NO169490C - Analogifremgangsmaate for fremstilling av terapeutisk aktive pyrrolopyrimidinderivater - Google Patents

Analogifremgangsmaate for fremstilling av terapeutisk aktive pyrrolopyrimidinderivater

Info

Publication number
NO169490C
NO169490C NO891206A NO891206A NO169490C NO 169490 C NO169490 C NO 169490C NO 891206 A NO891206 A NO 891206A NO 891206 A NO891206 A NO 891206A NO 169490 C NO169490 C NO 169490C
Authority
NO
Norway
Prior art keywords
group
preparation
therapeutic active
analogy procedure
pyrrolopyrimidine derivatives
Prior art date
Application number
NO891206A
Other languages
English (en)
Other versions
NO891206D0 (no
NO169490B (no
NO891206L (no
Inventor
Hiroshi Akimoto
Takenori Hitsaka
Tetsuo Miwa
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26412276&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO169490(C) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Publication of NO891206D0 publication Critical patent/NO891206D0/no
Publication of NO891206L publication Critical patent/NO891206L/no
Priority to NO910661A priority Critical patent/NO178304C/no
Publication of NO169490B publication Critical patent/NO169490B/no
Publication of NO169490C publication Critical patent/NO169490C/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
NO891206A 1988-03-24 1989-03-20 Analogifremgangsmaate for fremstilling av terapeutisk aktive pyrrolopyrimidinderivater NO169490C (no)

Priority Applications (1)

Application Number Priority Date Filing Date Title
NO910661A NO178304C (no) 1988-03-24 1991-02-19 Mellomprodukt for fremstilling av pyrrolopyrimidinderivater

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP7114988 1988-03-24
JP24537988 1988-09-29

Publications (4)

Publication Number Publication Date
NO891206D0 NO891206D0 (no) 1989-03-20
NO891206L NO891206L (no) 1989-09-25
NO169490B NO169490B (no) 1992-03-23
NO169490C true NO169490C (no) 1992-07-01

Family

ID=26412276

Family Applications (1)

Application Number Title Priority Date Filing Date
NO891206A NO169490C (no) 1988-03-24 1989-03-20 Analogifremgangsmaate for fremstilling av terapeutisk aktive pyrrolopyrimidinderivater

Country Status (12)

Country Link
US (4) US4997838A (no)
EP (1) EP0334636B1 (no)
KR (1) KR960015967B1 (no)
CN (1) CN1029970C (no)
AT (1) ATE144513T1 (no)
CA (1) CA1340794C (no)
DE (1) DE68927354T2 (no)
DK (1) DK173980B1 (no)
ES (1) ES2092994T3 (no)
GR (1) GR3021733T3 (no)
HU (3) HU215928B (no)
NO (1) NO169490C (no)

Families Citing this family (56)

* Cited by examiner, † Cited by third party
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NO169490C (no) * 1988-03-24 1992-07-01 Takeda Chemical Industries Ltd Analogifremgangsmaate for fremstilling av terapeutisk aktive pyrrolopyrimidinderivater
JP2760364B2 (ja) * 1989-02-27 1998-05-28 バイオクライシス・ファーマシューティカルズ、インコーポレイテッド ９―置換―８―非置換―９―デアザグアニン類
JP3015957B2 (ja) * 1989-05-29 2000-03-06 武田薬品工業株式会社 ピロロ［２，３―ｄ］ピリミジン誘導体およびその製造法
JP2983254B2 (ja) * 1989-06-14 1999-11-29 武田薬品工業株式会社 ピロロ〔２，３―ｄ〕ピリミジン誘導体の製造法およびその中間体
JPH03173890A (ja) * 1989-09-21 1991-07-29 Takeda Chem Ind Ltd ピロロ［２，３―ｄ］ピリミジン誘導体，その製造法，用途及び中間体
CA2031769A1 (en) * 1989-12-08 1991-06-09 Hiroshi Akimoto Pyrrolopyrimidine derivatives, their production and use
IL96531A (en) * 1989-12-11 1995-08-31 Univ Princeton History of Acid N- (Diomeric-H1-Pyrolo] D-2,3 [Pyrimidine-3-Ilacyl (-glutamic, preparation and pharmaceutical preparations containing them)
US5248775A (en) * 1989-12-11 1993-09-28 The Trustees Of Princeton University Pyrrolo(2,3-d)pyrimidines
KR0162654B1 (ko) * 1989-12-11 1998-11-16 알렌 제이. 시니스갤리 N-(피롤로[2,3-d]피리미딘-3-일아크릴)-글루타민산 유도체
US5028608A (en) * 1989-12-11 1991-07-02 The Trustees Of Princeton University N-(6-Amino-(pyrrolo(2,3-d)pyrimidin-3-ylacyl) )-glutamic acid derivatives
CA2032695A1 (en) * 1989-12-20 1991-06-21 Hiroshi Akimoto Condensed heterocyclic compounds, their production and use
EP0438261A3 (en) * 1990-01-16 1992-02-26 Takeda Chemical Industries, Ltd. Condensed heterocyclic glutamic acid derivatives, their production and use
CA2057635A1 (en) * 1990-12-14 1992-06-15 Hiroshi Akimoto Condensed heterocyclic compounds, their production and use
US5217974A (en) * 1991-03-29 1993-06-08 Eli Lilly And Company Method for treating gar-transformylase tumors in mammals and reducing mammalian toxicity
DE69216509T2 (de) * 1991-08-12 1997-05-28 Takeda Chemical Industries Ltd Kondensierte Pyrimidinderivate, ihre Herstellung und ihre Verwendung als Antitumormittel
ATE173251T1 (de) * 1991-08-21 1998-11-15 Eisai Co Ltd Kondensierte pyrimidinderivate als antitumorverbindungen
US5254687A (en) 1991-12-04 1993-10-19 The Trustees Of Princeton University Process for the preparation of pyrrolo[2,3-d]pyrimidines
US5196424A (en) * 1992-03-24 1993-03-23 Eli Lilly And Company N-[2-amino-4-substituted[[(pyrrollo or pyrido)[2,3-d]pyrimidinyl]-alkyl]benzoyl]-L-glutamic acids
US5235053A (en) 1992-06-22 1993-08-10 Eli Lilly And Company Process for the synthesis of 4-hydroxy-5-halopyrrold[2,3-d]pyrimidine intermediates
US5278307A (en) * 1992-09-25 1994-01-11 Eli Lilly And Company Process for preparing 4-hydroxypyrrolo(2,3-d)pyrimidine based antifolate compounds and intermediates
US5416211A (en) * 1992-09-25 1995-05-16 Eli Lilly And Company Process for preparing 5-substituted pyrrolo-[2,3-d]pyrimidines
CZ283281B6 (cs) * 1992-09-25 1998-02-18 Eli Lilly And Company Způsob přípravy v poloze 5 substituovaných pyrrolo(2,3-d)pyrimidinů
US5426187A (en) * 1993-11-30 1995-06-20 Eli Lilly And Company Process for the preparation of 4-hydroxy-5-substituted ethynylpyrrolo [2,3-d]pyrimidine intermediates
CA2223081C (en) * 1995-06-07 2001-03-06 Pfizer Inc. Heterocyclic ring-fused pyrimidine derivatives
US6395733B1 (en) 1995-06-07 2002-05-28 Pfizer Inc Heterocyclic ring-fused pyrimidine derivatives
AU1794697A (en) * 1996-03-06 1997-09-22 Novartis Ag 7-alkyl-pyrrolo{2,3-d}pyrimidines
CA2263907A1 (en) * 1996-08-30 1998-03-05 Christopher Leighon Jordan Nonclassical pyrrolo[2,3-d]pyrimidine antifolates
TR200001220T2 (tr) * 1997-09-26 2001-05-21 Eli Lilly And Company Antifolatlar yapmak için yararlı işlemler ve aramaddeler.
US6162914A (en) * 1998-04-24 2000-12-19 Cerbios-Pharma S.A. Process for the reduction of pterins
PA8474101A1 (es) 1998-06-19 2000-09-29 Pfizer Prod Inc Compuestos de pirrolo [2,3-d] pirimidina
US6066732A (en) * 1998-08-21 2000-05-23 The Trustees Of Princeton University Process for the preparation of pyrrolo[2,3-d]pyrimidines
EP1180369A4 (en) 1999-05-24 2002-07-24 Sankyo Co ANTI-FAS ANTIBODY MEDICAL COMPOSITIONS
HK1049787B (en) 1999-10-01 2014-07-25 Immunogen, Inc. Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents
US6229413B1 (en) 1999-10-19 2001-05-08 General Electric Company Support of stationary conductors for a circuit breaker
PT1382339E (pt) 1999-12-10 2008-02-06 Pfizer Prod Inc Composições que contêm derivados de pirrolo[2,3-d]- pirimidina
WO2001062760A2 (en) * 2000-02-25 2001-08-30 Eli Lilly And Company A NOVEL CRYSTALLINE FORM OF N-[4-[2-(2-AMINO-4,7-DIHYDRO-4-OXO-3H-PYRROLO[2,3-d]PYRIMIDIN-5-YL)ETHYL]BENZOYL]-L-GLUTAMIC ACID AND PROCESS THEREFOR
US6380829B1 (en) 2000-11-21 2002-04-30 General Electric Company Motor operator interlock and method for circuit breakers
WO2003002661A1 (fr) * 2001-06-28 2003-01-09 Toray Industries, Inc. Composition de resine epoxyde qui presente une excellente aux intemperies et materiaux composites renforces en fibres
WO2004047843A1 (en) 2002-11-26 2004-06-10 Pfizer Products Inc. Method of treatment of transplant rejection
CN100379729C (zh) * 2006-04-06 2008-04-09 海南天源康泽医药科技有限公司 硝基化合物及其在培美曲塞制备中的应用
EP2125818A1 (en) * 2007-01-19 2009-12-02 Chelsea Therapeutics, Inc. New classical antifolates
JP2010523589A (ja) * 2007-04-03 2010-07-15 ドクター レディズ ラボラトリーズ リミテッド ペメトレキセドの固体形
KR20100132061A (ko) * 2008-04-07 2010-12-16 첼시 쎄라퓨틱스, 인코포레이티드 항엽산제 화합물의 결정 염 형태 및 이의 제조 방법
EP2384326B1 (en) 2008-08-20 2014-04-23 Zoetis LLC Pyrrolo[2,3-d]pyrimidine compounds
CN101684121B (zh) * 2008-09-22 2013-04-03 重庆医药工业研究院有限责任公司 培美曲塞二酸的新晶型及其制备方法
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CA2779642A1 (en) * 2009-11-06 2011-05-12 Chelsea Therapeutics, Inc. Enzyme inhibiting compounds
US20110237609A1 (en) * 2010-03-29 2011-09-29 Chelsea Therapeutics, Inc. Antifolate compositions
US20130183268A1 (en) 2010-07-19 2013-07-18 Bayer Healthcare Llc Drug combinations with fluoro-substituted omega-carboxyaryl diphenyl urea for the treatment and prevention of diseases and conditions
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US8658652B2 (en) 2010-12-07 2014-02-25 Chelsea Therapeutics, Inc. Antifolate combinations
US9051322B2 (en) * 2011-03-23 2015-06-09 Scinopharm Taiwan, Ltd. Process for the production of a pemetrexed salt
CN103030640B (zh) * 2012-06-11 2015-04-22 江苏豪森医药集团连云港宏创医药有限公司 一种培美曲塞或其盐的制备方法
US10793573B2 (en) * 2017-08-31 2020-10-06 Duquesne University Of The Holy Spirit First-in-class of SHMT2 and MTHFD2 inhibitors as antitumor agents
NL2022471B1 (en) 2019-01-29 2020-08-18 Vationpharma B V Solid state forms of oclacitinib

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4532241A (en) * 1982-08-26 1985-07-30 Sri International 8,10-Dideazaminopterins
US4684653A (en) * 1985-03-08 1987-08-04 The Trustees Of Princeton University Pyrido(2,3-d)pyrimidine derivatives
NO169490C (no) * 1988-03-24 1992-07-01 Takeda Chemical Industries Ltd Analogifremgangsmaate for fremstilling av terapeutisk aktive pyrrolopyrimidinderivater

Also Published As

Publication number Publication date
DK143789A (da) 1989-09-25
EP0334636A2 (en) 1989-09-27
DK173980B1 (da) 2002-03-25
KR960015967B1 (ko) 1996-11-25
EP0334636B1 (en) 1996-10-23
GR3021733T3 (en) 1997-02-28
HUT51624A (en) 1990-05-28
CN1029970C (zh) 1995-10-11
NO891206D0 (no) 1989-03-20
CN1037513A (zh) 1989-11-29
US5296600A (en) 1994-03-22
US5539113A (en) 1996-07-23
HU215928B (hu) 1999-03-29
NO169490B (no) 1992-03-23
ES2092994T3 (es) 1996-12-16
CA1340794C (en) 1999-10-19
HUT55396A (en) 1991-05-28
HU908458D0 (en) 1991-07-29
EP0334636A3 (en) 1991-05-02
DE68927354D1 (de) 1996-11-28
DE68927354T2 (de) 1997-03-20
US5106974A (en) 1992-04-21
US4997838A (en) 1991-03-05
KR890014543A (ko) 1989-10-24
DK143789D0 (da) 1989-03-22
ATE144513T1 (de) 1996-11-15
HU203105B (en) 1991-05-28
NO891206L (no) 1989-09-25

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Legal Events

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MK1K Patent expired