DE69417748T2 - Carbo-acyclische nukleosidderivate als antivirale und antineoplastische mittel - Google Patents

Carbo-acyclische nukleosidderivate als antivirale und antineoplastische mittel

Info

Publication number
DE69417748T2
DE69417748T2 DE69417748T DE69417748T DE69417748T2 DE 69417748 T2 DE69417748 T2 DE 69417748T2 DE 69417748 T DE69417748 T DE 69417748T DE 69417748 T DE69417748 T DE 69417748T DE 69417748 T2 DE69417748 T2 DE 69417748T2
Authority
DE
Germany
Prior art keywords
group
hydrogen
carbo
antiviral
antineoplastic agents
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69417748T
Other languages
English (en)
Other versions
DE69417748D1 (de
Inventor
Jeffrey Sabol
Sai Sunkara
Shawn C Miller
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharmaceuticals Inc
Original Assignee
Merrell Dow Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharmaceuticals Inc filed Critical Merrell Dow Pharmaceuticals Inc
Application granted granted Critical
Publication of DE69417748D1 publication Critical patent/DE69417748D1/de
Publication of DE69417748T2 publication Critical patent/DE69417748T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DE69417748T 1993-06-23 1994-05-31 Carbo-acyclische nukleosidderivate als antivirale und antineoplastische mittel Expired - Fee Related DE69417748T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US8172793A 1993-06-23 1993-06-23
PCT/US1994/006119 WO1995000515A1 (en) 1993-06-23 1994-05-31 Carbo-acyclic nucleoside derivatives as antiviral and antineoplastic agents

Publications (2)

Publication Number Publication Date
DE69417748D1 DE69417748D1 (de) 1999-05-12
DE69417748T2 true DE69417748T2 (de) 1999-08-19

Family

ID=22166006

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69417748T Expired - Fee Related DE69417748T2 (de) 1993-06-23 1994-05-31 Carbo-acyclische nukleosidderivate als antivirale und antineoplastische mittel

Country Status (19)

Country Link
US (1) US6017923A (de)
EP (1) EP0705264B1 (de)
JP (1) JP3468423B2 (de)
CN (1) CN1040759C (de)
AT (1) ATE178605T1 (de)
AU (1) AU679763B2 (de)
CA (1) CA2165419C (de)
DE (1) DE69417748T2 (de)
DK (1) DK0705264T3 (de)
ES (1) ES2132411T3 (de)
FI (1) FI956246A (de)
GR (1) GR3030003T3 (de)
HU (1) HUT73410A (de)
IL (1) IL110051A (de)
NO (1) NO955254L (de)
NZ (1) NZ268479A (de)
TW (1) TW269690B (de)
WO (1) WO1995000515A1 (de)
ZA (1) ZA944344B (de)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1061062B1 (de) 1998-01-30 2009-02-18 Daiso Co., Ltd. Verfahren zur herstellung von butantriol-derivaten

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4199575A (en) * 1978-03-27 1980-04-22 Gunther Roland E Method of treating dermatitis venenata
US4221794A (en) * 1979-06-21 1980-09-09 Newport Pharmaceuticals International, Inc. Method of imparting immunomodulating and antiviral activity
US4355032B2 (en) * 1981-05-21 1990-10-30 9-(1,3-dihydroxy-2-propoxymethyl)guanine as antiviral agent
IL73682A (en) * 1983-12-20 1991-08-16 Medivir Ab Antiviral pharmaceutical compositions containing 9-hydroxy aliphatic derivatives of guanine,some new such derivatives and process for their preparation
US4935427A (en) * 1987-12-31 1990-06-19 The United States Of America As Represented By The Department Of Health And Human Services Pyrimidine and purine 1,2-butadiene-4-ols as anti-retroviral agents
AU618436B2 (en) * 1988-12-19 1991-12-19 Wellcome Foundation Limited, The Antiviral cytosine and guanine derivatives

Also Published As

Publication number Publication date
US6017923A (en) 2000-01-25
GR3030003T3 (en) 1999-07-30
IL110051A0 (en) 1994-10-07
EP0705264A1 (de) 1996-04-10
CA2165419C (en) 1999-03-02
HUT73410A (en) 1996-07-29
ATE178605T1 (de) 1999-04-15
CN1125947A (zh) 1996-07-03
AU7139494A (en) 1995-01-17
CA2165419A1 (en) 1994-12-24
EP0705264B1 (de) 1999-04-07
JPH08512030A (ja) 1996-12-17
FI956246A0 (fi) 1995-12-22
WO1995000515A1 (en) 1995-01-05
CN1040759C (zh) 1998-11-18
AU679763B2 (en) 1997-07-10
TW269690B (de) 1996-02-01
JP3468423B2 (ja) 2003-11-17
DK0705264T3 (da) 1999-10-18
DE69417748D1 (de) 1999-05-12
FI956246A (fi) 1995-12-22
IL110051A (en) 2000-01-31
ES2132411T3 (es) 1999-08-16
ZA944344B (en) 1995-02-15
HU9503707D0 (en) 1996-02-28
NO955254D0 (no) 1995-12-22
NZ268479A (en) 1997-07-27
NO955254L (no) 1996-02-21

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee