GB910262A - New nicotinic acid esters and methods of producing them - Google Patents
New nicotinic acid esters and methods of producing themInfo
- Publication number
- GB910262A GB910262A GB20748/61A GB2074861A GB910262A GB 910262 A GB910262 A GB 910262A GB 20748/61 A GB20748/61 A GB 20748/61A GB 2074861 A GB2074861 A GB 2074861A GB 910262 A GB910262 A GB 910262A
- Authority
- GB
- United Kingdom
- Prior art keywords
- nicotinic acid
- acid esters
- producing
- methods
- esters
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical class OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 title abstract 5
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 229960003512 nicotinic acid Drugs 0.000 abstract 2
- 235000001968 nicotinic acid Nutrition 0.000 abstract 2
- 239000011664 nicotinic acid Substances 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- -1 nicotinic acid ester Chemical class 0.000 abstract 1
- 239000002674 ointment Substances 0.000 abstract 1
- ATBIAJXSKNPHEI-UHFFFAOYSA-N pyridine-3-carbonyl chloride Chemical compound ClC(=O)C1=CC=CN=C1 ATBIAJXSKNPHEI-UHFFFAOYSA-N 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/79—Acids; Esters
- C07D213/80—Acids; Esters in position 3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/455—Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention comprises nicotinic acid esters of the general formula <FORM:0910262/IV (b)/1> and their acid addition salts in which R1 and R2 which may be the same or different, are hydrogen atoms, or alkyl groups containing not more than 6 carbon atoms, and R3 and R4 which may be the same or different are straight or branched chain groups having the empirical formula (CH2)m in which m is an integer between 1 and 6 inclusive and the preparation thereof by reacting a dialcohol of the general formula <FORM:0910262/IV (b)/2> with a nicotinic acid, nicotinic acid chloride or a lower nicotinic acid ester. Ointments with a hyperaemic effect may be prepared from the esters of the invention.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE574160 | 1960-06-11 |
Publications (1)
Publication Number | Publication Date |
---|---|
GB910262A true GB910262A (en) | 1962-11-14 |
Family
ID=20267116
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB20748/61A Expired GB910262A (en) | 1960-06-11 | 1961-06-08 | New nicotinic acid esters and methods of producing them |
Country Status (3)
Country | Link |
---|---|
BE (1) | BE604823A (en) |
FR (1) | FR1154M (en) |
GB (1) | GB910262A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2020117444A (en) * | 2019-01-18 | 2020-08-06 | 三井化学株式会社 | Ester compound and method for producing the same, plasticizer for thermoplastic resin, and thermoplastic resin composition |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1168389B (en) * | 1981-05-06 | 1987-05-20 | Alfa Farmaceutici Spa | ALCANDIOL DERIVATIVES WITH HYPOLIPIDEMIZING ACTIVITY, METHODS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM |
-
1961
- 1961-06-08 GB GB20748/61A patent/GB910262A/en not_active Expired
- 1961-06-09 FR FR864462A patent/FR1154M/en not_active Expired
- 1961-06-09 BE BE604823A patent/BE604823A/en unknown
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2020117444A (en) * | 2019-01-18 | 2020-08-06 | 三井化学株式会社 | Ester compound and method for producing the same, plasticizer for thermoplastic resin, and thermoplastic resin composition |
Also Published As
Publication number | Publication date |
---|---|
FR1154M (en) | 1962-02-26 |
BE604823A (en) | 1961-10-02 |
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