HK67088A - 9-(1,3-dihydroxy-2-propoxymethyl)-guanine as antiviral agent - Google Patents

9-(1,3-dihydroxy-2-propoxymethyl)-guanine as antiviral agent

Info

Publication number
HK67088A
HK67088A HK670/88A HK67088A HK67088A HK 67088 A HK67088 A HK 67088A HK 670/88 A HK670/88 A HK 670/88A HK 67088 A HK67088 A HK 67088A HK 67088 A HK67088 A HK 67088A
Authority
HK
Hong Kong
Prior art keywords
propoxymethyl
guanine
dihydroxy
antiviral agent
antiviral
Prior art date
Application number
HK670/88A
Other languages
English (en)
Inventor
Julien P Verheyden
John C Martin
Original Assignee
Syntex Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23017790&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HK67088(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Syntex Inc filed Critical Syntex Inc
Publication of HK67088A publication Critical patent/HK67088A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
HK670/88A 1981-05-21 1988-08-25 9-(1,3-dihydroxy-2-propoxymethyl)-guanine as antiviral agent HK67088A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06267210 US4355032B2 (en) 1981-05-21 1981-05-21 9-(1,3-dihydroxy-2-propoxymethyl)guanine as antiviral agent

Publications (1)

Publication Number Publication Date
HK67088A true HK67088A (en) 1988-09-02

Family

ID=23017790

Family Applications (1)

Application Number Title Priority Date Filing Date
HK670/88A HK67088A (en) 1981-05-21 1988-08-25 9-(1,3-dihydroxy-2-propoxymethyl)-guanine as antiviral agent

Country Status (33)

Country Link
US (1) US4355032B2 (es)
EP (1) EP0066208B1 (es)
JP (2) JPS57203086A (es)
KR (1) KR890004663B1 (es)
AR (1) AR244227A1 (es)
AT (1) ATE15899T1 (es)
AU (1) AU572086B2 (es)
BR (1) BR8202931A (es)
CA (3) CA1305139C (es)
CS (4) CS235018B2 (es)
DD (2) DD203052A5 (es)
DE (1) DE3266644D1 (es)
DK (2) DK150304C (es)
ES (7) ES512414A0 (es)
FI (1) FI73682C (es)
GR (1) GR76459B (es)
HK (1) HK67088A (es)
HU (2) HU188000B (es)
IE (1) IE53731B1 (es)
IL (1) IL65836A (es)
IN (1) IN156469B (es)
LU (1) LU88334I2 (es)
MY (1) MY8700793A (es)
NL (2) NL930022I1 (es)
NO (2) NO161740C (es)
NZ (1) NZ200691A (es)
PH (1) PH17975A (es)
PL (4) PL136637B1 (es)
PT (1) PT74934B (es)
RO (2) RO87387B (es)
SG (1) SG81687G (es)
SU (1) SU1176841A3 (es)
ZA (1) ZA823532B (es)

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US4806642A (en) * 1984-10-05 1989-02-21 Warner-Lambert Company Purine derivatives
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US4642346A (en) * 1985-06-24 1987-02-10 Syntex (U.S.A.) Inc. Anhydrous crystalline 9-(1,3-dihydroxy-2-propoxymethyl)guanine
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US5068119A (en) * 1990-09-28 1991-11-26 Nabisco Brands, Inc. Acid-hydrolyzable ester derivatives as low calorie fat mimetics
GB2260319B (en) 1991-10-07 1995-12-06 Norsk Hydro As Acyl derivatives of nucleosides and nucleoside analogues having anti-viral activity
ATE178605T1 (de) * 1993-06-23 1999-04-15 Merrell Pharma Inc Carbo-acyclische nukleosidderivate als antivirale und antineoplastische mittel
US5543414A (en) * 1994-07-28 1996-08-06 Syntex (Usa) Inc. Achiral amino acid acyl esters of ganciclovir and its derivatives
US5856481A (en) * 1994-07-28 1999-01-05 Syntex (U.S.A.) Inc. 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl)methoxy-1,3-propanediol derivative
US5565565A (en) 1994-08-04 1996-10-15 Syntex (U.S.A.) Inc. Preparation of N-9 substituted guanine compounds
US5627185A (en) * 1994-11-23 1997-05-06 Gosselin; Gilles Acyclovir derivatives as antiviral agents
US5840763A (en) * 1994-12-12 1998-11-24 Smithkline Beecham Plc Treatment of a latent infection of herpes viruses
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US5700936A (en) * 1996-01-26 1997-12-23 Syntex (U.S.A.) Inc. Process for preparing a 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl) methoxy-1,3-propanediol valinate
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US7078524B2 (en) * 2002-11-22 2006-07-18 Ranbaxy Laboratories Limited Process for the synthesis of ganciclovir
SI1583542T1 (sl) * 2003-01-14 2008-12-31 Gilead Sciences Inc Sestavki in postopki za kombinacijsko antivirusnoterapijo
ITMI20031202A1 (it) * 2003-06-13 2004-12-14 Lyogen Ltd Forma di cristallina del ganciclovir
US20070129385A1 (en) * 2003-08-28 2007-06-07 Sharma Mukesh K Amorphous valganciclovir hydrochloride
JP4746866B2 (ja) * 2004-11-19 2011-08-10 Ｔｃｍ株式会社 キャリッジ用ガタ抑制装置
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CN101851239B (zh) * 2009-04-03 2012-11-28 上海益威实业有限公司 一种更昔洛韦的回收方法
PT3290428T (pt) 2010-03-31 2021-12-27 Gilead Pharmasset Llc Comprimido compreendendo 2-(((s)-(((2r,3r,4r,5r)-5-(2,4-dioxo-3,4-dihidropirimidin-1-(2h)-il)¿4¿fluoro¿3¿hidroxi¿4¿metiltetrahidrofuran¿2¿il)metoxi) (fenoxi)fosforil)amino)propanoato de (s)- isopropil cristalino
US9550803B2 (en) * 2011-05-06 2017-01-24 University Of Southern California Method to improve antiviral activity of nucleotide analogue drugs
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GB1523865A (en) * 1974-09-02 1978-09-06 Wellcome Found Purine compunds and salts thereof
US4199574A (en) * 1974-09-02 1980-04-22 Burroughs Wellcome Co. Methods and compositions for treating viral infections and guanine acyclic nucleosides
US4060616A (en) * 1976-03-01 1977-11-29 Burroughs Wellcome Co. Purine derivatives with repeating unit
US4221910A (en) * 1978-09-15 1980-09-09 Newport Pharmaceuticals International, Inc. 9-(Hydroxy alkyl)purines
US4347360A (en) * 1980-09-16 1982-08-31 Ens Bio Logicals Inc. Ring open nucleoside analogues
AU7938482A (en) * 1980-12-22 1982-07-20 Astra Lakemedel Aktiebolag Novel derivatives of guanine
KR880002276B1 (ko) * 1981-08-11 1988-10-21 더 웰컴 화운데이션 리미티드 항비루스성 화합물의 제조방법

Also Published As

Publication number Publication date
ES529384A0 (es) 1987-01-01
PT74934B (en) 1984-05-08
DK150304C (da) 1988-01-04
FI73682B (fi) 1987-07-31
RO87387A (ro) 1985-08-31
CA1305140C (en) 1992-07-14
ES8500276A1 (es) 1984-11-01
DK504183A (da) 1983-11-03
NL930139I1 (nl) 1993-11-01
PH17975A (en) 1985-02-22
IE821210L (en) 1982-11-21
DK149001C (da) 1988-11-28
SG81687G (en) 1989-07-07
NO161740C (no) 1989-09-20
IE53731B1 (en) 1989-02-01
CA1305141C (en) 1992-07-14
JPH046195B2 (es) 1992-02-05
ES8505681A1 (es) 1985-06-16
ES529383A0 (es) 1986-05-16
DK504183D0 (da) 1983-11-03
JPH04217983A (ja) 1992-08-07
ES8404355A1 (es) 1984-05-01
KR830010112A (ko) 1983-12-26
AU8389282A (en) 1982-11-25
NL930139I2 (nl) 1997-07-01
DK149001B (da) 1985-12-16
MY8700793A (en) 1987-12-31
ES8701496A1 (es) 1987-01-01
ES8606869A1 (es) 1986-05-16
PL136332B1 (en) 1986-02-28
ES524900A0 (es) 1985-11-16
ES520849A0 (es) 1984-11-01
NO821676L (no) 1982-11-22
PL246770A1 (en) 1984-08-27
PL136579B1 (en) 1986-02-28
BR8202931A (pt) 1983-05-03
NO1994005I1 (no) 1994-07-29
CS235044B2 (en) 1985-04-16
AU572086B2 (en) 1988-05-05
CA1305139C (en) 1992-07-14
RO84860A (ro) 1984-09-29
FI821794A0 (fi) 1982-05-20
US4355032A (en) 1982-10-19
SU1176841A3 (ru) 1985-08-30
PL242101A1 (en) 1984-07-16
KR890004663B1 (ko) 1989-11-24
JPH0529399B2 (es) 1993-04-30
DD203052A5 (de) 1983-10-12
ATE15899T1 (de) 1985-10-15
HU186514B (en) 1985-08-28
JPS57203086A (en) 1982-12-13
GR76459B (es) 1984-08-10
CS235043B2 (en) 1985-04-16
CS235042B2 (en) 1985-04-16
ES8507549A1 (es) 1985-09-16
NL930022I1 (nl) 1993-05-03
EP0066208A1 (en) 1982-12-08
PT74934A (en) 1982-06-01
ZA823532B (en) 1983-03-30
IL65836A (en) 1991-04-15
AR244227A1 (es) 1993-10-29
US4355032B1 (es) 1983-06-14
NZ200691A (en) 1986-11-12
ES524899A0 (es) 1985-09-16
LU88334I2 (fr) 1994-09-09
NO161740B (no) 1989-06-12
IN156469B (es) 1985-08-10
DK227782A (da) 1982-11-22
IL65836A0 (en) 1982-08-31
DE3266644D1 (en) 1985-11-07
PL236521A1 (en) 1984-01-02
DD213218A5 (de) 1984-09-05
ES8601204A1 (es) 1985-11-16
ES512414A0 (es) 1984-05-01
CS235018B2 (en) 1985-04-16
PL242100A1 (en) 1984-04-24
PL136004B1 (en) 1986-01-31
RO84860B (ro) 1984-10-30
FI73682C (fi) 1987-11-09
HU188000B (en) 1986-03-28
DK150304B (da) 1987-02-02
EP0066208B1 (en) 1985-10-02
ES533821A0 (es) 1985-06-16
RO87387B (ro) 1985-08-31
PL136637B1 (en) 1986-03-31
US4355032B2 (en) 1990-10-30

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