FR2261763A1 - 1-Alkyl-2-pyrrolidylmethyl glycyrrhetinate derivs - prepd by reacting 1-alkyl-2-halomethylpyrrolidines with glycyrrhetinic acid cpds - Google Patents

1-Alkyl-2-pyrrolidylmethyl glycyrrhetinate derivs - prepd by reacting 1-alkyl-2-halomethylpyrrolidines with glycyrrhetinic acid cpds

Info

Publication number
FR2261763A1
FR2261763A1 FR7505649A FR7505649A FR2261763A1 FR 2261763 A1 FR2261763 A1 FR 2261763A1 FR 7505649 A FR7505649 A FR 7505649A FR 7505649 A FR7505649 A FR 7505649A FR 2261763 A1 FR2261763 A1 FR 2261763A1
Authority
FR
France
Prior art keywords
alkyl
glycyrrhetinate
derivs
halomethylpyrrolidines
pyrrolidylmethyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7505649A
Other languages
French (fr)
Other versions
FR2261763B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Laboratorios Landerlan SA
Original Assignee
Laboratorios Landerlan SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratorios Landerlan SA filed Critical Laboratorios Landerlan SA
Publication of FR2261763A1 publication Critical patent/FR2261763A1/en
Application granted granted Critical
Publication of FR2261763B1 publication Critical patent/FR2261763B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pyrrole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)

Abstract

Glycyrrhetinate derivs. of formula (I) (where R is H or 2 acyl and R1 is lower alkyl), e.g. 2-(glycyrrhetin-cyloxymethyl)-N-methylpyrrolidine, and corresponding quaternaryammonium salts in which the pyrrolidine N-atom carries a second lower alkyl group and the anion is a halide or alkylsulphate anion, are new cpds. which are inhibitors of gastroduodenal ulcers.
FR7505649A 1974-02-23 1975-02-24 1-Alkyl-2-pyrrolidylmethyl glycyrrhetinate derivs - prepd by reacting 1-alkyl-2-halomethylpyrrolidines with glycyrrhetinic acid cpds Granted FR2261763A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES423577A ES423577A1 (en) 1974-02-23 1974-02-23 Manufacture of quaternary ammonium compound of 2-(glycylretinoylmethyl)-n-methylpyrrolidine

Publications (2)

Publication Number Publication Date
FR2261763A1 true FR2261763A1 (en) 1975-09-19
FR2261763B1 FR2261763B1 (en) 1980-01-25

Family

ID=8466051

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7505649A Granted FR2261763A1 (en) 1974-02-23 1975-02-24 1-Alkyl-2-pyrrolidylmethyl glycyrrhetinate derivs - prepd by reacting 1-alkyl-2-halomethylpyrrolidines with glycyrrhetinic acid cpds

Country Status (6)

Country Link
JP (2) JPS5824431B2 (en)
DE (1) DE2423491A1 (en)
DK (1) DK175874A (en)
ES (1) ES423577A1 (en)
FR (1) FR2261763A1 (en)
SE (1) SE421306B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003062260A1 (en) * 2002-01-18 2003-07-31 Regents Of The University Of Minnesota Triterpene quaternary salts as biologically active surfactants

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003062260A1 (en) * 2002-01-18 2003-07-31 Regents Of The University Of Minnesota Triterpene quaternary salts as biologically active surfactants
US7199114B2 (en) 2002-01-18 2007-04-03 The Regents Of The University Of Minnesota Triterpene quaternary salts as biologically active surfactants
US7410958B2 (en) 2002-01-18 2008-08-12 Regents Of The University Of Minnesota Triterpene quaternary salts as biologically active surfactants

Also Published As

Publication number Publication date
SE7502018L (en) 1975-08-25
JPS5890547A (en) 1983-05-30
JPS5824431B2 (en) 1983-05-20
DK175874A (en) 1975-10-20
JPS5842188B2 (en) 1983-09-17
SE421306B (en) 1981-12-14
ES423577A1 (en) 1976-05-16
JPS50112364A (en) 1975-09-03
DE2423491A1 (en) 1975-09-04
FR2261763B1 (en) 1980-01-25

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Legal Events

Date Code Title Description
ST Notification of lapse