DE69415445T2 - Zytotoxische Stilben-Derivate und diese enthaltende pharmazeutische Zusammensetzungen - Google Patents
Zytotoxische Stilben-Derivate und diese enthaltende pharmazeutische ZusammensetzungenInfo
- Publication number
- DE69415445T2 DE69415445T2 DE69415445T DE69415445T DE69415445T2 DE 69415445 T2 DE69415445 T2 DE 69415445T2 DE 69415445 T DE69415445 T DE 69415445T DE 69415445 T DE69415445 T DE 69415445T DE 69415445 T2 DE69415445 T2 DE 69415445T2
- Authority
- DE
- Germany
- Prior art keywords
- stilbene derivatives
- cytotoxic
- pharmaceutical compositions
- compositions containing
- carbon atoms
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/78—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
- C07C217/80—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of non-condensed six-membered aromatic rings
- C07C217/82—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of non-condensed six-membered aromatic rings of the same non-condensed six-membered aromatic ring
- C07C217/84—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of non-condensed six-membered aromatic rings of the same non-condensed six-membered aromatic ring the oxygen atom of at least one of the etherified hydroxy groups being further bound to an acyclic carbon atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
- C07C205/27—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups
- C07C205/35—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups having nitro groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
- C07C205/27—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups
- C07C205/35—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups having nitro groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
- C07C205/36—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups having nitro groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton to carbon atoms of the same non-condensed six-membered aromatic ring or to carbon atoms of six-membered aromatic rings being part of the same condensed ring system
- C07C205/37—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups having nitro groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton to carbon atoms of the same non-condensed six-membered aromatic ring or to carbon atoms of six-membered aromatic rings being part of the same condensed ring system the oxygen atom of at least one of the etherified hydroxy groups being further bound to an acyclic carbon atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/78—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
- C07C217/80—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of non-condensed six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
- C07C255/32—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring
- C07C255/42—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being further bound to other hetero atoms
- C07C255/43—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being further bound to other hetero atoms the carbon skeleton being further substituted by singly-bound oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C43/00—Ethers; Compounds having groups, groups or groups
- C07C43/02—Ethers
- C07C43/03—Ethers having all ether-oxygen atoms bound to acyclic carbon atoms
- C07C43/14—Unsaturated ethers
- C07C43/164—Unsaturated ethers containing six-membered aromatic rings
- C07C43/166—Unsaturated ethers containing six-membered aromatic rings having unsaturation outside the aromatic rings
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP22357393 | 1993-09-08 | ||
JP32283293 | 1993-12-21 |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69415445D1 DE69415445D1 (de) | 1999-02-04 |
DE69415445T2 true DE69415445T2 (de) | 1999-07-22 |
Family
ID=26525559
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69415445T Expired - Lifetime DE69415445T2 (de) | 1993-09-08 | 1994-09-05 | Zytotoxische Stilben-Derivate und diese enthaltende pharmazeutische Zusammensetzungen |
Country Status (13)
Country | Link |
---|---|
US (1) | US5525632A (de) |
EP (1) | EP0641767B1 (de) |
JP (1) | JP3045017B2 (de) |
KR (1) | KR100308463B1 (de) |
CN (1) | CN1035996C (de) |
AT (1) | ATE174899T1 (de) |
CA (1) | CA2131683C (de) |
DE (1) | DE69415445T2 (de) |
DK (1) | DK0641767T3 (de) |
ES (1) | ES2126068T3 (de) |
GR (1) | GR3029603T3 (de) |
SI (1) | SI0641767T1 (de) |
TW (1) | TW325458B (de) |
Families Citing this family (53)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TW334418B (en) * | 1995-03-07 | 1998-06-21 | Ajinomoto Kk | Stilbene derivatives and pharmaceutical compositions |
JP4470321B2 (ja) | 1998-04-03 | 2010-06-02 | 味の素株式会社 | 抗腫瘍剤 |
US6624197B1 (en) | 1998-05-08 | 2003-09-23 | Calyx Therapeutics, Inc. | Diphenylethylene compounds |
US7105552B2 (en) * | 1998-05-08 | 2006-09-12 | Theracos, Inc. | Heterocyclic analogs of diphenylethylene compounds |
US6245814B1 (en) | 1998-05-08 | 2001-06-12 | Calyx Therapeutics, Inc. | Diphenylethylene compounds |
US6331633B1 (en) | 1998-05-08 | 2001-12-18 | Calyx Therapeutics Inc. | Heterocyclic analogs of diphenylethylene compounds |
GB9903403D0 (en) * | 1999-02-16 | 1999-04-07 | Angiogene Pharm Ltd | Substituted stilbene compounds with vascular damaging activity |
US7407978B2 (en) * | 1999-04-06 | 2008-08-05 | Theracos, Inc. | Heterocyclic analogs of diphenylethylene compounds |
GB9918912D0 (en) * | 1999-08-12 | 1999-10-13 | Angiogene Pharm Ltd | New stilbenes with vascular damaging activity |
US6849656B1 (en) | 1999-09-17 | 2005-02-01 | Baylor University | Indole-containing and combretastatin-related anti-mitotic and anti-tubulin polymerization agents |
US20020002200A1 (en) * | 2000-02-04 | 2002-01-03 | Bishwagit Nag | Novel diphenylethylene compounds |
US7323496B2 (en) * | 1999-11-08 | 2008-01-29 | Theracos, Inc. | Compounds for treatment of inflammation, diabetes and related disorders |
US6525093B1 (en) | 1999-11-08 | 2003-02-25 | Calyx Therapeutics Inc. | Compounds to treat diabetes and associated conditions |
US20080108825A1 (en) * | 1999-11-08 | 2008-05-08 | Theracos, Inc. | Compounds for treatment of inflammation, diabetes and related disorders |
CA2397076A1 (en) * | 2000-02-04 | 2001-08-09 | Calyx Therapeutics, Inc. | Novel diphenylethylene compounds |
US20080103302A1 (en) * | 2000-02-04 | 2008-05-01 | Theracos, Inc. | Compounds for treatment of inflammation, diabetes and related disorders |
AU4352701A (en) | 2000-03-10 | 2001-09-24 | Univ Baylor | Tubulin binding ligands and corresponding prodrug constructs |
CA2408220A1 (en) * | 2000-05-09 | 2001-11-15 | George R. Pettit | Antitubulin assembly and cell growth inhibitor denominated "dioxostatin" |
JP2004517821A (ja) * | 2000-10-27 | 2004-06-17 | アベンティス・ファーマ・ソシエテ・アノニム | 癌治療のためのカンプトセシン及びスチルベン誘導体からなる組合せ |
EP1351912A2 (de) | 2000-12-21 | 2003-10-15 | Cancer Research Ventures Limited | Substituierte stilbene, ihre reaktionen und antikrebsaktivität |
US20020183266A1 (en) * | 2001-03-15 | 2002-12-05 | Aventis Pharma, S.A. | Combination comprising combretastatin and anticancer agents |
DE60228448D1 (de) | 2001-06-22 | 2008-10-02 | Ajinomoto Kk | Verfahren zur herstellung von aminostilbenderivaten |
CN1543356B (zh) | 2001-06-25 | 2011-09-28 | 味之素株式会社 | 抗肿瘤剂 |
CN1299777C (zh) * | 2001-08-27 | 2007-02-14 | 宾夕法尼亚州大学理事会 | 茋衍生物及其用于结合和成像淀粉样蛋白斑的用途 |
US6919324B2 (en) * | 2001-10-26 | 2005-07-19 | Oxigene, Inc. | Functionalized stilbene derivatives as improved vascular targeting agents |
US6759555B2 (en) * | 2002-04-11 | 2004-07-06 | Aventis Pharma S.A. | Process for the preparation of combretastatins |
FR2838437B1 (fr) * | 2002-04-11 | 2004-06-04 | Aventis Pharma Sa | Procedes de preparation de combretastatines |
EP1591117A4 (de) * | 2003-02-04 | 2006-04-26 | Yakult Honsha Kk | Bcrp (breast cancer resistance protein) inhibitor |
EP1601348A4 (de) * | 2003-02-28 | 2008-12-10 | Oxigene Inc | Zusammensetzungen und verfahren mit verbesserter therapeutischer aktivität |
CN1723884A (zh) * | 2004-07-21 | 2006-01-25 | 中国人民解放军军事医学科学院放射医学研究所 | 顺式-1,2-取代的二苯乙烯衍生物用于制备治疗或预防糖尿病的药物的用途 |
EP1838298A4 (de) * | 2004-12-17 | 2009-03-04 | Univ Pennsylvania | Stilben-derivate und ihre verwendung zur bindung und bilddarstellung von amyloid-plaque |
US7858072B2 (en) * | 2004-12-17 | 2010-12-28 | The Trustees Of The University Of Pennsylvania | Stilbene derivatives and their use for binding and imaging amyloid plaques |
FR2895258B1 (fr) * | 2005-12-22 | 2008-03-21 | Aventis Pharma Sa | Combinaison comprenant de la combretastatine et des agents anticancereux |
CN101139358B (zh) * | 2006-09-07 | 2011-10-12 | 浙江大德药业集团有限公司 | 乙氧基康普立停及其前药的制备和用途 |
TW200819409A (en) | 2006-10-19 | 2008-05-01 | Univ Taipei Medical | Z-stilbenes derivatives and the pharmaceutical composition thereof |
CN100532353C (zh) * | 2006-12-06 | 2009-08-26 | 中国科学院广州化学研究所 | (z)-3'-氨基-3,4,4',5-四甲氧基二苯乙烯的制备方法 |
US20090192098A1 (en) | 2007-11-21 | 2009-07-30 | Oxigene, Inc. | Method for treating hematopoietic neoplasms |
CN101450889B (zh) * | 2007-12-03 | 2012-05-30 | 中国科学院理化技术研究所 | 光催化1,2-二苯乙烯类似物发生顺反异构化反应的方法 |
FR2928148B1 (fr) | 2008-02-28 | 2013-01-18 | Sanofi Aventis | Procede de preparation de combretastatine |
CN101723813A (zh) * | 2008-10-15 | 2010-06-09 | 上海华理生物医药有限公司 | 一种乙氧基二苯乙烷衍生物及其制备方法和用途 |
FR2953518B1 (fr) * | 2009-12-03 | 2012-01-20 | Sanofi Aventis | Procede de preparation d'un derive de combretastatine |
FR2968557A1 (fr) | 2010-12-09 | 2012-06-15 | Sanofi Aventis | Combinaison antitumorale comprenant un derive de la famille des combretastatines et le cetuximab |
JP2014512337A (ja) * | 2011-01-28 | 2014-05-22 | ユニバーシティ オブ ケンタッキー リサーチ ファウンデーション | スチルベン類似体およびがんを処置する方法 |
WO2013003112A1 (en) | 2011-06-27 | 2013-01-03 | The Jackson Laboratory | Methods and compositions for treatment of cancer and autoimmune disease |
CN103288701B (zh) * | 2012-02-24 | 2016-01-27 | 中南大学 | 1,5-二芳基吡咯衍生物、制备方法及其抗肿瘤应用 |
WO2014089177A2 (en) | 2012-12-04 | 2014-06-12 | Massachusetts Institute Of Technology | Compounds, conjugates and compositions of epipolythiodiketopiperazines and polythiodiketopiperazines |
AU2014228822A1 (en) | 2013-03-15 | 2015-10-01 | Memorial Sloan-Kettering Cancer Center | HSP90-targeted cardiac imaging and therapy |
JP2018523712A (ja) | 2015-08-18 | 2018-08-23 | マテオン セラピューティクス, インク.Mateon Therapeutics, Inc. | 腫瘍に対する免疫調節療法を向上させる為のvdasの使用 |
WO2017197045A1 (en) | 2016-05-11 | 2017-11-16 | Movassaghi Mohammad | Convergent and enantioselective total synthesis of communesin analogs |
CN108727222B (zh) * | 2017-04-24 | 2020-12-08 | 延边大学 | 一种选择性抗癌活性的tyd1608及其制备及用途 |
US11932650B2 (en) | 2017-05-11 | 2024-03-19 | Massachusetts Institute Of Technology | Potent agelastatin derivatives as modulators for cancer invasion and metastasis |
US10640508B2 (en) | 2017-10-13 | 2020-05-05 | Massachusetts Institute Of Technology | Diazene directed modular synthesis of compounds with quaternary carbon centers |
US11535634B2 (en) | 2019-06-05 | 2022-12-27 | Massachusetts Institute Of Technology | Compounds, conjugates, and compositions of epipolythiodiketopiperazines and polythiodiketopiperazines and uses thereof |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3832204A1 (de) * | 1988-09-22 | 1990-03-29 | Basf Ag | Neue stilbenverbindungen und deren verwendung bei der anionischen polymerisation |
US5430062A (en) * | 1992-05-21 | 1995-07-04 | Research Corporation Technologies, Inc. | Stilbene derivatives as anticancer agents |
EP0641301A1 (de) * | 1992-05-21 | 1995-03-08 | Research Corporation Technologies, Inc. | Stilbenderivate als antikrebsmittel |
-
1994
- 1994-08-26 TW TW083107859A patent/TW325458B/zh not_active IP Right Cessation
- 1994-09-05 AT AT94306522T patent/ATE174899T1/de active
- 1994-09-05 SI SI9430218T patent/SI0641767T1/xx unknown
- 1994-09-05 DE DE69415445T patent/DE69415445T2/de not_active Expired - Lifetime
- 1994-09-05 ES ES94306522T patent/ES2126068T3/es not_active Expired - Lifetime
- 1994-09-05 DK DK94306522T patent/DK0641767T3/da active
- 1994-09-05 EP EP94306522A patent/EP0641767B1/de not_active Expired - Lifetime
- 1994-09-06 JP JP6236046A patent/JP3045017B2/ja not_active Expired - Lifetime
- 1994-09-07 KR KR1019940022423A patent/KR100308463B1/ko not_active IP Right Cessation
- 1994-09-08 CN CN94116204A patent/CN1035996C/zh not_active Expired - Lifetime
- 1994-09-08 US US08/302,210 patent/US5525632A/en not_active Expired - Lifetime
- 1994-09-08 CA CA002131683A patent/CA2131683C/en not_active Expired - Lifetime
-
1999
- 1999-03-08 GR GR990400690T patent/GR3029603T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
EP0641767A1 (de) | 1995-03-08 |
JPH07228558A (ja) | 1995-08-29 |
US5525632A (en) | 1996-06-11 |
CN1035996C (zh) | 1997-10-01 |
SI0641767T1 (en) | 1999-04-30 |
DK0641767T3 (da) | 1999-08-23 |
ATE174899T1 (de) | 1999-01-15 |
CA2131683C (en) | 2005-01-25 |
DE69415445D1 (de) | 1999-02-04 |
GR3029603T3 (en) | 1999-06-30 |
KR950008476A (ko) | 1995-04-17 |
JP3045017B2 (ja) | 2000-05-22 |
ES2126068T3 (es) | 1999-03-16 |
TW325458B (en) | 1998-01-21 |
EP0641767B1 (de) | 1998-12-23 |
CN1105967A (zh) | 1995-08-02 |
KR100308463B1 (ko) | 2001-12-01 |
CA2131683A1 (en) | 1995-03-09 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DE69415445D1 (de) | Zytotoxische Stilben-Derivate und diese enthaltende pharmazeutische Zusammensetzungen | |
DE69604714D1 (de) | Stilbenderivate und diese enthaltende pharmazeutische Zusammensetzungen | |
FR2669336B1 (fr) | Nouveaux derives d'oxazolo pyridines, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent. | |
GR3019341T3 (en) | USE OF AN alpha-tocoPHEROL PHOSPHATE OR A DERIVATIVE THEREOF FOR PREPARING COSMETIC, DERMATOLOGICAL OR PHARMACEUTICAL COMPOSITIONS, AND COMPOSITIONS THEREBY OBTAINED | |
EP0487502A3 (en) | Pharmaceutically active aryl-substituted amine derivatives | |
ES2057959T3 (es) | Derivados de tienopiridina y composiciones farmaceuticas que los contienen. | |
IL114785A0 (en) | Pyrrolocarbazoles their preparation and pharmaceutical compositions containing them | |
ES2055235T3 (es) | Composicion anti-inflamatoria y/o antialergica que comprende derivados de glutation. | |
DK0420121T3 (da) | Antitumormiddel | |
FR2623504B1 (fr) | Nouveaux derives n-(vinblastinoyl-23) d'acide amino-1 methylphosphonique, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent | |
DE69001004D1 (de) | Zusammensetzung gegen leberkrankheiten. | |
ATE184282T1 (de) | Cyclopropan-derivate und diese enthaltende antivirale mittel | |
ATE43594T1 (de) | 3-alkoxy-2-(n-pyrrolidino)-n-pyridyl-n-furyl(od r thienyl)-methyl-propylamine, ihre herstellung und diese enthaltende pharmazeutische mittel. | |
ATE147755T1 (de) | Dipeptidderivate und diese als aktive bestandteile enthaltendes prophylaktisches oder therapeutisches mittel gegen knochenkrankheiten | |
CA2213054A1 (fr) | Nouveaux derives de bis-imides, leur procede de preparation et les compositions pharmaceutiques qui les contiennent | |
IL106564A (en) | Tetrahydronaphthalene derivatives their preparation and pharmaceutical compositions containing them | |
MY104099A (en) | Anti inflammatory carbinoloimidazoles. | |
ES8300709A1 (es) | Un metodo para la preparacion de derivados de pirazolidinona | |
TH20908B (th) | อนุพันธ์คาร์โบไฮเดรต | |
TH31635A (th) | อนุพันธ์คาร์โบไฮเดรต |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |