ATE178605T1 - Carbo-acyclische nukleosidderivate als antivirale und antineoplastische mittel - Google Patents

Carbo-acyclische nukleosidderivate als antivirale und antineoplastische mittel

Info

Publication number
ATE178605T1
ATE178605T1 AT94920695T AT94920695T ATE178605T1 AT E178605 T1 ATE178605 T1 AT E178605T1 AT 94920695 T AT94920695 T AT 94920695T AT 94920695 T AT94920695 T AT 94920695T AT E178605 T1 ATE178605 T1 AT E178605T1
Authority
AT
Austria
Prior art keywords
group
hydrogen
carbo
antiviral
antineoplastic agents
Prior art date
Application number
AT94920695T
Other languages
English (en)
Inventor
Jeffrey S Sabol
Sai P Sunkara
Shawn C Miller
Original Assignee
Merrell Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Pharma Inc filed Critical Merrell Pharma Inc
Application granted granted Critical
Publication of ATE178605T1 publication Critical patent/ATE178605T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/47One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52Two oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52Two oxygen atoms
    • C07D239/54Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D473/00Heterocyclic compounds containing purine ring systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AT94920695T 1993-06-23 1994-05-31 Carbo-acyclische nukleosidderivate als antivirale und antineoplastische mittel ATE178605T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US8172793A 1993-06-23 1993-06-23

Publications (1)

Publication Number Publication Date
ATE178605T1 true ATE178605T1 (de) 1999-04-15

Family

ID=22166006

Family Applications (1)

Application Number Title Priority Date Filing Date
AT94920695T ATE178605T1 (de) 1993-06-23 1994-05-31 Carbo-acyclische nukleosidderivate als antivirale und antineoplastische mittel

Country Status (19)

Country Link
US (1) US6017923A (de)
EP (1) EP0705264B1 (de)
JP (1) JP3468423B2 (de)
CN (1) CN1040759C (de)
AT (1) ATE178605T1 (de)
AU (1) AU679763B2 (de)
CA (1) CA2165419C (de)
DE (1) DE69417748T2 (de)
DK (1) DK0705264T3 (de)
ES (1) ES2132411T3 (de)
FI (1) FI956246A (de)
GR (1) GR3030003T3 (de)
HU (1) HUT73410A (de)
IL (1) IL110051A (de)
NO (1) NO955254L (de)
NZ (1) NZ268479A (de)
TW (1) TW269690B (de)
WO (1) WO1995000515A1 (de)
ZA (1) ZA944344B (de)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE423089T1 (de) 1998-01-30 2009-03-15 Daiso Co Ltd Verfahren zur herstellung von butantriol- derivaten

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4199575A (en) * 1978-03-27 1980-04-22 Gunther Roland E Method of treating dermatitis venenata
US4221794A (en) * 1979-06-21 1980-09-09 Newport Pharmaceuticals International, Inc. Method of imparting immunomodulating and antiviral activity
US4355032B2 (en) * 1981-05-21 1990-10-30 9-(1,3-dihydroxy-2-propoxymethyl)guanine as antiviral agent
IL73682A (en) * 1983-12-20 1991-08-16 Medivir Ab Antiviral pharmaceutical compositions containing 9-hydroxy aliphatic derivatives of guanine,some new such derivatives and process for their preparation
US4935427A (en) * 1987-12-31 1990-06-19 The United States Of America As Represented By The Department Of Health And Human Services Pyrimidine and purine 1,2-butadiene-4-ols as anti-retroviral agents
AU618436B2 (en) * 1988-12-19 1991-12-19 Wellcome Foundation Limited, The Antiviral cytosine and guanine derivatives

Also Published As

Publication number Publication date
ES2132411T3 (es) 1999-08-16
HUT73410A (en) 1996-07-29
CN1125947A (zh) 1996-07-03
EP0705264B1 (de) 1999-04-07
JPH08512030A (ja) 1996-12-17
NZ268479A (en) 1997-07-27
US6017923A (en) 2000-01-25
IL110051A (en) 2000-01-31
ZA944344B (en) 1995-02-15
TW269690B (de) 1996-02-01
IL110051A0 (en) 1994-10-07
DE69417748D1 (de) 1999-05-12
CA2165419A1 (en) 1994-12-24
AU679763B2 (en) 1997-07-10
CN1040759C (zh) 1998-11-18
HU9503707D0 (en) 1996-02-28
JP3468423B2 (ja) 2003-11-17
FI956246A0 (fi) 1995-12-22
GR3030003T3 (en) 1999-07-30
EP0705264A1 (de) 1996-04-10
NO955254D0 (no) 1995-12-22
DK0705264T3 (da) 1999-10-18
WO1995000515A1 (en) 1995-01-05
CA2165419C (en) 1999-03-02
AU7139494A (en) 1995-01-17
FI956246A (fi) 1995-12-22
NO955254L (no) 1996-02-21
DE69417748T2 (de) 1999-08-19

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee