ES524899A0 - Procedimiento para preparar 9-1 3 dihidroxi 2 propoximetil guanina y sales farmaceuticamente aceptable - Google Patents

Procedimiento para preparar 9-1 3 dihidroxi 2 propoximetil guanina y sales farmaceuticamente aceptable

Info

Publication number
ES524899A0
ES524899A0 ES524899A ES524899A ES524899A0 ES 524899 A0 ES524899 A0 ES 524899A0 ES 524899 A ES524899 A ES 524899A ES 524899 A ES524899 A ES 524899A ES 524899 A0 ES524899 A0 ES 524899A0
Authority
ES
Spain
Prior art keywords
propoximetil
guanina
dihidroxi
preparing
procedure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES524899A
Other languages
English (en)
Other versions
ES8507549A1 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Syntex USA LLC
Original Assignee
Syntex USA LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23017790&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES524899(A0) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Syntex USA LLC filed Critical Syntex USA LLC
Publication of ES524899A0 publication Critical patent/ES524899A0/es
Publication of ES8507549A1 publication Critical patent/ES8507549A1/es
Expired legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D473/00Heterocyclic compounds containing purine ring systems
    • C07D473/02Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/18Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D473/00Heterocyclic compounds containing purine ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/20Antivirals for DNA viruses
    • A61P31/22Antivirals for DNA viruses for herpes viruses
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
ES524899A 1981-05-21 1983-08-12 Procedimiento para preparar 9-1 3 dihidroxi 2 propoximetil guanina y sales farmaceuticamente aceptable Expired ES8507549A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06267210 US4355032B2 (en) 1981-05-21 1981-05-21 9-(1,3-dihydroxy-2-propoxymethyl)guanine as antiviral agent

Publications (2)

Publication Number Publication Date
ES524899A0 true ES524899A0 (es) 1985-09-16
ES8507549A1 ES8507549A1 (es) 1985-09-16

Family

ID=23017790

Family Applications (7)

Application Number Title Priority Date Filing Date
ES512414A Granted ES512414A0 (es) 1981-05-21 1982-05-20 "procedimiento para preparar 9-(1,3-dihidroxi-2-propoximetil)-guanina y sus sales farmaceuticamente aceptables".
ES520849A Expired ES8500276A1 (es) 1981-05-21 1983-03-22 Procedimiento para preparar n2-acil-9-(1,3-dihidroxi-2-propoximetil)-guaninas y sus sales famaceuticamente aceptables.
ES524899A Expired ES8507549A1 (es) 1981-05-21 1983-08-12 Procedimiento para preparar 9-1 3 dihidroxi 2 propoximetil guanina y sales farmaceuticamente aceptable
ES524900A Expired ES8601204A1 (es) 1981-05-21 1983-08-12 Procedimiento para preparar 9-(1,3-dihidroxi-2-propoximetil)-guanina y sus sales farmaceuticamente aceptables.
ES529383A Expired ES8606869A1 (es) 1981-05-21 1984-02-01 Procedimiento para preparar 9-(1, 3-dihidroxi-2-propoximetil)-guanina y sus sales farmaceuticamente aceptables
ES529384A Expired ES8701496A1 (es) 1981-05-21 1984-02-01 Procedimiento para preparar una sal de 9-(1, 3-dihidroxi-2-propoximetil)-guanina farmaceuticamente aceptable
ES533821A Expired ES8505681A1 (es) 1981-05-21 1984-06-28 Procedimiento para preparar n2-acil-9-(1, 3-dihidroxi-2-propoximetil)-guaninas y sus sales farmaceuticamente aceptables

Family Applications Before (2)

Application Number Title Priority Date Filing Date
ES512414A Granted ES512414A0 (es) 1981-05-21 1982-05-20 "procedimiento para preparar 9-(1,3-dihidroxi-2-propoximetil)-guanina y sus sales farmaceuticamente aceptables".
ES520849A Expired ES8500276A1 (es) 1981-05-21 1983-03-22 Procedimiento para preparar n2-acil-9-(1,3-dihidroxi-2-propoximetil)-guaninas y sus sales famaceuticamente aceptables.

Family Applications After (4)

Application Number Title Priority Date Filing Date
ES524900A Expired ES8601204A1 (es) 1981-05-21 1983-08-12 Procedimiento para preparar 9-(1,3-dihidroxi-2-propoximetil)-guanina y sus sales farmaceuticamente aceptables.
ES529383A Expired ES8606869A1 (es) 1981-05-21 1984-02-01 Procedimiento para preparar 9-(1, 3-dihidroxi-2-propoximetil)-guanina y sus sales farmaceuticamente aceptables
ES529384A Expired ES8701496A1 (es) 1981-05-21 1984-02-01 Procedimiento para preparar una sal de 9-(1, 3-dihidroxi-2-propoximetil)-guanina farmaceuticamente aceptable
ES533821A Expired ES8505681A1 (es) 1981-05-21 1984-06-28 Procedimiento para preparar n2-acil-9-(1, 3-dihidroxi-2-propoximetil)-guaninas y sus sales farmaceuticamente aceptables

Country Status (33)

Country Link
US (1) US4355032B2 (es)
EP (1) EP0066208B1 (es)
JP (2) JPS57203086A (es)
KR (1) KR890004663B1 (es)
AR (1) AR244227A1 (es)
AT (1) ATE15899T1 (es)
AU (1) AU572086B2 (es)
BR (1) BR8202931A (es)
CA (3) CA1305141C (es)
CS (4) CS235044B2 (es)
DD (2) DD203052A5 (es)
DE (1) DE3266644D1 (es)
DK (2) DK150304C (es)
ES (7) ES512414A0 (es)
FI (1) FI73682C (es)
GR (1) GR76459B (es)
HK (1) HK67088A (es)
HU (2) HU186514B (es)
IE (1) IE53731B1 (es)
IL (1) IL65836A (es)
IN (1) IN156469B (es)
LU (1) LU88334I2 (es)
MY (1) MY8700793A (es)
NL (2) NL930022I1 (es)
NO (2) NO161740C (es)
NZ (1) NZ200691A (es)
PH (1) PH17975A (es)
PL (4) PL136004B1 (es)
PT (1) PT74934B (es)
RO (2) RO84860B (es)
SG (1) SG81687G (es)
SU (1) SU1176841A3 (es)
ZA (1) ZA823532B (es)

Families Citing this family (73)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4347360A (en) * 1980-09-16 1982-08-31 Ens Bio Logicals Inc. Ring open nucleoside analogues
US4508898A (en) * 1980-09-16 1985-04-02 Ogilvie Kelvin K Antiviral triazine compounds
US5157120A (en) * 1980-09-16 1992-10-20 Syntex (U.S.A.) Inc. Guanine derivatives
US4423050A (en) * 1981-05-21 1983-12-27 Syntex (U.S.A.) Inc. 9-(1,3-Dihydroxy-2-propoxymethyl)guanine as antiviral agent
US4507305A (en) * 1981-05-21 1985-03-26 Syntex (U.S.A.) Inc. 9-(1,3-Dihydroxy-2-propoxymethyl)guanine as antiviral agent
AT380252B (de) * 1981-08-11 1986-05-12 Wellcome Found Verfahren zur herstellung von neuen guanin- und 2,6-diaminopurinderivaten und ihren salzen
NZ201662A (en) * 1981-08-26 1986-07-11 Merck & Co Inc 9-(1,3-(and 2,3)-dihydroxy-1-(and 2)-propoxy-methyl)guanine derivatives and methods for their preparation
JPS58135885A (ja) * 1982-02-01 1983-08-12 シンテツクス(ユ−・エス・エイ)インコ−ポレイテツド 置換されたプリン、その製造方法およびそれからなる抗ウイルス剤
US5250535A (en) * 1982-02-01 1993-10-05 Syntex Inc. Substituted 9-(1 or 3-monoacyloxy or 1,3-diacyloxy-2-propoxymethyl) purines as antiviral agent
US4902678A (en) * 1982-02-12 1990-02-20 Syntex (U.S.A.) Inc. Anti-viral compositions
US4609662A (en) * 1982-10-14 1986-09-02 Burroughs Wellcome Co. Method for using purine derivatives
US4462986A (en) * 1982-11-04 1984-07-31 Ens Bio Logicals, Inc. Synergistic anti-herpes compositions
US4814335A (en) * 1982-12-30 1989-03-21 Biomeasure, Incorporated Antiviral compounds
US4461757A (en) * 1983-02-23 1984-07-24 Ens Bio Logicals Inc. Dimethylaminomethylenated anti-herpes compounds
US5047533A (en) * 1983-05-24 1991-09-10 Sri International Acyclic purine phosphonate nucleotide analogs
US4880820A (en) * 1983-06-24 1989-11-14 Merck & Co., Inc. Guanine derivatives
GB8320308D0 (en) * 1983-07-28 1983-09-01 Wellcome Found Antiviral combinations
EP0138683A3 (en) * 1983-09-30 1988-01-20 Merck & Co. Inc. Purine derivatives, their application in anti-viral compositions
US4897479A (en) * 1983-09-30 1990-01-30 Merck & Co., Inc. Arylsulfonyloxy purine intermediates
IE842642L (en) * 1983-10-31 1985-04-30 Harvard College Purine Derivatives
US4806642A (en) * 1984-10-05 1989-02-21 Warner-Lambert Company Purine derivatives
IL73682A (en) * 1983-12-20 1991-08-16 Medivir Ab Antiviral pharmaceutical compositions containing 9-hydroxy aliphatic derivatives of guanine,some new such derivatives and process for their preparation
US4621140A (en) * 1984-02-23 1986-11-04 Syntex (U.S.A.) Inc. Process for preparing 2,6-substituted-9-(1,3-dihydroxy-2-propoxymethyl)-purines and certain derivatives
US4579849A (en) * 1984-04-06 1986-04-01 Merck & Co., Inc. N-alkylguanine acyclonucleosides as antiviral agents
WO1986000901A1 (en) * 1984-07-20 1986-02-13 Gauntt Charles O Immunoregulatory and anti-viral compound
IL77298A (en) * 1984-12-12 1999-11-30 Syntex Inc Process for the preparation of 2 -) alkanoyl oxymethoxy (- 1, 3 - propanediols, esters and sites for their use, their use for the preparation of progeny) H9 - guanine sweet
SE8406538D0 (sv) 1984-12-21 1984-12-21 Astra Laekemedel Ab Novel derivatives of purine
US4642346A (en) * 1985-06-24 1987-02-10 Syntex (U.S.A.) Inc. Anhydrous crystalline 9-(1,3-dihydroxy-2-propoxymethyl)guanine
US4863927A (en) * 1987-05-11 1989-09-05 Merck & Co., Inc. 1-(2-hydroxymethyl)cycloalkylmethyl)-5-substituted uracils
CA2005815C (en) * 1988-12-19 1999-08-03 Wellcome Foundation Limited (The) Antiviral acyclic nucleoside derivatives
US5068119A (en) * 1990-09-28 1991-11-26 Nabisco Brands, Inc. Acid-hydrolyzable ester derivatives as low calorie fat mimetics
GB2260319B (en) 1991-10-07 1995-12-06 Norsk Hydro As Acyl derivatives of nucleosides and nucleoside analogues having anti-viral activity
NZ268479A (en) * 1993-06-23 1997-07-27 Merrell Pharma Inc Carbo-acyclic nucleoside analogues and antiviral and antineoplastic compositions
US5840891A (en) * 1994-07-28 1998-11-24 Syntex (U.S.A.) Inc. 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl) methoxy-1,3-propanediol derivative
US5543414A (en) * 1994-07-28 1996-08-06 Syntex (Usa) Inc. Achiral amino acid acyl esters of ganciclovir and its derivatives
US5565565A (en) 1994-08-04 1996-10-15 Syntex (U.S.A.) Inc. Preparation of N-9 substituted guanine compounds
US5627185A (en) * 1994-11-23 1997-05-06 Gosselin; Gilles Acyclovir derivatives as antiviral agents
US5840763A (en) * 1994-12-12 1998-11-24 Smithkline Beecham Plc Treatment of a latent infection of herpes viruses
DE19536164A1 (de) * 1995-09-28 1997-04-03 Boehringer Ingelheim Kg Verbessertes Verfahren zur Herstellung von 9-[(2-Hyroxyethoxy)methyl]guanin (Acyclovir)
US6040446A (en) 1996-01-26 2000-03-21 Syntex (U.S.A.) Inc. Process for preparing a 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl) methoxy-1,3-propanediol derivative
US5840890A (en) * 1996-01-26 1998-11-24 Syntex (U.S.A.) Inc. Process for preparing a 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl)methoxy-1,3-propanediol derivative
US5700936A (en) * 1996-01-26 1997-12-23 Syntex (U.S.A.) Inc. Process for preparing a 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl) methoxy-1,3-propanediol valinate
US5756736A (en) * 1996-01-26 1998-05-26 Syntex (U.S.A.) Inc. Process for preparing a 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl)methoxy-1,3-propanediol derivative
IN179493B (es) * 1996-02-22 1997-10-11 Lupin Laboraties Ltd
EP0976751A1 (en) * 1996-04-09 2000-02-02 Lupin Laboratories Limited A process for the isomerisation of an N-7 isomer into an N-9 isomer useful in the synthesis of acyclic nucleosides
US5852208A (en) * 1996-08-30 1998-12-22 Dixie Chemical Company, Inc. Method of producing compounds containing acyloxyalkoxy groups from alcohols
CN1091445C (zh) * 1999-12-29 2002-09-25 湖北省医药工业研究院 抗病毒药物中间体、它们的制备及应用
IL163666A0 (en) 2002-02-22 2005-12-18 New River Pharmaceuticals Inc Active agent delivery systems and methods for protecting and administering active agents
EP1556050A1 (en) * 2002-10-22 2005-07-27 Ranbaxy Laboratories Limited Pharmaceutical compositions of ganciclovir
EP1565470A2 (en) * 2002-10-31 2005-08-24 Ranbaxy Laboratories Limited Process for the preparation of ganciclovir
WO2004048380A1 (en) * 2002-11-22 2004-06-10 Ranbaxy Laboratories Limited Process for the synthesis of ganciclovir
CA2512319A1 (en) 2003-01-14 2004-08-05 Gilead Sciences, Inc. Compositions and methods for combination antiviral therapy
ITMI20031202A1 (it) * 2003-06-13 2004-12-14 Lyogen Ltd Forma di cristallina del ganciclovir
RU2006109365A (ru) * 2003-08-28 2007-10-10 Рэнбакси Лабораториз Лимитед (In) Аморфный гидрохлорид валганцикловира
JP4746866B2 (ja) * 2004-11-19 2011-08-10 Tcm株式会社 キャリッジ用ガタ抑制装置
TWI375560B (en) 2005-06-13 2012-11-01 Gilead Sciences Inc Composition comprising dry granulated emtricitabine and tenofovir df and method for making the same
TWI471145B (zh) 2005-06-13 2015-02-01 Bristol Myers Squibb & Gilead Sciences Llc 單一式藥學劑量型
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CN101851239B (zh) * 2009-04-03 2012-11-28 上海益威实业有限公司 一种更昔洛韦的回收方法
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WO2012154698A2 (en) * 2011-05-06 2012-11-15 Mckenna Charles E Method to improve antiviral activity of nucleotide analogue drugs
CN102627643B (zh) * 2012-04-10 2014-01-08 常州康丽制药有限公司 更昔洛韦的精制方法
US9227990B2 (en) 2012-10-29 2016-01-05 Cipla Limited Antiviral phosphonate analogues and process for preparation thereof
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CN103059023B (zh) * 2012-12-31 2015-09-30 浙江车头制药股份有限公司 一种制备更昔洛韦晶型ⅱ的方法
US9486530B1 (en) 2013-08-30 2016-11-08 Exela Pharma Sciences, LLC Ganciclovir compositions and related methods
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CN113476413B (zh) * 2021-08-09 2022-06-28 海南海灵化学制药有限公司 一种注射用更昔洛韦钠冻干粉的制备方法

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US4199574A (en) * 1974-09-02 1980-04-22 Burroughs Wellcome Co. Methods and compositions for treating viral infections and guanine acyclic nucleosides
GB1523865A (en) * 1974-09-02 1978-09-06 Wellcome Found Purine compunds and salts thereof
US4060616A (en) * 1976-03-01 1977-11-29 Burroughs Wellcome Co. Purine derivatives with repeating unit
US4221910A (en) * 1978-09-15 1980-09-09 Newport Pharmaceuticals International, Inc. 9-(Hydroxy alkyl)purines
US4347360A (en) * 1980-09-16 1982-08-31 Ens Bio Logicals Inc. Ring open nucleoside analogues
AU7938482A (en) * 1980-12-22 1982-07-20 Astra Lakemedel Aktiebolag Novel derivatives of guanine
AT380252B (de) * 1981-08-11 1986-05-12 Wellcome Found Verfahren zur herstellung von neuen guanin- und 2,6-diaminopurinderivaten und ihren salzen

Also Published As

Publication number Publication date
SU1176841A3 (ru) 1985-08-30
NL930139I1 (nl) 1993-11-01
DK227782A (da) 1982-11-22
ES520849A0 (es) 1984-11-01
PT74934A (en) 1982-06-01
ES8404355A1 (es) 1984-05-01
DK149001B (da) 1985-12-16
ES8500276A1 (es) 1984-11-01
JPH0529399B2 (es) 1993-04-30
PL242100A1 (en) 1984-04-24
DK504183A (da) 1983-11-03
AR244227A1 (es) 1993-10-29
RO87387B (ro) 1985-08-31
PL246770A1 (en) 1984-08-27
ZA823532B (en) 1983-03-30
NL930022I1 (nl) 1993-05-03
IE53731B1 (en) 1989-02-01
DE3266644D1 (en) 1985-11-07
AU572086B2 (en) 1988-05-05
PL242101A1 (en) 1984-07-16
PL136637B1 (en) 1986-03-31
ES512414A0 (es) 1984-05-01
HU186514B (en) 1985-08-28
FI73682B (fi) 1987-07-31
IE821210L (en) 1982-11-21
LU88334I2 (fr) 1994-09-09
ES8507549A1 (es) 1985-09-16
SG81687G (en) 1989-07-07
ES533821A0 (es) 1985-06-16
CA1305140C (en) 1992-07-14
ATE15899T1 (de) 1985-10-15
NO1994005I1 (no) 1994-07-29
FI73682C (fi) 1987-11-09
US4355032B2 (en) 1990-10-30
HK67088A (en) 1988-09-02
GR76459B (es) 1984-08-10
PT74934B (en) 1984-05-08
EP0066208A1 (en) 1982-12-08
FI821794A0 (fi) 1982-05-20
KR890004663B1 (ko) 1989-11-24
ES529384A0 (es) 1987-01-01
RO84860B (ro) 1984-10-30
ES524900A0 (es) 1985-11-16
DD213218A5 (de) 1984-09-05
PH17975A (en) 1985-02-22
ES8701496A1 (es) 1987-01-01
NO161740C (no) 1989-09-20
PL236521A1 (en) 1984-01-02
CA1305139C (en) 1992-07-14
JPS57203086A (en) 1982-12-13
IN156469B (es) 1985-08-10
CA1305141C (en) 1992-07-14
NO161740B (no) 1989-06-12
CS235043B2 (en) 1985-04-16
DK149001C (da) 1988-11-28
BR8202931A (pt) 1983-05-03
US4355032B1 (es) 1983-06-14
RO87387A (ro) 1985-08-31
JPH046195B2 (es) 1992-02-05
IL65836A (en) 1991-04-15
ES8601204A1 (es) 1985-11-16
MY8700793A (en) 1987-12-31
IL65836A0 (en) 1982-08-31
CS235042B2 (en) 1985-04-16
DK504183D0 (da) 1983-11-03
JPH04217983A (ja) 1992-08-07
DD203052A5 (de) 1983-10-12
NO821676L (no) 1982-11-22
US4355032A (en) 1982-10-19
PL136332B1 (en) 1986-02-28
ES8606869A1 (es) 1986-05-16
AU8389282A (en) 1982-11-25
ES529383A0 (es) 1986-05-16
NL930139I2 (nl) 1997-07-01
HU188000B (en) 1986-03-28
PL136004B1 (en) 1986-01-31
DK150304B (da) 1987-02-02
EP0066208B1 (en) 1985-10-02
KR830010112A (ko) 1983-12-26
ES8505681A1 (es) 1985-06-16
RO84860A (ro) 1984-09-29
CS235044B2 (en) 1985-04-16
CS235018B2 (en) 1985-04-16
NZ200691A (en) 1986-11-12
PL136579B1 (en) 1986-02-28
DK150304C (da) 1988-01-04

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