NO931008L - Farmasoeytiske forbindelser - Google Patents

Farmasoeytiske forbindelser

Info

Publication number
NO931008L
NO931008L NO93931008A NO931008A NO931008L NO 931008 L NO931008 L NO 931008L NO 93931008 A NO93931008 A NO 93931008A NO 931008 A NO931008 A NO 931008A NO 931008 L NO931008 L NO 931008L
Authority
NO
Norway
Prior art keywords
compounds
pharmaceutical
relations
pyrrolo
alkylamino
Prior art date
Application number
NO93931008A
Other languages
English (en)
Other versions
NO931008D0 (no
Inventor
Lynn Stacy Gossett
Chuan Shih
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of NO931008D0 publication Critical patent/NO931008D0/no
Publication of NO931008L publication Critical patent/NO931008L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Det ble beskrevet N-[2-amlno-4-substituerte-[[(pyrrolo eller pyrido)[2,3-d]pyrlmidinyl]alkyl]benzoyl]-L- glutamlnsyreforbindelser, mellomprodukter for deres syntese, farmasøytiske formuleringer som inneholder disse forbindelsene og deres anvendelse som antl- neoplastiske midler. Forbindelsene har formelen: R1 COOH «r-H H CH2CH2COOH hvor Ar er dihydropyrrolo, pyrrolo, pyrldo eller tetrahydropyrldo; R1 er hydrogen, klor, C1-C4-alkyltlo, C1-C4-alkoksy, Cj-C^ alkylamlno eller dl(C^-C^ )alkylamino; og E2 er C2-C3-alkyl; eller et farmasøytisk akseptabelt salt av disse.
NO93931008A 1992-03-24 1993-03-19 Farmasoeytiske forbindelser NO931008L (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/856,611 US5196424A (en) 1992-03-24 1992-03-24 N-[2-amino-4-substituted[[(pyrrollo or pyrido)[2,3-d]pyrimidinyl]-alkyl]benzoyl]-L-glutamic acids

Publications (2)

Publication Number Publication Date
NO931008D0 NO931008D0 (no) 1993-03-19
NO931008L true NO931008L (no) 1993-09-27

Family

ID=25324069

Family Applications (1)

Application Number Title Priority Date Filing Date
NO93931008A NO931008L (no) 1992-03-24 1993-03-19 Farmasoeytiske forbindelser

Country Status (18)

Country Link
US (1) US5196424A (no)
EP (1) EP0567223A1 (no)
JP (1) JPH0625246A (no)
KR (1) KR930019676A (no)
CN (1) CN1078235A (no)
AU (1) AU3542993A (no)
BR (1) BR9301273A (no)
CA (1) CA2091978A1 (no)
CZ (1) CZ44093A3 (no)
FI (1) FI931251A (no)
HU (1) HUT70036A (no)
IL (1) IL105100A0 (no)
MX (1) MX9301544A (no)
MY (1) MY131322A (no)
NO (1) NO931008L (no)
NZ (1) NZ247193A (no)
TW (1) TW224098B (no)
ZA (1) ZA931944B (no)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5457056A (en) * 1993-07-06 1995-10-10 Fiberchem, Inc. Halohydrocarbon sensing chemistry with base modifier
US6537999B2 (en) * 1996-06-06 2003-03-25 Duquesne University Of The Holy Ghost Pyrimidine derivatives and methods of making and using these derivatives
CA2263907A1 (en) * 1996-08-30 1998-03-05 Christopher Leighon Jordan Nonclassical pyrrolo[2,3-d]pyrimidine antifolates
US20030129186A1 (en) 2001-07-25 2003-07-10 Biomarin Pharmaceutical Inc. Compositions and methods for modulating blood-brain barrier transport
US8030319B2 (en) * 2005-02-10 2011-10-04 Duquesne University Of The Holy Ghost Methods for treating cancer and other pathological proliferating disorders by inhibiting mitosis using pyrrolo[2 3-d]pyrimidines
PT1889198E (pt) 2005-04-28 2015-03-06 Proteus Digital Health Inc Sistema fármaco-informático
CN1962658B (zh) * 2005-11-10 2010-05-12 北京大学 一种四氢吡啶并[3,2-d]嘧啶类化合物及制备抗肿瘤药物的用途
WO2008036682A2 (en) 2006-09-18 2008-03-27 Raptor Pharmaceutical Inc. Treatment of liver disorders by administration of receptor-associated protein (rap)-conjugates
PT2398500T (pt) 2009-02-20 2019-06-14 2 Bbb Medicines B V Sistema de entrega de medicamentos à base de glutationas
ES2942923T3 (es) 2009-05-06 2023-06-07 Laboratory Skin Care Inc Composiciones de administración dérmica que comprenden complejos de agente activo-partículas de fosfato de calcio y métodos de uso de las mismas
WO2011056957A2 (en) * 2009-11-06 2011-05-12 Chelsea Therapeutics, Inc. Enzyme inhibiting compounds
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates
CN102977107B (zh) * 2012-12-25 2015-04-22 山西普德药业股份有限公司 一种培美曲塞二钠化合物及其组合物

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59170091A (ja) * 1983-03-17 1984-09-26 Takeda Chem Ind Ltd ６−チオ−７−デアザプリン誘導体およびその製造法
EP0119591B1 (en) * 1983-03-17 1988-06-22 Takeda Chemical Industries, Ltd. Thiodeazapurine derivatives
GB2160525B (en) * 1983-12-27 1987-08-26 Stanford Res Inst Int 8,10-dideazaminopterins
US5026851A (en) * 1985-03-08 1991-06-25 The Trustees Of Princeton University Pyrido[2,3-]pyrimidine derivatives
ZA861235B (en) * 1985-03-08 1986-10-29 Univ Princeton Pyrido(2,3-d)pyrimidine derivatives
US4927828A (en) * 1985-03-08 1990-05-22 The Trustees Of Princeton University Diastereoisomeric tetrahydropyrido-(2,3,d) pyrimidine derivatives
US4684653A (en) * 1985-03-08 1987-08-04 The Trustees Of Princeton University Pyrido(2,3-d)pyrimidine derivatives
US4988702A (en) * 1986-08-26 1991-01-29 Warner-Lambert Company Novel 9-deazaguanines
US4923872A (en) * 1986-08-26 1990-05-08 Warner-Lambert Co. Analogues of pyrrolo[3,2d]pyrimidin-4-ones
US4988813A (en) * 1986-10-20 1991-01-29 The Trustees Of Princeton University Process for the preparation of fused pyridine compounds
US4902796A (en) * 1986-10-20 1990-02-20 The Trustees Of Princeton University 6-alkenyl and ethynyl derivatives of 2-amino-4-hydroxypyrido[2,3-d]pyrimidines
US4921858A (en) * 1986-10-24 1990-05-01 Warner-Lambert Company 7-deazaguanines as immunomodulators
JP2830008B2 (ja) * 1988-04-01 1998-12-02 武田薬品工業株式会社 縮合ピリミジン誘導体
NO169490C (no) * 1988-03-24 1992-07-01 Takeda Chemical Industries Ltd Analogifremgangsmaate for fremstilling av terapeutisk aktive pyrrolopyrimidinderivater
US4882333A (en) * 1988-05-25 1989-11-21 The Trustess Of Princeton University N-(5,6,7,8-tetrahydropyrido[2,3-d]pyrimidin-6-yl-alkanoyl)-glutamic acid derivatives
CH677140A5 (no) * 1988-10-11 1991-04-15 W & E Umwelttechnik Ag
AU641183B2 (en) * 1989-09-19 1993-09-16 Teijin Limited Pyrrolo(2,3-d)pyrimidine derivative, process for preparing the same, and pharmaceutical preparation comprising the derivative as active ingredient
CA2032695A1 (en) * 1989-12-20 1991-06-21 Hiroshi Akimoto Condensed heterocyclic compounds, their production and use

Also Published As

Publication number Publication date
CA2091978A1 (en) 1993-09-25
JPH0625246A (ja) 1994-02-01
FI931251A (fi) 1993-09-25
NO931008D0 (no) 1993-03-19
NZ247193A (en) 1995-05-26
HUT70036A (en) 1995-09-28
ZA931944B (en) 1994-09-18
US5196424A (en) 1993-03-23
CN1078235A (zh) 1993-11-10
FI931251A0 (fi) 1993-03-22
MY131322A (en) 2007-08-30
AU3542993A (en) 1993-09-30
HU9300804D0 (en) 1993-06-28
CZ44093A3 (en) 1994-02-16
MX9301544A (es) 1994-07-29
BR9301273A (pt) 1993-09-28
KR930019676A (ko) 1993-10-18
EP0567223A1 (en) 1993-10-27
IL105100A0 (en) 1993-12-28
TW224098B (no) 1994-05-21

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