EP0904271A4 - 5,6,7,8-TETRAHYDROPYRIDO[2,3-d]PYRIMIDINES - Google Patents

5,6,7,8-TETRAHYDROPYRIDO[2,3-d]PYRIMIDINES

Info

Publication number
EP0904271A4
EP0904271A4 EP96931596A EP96931596A EP0904271A4 EP 0904271 A4 EP0904271 A4 EP 0904271A4 EP 96931596 A EP96931596 A EP 96931596A EP 96931596 A EP96931596 A EP 96931596A EP 0904271 A4 EP0904271 A4 EP 0904271A4
Authority
EP
European Patent Office
Prior art keywords
tetrahydropyrido
pyrimidines
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP96931596A
Other languages
German (de)
French (fr)
Other versions
EP0904271A1 (en
Inventor
Edward C Taylor
Chuan Shih
Koo Lee
Lynn S Gossett
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Princeton University
Original Assignee
Eli Lilly and Co
Princeton University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co, Princeton University filed Critical Eli Lilly and Co
Publication of EP0904271A1 publication Critical patent/EP0904271A1/en
Publication of EP0904271A4 publication Critical patent/EP0904271A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
EP96931596A 1996-05-01 1996-09-17 5,6,7,8-TETRAHYDROPYRIDO[2,3-d]PYRIMIDINES Withdrawn EP0904271A4 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US64066996A 1996-05-01 1996-05-01
US2117496P 1996-05-01 1996-05-01
US21174P 1996-05-01
PCT/US1996/014822 WO1997041115A1 (en) 1996-05-01 1996-09-17 5,6,7,8-TETRAHYDROPYRIDO[2,3-d]PYRIMIDINES

Publications (2)

Publication Number Publication Date
EP0904271A1 EP0904271A1 (en) 1999-03-31
EP0904271A4 true EP0904271A4 (en) 2002-01-23

Family

ID=26694360

Family Applications (1)

Application Number Title Priority Date Filing Date
EP96931596A Withdrawn EP0904271A4 (en) 1996-05-01 1996-09-17 5,6,7,8-TETRAHYDROPYRIDO[2,3-d]PYRIMIDINES

Country Status (5)

Country Link
EP (1) EP0904271A4 (en)
JP (1) JP2001524927A (en)
AU (1) AU7073296A (en)
CA (1) CA2251813A1 (en)
WO (1) WO1997041115A1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004113337A1 (en) * 2003-06-25 2004-12-29 Pfizer Inc. Convergent synthesis of a garft inhibitor containing a methyl substitute thiophene core and a tetrahydropyrido`2,3-d! pyrimidine ring system and intermediates therefor
RU2361862C2 (en) * 2003-12-29 2009-07-20 Сепракор Инк. Pyrrole and pyrazole daao inhibitors

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0343801A2 (en) * 1988-05-25 1989-11-29 The Trustees Of Princeton University N-(5,6,7,8-tetrahydropyrido(2,3-D)pyrimidin-6-yl-alkanoyl)-glutamic acid derivatives
US5354751A (en) * 1992-03-03 1994-10-11 Sri International Heteroaroyl 10-deazaamino-pterine compounds and use for rheumatoid arthritis

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4895946A (en) * 1987-10-26 1990-01-23 The Trustees Of Princeton University Process for the preparation of fused pyridine compounds
US5008391A (en) * 1989-07-07 1991-04-16 Eli Lilly And Company Enantioselective synthesis of antifolates
US5508281A (en) * 1991-04-08 1996-04-16 Duquesne University Of The Holy Ghost Derivatives of pyrido [2,3-d] and [3,2-d] pyrimidine and methods of using these derivatives
US5536724A (en) * 1992-03-03 1996-07-16 Sri International Antiinflammatory and antineoplastic 5-deazaaminopterins and 5,10-dideazaaminopterins

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0343801A2 (en) * 1988-05-25 1989-11-29 The Trustees Of Princeton University N-(5,6,7,8-tetrahydropyrido(2,3-D)pyrimidin-6-yl-alkanoyl)-glutamic acid derivatives
US5354751A (en) * 1992-03-03 1994-10-11 Sri International Heteroaroyl 10-deazaamino-pterine compounds and use for rheumatoid arthritis

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO9741115A1 *

Also Published As

Publication number Publication date
JP2001524927A (en) 2001-12-04
WO1997041115A1 (en) 1997-11-06
AU7073296A (en) 1997-11-19
CA2251813A1 (en) 1997-11-06
EP0904271A1 (en) 1999-03-31

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