ES374752A1 - Procedure for the synthesis of nitrogenated heterociclic derivatives. (Machine-translation by Google Translate, not legally binding) - Google Patents

Procedure for the synthesis of nitrogenated heterociclic derivatives. (Machine-translation by Google Translate, not legally binding)

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Publication number
ES374752A1
ES374752A1 ES374752A ES374752A ES374752A1 ES 374752 A1 ES374752 A1 ES 374752A1 ES 374752 A ES374752 A ES 374752A ES 374752 A ES374752 A ES 374752A ES 374752 A1 ES374752 A1 ES 374752A1
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ES
Spain
Prior art keywords
formula
symbols
translation
synthesis
procedure
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
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ES374752A
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Spanish (es)
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BIOTERAPICO MILANESE DI VITTOR
Original Assignee
BIOTERAPICO MILANESE DI VITTOR
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Publication of ES374752A1 publication Critical patent/ES374752A1/en
Expired legal-status Critical Current

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Abstract

Procedure for the synthesis of nitrogenous heterocyclic derivatives, and more particularly of compounds of the general formula: **(See formula)** where X represents CH or N; R represents CN or COOH; R'is hydrogen or a branched or unbranched lower alkyl radical, with a carbon atom number of 1 to 4; R'' is hydrogen or one or more low-molecular-weight substituents chosen from alkyl or hydroxyalkyl radicals or halogens, characterized in that the aromatic or heterocyclic nitrogenous amines are condensed with the ethyl 2- (ethoxymethylene) cyanocetate and the resulting ethyl aminomethylene tetracetates are cyclized at high temperature, in a suitable solvent, to give compounds of the formula: **(See formula)** in which the symbols X and R'' have the indicated meaning and R = CN, which in turn are reacted with alkylating agents chosen from the alkyl esters of sulfuric acid or of halogenic acids to give compounds of the general formula: **(See formula)** in which the symbols X, R'and R''have the indicated meaning and R = CN, which are saponified in an acidic or alkaline environment to give the products of the general formula in which the symbols X, R' and R'' they have the indicated meaning and R = COOH. (Machine-translation by Google Translate, not legally binding)
ES374752A 1969-07-01 1969-12-11 Procedure for the synthesis of nitrogenated heterociclic derivatives. (Machine-translation by Google Translate, not legally binding) Expired ES374752A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT1899969 1969-07-01

Publications (1)

Publication Number Publication Date
ES374752A1 true ES374752A1 (en) 1972-01-16

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ID=11153723

Family Applications (1)

Application Number Title Priority Date Filing Date
ES374752A Expired ES374752A1 (en) 1969-07-01 1969-12-11 Procedure for the synthesis of nitrogenated heterociclic derivatives. (Machine-translation by Google Translate, not legally binding)

Country Status (1)

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ES (1) ES374752A1 (en)

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