exhibit a serotonin inhibiting effect, and may be used in treatment of inflammatory and psychic disturbances.
GB2547661A 1961-07-13 1961-07-13 Improvements in or relating to lysergic acid compounds Expired GB996062A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB2547661A GB996062A (en) 1961-07-13 1961-07-13 Improvements in or relating to lysergic acid compounds

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB2547661A GB996062A (en) 1961-07-13 1961-07-13 Improvements in or relating to lysergic acid compounds

Publications (1)

Publication Number Publication Date
GB996062A true GB996062A (en) 1965-06-23

Family

ID=10228327

Family Applications (1)

Application Number Title Priority Date Filing Date
GB2547661A Expired GB996062A (en) 1961-07-13 1961-07-13 Improvements in or relating to lysergic acid compounds

Country Status (1)

Country Link
GB (1) GB996062A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0296748A1 (en) * 1987-06-15 1988-12-28 Eli Lilly And Company Cycloalkylamides of (8Beta)-1-alkyl-6-(substituted) ergolines
WO2014100354A1 (en) * 2012-12-21 2014-06-26 Map Pharmaceuticals, Inc. Novel methysergide derivatives

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0296748A1 (en) * 1987-06-15 1988-12-28 Eli Lilly And Company Cycloalkylamides of (8Beta)-1-alkyl-6-(substituted) ergolines
AU613641B2 (en) * 1987-06-15 1991-08-08 Eli Lilly And Company Cycloalkylamides of (8beta)-1-isopropyl-6-(substituted) ergolines
WO2014100354A1 (en) * 2012-12-21 2014-06-26 Map Pharmaceuticals, Inc. Novel methysergide derivatives
US8895743B2 (en) 2012-12-21 2014-11-25 Map Pharmaceuticals, Inc. Methysergide derivatives

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