ES367735A1 - Procedure for the production of new derivatives of ftalimidine. (Machine-translation by Google Translate, not legally binding) - Google Patents

Abstract

Procedure for the production of new phthalimidine derivatives of general formula **(See formula)** in which R1 represents a hydrogen atom, an alkyl or alkenyl residue with 1 to 6 carbon atoms, if appropriate substituted by oxy or mercapto groups, by amino groups, carboxyl groups or halogen atoms or, aralkyl, cycloalkyl or aryl, if substituted, and m and n represent the figures 0, 1 or 2, reaching the sum of m and n, 1 or 2, characterized in that -a) an acid of the general formula is reacted **(See formula)** in which m and n have the aforementioned significance, or one of its functional derivatives with an amine of the general formula H2N-R1, III wherein R1 has the above significance, or with a compound which, under the reaction conditions, yields an amine of formula III, or -b) a monoamide or diamide of an acid of formula II derived from an amine of formula III is reacted to arrive at a compound of general formula I, preferably, by heating, cycling, and for the case in which, in the obtained compound I, R1 represents a hydrogen atom, this compound of the general formula **(See formula)** where m and n have the meaning, above, if desired, -α) is reacted with a compound of the formula **(See formula)** in which R2 and R3 are different and represent hydrogen, where appropriate, substituted low alkyl, aryl or aralkyl residues, or, together with the nitrogen atom to which they are attached, a residue, if any, still containing another heteroatom and where appropriate, a 506-membered heterocyclic substituted radical, or else with a salt of a compound of the general formula Y, preferably in the presence of a solvent, in the presence of formaldehyde or in the presence of substances which, under the reaction conditions are capable of producing formaldehyde, O well, -β) first, it is transformed with formaldehyde or with substances that, under the reaction conditions, may yield formaldehyde, if appropriate, followed by the action of a salt, into a compound of the general formula **(See formula)** where m and n have the aforementioned significance and X represents an oxy group, a halogen atom or an esterified oxy group, and compound VI is then condensed with an amine of the general formula V, or respectively its salt, to arrive at a corresponding compound of the general formula I, O well, - γ) is reacted with a compound of the general formula **(See formula)** wherein R2, R3 and X have the same significance as above. (Machine-translation by Google Translate, not legally binding)