FR2272994A1 - Ethylene glycol mixed ester with clofibric and nicotinic acids - prepd by reacting ethylene chlorohydrin with a clofibric acid salt and nicotinoyl chloride - Google Patents

Ethylene glycol mixed ester with clofibric and nicotinic acids - prepd by reacting ethylene chlorohydrin with a clofibric acid salt and nicotinoyl chloride

Info

Publication number
FR2272994A1
FR2272994A1 FR7513271A FR7513271A FR2272994A1 FR 2272994 A1 FR2272994 A1 FR 2272994A1 FR 7513271 A FR7513271 A FR 7513271A FR 7513271 A FR7513271 A FR 7513271A FR 2272994 A1 FR2272994 A1 FR 2272994A1
Authority
FR
France
Prior art keywords
clofibric
prepd
acid salt
mixed ester
nicotinoyl chloride
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7513271A
Other languages
French (fr)
Other versions
FR2272994B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alter SA
Original Assignee
Alter SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alter SA filed Critical Alter SA
Publication of FR2272994A1 publication Critical patent/FR2272994A1/en
Application granted granted Critical
Publication of FR2272994B1 publication Critical patent/FR2272994B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C07D213/80—Acids; Esters in position 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pyridine Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The mixed ester of formula (I) is a new cpd. which can be obtained by reacting the Li, Na or K salt of clofibric acid (2-(p-chlorophenoxyl)-2-methylpropionic acid) with ethylene cholohydrin and reacting the resulting hydroxyethyl ester with nicotinoyl chloride in the presence of a base. (I) is a hypolipidaemic agent.
FR7513271A 1974-05-29 1975-04-28 Ethylene glycol mixed ester with clofibric and nicotinic acids - prepd by reacting ethylene chlorohydrin with a clofibric acid salt and nicotinoyl chloride Granted FR2272994A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES426755A ES426755A1 (en) 1974-05-29 1974-05-29 Echirengurikooru 11*22*paraakurorofuenokishi**22 mechirupuropioneeto**22 nikochineeto kongoesuteruno seizohoho

Publications (2)

Publication Number Publication Date
FR2272994A1 true FR2272994A1 (en) 1975-12-26
FR2272994B1 FR2272994B1 (en) 1978-02-24

Family

ID=8466799

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7513271A Granted FR2272994A1 (en) 1974-05-29 1975-04-28 Ethylene glycol mixed ester with clofibric and nicotinic acids - prepd by reacting ethylene chlorohydrin with a clofibric acid salt and nicotinoyl chloride

Country Status (4)

Country Link
JP (1) JPS511479A (en)
DE (1) DE2519535A1 (en)
ES (1) ES426755A1 (en)
FR (1) FR2272994A1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES469531A1 (en) * 1978-05-05 1978-12-01 Alter Lab Ethyleneglycol diesters and process for producing them
JPS60222445A (en) * 1984-04-19 1985-11-07 Yoshitomi Pharmaceut Ind Ltd Phthalic acid compound

Also Published As

Publication number Publication date
JPS511479A (en) 1976-01-08
ES426755A1 (en) 1976-07-16
DE2519535A1 (en) 1975-12-04
FR2272994B1 (en) 1978-02-24

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