GB826300A - New amino-thioacid esters and the production thereof - Google Patents

New amino-thioacid esters and the production thereof

Info

Publication number
GB826300A
GB826300A GB2954557A GB2954557A GB826300A GB 826300 A GB826300 A GB 826300A GB 2954557 A GB2954557 A GB 2954557A GB 2954557 A GB2954557 A GB 2954557A GB 826300 A GB826300 A GB 826300A
Authority
GB
United Kingdom
Prior art keywords
compound
general formula
reacting
radical
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB2954557A
Inventor
Lambert Hoenen
Heinrich Mueckter
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Gruenenthal GmbH
Original Assignee
Gruenenthal GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gruenenthal GmbH filed Critical Gruenenthal GmbH
Priority to GB2954557A priority Critical patent/GB826300A/en
Publication of GB826300A publication Critical patent/GB826300A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
    • C07D207/27—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention comprises compounds of the general formula <FORM:0826300/IV (b)/1> in which R1 is a residue of an imide of a dicarboxylic acid attached to the carbon chain by the imido nitrogen atom; R2 is a hydrogen atom, an alkyl radical containing from 1 to 5 carbon atoms which may be substituted by a thiocarboxylic ester or by an alkylmercapto group, or an aralkyl radical which may be substituted by an hydroxy group; R3 and R4 may be the same or different, and are hydrogen atoms or alkyl radicals containing from 1 to 3 carbon atoms; n is an integer from 1 to 3; and R5 is an alkyl radical, an aralkyl radical which may be substituted by a halogen atom, or an aryl radical, and the preparation thereof by (a) reacting a compound of the general formula <FORM:0826300/IV (b)/2> or a salt thereof, with a compound of the formula Y-R5, Y being an acid radical; (b) reacting a compound of the general formula <FORM:0826300/IV (b)/3> or a functional derivative thereof with a compound of the formula HS-R5 or with a salt of such a compound; (c) reacting a compound of the general formula <FORM:0826300/IV (b)/4> Hal being a halogen atom, with a compound of the formula R1-H or with a metal derivative of such a compound; or (d) reacting a compound of the general formula <FORM:0826300/IV (b)/5> with a dicarboxylic acid or a functional derivative thereof. b -Bromo thiopivalic acid ethyl ester is prepared from b -bromopivalic acid chloride and ethyl mercaptan.
GB2954557A 1957-09-19 1957-09-19 New amino-thioacid esters and the production thereof Expired GB826300A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB2954557A GB826300A (en) 1957-09-19 1957-09-19 New amino-thioacid esters and the production thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB2954557A GB826300A (en) 1957-09-19 1957-09-19 New amino-thioacid esters and the production thereof

Publications (1)

Publication Number Publication Date
GB826300A true GB826300A (en) 1959-12-31

Family

ID=10293224

Family Applications (1)

Application Number Title Priority Date Filing Date
GB2954557A Expired GB826300A (en) 1957-09-19 1957-09-19 New amino-thioacid esters and the production thereof

Country Status (1)

Country Link
GB (1) GB826300A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11440881B2 (en) * 2019-05-09 2022-09-13 The Feinstein Institutes For Medical Research Thiosemicarbazates and uses thereof

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11440881B2 (en) * 2019-05-09 2022-09-13 The Feinstein Institutes For Medical Research Thiosemicarbazates and uses thereof

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