EP0923287A4 - Nonclassical pyrrolo 2,3-d]pyrimidine antifolates - Google Patents

Nonclassical pyrrolo 2,3-d]pyrimidine antifolates

Info

Publication number
EP0923287A4
EP0923287A4 EP97939567A EP97939567A EP0923287A4 EP 0923287 A4 EP0923287 A4 EP 0923287A4 EP 97939567 A EP97939567 A EP 97939567A EP 97939567 A EP97939567 A EP 97939567A EP 0923287 A4 EP0923287 A4 EP 0923287A4
Authority
EP
European Patent Office
Prior art keywords
nonclassical
pyrrolo
pyrimidine antifolates
antifolates
pyrimidine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP97939567A
Other languages
German (de)
French (fr)
Other versions
EP0923287A1 (en
Inventor
Christopher L Jordan
Vinod F Patel
Daniel J Soose
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of EP0923287A1 publication Critical patent/EP0923287A1/en
Publication of EP0923287A4 publication Critical patent/EP0923287A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
EP97939567A 1996-08-30 1997-08-27 Nonclassical pyrrolo 2,3-d]pyrimidine antifolates Withdrawn EP0923287A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US2496496P 1996-08-30 1996-08-30
US24964P 1996-08-30
PCT/US1997/015017 WO1998008382A1 (en) 1996-08-30 1997-08-27 Nonclassical pyrrolo[2,3-d]pyrimidine antifolates

Publications (2)

Publication Number Publication Date
EP0923287A1 EP0923287A1 (en) 1999-06-23
EP0923287A4 true EP0923287A4 (en) 2001-08-01

Family

ID=21823289

Family Applications (1)

Application Number Title Priority Date Filing Date
EP97939567A Withdrawn EP0923287A4 (en) 1996-08-30 1997-08-27 Nonclassical pyrrolo 2,3-d]pyrimidine antifolates

Country Status (5)

Country Link
EP (1) EP0923287A4 (en)
JP (1) JP2000516961A (en)
AU (1) AU4163197A (en)
CA (1) CA2263907A1 (en)
WO (1) WO1998008382A1 (en)

Families Citing this family (33)

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US6686366B1 (en) 1998-06-02 2004-02-03 Osi Pharmaceuticals, Inc. Compounds specific to adenosine A3 receptor and uses thereof
US6878716B1 (en) 1998-06-02 2005-04-12 Osi Pharmaceuticals, Inc. Compounds specific to adenosine A1 receptor and uses thereof
BR9911612A (en) 1998-06-02 2001-02-06 Osi Pharm Inc Pyrrole [2,3d] pyrimidine compositions and their uses
US6664252B2 (en) 1999-12-02 2003-12-16 Osi Pharmaceuticals, Inc. 4-aminopyrrolo[2,3-d]pyrimidine compounds specific to adenosine A2a receptor and uses thereof
US6680322B2 (en) 1999-12-02 2004-01-20 Osi Pharmaceuticals, Inc. Compounds specific to adenosine A1 receptors and uses thereof
US7160890B2 (en) 1999-12-02 2007-01-09 Osi Pharmaceuticals, Inc. Compounds specific to adenosine A3 receptor and uses thereof
PT1259513E (en) * 2000-02-25 2004-02-27 Lilly Co Eli NEW CRYSTALLINE FORM OF N-4 - [(2-AMINO-4,7-DIHYDRO-4-OXO-3H-PYRROLO-2,3-D | PYRIMIDIN-5-YL) ETHYL ACID | - BENZOIL | -L-GLUTAMIC AND PROCESS FOR THEIR OBTENTION
US6680324B2 (en) 2000-12-01 2004-01-20 Osi Pharmaceuticals, Inc. Compounds specific to adenosine A1 receptors and uses thereof
US6673802B2 (en) 2000-12-01 2004-01-06 Osi Pharmaceuticals, Inc. Compounds specific to adenosine A3 receptor and uses thereof
JP3798987B2 (en) * 2001-02-15 2006-07-19 レオン自動機株式会社 Food dough spreading device
JP2005529062A (en) 2001-11-30 2005-09-29 オーエスアイ・ファーマスーティカルズ・インコーポレーテッド Compounds specific for adenosine A1 and A3 receptors and uses thereof
CN101973998A (en) 2001-12-20 2011-02-16 Osi药物公司 Pyrrolopyrimidine A2b selective antagonist compounds, their synthesis and use
EP1465631B1 (en) 2001-12-20 2010-02-24 OSI Pharmaceuticals, Inc. Pyrimidine a2b selective antagonist compounds, their synthesis and use
ATE410429T1 (en) 2002-03-07 2008-10-15 Hoffmann La Roche BICYCLIC PYRIDINE AND PYRIMIDINE INHIBITORS OF P38 KINASE
EP1462472A1 (en) * 2003-03-26 2004-09-29 Sigma Kalon Services B.V. A process for the protection of acid groups in polymers
US8288557B2 (en) 2004-07-23 2012-10-16 Endocyte, Inc. Bivalent linkers and conjugates thereof
TWI374886B (en) * 2006-08-14 2012-10-21 Sicor Inc Processes for preparing intermediates of pemetrexed
EP2481427A1 (en) 2007-03-14 2012-08-01 Endocyte, Inc. Folate-Tubulysin conjugates
US9877965B2 (en) 2007-06-25 2018-01-30 Endocyte, Inc. Vitamin receptor drug delivery conjugates for treating inflammation
CN101784565B (en) 2007-06-25 2014-12-10 恩多塞特公司 Conjugates containing hydrophilic spacer linkers
CN101423524B (en) * 2007-10-30 2010-12-22 齐鲁制药有限公司 Diglutamate derivates and application thereof in preparation of pemetrexed
US8252804B2 (en) 2008-10-01 2012-08-28 Duquesne University Of The Holy Spirit Selective proton coupled folate transporter and folate receptor, and GARFTase inhibitor compounds and methods of using the same
US20110082158A1 (en) * 2008-10-01 2011-04-07 Aleem Gangjee Selective proton coupled folate transporter and folate receptor, and garftase and/or other folate metabolizing enzymes inhibitor compounds and methods of using the same
US10080805B2 (en) 2012-02-24 2018-09-25 Purdue Research Foundation Cholecystokinin B receptor targeting for imaging and therapy
AU2013331440A1 (en) 2012-10-16 2015-04-30 Endocyte, Inc. Drug delivery conjugates containing unnatural amino acids and methods for using
WO2014121884A1 (en) * 2013-02-06 2014-08-14 Merck Patent Gmbh Substituted carboxylic acid derivatives as aggrecanase inhibitors for the treatment of osteoarthritis
CN104341427A (en) * 2014-10-01 2015-02-11 山东铂源药业有限公司 Synthesis method of pemetrexed disodium impurity
US9481678B2 (en) * 2015-02-09 2016-11-01 Duquesne University Of The Holy Ghost Substituted pyrrolo[2,3-D]dipyrimidines for selectively targeting tumor cells with FR-alpha and FR-beta type receptors
WO2016168637A2 (en) 2015-04-17 2016-10-20 Duquesne University Of The Holy Spirit Cyclopenta[d]pyrimidines and substituted cyclopenta[d]pyrimidines as antitubulin and microtubule targeting agents, monocyclic pyrimidines as tubulin inhibitors, and pyrrolopyrimidines as targeted antifolates and tubulin and multiple receptor tyrosine kinase inhibition and antitumor agents
CN110305135B (en) * 2018-03-20 2022-02-22 鲁南制药集团股份有限公司 Pemetrexed disodium intermediate and preparation method thereof
CN110305136A (en) * 2018-03-20 2019-10-08 鲁南制药集团股份有限公司 A kind of pemetrexed disodium intermediate and preparation method thereof
CN110305134B (en) * 2018-03-20 2022-02-22 鲁南制药集团股份有限公司 Pemetrexed disodium intermediate and preparation method thereof
CN110305137A (en) * 2018-03-20 2019-10-08 鲁南制药集团股份有限公司 A kind of pemetrexed disodium intermediate and preparation method thereof

Citations (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0334636A2 (en) * 1988-03-24 1989-09-27 Takeda Chemical Industries, Ltd. Pyrrolopyrimidine derivatives, their production and use
EP0400562A1 (en) * 1989-05-29 1990-12-05 Takeda Chemical Industries, Ltd. Pyrrolopyrimidines, their production and use as tumoricidal agents
EP0402903A1 (en) * 1989-06-14 1990-12-19 Takeda Chemical Industries, Ltd. Production of pyrrolopyrimidines and intermediates therefor
US4996206A (en) * 1989-12-11 1991-02-26 The Trustees Of Princeton University N-(pyrrolo[2,3-d]pyrimidin-3-ylacyl)-glutamic acid derivatives
EP0418924A2 (en) * 1989-09-21 1991-03-27 Takeda Chemical Industries, Ltd. Pyrrolopyrimidines, their production and use
EP0431953A2 (en) * 1989-12-08 1991-06-12 Takeda Chemical Industries, Ltd. Pyrrolopyrimidine derivatives, their production and use
EP0434426A1 (en) * 1989-12-20 1991-06-26 Takeda Chemical Industries, Ltd. Condensed heterocyclic compounds, their production and use
EP0438261A2 (en) * 1990-01-16 1991-07-24 Takeda Chemical Industries, Ltd. Condensed heterocyclic glutamic acid derivatives, their production and use
EP0530537A1 (en) * 1991-08-12 1993-03-10 Takeda Chemical Industries, Ltd. Condensed pyrimidine derivatives, their production and use as antitumor agents
JPH0565286A (en) * 1990-12-14 1993-03-19 Takeda Chem Ind Ltd Determination of anti-malignant tumor agent and reagent therefor
EP0549291A1 (en) * 1991-12-27 1993-06-30 Takeda Chemical Industries, Ltd. Thymidylate synthase inhibitors
US5248775A (en) * 1989-12-11 1993-09-28 The Trustees Of Princeton University Pyrrolo(2,3-d)pyrimidines
EP0567223A1 (en) * 1992-03-24 1993-10-27 Eli Lilly And Company Glutamic acid derivatives as antineoplastic agents
JPH069637A (en) * 1992-04-17 1994-01-18 Takeda Chem Ind Ltd Condensed pyrimidine derivative, its production and use

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5661148A (en) * 1989-09-19 1997-08-26 Teijin Limited Pyrrolo[2,3-d]pyrimidine derivatives, process for producing the same and pharmaceutical preparation comprising the same as active ingredient
HUT70208A (en) * 1992-09-25 1995-09-28 Lilly Co Eli Process for preparing 5-substituted pyrrolo[2,3-d]-pyrimidines
US5646152A (en) * 1994-06-15 1997-07-08 Pfizer Inc. Methods of administering CRF antagonists
US5650511A (en) * 1995-12-12 1997-07-22 Biocryst Pharmaceuticals, Inc. Process for the preparation of 9-deazaguanine derivatives

Patent Citations (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0334636A2 (en) * 1988-03-24 1989-09-27 Takeda Chemical Industries, Ltd. Pyrrolopyrimidine derivatives, their production and use
EP0400562A1 (en) * 1989-05-29 1990-12-05 Takeda Chemical Industries, Ltd. Pyrrolopyrimidines, their production and use as tumoricidal agents
EP0402903A1 (en) * 1989-06-14 1990-12-19 Takeda Chemical Industries, Ltd. Production of pyrrolopyrimidines and intermediates therefor
EP0418924A2 (en) * 1989-09-21 1991-03-27 Takeda Chemical Industries, Ltd. Pyrrolopyrimidines, their production and use
EP0431953A2 (en) * 1989-12-08 1991-06-12 Takeda Chemical Industries, Ltd. Pyrrolopyrimidine derivatives, their production and use
US5248775A (en) * 1989-12-11 1993-09-28 The Trustees Of Princeton University Pyrrolo(2,3-d)pyrimidines
US4996206A (en) * 1989-12-11 1991-02-26 The Trustees Of Princeton University N-(pyrrolo[2,3-d]pyrimidin-3-ylacyl)-glutamic acid derivatives
EP0434426A1 (en) * 1989-12-20 1991-06-26 Takeda Chemical Industries, Ltd. Condensed heterocyclic compounds, their production and use
EP0438261A2 (en) * 1990-01-16 1991-07-24 Takeda Chemical Industries, Ltd. Condensed heterocyclic glutamic acid derivatives, their production and use
JPH0565286A (en) * 1990-12-14 1993-03-19 Takeda Chem Ind Ltd Determination of anti-malignant tumor agent and reagent therefor
EP0530537A1 (en) * 1991-08-12 1993-03-10 Takeda Chemical Industries, Ltd. Condensed pyrimidine derivatives, their production and use as antitumor agents
EP0549291A1 (en) * 1991-12-27 1993-06-30 Takeda Chemical Industries, Ltd. Thymidylate synthase inhibitors
EP0567223A1 (en) * 1992-03-24 1993-10-27 Eli Lilly And Company Glutamic acid derivatives as antineoplastic agents
JPH069637A (en) * 1992-04-17 1994-01-18 Takeda Chem Ind Ltd Condensed pyrimidine derivative, its production and use

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
PATENT ABSTRACTS OF JAPAN vol. 017, no. 376 (C - 1084) 15 July 1993 (1993-07-15) *
PATENT ABSTRACTS OF JAPAN vol. 018, no. 209 (C - 1190) 13 April 1994 (1994-04-13) *
See also references of WO9808382A1 *

Also Published As

Publication number Publication date
CA2263907A1 (en) 1998-03-05
JP2000516961A (en) 2000-12-19
AU4163197A (en) 1998-03-19
WO1998008382A1 (en) 1998-03-05
EP0923287A1 (en) 1999-06-23

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