DE69216509D1 - Kondensierte Pyrimidinderivate, ihre Herstellung und ihre Verwendung als Antitumormittel - Google Patents

Kondensierte Pyrimidinderivate, ihre Herstellung und ihre Verwendung als Antitumormittel

Info

Publication number
DE69216509D1
DE69216509D1 DE69216509T DE69216509T DE69216509D1 DE 69216509 D1 DE69216509 D1 DE 69216509D1 DE 69216509 T DE69216509 T DE 69216509T DE 69216509 T DE69216509 T DE 69216509T DE 69216509 D1 DE69216509 D1 DE 69216509D1
Authority
DE
Germany
Prior art keywords
stands
group
denotes
optionally
coor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69216509T
Other languages
English (en)
Other versions
DE69216509T2 (de
Inventor
Hiroshi Akimoto
Koichiro Ootsu
Fumio Itoh
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda Pharmaceutical Co Ltd
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Application granted granted Critical
Publication of DE69216509D1 publication Critical patent/DE69216509D1/de
Publication of DE69216509T2 publication Critical patent/DE69216509T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DE69216509T 1991-08-12 1992-08-07 Kondensierte Pyrimidinderivate, ihre Herstellung und ihre Verwendung als Antitumormittel Expired - Fee Related DE69216509T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP20204291 1991-08-12
JP7151392 1992-03-27
JP14585192 1992-06-05

Publications (2)

Publication Number Publication Date
DE69216509D1 true DE69216509D1 (de) 1997-02-20
DE69216509T2 DE69216509T2 (de) 1997-05-28

Family

ID=27300665

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69216509T Expired - Fee Related DE69216509T2 (de) 1991-08-12 1992-08-07 Kondensierte Pyrimidinderivate, ihre Herstellung und ihre Verwendung als Antitumormittel

Country Status (5)

Country Link
US (1) US5403843A (de)
EP (1) EP0530537B1 (de)
AT (1) ATE147386T1 (de)
CA (1) CA2075787A1 (de)
DE (1) DE69216509T2 (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE173251T1 (de) * 1991-08-21 1998-11-15 Eisai Co Ltd Kondensierte pyrimidinderivate als antitumorverbindungen
CZ283281B6 (cs) * 1992-09-25 1998-02-18 Eli Lilly And Company Způsob přípravy v poloze 5 substituovaných pyrrolo(2,3-d)pyrimidinů
US5753664A (en) * 1995-03-16 1998-05-19 Takeda Chemical Industries, Ltd. Heterocyclic compounds, their production and use
EP0923287A4 (de) * 1996-08-30 2001-08-01 Lilly Co Eli Nichtklassische pyrrolo(2,3-d)pyrimidin antifolate
DK0896822T3 (da) * 1997-08-05 2003-06-02 Pfizer Prod Inc 4-aminopyrrol (3,2-d) pyrimidiner som neuropeptide Y receptorantagonister
KR100596109B1 (ko) * 1998-03-27 2006-07-05 제넨테크, 인크. Ｃｄ11/ｃｄ18 부착 수용체 매개 질환 치료용 길항제
BR0312744A (pt) * 2002-07-17 2005-04-26 Warner Lambert Co Associação de um inibidor carboxìlico alostérico da metaloproteinase-13 de matriz com um inibidor selectivo da ciclooxigenase-2, à excepção do celecoxib ou valdecoxib
US20060258691A1 (en) * 2005-05-13 2006-11-16 Joseph Barbosa Methods and compositions for improving cognition
EP1919482A1 (de) * 2005-08-24 2008-05-14 Lexicon Pharmaceuticals, Inc. Pyrrolopyridin-, pyrrolopyrimidin- und pyrazolopyridinverbindungen, zusammensetzungen damit und verfahren zu ihrer anwendung
ATE531720T1 (de) * 2006-08-21 2011-11-15 Genentech Inc Aza-benzofuranylverbindungen und anwendungsverfahren dafür
ES2528797T3 (es) * 2006-08-21 2015-02-12 Genentech, Inc. Compuestos de aza-benzotiofenilo y métodos de uso
US20110250137A1 (en) * 2008-12-04 2011-10-13 Bayer Schering Pharma Aktiengesellchaft Radioisotope-labeled lysine and ornithine derivatives, their use and processes for their preparation
JP5796570B2 (ja) 2010-03-24 2015-10-21 味の素株式会社 グルタミン酸エステル誘導体又はその塩
KR101029091B1 (ko) * 2010-04-08 2011-04-13 강원대학교산학협력단 다이하이드로퓨란 유도체의 제조방법
DE202011111014U1 (de) 2010-11-05 2018-05-02 Senomyx, Inc. Verbindungen, die als Modulatoren von TRPM8 nützlich sind
EP2675808A4 (de) * 2011-02-15 2014-07-09 Hetero Research Foundation Verfahren für pemetrexed-dinatrium
WO2015168269A1 (en) * 2014-05-01 2015-11-05 Novartis Ag Compounds and compositions as toll-like receptor 7 agonists
SG11201608299TA (en) 2014-05-01 2016-11-29 Novartis Ag Compounds and compositions as toll-like receptor 7 agonists
BR112018002399A2 (pt) 2015-08-06 2018-09-25 Chimerix, Inc. nucleosídeos de pirrolopirimidina e análogos dos mesmos, úteis como agentes antivirais
RU2745616C1 (ru) 2015-10-01 2021-03-29 Сеномикс, Инк. Соединения, используемые в качестве модуляторов trpm8
MA44334A (fr) 2015-10-29 2018-09-05 Novartis Ag Conjugués d'anticorps comprenant un agoniste du récepteur de type toll
US11111264B2 (en) 2017-09-21 2021-09-07 Chimerix, Inc. Morphic forms of 4-amino-7-(3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-2-methyl-7H-pyrrolo[2,3-d]pyrimidine-5-carboxamide and uses thereof
IL309732A (en) 2021-07-09 2024-02-01 Aligos Therapeutics Inc Antiviral compounds

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8607683D0 (en) * 1986-03-27 1986-04-30 Ici Plc Anti-tumor agents
US4895946A (en) * 1987-10-26 1990-01-23 The Trustees Of Princeton University Process for the preparation of fused pyridine compounds
US4767761A (en) * 1987-11-04 1988-08-30 Dana-Farber Cancer Institute, Inc. Ornithine derivatives and their use as methotrexate-resistant cell inhibitors
JP2830008B2 (ja) * 1988-04-01 1998-12-02 武田薬品工業株式会社 縮合ピリミジン誘導体
NO169490C (no) * 1988-03-24 1992-07-01 Takeda Chemical Industries Ltd Analogifremgangsmaate for fremstilling av terapeutisk aktive pyrrolopyrimidinderivater
JP3015957B2 (ja) * 1989-05-29 2000-03-06 武田薬品工業株式会社 ピロロ［２，３―ｄ］ピリミジン誘導体およびその製造法
JP2983254B2 (ja) * 1989-06-14 1999-11-29 武田薬品工業株式会社 ピロロ〔２，３―ｄ〕ピリミジン誘導体の製造法およびその中間体
JPH03173890A (ja) * 1989-09-21 1991-07-29 Takeda Chem Ind Ltd ピロロ［２，３―ｄ］ピリミジン誘導体，その製造法，用途及び中間体
CA2031769A1 (en) * 1989-12-08 1991-06-09 Hiroshi Akimoto Pyrrolopyrimidine derivatives, their production and use
US4996206A (en) * 1989-12-11 1991-02-26 The Trustees Of Princeton University N-(pyrrolo[2,3-d]pyrimidin-3-ylacyl)-glutamic acid derivatives
CA2032695A1 (en) * 1989-12-20 1991-06-21 Hiroshi Akimoto Condensed heterocyclic compounds, their production and use
EP0438261A3 (en) * 1990-01-16 1992-02-26 Takeda Chemical Industries, Ltd. Condensed heterocyclic glutamic acid derivatives, their production and use

Also Published As

Publication number Publication date
EP0530537B1 (de) 1997-01-08
US5403843A (en) 1995-04-04
CA2075787A1 (en) 1993-02-13
DE69216509T2 (de) 1997-05-28
ATE147386T1 (de) 1997-01-15
EP0530537A1 (de) 1993-03-10

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee