DE69216509T2 - Kondensierte Pyrimidinderivate, ihre Herstellung und ihre Verwendung als Antitumormittel - Google Patents

Kondensierte Pyrimidinderivate, ihre Herstellung und ihre Verwendung als Antitumormittel

Info

Publication number
DE69216509T2
DE69216509T2 DE69216509T DE69216509T DE69216509T2 DE 69216509 T2 DE69216509 T2 DE 69216509T2 DE 69216509 T DE69216509 T DE 69216509T DE 69216509 T DE69216509 T DE 69216509T DE 69216509 T2 DE69216509 T2 DE 69216509T2
Authority
DE
Germany
Prior art keywords
stands
group
denotes
optionally
coor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69216509T
Other languages
English (en)
Other versions
DE69216509D1 (de
Inventor
Hiroshi Akimoto
Koichiro Ootsu
Fumio Itoh
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda Pharmaceutical Co Ltd
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Application granted granted Critical
Publication of DE69216509D1 publication Critical patent/DE69216509D1/de
Publication of DE69216509T2 publication Critical patent/DE69216509T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
DE69216509T 1991-08-12 1992-08-07 Kondensierte Pyrimidinderivate, ihre Herstellung und ihre Verwendung als Antitumormittel Expired - Fee Related DE69216509T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP20204291 1991-08-12
JP7151392 1992-03-27
JP14585192 1992-06-05

Publications (2)

Publication Number Publication Date
DE69216509D1 DE69216509D1 (de) 1997-02-20
DE69216509T2 true DE69216509T2 (de) 1997-05-28

Family

ID=27300665

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69216509T Expired - Fee Related DE69216509T2 (de) 1991-08-12 1992-08-07 Kondensierte Pyrimidinderivate, ihre Herstellung und ihre Verwendung als Antitumormittel

Country Status (5)

Country Link
US (1) US5403843A (de)
EP (1) EP0530537B1 (de)
AT (1) ATE147386T1 (de)
CA (1) CA2075787A1 (de)
DE (1) DE69216509T2 (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69227561T2 (de) * 1991-08-21 1999-06-02 Eisai Co Ltd Kondensierte Pyrimidinderivate als Antitumorverbindungen
HUT70208A (en) * 1992-09-25 1995-09-28 Lilly Co Eli Process for preparing 5-substituted pyrrolo[2,3-d]-pyrimidines
US5753664A (en) * 1995-03-16 1998-05-19 Takeda Chemical Industries, Ltd. Heterocyclic compounds, their production and use
EP0923287A4 (de) * 1996-08-30 2001-08-01 Lilly Co Eli Nichtklassische pyrrolo(2,3-d)pyrimidin antifolate
PT896822E (pt) * 1997-08-05 2003-07-31 Pfizer Prod Inc 4-aminopirrolo (3,2-d)pirimidinas como antagonistas do receptor de neuropeptideo y
DE69935133T2 (de) * 1998-03-27 2007-11-22 Genentech, Inc., South San Francisco Antagonisten zur behandlung von cd11/cd18 adhäsionsrezeptor-vermittelten krankheiten
BR0312744A (pt) * 2002-07-17 2005-04-26 Warner Lambert Co Associação de um inibidor carboxìlico alostérico da metaloproteinase-13 de matriz com um inibidor selectivo da ciclooxigenase-2, à excepção do celecoxib ou valdecoxib
US20060258691A1 (en) * 2005-05-13 2006-11-16 Joseph Barbosa Methods and compositions for improving cognition
US20070049608A1 (en) * 2005-08-24 2007-03-01 Fink Cynthia A Pyrrolopyridine, pyrrolopyrimidine and pyrazolopyridine compounds, compositions comprising them, and methods of their use
WO2008024724A1 (en) * 2006-08-21 2008-02-28 Genentech, Inc. Aza-benzothiophenyl compounds and methods of use
WO2008024725A1 (en) * 2006-08-21 2008-02-28 Genentech, Inc. Aza-benzofuranyl compounds and methods of use
WO2010063403A2 (en) * 2008-12-04 2010-06-10 Bayer Schering Pharma Aktiengesellschaft Radioisotope-labeled lysine and ornithine derivatives, their use and processes for their preparation
JP5796570B2 (ja) 2010-03-24 2015-10-21 味の素株式会社 グルタミン酸エステル誘導体又はその塩
KR101029091B1 (ko) * 2010-04-08 2011-04-13 강원대학교산학협력단 다이하이드로퓨란 유도체의 제조방법
BR112013011188B1 (pt) 2010-11-05 2022-01-04 Senomyx, Inc Método não-médico para modular canal potencial de receptor transiente de melastina 8 (trpm8), método não-médico para modular a sensação de resfriamento de uma composição, método não-médico para induzir uma sensação de resfriamento em um humano ou animal e composto
EP2675808A4 (de) * 2011-02-15 2014-07-09 Hetero Research Foundation Verfahren für pemetrexed-dinatrium
BR112016025048A2 (pt) * 2014-05-01 2017-10-31 Novartis Ag compostos e composições como agonistas do receptor tipo toll7
KR102139847B1 (ko) 2014-05-01 2020-07-31 노파르티스 아게 톨-유사 수용체 7 효능제로서의 화합물 및 조성물
EP3331895B1 (de) 2015-08-06 2020-07-29 Chimerix, Inc. Pyrrolopyrimidin nucleoside und analaoga davon nützlich als antivirale mittel
EP3356356B1 (de) 2015-10-01 2021-05-26 Firmenich Incorporated Verbindungen als trpm8-modulatoren
MA44334A (fr) 2015-10-29 2018-09-05 Novartis Ag Conjugués d'anticorps comprenant un agoniste du récepteur de type toll
WO2019060692A1 (en) 2017-09-21 2019-03-28 Chimerix, Inc. MORPHIC FORMS OF 4-AMINO-7- (3,4-DIHYDROXY-5- (HYDROXYMETHYL) -ETRAHYDROFURAN-2-YL) -2-METHYL-7H-PYRROLO [2,3-D] PYRIMIDINE-5-CARBOXAMIDE AND THEIR USES
US11851422B2 (en) 2021-07-09 2023-12-26 Aligos Therapeutics, Inc. Anti-viral compounds

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8607683D0 (en) * 1986-03-27 1986-04-30 Ici Plc Anti-tumor agents
US4895946A (en) * 1987-10-26 1990-01-23 The Trustees Of Princeton University Process for the preparation of fused pyridine compounds
US4767761A (en) * 1987-11-04 1988-08-30 Dana-Farber Cancer Institute, Inc. Ornithine derivatives and their use as methotrexate-resistant cell inhibitors
JP2830008B2 (ja) * 1988-04-01 1998-12-02 武田薬品工業株式会社 縮合ピリミジン誘導体
NO169490C (no) * 1988-03-24 1992-07-01 Takeda Chemical Industries Ltd Analogifremgangsmaate for fremstilling av terapeutisk aktive pyrrolopyrimidinderivater
JP3015957B2 (ja) * 1989-05-29 2000-03-06 武田薬品工業株式会社 ピロロ［２，３―ｄ］ピリミジン誘導体およびその製造法
JP2983254B2 (ja) * 1989-06-14 1999-11-29 武田薬品工業株式会社 ピロロ〔２，３―ｄ〕ピリミジン誘導体の製造法およびその中間体
JPH03173890A (ja) * 1989-09-21 1991-07-29 Takeda Chem Ind Ltd ピロロ［２，３―ｄ］ピリミジン誘導体，その製造法，用途及び中間体
EP0431953A3 (en) * 1989-12-08 1992-01-02 Takeda Chemical Industries, Ltd. Pyrrolopyrimidine derivatives, their production and use
US5028608A (en) * 1989-12-11 1991-07-02 The Trustees Of Princeton University N-(6-Amino-(pyrrolo(2,3-d)pyrimidin-3-ylacyl) )-glutamic acid derivatives
CA2032695A1 (en) * 1989-12-20 1991-06-21 Hiroshi Akimoto Condensed heterocyclic compounds, their production and use
EP0438261A3 (en) * 1990-01-16 1992-02-26 Takeda Chemical Industries, Ltd. Condensed heterocyclic glutamic acid derivatives, their production and use

Also Published As

Publication number Publication date
EP0530537A1 (de) 1993-03-10
CA2075787A1 (en) 1993-02-13
DE69216509D1 (de) 1997-02-20
US5403843A (en) 1995-04-04
EP0530537B1 (de) 1997-01-08
ATE147386T1 (de) 1997-01-15

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee