EP0923287A4 - Nichtklassische pyrrolo(2,3-d)pyrimidin antifolate - Google Patents

Nichtklassische pyrrolo(2,3-d)pyrimidin antifolate

Info

Publication number
EP0923287A4
EP0923287A4 EP97939567A EP97939567A EP0923287A4 EP 0923287 A4 EP0923287 A4 EP 0923287A4 EP 97939567 A EP97939567 A EP 97939567A EP 97939567 A EP97939567 A EP 97939567A EP 0923287 A4 EP0923287 A4 EP 0923287A4
Authority
EP
European Patent Office
Prior art keywords
nonclassical
pyrrolo
pyrimidine antifolates
antifolates
pyrimidine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP97939567A
Other languages
English (en)
French (fr)
Other versions
EP0923287A1 (de
Inventor
Christopher L Jordan
Vinod F Patel
Daniel J Soose
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of EP0923287A1 publication Critical patent/EP0923287A1/de
Publication of EP0923287A4 publication Critical patent/EP0923287A4/de
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
EP97939567A 1996-08-30 1997-08-27 Nichtklassische pyrrolo(2,3-d)pyrimidin antifolate Withdrawn EP0923287A4 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US2496496P 1996-08-30 1996-08-30
US24964P 1996-08-30
PCT/US1997/015017 WO1998008382A1 (en) 1996-08-30 1997-08-27 Nonclassical pyrrolo[2,3-d]pyrimidine antifolates

Publications (2)

Publication Number Publication Date
EP0923287A1 EP0923287A1 (de) 1999-06-23
EP0923287A4 true EP0923287A4 (de) 2001-08-01

Family

ID=21823289

Family Applications (1)

Application Number Title Priority Date Filing Date
EP97939567A Withdrawn EP0923287A4 (de) 1996-08-30 1997-08-27 Nichtklassische pyrrolo(2,3-d)pyrimidin antifolate

Country Status (5)

Country Link
EP (1) EP0923287A4 (de)
JP (1) JP2000516961A (de)
AU (1) AU4163197A (de)
CA (1) CA2263907A1 (de)
WO (1) WO1998008382A1 (de)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
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US6878716B1 (en) 1998-06-02 2005-04-12 Osi Pharmaceuticals, Inc. Compounds specific to adenosine A1 receptor and uses thereof
US6686366B1 (en) 1998-06-02 2004-02-03 Osi Pharmaceuticals, Inc. Compounds specific to adenosine A3 receptor and uses thereof
IL139787A0 (en) 1998-06-02 2002-02-10 Osi Pharm Inc PYRROLO [2, 3d] PYRIMIDINE COMPOSITIONS AND THEIR USE
US7160890B2 (en) 1999-12-02 2007-01-09 Osi Pharmaceuticals, Inc. Compounds specific to adenosine A3 receptor and uses thereof
US6680322B2 (en) 1999-12-02 2004-01-20 Osi Pharmaceuticals, Inc. Compounds specific to adenosine A1 receptors and uses thereof
US6664252B2 (en) 1999-12-02 2003-12-16 Osi Pharmaceuticals, Inc. 4-aminopyrrolo[2,3-d]pyrimidine compounds specific to adenosine A2a receptor and uses thereof
MXPA02008242A (es) * 2000-02-25 2002-11-29 Lilly Co Eli Nueva forma cristalina del acido n-[4- [2-(2-amino -4, 7- dihidro -4 -oxo-3h- pirrolo [2, 3-d]pirimidin -5-il) eitl]benzoil] -l-glutamico y procedimiento para su obtencion.
US6673802B2 (en) 2000-12-01 2004-01-06 Osi Pharmaceuticals, Inc. Compounds specific to adenosine A3 receptor and uses thereof
US6680324B2 (en) 2000-12-01 2004-01-20 Osi Pharmaceuticals, Inc. Compounds specific to adenosine A1 receptors and uses thereof
JP3798987B2 (ja) * 2001-02-15 2006-07-19 レオン自動機株式会社 食品生地延展装置
DK1450811T3 (da) 2001-11-30 2010-02-15 Osi Pharm Inc Forbindelser specifikke af adenosin A1- og A3-receptorer og anvendelser heraf
DE60236458D1 (de) 2001-12-20 2010-07-01 Osi Pharm Inc Pyrrolopyrimidin a2b selektive antagonistische verbindungen, deren synthese und verwendung
CN1620294A (zh) 2001-12-20 2005-05-25 Osi药物公司 嘧啶a2b选择性拮抗剂化合物,它们的合成及用途
KR100714519B1 (ko) 2002-03-07 2007-05-07 에프. 호프만-라 로슈 아게 이환 피리딘 및 피리미딘 ｐ38 키나아제 억제제
EP1462472A1 (de) * 2003-03-26 2004-09-29 Sigma Kalon Services B.V. Verfahren zum Schutz von Säuregruppen in Polymeren
US8288557B2 (en) 2004-07-23 2012-10-16 Endocyte, Inc. Bivalent linkers and conjugates thereof
TWI374886B (en) * 2006-08-14 2012-10-21 Sicor Inc Processes for preparing intermediates of pemetrexed
NZ580132A (en) 2007-03-14 2012-11-30 Endocyte Inc Binding ligand linked drug delivery conjugates of tubulysins to vitamins
AU2008268432B2 (en) 2007-06-25 2015-01-15 Endocyte, Inc. Conjugates containing hydrophilic spacer linkers
US9877965B2 (en) 2007-06-25 2018-01-30 Endocyte, Inc. Vitamin receptor drug delivery conjugates for treating inflammation
CN101423524B (zh) * 2007-10-30 2010-12-22 齐鲁制药有限公司 二谷氨酸酯衍生物及其在培美曲塞制备中的应用
US8252804B2 (en) 2008-10-01 2012-08-28 Duquesne University Of The Holy Spirit Selective proton coupled folate transporter and folate receptor, and GARFTase inhibitor compounds and methods of using the same
US20110082158A1 (en) * 2008-10-01 2011-04-07 Aleem Gangjee Selective proton coupled folate transporter and folate receptor, and garftase and/or other folate metabolizing enzymes inhibitor compounds and methods of using the same
WO2013126797A1 (en) 2012-02-24 2013-08-29 Purdue Research Foundation Cholecystokinin b receptor targeting for imaging and therapy
CA2887727A1 (en) 2012-10-16 2014-04-24 Endocyte, Inc. Drug delivery conjugates containing unnatural amino acids and methods for using
AU2014214325B2 (en) * 2013-02-06 2018-06-07 Merck Patent Gmbh Substituted carboxylic acid derivatives as aggrecanase inhibitors for the treatment of osteoarthritis
CN104341427A (zh) * 2014-10-01 2015-02-11 山东铂源药业有限公司 一种培美曲塞二钠杂质的合成方法
US9481678B2 (en) * 2015-02-09 2016-11-01 Duquesne University Of The Holy Ghost Substituted pyrrolo[2,3-D]dipyrimidines for selectively targeting tumor cells with FR-alpha and FR-beta type receptors
GB2553716B (en) 2015-04-17 2020-06-17 Univ Holy Ghost Duquesne Pyrrolopyrimidines as antitumor agents
CN110305135B (zh) * 2018-03-20 2022-02-22 鲁南制药集团股份有限公司 一种培美曲塞二钠中间体及其制备方法
CN110305134B (zh) * 2018-03-20 2022-02-22 鲁南制药集团股份有限公司 一种培美曲塞二钠中间体及其制备方法
CN110305136A (zh) * 2018-03-20 2019-10-08 鲁南制药集团股份有限公司 一种培美曲塞二钠中间体及其制备方法
CN110305137A (zh) * 2018-03-20 2019-10-08 鲁南制药集团股份有限公司 一种培美曲塞二钠中间体及其制备方法

Citations (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0334636A2 (de) * 1988-03-24 1989-09-27 Takeda Chemical Industries, Ltd. Pyrrolopyrimidinderivate, ihre Herstellung und Verwendung
EP0400562A1 (de) * 1989-05-29 1990-12-05 Takeda Chemical Industries, Ltd. Pyrrolopyrimidine, ihre Herstellung und Verwendung als tumorizide Wirkstoffe
EP0402903A1 (de) * 1989-06-14 1990-12-19 Takeda Chemical Industries, Ltd. Herstellung von Pyrrolopyrimidinen und Zwischenprodukte
US4996206A (en) * 1989-12-11 1991-02-26 The Trustees Of Princeton University N-(pyrrolo[2,3-d]pyrimidin-3-ylacyl)-glutamic acid derivatives
EP0418924A2 (de) * 1989-09-21 1991-03-27 Takeda Chemical Industries, Ltd. Pyrrolopyrimidine, ihre Herstellung und Verwendung
EP0431953A2 (de) * 1989-12-08 1991-06-12 Takeda Chemical Industries, Ltd. Pyrrolopyrimidinderivate, ihre Herstellung und Anwendung
EP0434426A1 (de) * 1989-12-20 1991-06-26 Takeda Chemical Industries, Ltd. Kondensierte heterocyclische Verbindungen, ihre Herstellung und Verwendung
EP0438261A2 (de) * 1990-01-16 1991-07-24 Takeda Chemical Industries, Ltd. Kondensierte heterocyclische Glutaminsäure-Derivate, ihre Herstellung und Verwendung
EP0530537A1 (de) * 1991-08-12 1993-03-10 Takeda Chemical Industries, Ltd. Kondensierte Pyrimidinderivate, ihre Herstellung und ihre Verwendung als Antitumormittel
JPH0565286A (ja) * 1990-12-14 1993-03-19 Takeda Chem Ind Ltd 抗悪性腫瘍剤の測定法および試薬
EP0549291A1 (de) * 1991-12-27 1993-06-30 Takeda Chemical Industries, Ltd. Thymidylate Synthase-Inhibitoren
US5248775A (en) * 1989-12-11 1993-09-28 The Trustees Of Princeton University Pyrrolo(2,3-d)pyrimidines
EP0567223A1 (de) * 1992-03-24 1993-10-27 Eli Lilly And Company Glutaminsäurederivate als antineoplastische Mittel
JPH069637A (ja) * 1992-04-17 1994-01-18 Takeda Chem Ind Ltd 縮合ピリミジン誘導体、その製造法および用途

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5661148A (en) * 1989-09-19 1997-08-26 Teijin Limited Pyrrolo[2,3-d]pyrimidine derivatives, process for producing the same and pharmaceutical preparation comprising the same as active ingredient
CZ283281B6 (cs) * 1992-09-25 1998-02-18 Eli Lilly And Company Způsob přípravy v poloze 5 substituovaných pyrrolo(2,3-d)pyrimidinů
US5646152A (en) * 1994-06-15 1997-07-08 Pfizer Inc. Methods of administering CRF antagonists
US5650511A (en) * 1995-12-12 1997-07-22 Biocryst Pharmaceuticals, Inc. Process for the preparation of 9-deazaguanine derivatives

Patent Citations (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0334636A2 (de) * 1988-03-24 1989-09-27 Takeda Chemical Industries, Ltd. Pyrrolopyrimidinderivate, ihre Herstellung und Verwendung
EP0400562A1 (de) * 1989-05-29 1990-12-05 Takeda Chemical Industries, Ltd. Pyrrolopyrimidine, ihre Herstellung und Verwendung als tumorizide Wirkstoffe
EP0402903A1 (de) * 1989-06-14 1990-12-19 Takeda Chemical Industries, Ltd. Herstellung von Pyrrolopyrimidinen und Zwischenprodukte
EP0418924A2 (de) * 1989-09-21 1991-03-27 Takeda Chemical Industries, Ltd. Pyrrolopyrimidine, ihre Herstellung und Verwendung
EP0431953A2 (de) * 1989-12-08 1991-06-12 Takeda Chemical Industries, Ltd. Pyrrolopyrimidinderivate, ihre Herstellung und Anwendung
US5248775A (en) * 1989-12-11 1993-09-28 The Trustees Of Princeton University Pyrrolo(2,3-d)pyrimidines
US4996206A (en) * 1989-12-11 1991-02-26 The Trustees Of Princeton University N-(pyrrolo[2,3-d]pyrimidin-3-ylacyl)-glutamic acid derivatives
EP0434426A1 (de) * 1989-12-20 1991-06-26 Takeda Chemical Industries, Ltd. Kondensierte heterocyclische Verbindungen, ihre Herstellung und Verwendung
EP0438261A2 (de) * 1990-01-16 1991-07-24 Takeda Chemical Industries, Ltd. Kondensierte heterocyclische Glutaminsäure-Derivate, ihre Herstellung und Verwendung
JPH0565286A (ja) * 1990-12-14 1993-03-19 Takeda Chem Ind Ltd 抗悪性腫瘍剤の測定法および試薬
EP0530537A1 (de) * 1991-08-12 1993-03-10 Takeda Chemical Industries, Ltd. Kondensierte Pyrimidinderivate, ihre Herstellung und ihre Verwendung als Antitumormittel
EP0549291A1 (de) * 1991-12-27 1993-06-30 Takeda Chemical Industries, Ltd. Thymidylate Synthase-Inhibitoren
EP0567223A1 (de) * 1992-03-24 1993-10-27 Eli Lilly And Company Glutaminsäurederivate als antineoplastische Mittel
JPH069637A (ja) * 1992-04-17 1994-01-18 Takeda Chem Ind Ltd 縮合ピリミジン誘導体、その製造法および用途

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
PATENT ABSTRACTS OF JAPAN vol. 017, no. 376 (C - 1084) 15 July 1993 (1993-07-15) *
PATENT ABSTRACTS OF JAPAN vol. 018, no. 209 (C - 1190) 13 April 1994 (1994-04-13) *
See also references of WO9808382A1 *

Also Published As

Publication number Publication date
CA2263907A1 (en) 1998-03-05
WO1998008382A1 (en) 1998-03-05
JP2000516961A (ja) 2000-12-19
EP0923287A1 (de) 1999-06-23
AU4163197A (en) 1998-03-19

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