GR3030003T3 - Carbo-acyclic nucleoside derivatives as antiviral and antineoplastic agents - Google Patents

Carbo-acyclic nucleoside derivatives as antiviral and antineoplastic agents

Info

Publication number
GR3030003T3
GR3030003T3 GR990401082T GR990401082T GR3030003T3 GR 3030003 T3 GR3030003 T3 GR 3030003T3 GR 990401082 T GR990401082 T GR 990401082T GR 990401082 T GR990401082 T GR 990401082T GR 3030003 T3 GR3030003 T3 GR 3030003T3
Authority
GR
Greece
Prior art keywords
group
hydrogen
carbo
antiviral
antineoplastic agents
Prior art date
Application number
GR990401082T
Other languages
English (en)
Inventor
Jeffrey S Sabol
Sai P Sunkara
Shawn C Miller
Original Assignee
Merrell Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Pharma Inc filed Critical Merrell Pharma Inc
Publication of GR3030003T3 publication Critical patent/GR3030003T3/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
GR990401082T 1993-06-23 1999-04-20 Carbo-acyclic nucleoside derivatives as antiviral and antineoplastic agents GR3030003T3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US8172793A 1993-06-23 1993-06-23
PCT/US1994/006119 WO1995000515A1 (en) 1993-06-23 1994-05-31 Carbo-acyclic nucleoside derivatives as antiviral and antineoplastic agents

Publications (1)

Publication Number Publication Date
GR3030003T3 true GR3030003T3 (en) 1999-07-30

Family

ID=22166006

Family Applications (1)

Application Number Title Priority Date Filing Date
GR990401082T GR3030003T3 (en) 1993-06-23 1999-04-20 Carbo-acyclic nucleoside derivatives as antiviral and antineoplastic agents

Country Status (19)

Country Link
US (1) US6017923A (el)
EP (1) EP0705264B1 (el)
JP (1) JP3468423B2 (el)
CN (1) CN1040759C (el)
AT (1) ATE178605T1 (el)
AU (1) AU679763B2 (el)
CA (1) CA2165419C (el)
DE (1) DE69417748T2 (el)
DK (1) DK0705264T3 (el)
ES (1) ES2132411T3 (el)
FI (1) FI956246A0 (el)
GR (1) GR3030003T3 (el)
HU (1) HUT73410A (el)
IL (1) IL110051A (el)
NO (1) NO955254L (el)
NZ (1) NZ268479A (el)
TW (1) TW269690B (el)
WO (1) WO1995000515A1 (el)
ZA (1) ZA944344B (el)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6620977B1 (en) 1998-01-30 2003-09-16 Daiso Co., Ltd. Process for producing butanetriol derivative

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4199575A (en) * 1978-03-27 1980-04-22 Gunther Roland E Method of treating dermatitis venenata
US4221794A (en) * 1979-06-21 1980-09-09 Newport Pharmaceuticals International, Inc. Method of imparting immunomodulating and antiviral activity
US4355032B2 (en) * 1981-05-21 1990-10-30 9-(1,3-dihydroxy-2-propoxymethyl)guanine as antiviral agent
IL73682A (en) * 1983-12-20 1991-08-16 Medivir Ab Antiviral pharmaceutical compositions containing 9-hydroxy aliphatic derivatives of guanine,some new such derivatives and process for their preparation
US4935427A (en) * 1987-12-31 1990-06-19 The United States Of America As Represented By The Department Of Health And Human Services Pyrimidine and purine 1,2-butadiene-4-ols as anti-retroviral agents
CA2005815C (en) * 1988-12-19 1999-08-03 Wellcome Foundation Limited (The) Antiviral acyclic nucleoside derivatives

Also Published As

Publication number Publication date
NZ268479A (en) 1997-07-27
AU7139494A (en) 1995-01-17
HU9503707D0 (en) 1996-02-28
DE69417748T2 (de) 1999-08-19
IL110051A (en) 2000-01-31
EP0705264A1 (en) 1996-04-10
CA2165419C (en) 1999-03-02
CN1125947A (zh) 1996-07-03
AU679763B2 (en) 1997-07-10
TW269690B (el) 1996-02-01
JP3468423B2 (ja) 2003-11-17
EP0705264B1 (en) 1999-04-07
US6017923A (en) 2000-01-25
WO1995000515A1 (en) 1995-01-05
HUT73410A (en) 1996-07-29
NO955254L (no) 1996-02-21
ES2132411T3 (es) 1999-08-16
DK0705264T3 (da) 1999-10-18
CN1040759C (zh) 1998-11-18
DE69417748D1 (de) 1999-05-12
ATE178605T1 (de) 1999-04-15
FI956246A (fi) 1995-12-22
JPH08512030A (ja) 1996-12-17
FI956246A0 (fi) 1995-12-22
IL110051A0 (en) 1994-10-07
NO955254D0 (no) 1995-12-22
ZA944344B (en) 1995-02-15
CA2165419A1 (en) 1994-12-24

Similar Documents

Publication Publication Date Title
DK0545966T3 (da) Phospholipidderivater af nucleosider, deres fremstilling samt deres anvendelse som anti-virale lægemidler
IL110091A (en) POLYSUBSTITUTED IMIDAZO £4, 5-c| PYRIDIN-4-AMINES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
ATE404561T1 (de) Neue adeninderivate
MY106406A (en) Acryloyl substituted pyrrole derivatives.
TW360652B (en) Acryloyl substituted disstamycin derivatives, process for preparing them, and pharmaceutical composition comprising them
FI935517A0 (fi) Fenoxi- och fenoxialkylpiperidiner som virusmotverkande medel
GB2326412A (en) Naphthyridine derivatives and their analogues inhibiting cytomegalovirus
MY123083A (en) Acyclic nucleoside derivatives
IT1205729B (it) Derivati di diidrobenzofurano-e cromano-carbossammidi,procedimento per prepararli e loro impiego come neurolettici
DE60015945D1 (en) 2-hydroxy methylcyclopropylidenmethylpurine als antivirale wirkstoffe
GR3004627T3 (el)
NO931008L (no) Farmasoeytiske forbindelser
HU9503707D0 (en) Carbo-acyclic nucleoside derivatives as antiviral and antineoplastic agents
MX9303990A (es) Tetrazolil (fenoxi y fenoxialquil) piperidinil piridazinas como agentes antivirales.
TR200002318T2 (tr) Nükleositler
DK0719271T3 (da) 5-(1-Fluorvinyl)-1H-pyrimidin-2,4-dion-derivater som antineoplastiske midler
NO20000054D0 (no) Polyhydroksyalkylpyrazinderivater, deres fremstilling og medisiner inneholdende forbindelsene
ES8308335A1 (es) Un procedimiento para la preparacion de nuevos derivados de desoxiuridina.