NO891206L - Fremstilling og anvendelse av pyrrolopyrimidinderivater. - Google Patents

Fremstilling og anvendelse av pyrrolopyrimidinderivater.

Info

Publication number
NO891206L
NO891206L NO89891206A NO891206A NO891206L NO 891206 L NO891206 L NO 891206L NO 89891206 A NO89891206 A NO 89891206A NO 891206 A NO891206 A NO 891206A NO 891206 L NO891206 L NO 891206L
Authority
NO
Norway
Prior art keywords
group
coor
preparation
hydrogen atom
ring
Prior art date
Application number
NO89891206A
Other languages
English (en)
Other versions
NO891206D0 (no
NO169490C (no
NO169490B (no
Inventor
Hiroshi Akimoto
Takenori Hitsaka
Tetsuo Miwa
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26412276&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO891206(L) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Publication of NO891206D0 publication Critical patent/NO891206D0/no
Publication of NO891206L publication Critical patent/NO891206L/no
Priority to NO910661A priority Critical patent/NO178304C/no
Publication of NO169490B publication Critical patent/NO169490B/no
Publication of NO169490C publication Critical patent/NO169490C/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pyrrole Compounds (AREA)
NO891206A 1988-03-24 1989-03-20 Analogifremgangsmaate for fremstilling av terapeutisk aktive pyrrolopyrimidinderivater NO169490C (no)

Priority Applications (1)

Application Number Priority Date Filing Date Title
NO910661A NO178304C (no) 1988-03-24 1991-02-19 Mellomprodukt for fremstilling av pyrrolopyrimidinderivater

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP7114988 1988-03-24
JP24537988 1988-09-29

Publications (4)

Publication Number Publication Date
NO891206D0 NO891206D0 (no) 1989-03-20
NO891206L true NO891206L (no) 1989-09-25
NO169490B NO169490B (no) 1992-03-23
NO169490C NO169490C (no) 1992-07-01

Family

ID=26412276

Family Applications (1)

Application Number Title Priority Date Filing Date
NO891206A NO169490C (no) 1988-03-24 1989-03-20 Analogifremgangsmaate for fremstilling av terapeutisk aktive pyrrolopyrimidinderivater

Country Status (12)

Country Link
US (4) US4997838A (no)
EP (1) EP0334636B1 (no)
KR (1) KR960015967B1 (no)
CN (1) CN1029970C (no)
AT (1) ATE144513T1 (no)
CA (1) CA1340794C (no)
DE (1) DE68927354T2 (no)
DK (1) DK173980B1 (no)
ES (1) ES2092994T3 (no)
GR (1) GR3021733T3 (no)
HU (3) HU908458D0 (no)
NO (1) NO169490C (no)

Families Citing this family (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NO169490C (no) * 1988-03-24 1992-07-01 Takeda Chemical Industries Ltd Analogifremgangsmaate for fremstilling av terapeutisk aktive pyrrolopyrimidinderivater
DK0460116T3 (da) * 1989-02-27 1998-03-30 Biocryst Pharm Inc 9-substitueret-8-usubstitueret-9-deazaguaniner
JP3015957B2 (ja) * 1989-05-29 2000-03-06 武田薬品工業株式会社 ピロロ［２，３―ｄ］ピリミジン誘導体およびその製造法
JP2983254B2 (ja) * 1989-06-14 1999-11-29 武田薬品工業株式会社 ピロロ〔２，３―ｄ〕ピリミジン誘導体の製造法およびその中間体
JPH03173890A (ja) * 1989-09-21 1991-07-29 Takeda Chem Ind Ltd ピロロ［２，３―ｄ］ピリミジン誘導体，その製造法，用途及び中間体
CA2031769A1 (en) * 1989-12-08 1991-06-09 Hiroshi Akimoto Pyrrolopyrimidine derivatives, their production and use
US5248775A (en) * 1989-12-11 1993-09-28 The Trustees Of Princeton University Pyrrolo(2,3-d)pyrimidines
US4996206A (en) * 1989-12-11 1991-02-26 The Trustees Of Princeton University N-(pyrrolo[2,3-d]pyrimidin-3-ylacyl)-glutamic acid derivatives
KR0162654B1 (ko) * 1989-12-11 1998-11-16 알렌 제이. 시니스갤리 N-(피롤로[2,3-d]피리미딘-3-일아크릴)-글루타민산 유도체
IL96531A (en) * 1989-12-11 1995-08-31 Univ Princeton History of Acid N- (Diomeric-H1-Pyrolo] D-2,3 [Pyrimidine-3-Ilacyl (-glutamic, preparation and pharmaceutical preparations containing them)
CA2032695A1 (en) * 1989-12-20 1991-06-21 Hiroshi Akimoto Condensed heterocyclic compounds, their production and use
EP0438261A3 (en) * 1990-01-16 1992-02-26 Takeda Chemical Industries, Ltd. Condensed heterocyclic glutamic acid derivatives, their production and use
CA2057635A1 (en) * 1990-12-14 1992-06-15 Hiroshi Akimoto Condensed heterocyclic compounds, their production and use
US5217974A (en) * 1991-03-29 1993-06-08 Eli Lilly And Company Method for treating gar-transformylase tumors in mammals and reducing mammalian toxicity
EP0530537B1 (en) * 1991-08-12 1997-01-08 Takeda Chemical Industries, Ltd. Condensed pyrimidine derivatives, their production and use as antitumor agents
ATE173251T1 (de) * 1991-08-21 1998-11-15 Eisai Co Ltd Kondensierte pyrimidinderivate als antitumorverbindungen
US5254687A (en) 1991-12-04 1993-10-19 The Trustees Of Princeton University Process for the preparation of pyrrolo[2,3-d]pyrimidines
US5196424A (en) * 1992-03-24 1993-03-23 Eli Lilly And Company N-[2-amino-4-substituted[[(pyrrollo or pyrido)[2,3-d]pyrimidinyl]-alkyl]benzoyl]-L-glutamic acids
US5235053A (en) 1992-06-22 1993-08-10 Eli Lilly And Company Process for the synthesis of 4-hydroxy-5-halopyrrold[2,3-d]pyrimidine intermediates
CZ283281B6 (cs) * 1992-09-25 1998-02-18 Eli Lilly And Company Způsob přípravy v poloze 5 substituovaných pyrrolo(2,3-d)pyrimidinů
US5416211A (en) * 1992-09-25 1995-05-16 Eli Lilly And Company Process for preparing 5-substituted pyrrolo-[2,3-d]pyrimidines
US5278307A (en) * 1992-09-25 1994-01-11 Eli Lilly And Company Process for preparing 4-hydroxypyrrolo(2,3-d)pyrimidine based antifolate compounds and intermediates
US5426187A (en) * 1993-11-30 1995-06-20 Eli Lilly And Company Process for the preparation of 4-hydroxy-5-substituted ethynylpyrrolo [2,3-d]pyrimidine intermediates
PT831829E (pt) * 1995-06-07 2003-12-31 Pfizer Derivados de pirimidina heterociclicos de aneis fundidos
US6395733B1 (en) 1995-06-07 2002-05-28 Pfizer Inc Heterocyclic ring-fused pyrimidine derivatives
AU1794697A (en) * 1996-03-06 1997-09-22 Novartis Ag 7-alkyl-pyrrolo{2,3-d}pyrimidines
EP0923287A4 (en) * 1996-08-30 2001-08-01 Lilly Co Eli NON-CLASSIC PYRROLO (2,3-D) PYRIMIDINE ANTIFOLATE
CN1213998C (zh) * 1997-09-26 2005-08-10 伊莱利利公司 用于制造抗叶酸剂的方法和中间体
US6162914A (en) * 1998-04-24 2000-12-19 Cerbios-Pharma S.A. Process for the reduction of pterins
PA8474101A1 (es) 1998-06-19 2000-09-29 Pfizer Prod Inc Compuestos de pirrolo [2,3-d] pirimidina
US6066732A (en) * 1998-08-21 2000-05-23 The Trustees Of Princeton University Process for the preparation of pyrrolo[2,3-d]pyrimidines
KR20020008197A (ko) * 1999-05-24 2002-01-29 가와무라 요시부미 항-Ｆａｓ 항체를 함유하는 의약 조성물
EP2289549A3 (en) 1999-10-01 2011-06-15 Immunogen, Inc. Immunoconjugates for treating cancer
US6229413B1 (en) 1999-10-19 2001-05-08 General Electric Company Support of stationary conductors for a circuit breaker
CN1195755C (zh) 1999-12-10 2005-04-06 辉瑞产品公司 吡咯并[2,3－d]嘧啶化合物
MXPA02008242A (es) * 2000-02-25 2002-11-29 Lilly Co Eli Nueva forma cristalina del acido n-[4- [2-(2-amino -4, 7- dihidro -4 -oxo-3h- pirrolo [2, 3-d]pirimidin -5-il) eitl]benzoil] -l-glutamico y procedimiento para su obtencion.
US6380829B1 (en) 2000-11-21 2002-04-30 General Electric Company Motor operator interlock and method for circuit breakers
US6902811B2 (en) * 2001-06-28 2005-06-07 Toray Industries, Inc. Epoxy resin composition excellent in weather resistance and fiber-reinforced composite materials
PL378246A1 (pl) 2002-11-26 2006-03-20 Pfizer Products Inc. Sposób leczenia odrzucania przeszczepu
CN100379729C (zh) * 2006-04-06 2008-04-09 海南天源康泽医药科技有限公司 硝基化合物及其在培美曲塞制备中的应用
CA2674698A1 (en) * 2007-01-19 2008-07-24 Chelsea Therapeutics, Inc. New classical antifolates
WO2008124485A2 (en) * 2007-04-03 2008-10-16 Dr. Reddy's Laboratories Ltd. Solid forms of pemetrexed
US20090253720A1 (en) * 2008-04-07 2009-10-08 Chelsea Therapeutics, Inc. Antifolate compositions
PT2384326E (pt) 2008-08-20 2014-06-09 Zoetis Llc Compostos de pirrolo[2,3-d]pirimidina
CN101684121B (zh) * 2008-09-22 2013-04-03 重庆医药工业研究院有限责任公司 培美曲塞二酸的新晶型及其制备方法
WO2011005832A1 (en) * 2009-07-08 2011-01-13 Chelsea Therapeutics, Inc. Stable crystalline polymorphs of the dipotassium salt of (s) -2- {4- [2- (2, 4-diamin0-quinaz0lin-6-yl) -ethyl] -benzoylamino} -4-methylenξ-penta nedioic acid
EP2496237A2 (en) * 2009-11-06 2012-09-12 Chelsea Therapeutics, Inc. Enzyme inhibiting compounds
WO2012064377A1 (en) * 2010-03-29 2012-05-18 Chelsea Therapeutics, Inc. Antifolate compositions
EP2595628A1 (en) 2010-07-19 2013-05-29 Bayer HealthCare LLC Drug combinations with fluoro-substituted omega-carboxyaryl diphenyl urea for the treatment and prevention of diseases and conditions
RU2552519C2 (ru) 2010-08-02 2015-06-10 Неон Лэборэторис Лтд. Способ получения высокочистого диалкилпеметрекседа
WO2012056285A1 (en) 2010-10-25 2012-05-03 Fresenius Kabi Oncology Ltd. An improved process for the preparation of pemetrexed
US8658652B2 (en) 2010-12-07 2014-02-25 Chelsea Therapeutics, Inc. Antifolate combinations
US9051322B2 (en) * 2011-03-23 2015-06-09 Scinopharm Taiwan, Ltd. Process for the production of a pemetrexed salt
CN103030640B (zh) * 2012-06-11 2015-04-22 江苏豪森医药集团连云港宏创医药有限公司 一种培美曲塞或其盐的制备方法
EP3675864A4 (en) * 2017-08-31 2022-02-16 Duquesne University of The Holy Spirit FIRST REPRESENTATIVES OF SHMT2 AND MTHFD2 INHIBITORS AS ANTITUMORS

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4532241A (en) * 1982-08-26 1985-07-30 Sri International 8,10-Dideazaminopterins
US4684653A (en) * 1985-03-08 1987-08-04 The Trustees Of Princeton University Pyrido(2,3-d)pyrimidine derivatives
NO169490C (no) * 1988-03-24 1992-07-01 Takeda Chemical Industries Ltd Analogifremgangsmaate for fremstilling av terapeutisk aktive pyrrolopyrimidinderivater

Also Published As

Publication number Publication date
EP0334636B1 (en) 1996-10-23
CN1037513A (zh) 1989-11-29
DK143789A (da) 1989-09-25
HU908458D0 (en) 1991-07-29
DE68927354D1 (de) 1996-11-28
NO891206D0 (no) 1989-03-20
GR3021733T3 (en) 1997-02-28
US5296600A (en) 1994-03-22
EP0334636A2 (en) 1989-09-27
CN1029970C (zh) 1995-10-11
US5539113A (en) 1996-07-23
US4997838A (en) 1991-03-05
KR890014543A (ko) 1989-10-24
DK173980B1 (da) 2002-03-25
DK143789D0 (da) 1989-03-22
HU203105B (en) 1991-05-28
HUT55396A (en) 1991-05-28
ES2092994T3 (es) 1996-12-16
HU215928B (hu) 1999-03-29
NO169490C (no) 1992-07-01
NO169490B (no) 1992-03-23
HUT51624A (en) 1990-05-28
EP0334636A3 (en) 1991-05-02
CA1340794C (en) 1999-10-19
KR960015967B1 (ko) 1996-11-25
ATE144513T1 (de) 1996-11-15
US5106974A (en) 1992-04-21
DE68927354T2 (de) 1997-03-20

Similar Documents

Publication Publication Date Title
NO891206D0 (no) Fremstilling og anvendelse av pyrrolopyrimidinderivater.
ES2126068T3 (es) Derivados de estilbeno citotoxicos y composicion farmaceutica que los contiene.
AU583439B2 (en) Prodrugs of rapamycin
SE8603099D0 (sv) Distamycin derivatives and process for their preparation
ATE147386T1 (de) Kondensierte pyrimidinderivate, ihre herstellung und ihre verwendung als antitumormittel
PT623133E (pt) Compostos de aminoalquilo substituidos
MX172953B (es) Derivados de 2-aminopirimidina-4-carboxamida, su preparacion y su aplicacion en terapeutica
ATE35137T1 (de) Thieno(2,3-d)pyrimidin-derivate und deren salze.
GR900100035A (el) Παράγωγα υδροξυαλκανοκαρβονικού οξέος, η παρασευή και η χρησιμοπποίηση τους.
ES2096572T3 (es) Nuevos derivados de glucosidos de antraciclina y procedimiento para su preparacion.
DE69028140D1 (de) Pyrrolopyrimidine, ihre Herstellung und Verwendung als tumorizide Wirkstoffe
GR3017612T3 (en) 2-Aminopyrimidin-4-carboxamide derivatives, their preparation and their application in therapy.
ES2081957T3 (es) Nuevos derivados sustituidos en posicion 15, de la 20,21-dinoreburnamenina, su procedimiento de preparacion y los nuevos productos intermedios asi obtenidos, su aplicacion como medicamentos y composiciones que los contienen.
NZ240280A (en) Ergoline derivatives and pharmaceutical compositions
TW233263B (en) Polythiophene methanol medicine for immunoadjustment

Legal Events

Date Code Title Description
MK1K Patent expired