ATE147386T1 - Kondensierte pyrimidinderivate, ihre herstellung und ihre verwendung als antitumormittel - Google Patents
Kondensierte pyrimidinderivate, ihre herstellung und ihre verwendung als antitumormittelInfo
- Publication number
- ATE147386T1 ATE147386T1 AT92113523T AT92113523T ATE147386T1 AT E147386 T1 ATE147386 T1 AT E147386T1 AT 92113523 T AT92113523 T AT 92113523T AT 92113523 T AT92113523 T AT 92113523T AT E147386 T1 ATE147386 T1 AT E147386T1
- Authority
- AT
- Austria
- Prior art keywords
- stands
- group
- denotes
- optionally
- coor
- Prior art date
Links
- CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical class C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 title 1
- 239000002246 antineoplastic agent Substances 0.000 title 1
- 229940083082 pyrimidine derivative acting on arteriolar smooth muscle Drugs 0.000 title 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- 125000003277 amino group Chemical group 0.000 abstract 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 2
- 210000004881 tumor cell Anatomy 0.000 abstract 2
- FBOZXECLQNJBKD-ZDUSSCGKSA-N L-methotrexate Chemical compound C=1N=C2N=C(N)N=C(N)C2=NC=1CN(C)C1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 FBOZXECLQNJBKD-ZDUSSCGKSA-N 0.000 abstract 1
- 125000001931 aliphatic group Chemical group 0.000 abstract 1
- 125000004429 atom Chemical group 0.000 abstract 1
- 125000004122 cyclic group Chemical group 0.000 abstract 1
- 230000001747 exhibiting effect Effects 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 229960000485 methotrexate Drugs 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 150000003230 pyrimidines Chemical class 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 230000001988 toxicity Effects 0.000 abstract 1
- 231100000419 toxicity Toxicity 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP20204291 | 1991-08-12 | ||
| JP7151392 | 1992-03-27 | ||
| JP14585192 | 1992-06-05 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE147386T1 true ATE147386T1 (de) | 1997-01-15 |
Family
ID=27300665
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT92113523T ATE147386T1 (de) | 1991-08-12 | 1992-08-07 | Kondensierte pyrimidinderivate, ihre herstellung und ihre verwendung als antitumormittel |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US5403843A (de) |
| EP (1) | EP0530537B1 (de) |
| AT (1) | ATE147386T1 (de) |
| CA (1) | CA2075787A1 (de) |
| DE (1) | DE69216509T2 (de) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE173251T1 (de) * | 1991-08-21 | 1998-11-15 | Eisai Co Ltd | Kondensierte pyrimidinderivate als antitumorverbindungen |
| CZ283281B6 (cs) * | 1992-09-25 | 1998-02-18 | Eli Lilly And Company | Způsob přípravy v poloze 5 substituovaných pyrrolo(2,3-d)pyrimidinů |
| US5608082A (en) * | 1994-07-28 | 1997-03-04 | Agouron Pharmaceuticals, Inc. | Compounds useful as antiproliferative agents and GARFT inhibitors |
| US5753664A (en) * | 1995-03-16 | 1998-05-19 | Takeda Chemical Industries, Ltd. | Heterocyclic compounds, their production and use |
| CA2263907A1 (en) * | 1996-08-30 | 1998-03-05 | Christopher Leighon Jordan | Nonclassical pyrrolo[2,3-d]pyrimidine antifolates |
| ATE234098T1 (de) * | 1997-08-05 | 2003-03-15 | Pfizer Prod Inc | 4-aminopyrrole (3,2-d) pyrimidinen als antagonisten des neuropeptide y receptors |
| NZ506779A (en) * | 1998-03-27 | 2003-08-29 | Genentech Inc | Antagonists for treatment of cd11/cd18 adhesion receptor mediated disorders |
| BR0312744A (pt) * | 2002-07-17 | 2005-04-26 | Warner Lambert Co | Associação de um inibidor carboxìlico alostérico da metaloproteinase-13 de matriz com um inibidor selectivo da ciclooxigenase-2, à excepção do celecoxib ou valdecoxib |
| US20060258691A1 (en) * | 2005-05-13 | 2006-11-16 | Joseph Barbosa | Methods and compositions for improving cognition |
| WO2007024789A1 (en) * | 2005-08-24 | 2007-03-01 | Lexicon Genetics Incorporated | Pyrrolopyridine, pyrrolopyrimidine and pyrazolopyridine compounds, compositions comprising them, and methods of their use |
| EP2069354B1 (de) * | 2006-08-21 | 2011-11-02 | Genentech, Inc. | Aza-Benzofuranylverbindungen und Anwendungsverfahren dafür |
| MX2009001875A (es) * | 2006-08-21 | 2009-03-02 | Genentech Inc | Compuestos de aza-benzotiofenilo y metodos de uso de los mismos. |
| KR20110098724A (ko) * | 2008-12-04 | 2011-09-01 | 바이엘 파마 악티엔게젤샤프트 | 방사성동위원소-표지된 리신 및 오르니틴 유도체, 그의 용도 및 그의 제조 방법 |
| WO2011118843A1 (ja) * | 2010-03-24 | 2011-09-29 | 味の素株式会社 | グルタミン酸エステル誘導体又はその塩 |
| KR101029091B1 (ko) * | 2010-04-08 | 2011-04-13 | 강원대학교산학협력단 | 다이하이드로퓨란 유도체의 제조방법 |
| CA2816983A1 (en) | 2010-11-05 | 2012-05-10 | Senomyx, Inc. | Compounds useful as modulators of trpm8 |
| EP2675808A4 (de) * | 2011-02-15 | 2014-07-09 | Hetero Research Foundation | Verfahren für pemetrexed-dinatrium |
| WO2015168279A1 (en) | 2014-05-01 | 2015-11-05 | Novartis Ag | Compounds and compositions as toll-like receptor 7 agonists |
| WO2015168269A1 (en) | 2014-05-01 | 2015-11-05 | Novartis Ag | Compounds and compositions as toll-like receptor 7 agonists |
| KR102630013B1 (ko) | 2015-08-06 | 2024-01-25 | 키메릭스 인크. | 항바이러스제로서 유용한 피롤로피리미딘 뉴클레오시드 및 그의 유사체 |
| US10392371B2 (en) | 2015-10-01 | 2019-08-27 | Senomyx, Inc. | Compounds useful as modulators of TRPM8 |
| CN108430515B (zh) | 2015-10-29 | 2021-11-12 | 诺华股份有限公司 | 包含toll-样受体激动剂的抗体缀合物 |
| US11111264B2 (en) | 2017-09-21 | 2021-09-07 | Chimerix, Inc. | Morphic forms of 4-amino-7-(3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-2-methyl-7H-pyrrolo[2,3-d]pyrimidine-5-carboxamide and uses thereof |
| KR20240035513A (ko) | 2021-07-09 | 2024-03-15 | 알리고스 테라퓨틱스 인코포레이티드 | 항바이러스 화합물 |
| US12065428B2 (en) | 2021-09-17 | 2024-08-20 | Aligos Therapeutics, Inc. | Anti-viral compounds |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8607683D0 (en) * | 1986-03-27 | 1986-04-30 | Ici Plc | Anti-tumor agents |
| US4895946A (en) * | 1987-10-26 | 1990-01-23 | The Trustees Of Princeton University | Process for the preparation of fused pyridine compounds |
| US4767761A (en) * | 1987-11-04 | 1988-08-30 | Dana-Farber Cancer Institute, Inc. | Ornithine derivatives and their use as methotrexate-resistant cell inhibitors |
| JP2830008B2 (ja) * | 1988-04-01 | 1998-12-02 | 武田薬品工業株式会社 | 縮合ピリミジン誘導体 |
| NO169490C (no) * | 1988-03-24 | 1992-07-01 | Takeda Chemical Industries Ltd | Analogifremgangsmaate for fremstilling av terapeutisk aktive pyrrolopyrimidinderivater |
| JP3015957B2 (ja) * | 1989-05-29 | 2000-03-06 | 武田薬品工業株式会社 | ピロロ［２，３―ｄ］ピリミジン誘導体およびその製造法 |
| JP2983254B2 (ja) * | 1989-06-14 | 1999-11-29 | 武田薬品工業株式会社 | ピロロ〔２，３―ｄ〕ピリミジン誘導体の製造法およびその中間体 |
| JPH03173890A (ja) * | 1989-09-21 | 1991-07-29 | Takeda Chem Ind Ltd | ピロロ［２，３―ｄ］ピリミジン誘導体，その製造法，用途及び中間体 |
| CA2031769A1 (en) * | 1989-12-08 | 1991-06-09 | Hiroshi Akimoto | Pyrrolopyrimidine derivatives, their production and use |
| US5028608A (en) * | 1989-12-11 | 1991-07-02 | The Trustees Of Princeton University | N-(6-Amino-(pyrrolo(2,3-d)pyrimidin-3-ylacyl) )-glutamic acid derivatives |
| CA2032695A1 (en) * | 1989-12-20 | 1991-06-21 | Hiroshi Akimoto | Condensed heterocyclic compounds, their production and use |
| EP0438261A3 (en) * | 1990-01-16 | 1992-02-26 | Takeda Chemical Industries, Ltd. | Condensed heterocyclic glutamic acid derivatives, their production and use |
-
1992
- 1992-08-07 DE DE69216509T patent/DE69216509T2/de not_active Expired - Fee Related
- 1992-08-07 US US07/926,170 patent/US5403843A/en not_active Expired - Fee Related
- 1992-08-07 EP EP92113523A patent/EP0530537B1/de not_active Expired - Lifetime
- 1992-08-07 AT AT92113523T patent/ATE147386T1/de not_active IP Right Cessation
- 1992-08-11 CA CA002075787A patent/CA2075787A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP0530537A1 (de) | 1993-03-10 |
| DE69216509T2 (de) | 1997-05-28 |
| DE69216509D1 (de) | 1997-02-20 |
| CA2075787A1 (en) | 1993-02-13 |
| US5403843A (en) | 1995-04-04 |
| EP0530537B1 (de) | 1997-01-08 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |