ES423577A1 - Manufacture of quaternary ammonium compound of 2-(glycylretinoylmethyl)-n-methylpyrrolidine - Google Patents

Manufacture of quaternary ammonium compound of 2-(glycylretinoylmethyl)-n-methylpyrrolidine

Info

Publication number
ES423577A1
ES423577A1 ES423577A ES423577A ES423577A1 ES 423577 A1 ES423577 A1 ES 423577A1 ES 423577 A ES423577 A ES 423577A ES 423577 A ES423577 A ES 423577A ES 423577 A1 ES423577 A1 ES 423577A1
Authority
ES
Spain
Prior art keywords
formula
see formula
glycylretinoylmethyl
methylpyrrolidine
manufacture
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES423577A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Laboratorios Landerlan SA
Original Assignee
Laboratorios Landerlan SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratorios Landerlan SA filed Critical Laboratorios Landerlan SA
Priority to ES423577A priority Critical patent/ES423577A1/en
Priority to DK175874*A priority patent/DK175874A/da
Priority to DE2423491A priority patent/DE2423491A1/en
Priority to JP49127893A priority patent/JPS5824431B2/en
Priority to FR7505649A priority patent/FR2261763A1/en
Priority to SE7502018A priority patent/SE421306B/en
Publication of ES423577A1 publication Critical patent/ES423577A1/en
Priority to JP57195840A priority patent/JPS5842188B2/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

Procedure for obtaining triterpenic acid derivatives, characterized in that it consists of the reaction in a suitable solvent medium, between a glycyrrhetinic acid derivative of the formula **(See formula)** and a halomethyl pyrrolidine of the formula **(See formula)** with which the products of general formula are obtained **(See formula)** where R is a hydrogen or acid radical of 2 or more carbon atoms and R1 a lower alkyl, which are treated in a second phase with a suitable ester, transforming into the products of the general formula **(See formula)** where R and R1 have the meaning expressed above, R2 is a lower alkyl group, of 1 to 4 carbon atoms and Y is a halogen radical or an alkylsulfate. (Machine-translation by Google Translate, not legally binding)
ES423577A 1974-02-23 1974-02-23 Manufacture of quaternary ammonium compound of 2-(glycylretinoylmethyl)-n-methylpyrrolidine Expired ES423577A1 (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
ES423577A ES423577A1 (en) 1974-02-23 1974-02-23 Manufacture of quaternary ammonium compound of 2-(glycylretinoylmethyl)-n-methylpyrrolidine
DK175874*A DK175874A (en) 1974-02-23 1974-03-29
DE2423491A DE2423491A1 (en) 1974-02-23 1974-05-15 NEW TRITERPENDER DERIVATIVES
JP49127893A JPS5824431B2 (en) 1974-02-23 1974-11-06 Method for producing 2-(glycylletinoylmethyl)-N-X-thylpyrrolidine
FR7505649A FR2261763A1 (en) 1974-02-23 1975-02-24 1-Alkyl-2-pyrrolidylmethyl glycyrrhetinate derivs - prepd by reacting 1-alkyl-2-halomethylpyrrolidines with glycyrrhetinic acid cpds
SE7502018A SE421306B (en) 1974-02-23 1975-02-24 PROCEDURE FOR THE PREPARATION OF (N-ALKYL-2-PYRROLIDINYL) METHYL ESTERS OF GLYCYRRETINIC ACID AND CERTAIN ACYLIC DERIVATIVES AND QUARTER OF AMMONIUM COMPOUNDS THEREOF
JP57195840A JPS5842188B2 (en) 1974-02-23 1982-11-08 Method for producing quaternary ammonium compound of 2-(glycyretinoylmethyl)-N-methylpyrrolidine

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES423577A ES423577A1 (en) 1974-02-23 1974-02-23 Manufacture of quaternary ammonium compound of 2-(glycylretinoylmethyl)-n-methylpyrrolidine

Publications (1)

Publication Number Publication Date
ES423577A1 true ES423577A1 (en) 1976-05-16

Family

ID=8466051

Family Applications (1)

Application Number Title Priority Date Filing Date
ES423577A Expired ES423577A1 (en) 1974-02-23 1974-02-23 Manufacture of quaternary ammonium compound of 2-(glycylretinoylmethyl)-n-methylpyrrolidine

Country Status (6)

Country Link
JP (2) JPS5824431B2 (en)
DE (1) DE2423491A1 (en)
DK (1) DK175874A (en)
ES (1) ES423577A1 (en)
FR (1) FR2261763A1 (en)
SE (1) SE421306B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1465914B1 (en) * 2002-01-18 2008-12-17 Regents Of The University Of Minnesota Triterpene quaternary salts as biologically active surfactants

Also Published As

Publication number Publication date
DE2423491A1 (en) 1975-09-04
JPS5824431B2 (en) 1983-05-20
SE421306B (en) 1981-12-14
FR2261763A1 (en) 1975-09-19
FR2261763B1 (en) 1980-01-25
JPS5842188B2 (en) 1983-09-17
SE7502018L (en) 1975-08-25
JPS5890547A (en) 1983-05-30
DK175874A (en) 1975-10-20
JPS50112364A (en) 1975-09-03

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