FR2393802A1 - 4-Heterocyclyl-piperazine-1-carbodithioic acid derivs. - useful e.g. as hepatoprotectors, choleretics, hypocholesterolaemiants and having anti:lithiase activity - Google Patents

4-Heterocyclyl-piperazine-1-carbodithioic acid derivs. - useful e.g. as hepatoprotectors, choleretics, hypocholesterolaemiants and having anti:lithiase activity

Info

Publication number
FR2393802A1
FR2393802A1 FR787817256A FR7817256A FR2393802A1 FR 2393802 A1 FR2393802 A1 FR 2393802A1 FR 787817256 A FR787817256 A FR 787817256A FR 7817256 A FR7817256 A FR 7817256A FR 2393802 A1 FR2393802 A1 FR 2393802A1
Authority
FR
France
Prior art keywords
piperazine
lithiase
hypocholesterolaemiants
hepatoprotectors
choleretics
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR787817256A
Other languages
French (fr)
Other versions
FR2393802B1 (en
Inventor
Gilbert Regnier
Roger Canevari
Xavier Pascaud
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Science Union et Cie
Original Assignee
Science Union et Cie
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Science Union et Cie filed Critical Science Union et Cie
Publication of FR2393802A1 publication Critical patent/FR2393802A1/en
Application granted granted Critical
Publication of FR2393802B1 publication Critical patent/FR2393802B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics

Abstract

Piperazine derivs. of formula (I) and their alkali addn. salts are new: (one of A and B is N and the other is O, S or N-Y; or B is S and A is Y is H or CH3. R' is H, 1-5C alkyl, phenyl or benzyl. R is halo, 1-5C alkyl or phenyl. When B is S and A is - -R', R + R' may together be -CH=CH-CH=CH-, opt. substd. by one halo or by >=1 1-5C alkyl or alkoxy, so as to form opt. substd. benzothiazolyl).
FR787817256A 1977-06-10 1978-06-09 4-Heterocyclyl-piperazine-1-carbodithioic acid derivs. - useful e.g. as hepatoprotectors, choleretics, hypocholesterolaemiants and having anti:lithiase activity Granted FR2393802A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB2437077 1977-06-10
GB3085177 1977-07-22

Publications (2)

Publication Number Publication Date
FR2393802A1 true FR2393802A1 (en) 1979-01-05
FR2393802B1 FR2393802B1 (en) 1981-04-17

Family

ID=26257079

Family Applications (1)

Application Number Title Priority Date Filing Date
FR787817256A Granted FR2393802A1 (en) 1977-06-10 1978-06-09 4-Heterocyclyl-piperazine-1-carbodithioic acid derivs. - useful e.g. as hepatoprotectors, choleretics, hypocholesterolaemiants and having anti:lithiase activity

Country Status (13)

Country Link
JP (1) JPS545987A (en)
AT (1) AT360545B (en)
AU (1) AU3692878A (en)
CA (1) CA1098524A (en)
DE (1) DE2825407C3 (en)
ES (1) ES470679A1 (en)
FR (1) FR2393802A1 (en)
GR (1) GR63662B (en)
IT (1) IT1104750B (en)
NL (1) NL7806321A (en)
NZ (1) NZ187474A (en)
PT (1) PT68159A (en)
YU (1) YU135378A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0005091A1 (en) * 1978-04-13 1979-10-31 SCIENCE UNION ET Cie SOCIETE FRANCAISE DE RECHERCHE MEDICALE Monosubstituted piperazines, processes for their preparation and pharmaceutical compositions containing them

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000000482A1 (en) * 1998-06-30 2000-01-06 Neurogen Corporation 1-(benzothiazol-2-yl)-4-(1-phenylmethyl)piperazines: dopamine receptor subtype specific ligands
ES2388681T3 (en) 2006-03-28 2012-10-17 High Point Pharmaceuticals, Llc Benzothiazoles with histamine H3 receptor activity
AU2009303441A1 (en) * 2008-10-16 2010-04-22 Schering Corporation Pyrrolidine, piperidine and piperazine derivatives and methods of use thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2215960A1 (en) * 1973-02-02 1974-08-30 Wander Ag Dr A

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1307256A (en) 1970-09-15 1973-02-14 Science Union & Cie Piperazine derivatives and a process for their preparation
GB1432660A (en) 1973-10-30 1976-04-22 Science Union & Cie Piperazine derivatives processes for their preparation and and pharamacueitcal compositions containing them

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2215960A1 (en) * 1973-02-02 1974-08-30 Wander Ag Dr A

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0005091A1 (en) * 1978-04-13 1979-10-31 SCIENCE UNION ET Cie SOCIETE FRANCAISE DE RECHERCHE MEDICALE Monosubstituted piperazines, processes for their preparation and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
DE2825407B2 (en) 1980-07-10
DE2825407A1 (en) 1978-12-14
IT1104750B (en) 1985-10-28
JPS545987A (en) 1979-01-17
NL7806321A (en) 1978-12-12
DE2825407C3 (en) 1981-04-30
CA1098524A (en) 1981-03-31
ATA420878A (en) 1980-06-15
AU3692878A (en) 1979-12-13
YU135378A (en) 1982-08-31
NZ187474A (en) 1981-03-16
ES470679A1 (en) 1979-03-16
FR2393802B1 (en) 1981-04-17
IT7849764A0 (en) 1978-06-08
AT360545B (en) 1981-01-12
GR63662B (en) 1979-11-28
PT68159A (en) 1978-07-01

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Legal Events

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