ATE129714T1 - Heterocyclische biphosphonsäurederivate. - Google Patents

Heterocyclische biphosphonsäurederivate.

Info

Publication number
ATE129714T1
ATE129714T1 AT89308180T AT89308180T ATE129714T1 AT E129714 T1 ATE129714 T1 AT E129714T1 AT 89308180 T AT89308180 T AT 89308180T AT 89308180 T AT89308180 T AT 89308180T AT E129714 T1 ATE129714 T1 AT E129714T1
Authority
AT
Austria
Prior art keywords
chem
hydrogen atom
acid derivatives
hydroxyl group
biphosphoic
Prior art date
Application number
AT89308180T
Other languages
English (en)
Inventor
Yasuo Isomura
Makoto Takeuchi
Tetsushi Abe
Original Assignee
Yamanouchi Pharma Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yamanouchi Pharma Co Ltd filed Critical Yamanouchi Pharma Co Ltd
Application granted granted Critical
Publication of ATE129714T1 publication Critical patent/ATE129714T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Adhesives Or Adhesive Processes (AREA)
  • Detergent Compositions (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
AT89308180T 1988-08-12 1989-08-11 Heterocyclische biphosphonsäurederivate. ATE129714T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP20153588 1988-08-12
JP20153688 1988-08-12

Publications (1)

Publication Number Publication Date
ATE129714T1 true ATE129714T1 (de) 1995-11-15

Family

ID=26512843

Family Applications (1)

Application Number Title Priority Date Filing Date
AT89308180T ATE129714T1 (de) 1988-08-12 1989-08-11 Heterocyclische biphosphonsäurederivate.

Country Status (14)

Country Link
US (2) US4990503A (de)
EP (1) EP0354806B1 (de)
KR (1) KR0156239B1 (de)
CN (1) CN1027167C (de)
AT (1) ATE129714T1 (de)
AU (1) AU624405B2 (de)
CA (1) CA1332058C (de)
DE (1) DE68924681T2 (de)
DK (1) DK170257B1 (de)
ES (1) ES2082780T3 (de)
GR (1) GR3018086T3 (de)
HU (2) HU205766B (de)
IE (1) IE71185B1 (de)
PH (1) PH26376A (de)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0521622B1 (de) * 1991-07-03 1997-08-13 PHARMACIA & UPJOHN COMPANY Pyrazolopyrimiden- und Pyrimidinylbisphosphonsäureester als entzündungshemmende Mittel
TW222637B (de) * 1991-12-12 1994-04-21 Hoechst Ag
US5270365A (en) * 1991-12-17 1993-12-14 Merck & Co., Inc. Prevention and treatment of periodontal disease with alendronate
JPH05345791A (ja) * 1992-03-18 1993-12-27 Hoechst Japan Ltd 環状アミノメチレンビスホスホン酸誘導体
CA2137665A1 (en) * 1992-06-23 1994-01-06 Yasuo Isomura Novel crystal of monohydrate of heterocyclic bis(phosphonic acid) derivative
JPH08502287A (ja) * 1992-10-09 1996-03-12 ジ・アップジョン・カンパニー 抗炎症剤としてのピリミジンビスホスホン酸エステルおよび（アルコキシメチルホスフィニル）アルキルホスホン酸
JPH06298779A (ja) * 1993-04-15 1994-10-25 Hoechst Japan Ltd ヘテロ環イミノビスメチレンビスホスホン酸誘導体
US5728650A (en) * 1993-10-07 1998-03-17 Zeneca Limited Herbicidal aza bisphosphonic acids and compositions containing the same
US5854227A (en) * 1994-03-04 1998-12-29 Hartmann; John F. Therapeutic derivatives of diphosphonates
US5880111A (en) * 1995-06-07 1999-03-09 Farcasiu; Dan Therapeutic derivations of diphosphonates
AU6691798A (en) * 1997-03-07 1998-09-22 Metabasis Therapeutics, Inc. Novel indole and azaindole inhibitors of fructose-1,6-bisphosphatase
WO1998039344A1 (en) 1997-03-07 1998-09-11 Metabasis Therapeutics, Inc. Novel purine inhibitors of fructose-1,6-bisphosphatase
US7008645B2 (en) * 1998-07-14 2006-03-07 Yissum Research Development Company Of The Hebrew University Of Jerusalem Method of inhibiting restenosis using bisphosphonates
CN1151793C (zh) 1998-12-25 2004-06-02 山之内制药株式会社 多发性骨髓瘤的骨病变治疗用医药组合物
US20030036537A1 (en) * 2001-07-16 2003-02-20 Marc Lecouvey Bisphosphonate derivatives, their preparations and uses
ES2291749T5 (es) 2002-12-20 2011-07-21 F. Hoffmann-La Roche Ag Formulación de altas dosis de ibandronato.
HUP0300227A2 (hu) * 2003-01-28 2004-09-28 Richter Gedeon Vegyészeti Gyár Rt. Eljárás nagy tisztaságú 2-szubsztituált -1-(hidroxi-etilidén)-1,1-biszfoszfonsavak és sóik előállítására
US20060051407A1 (en) * 2003-06-27 2006-03-09 Yoram Richter Method of treating ischemia-reperfusion injury
US10517883B2 (en) 2003-06-27 2019-12-31 Zuli Holdings Ltd. Method of treating acute myocardial infarction
WO2005072746A1 (ja) * 2004-01-30 2005-08-11 Astellas Pharma Inc. P2x受容体阻害剤
CN101531681B (zh) * 2008-03-10 2013-06-05 北京德众万全医药科技有限公司 一种高纯度的米诺膦酸及其制备方法
KR20110079813A (ko) * 2008-09-22 2011-07-08 아이시스 이노베이션 리미티드 이미다조〔1,2－α〕피리디닐 비스포스포네이트
WO2010033980A2 (en) * 2008-09-22 2010-03-25 Isis Innovation Ltd. 4-azaindole bisphosphonates
MX2012004769A (es) 2009-10-26 2012-08-08 Warner Chilcott Co Llc Compuestos de bisfosfonato para tratar transtornos del metabolismo oseo.
CN101973993A (zh) * 2010-11-05 2011-02-16 天津药物研究院 一种制备2-[咪唑并(1,2-a)吡啶-3-基]乙酸的方法
CN102153585B (zh) * 2011-02-24 2013-04-17 北京欧克兰医药技术开发中心 一种米诺膦酸中间体的合成方法及米诺膦酸的合成
CN102268042B (zh) * 2011-06-01 2014-06-25 广东宏远集团药业有限公司 一种米诺膦酸晶型ii及其制备方法
US9993427B2 (en) 2013-03-14 2018-06-12 Biorest Ltd. Liposome formulation and manufacture
CN107033187A (zh) * 2017-04-28 2017-08-11 江苏笃诚医药科技股份有限公司 一种米诺膦酸的制备方法
KR20220115062A (ko) 2021-02-09 2022-08-17 (주)오스티오뉴로젠 크로몬 구조의 화합물을 포함하는 골다공증의 예방 및 치료용 약학적 조성물

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3203308A1 (de) * 1982-01-27 1983-07-28 Schering Ag, 1000 Berlin Und 4619 Bergkamen Diphosphonsaeure-derivate und diese enthaltende pharmazeutische praeparate
DE3428524A1 (de) * 1984-08-02 1986-02-13 Boehringer Mannheim Gmbh, 6800 Mannheim Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel
DE3626058A1 (de) * 1986-08-01 1988-02-11 Boehringer Mannheim Gmbh Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel
IL84493A (en) * 1986-11-21 1993-01-14 Ciba Geigy Ag Aromatically substituted azacycloalkylalk - anediphosphonic acids, their preparation and pharmaceutical compositions containing them
DE3640938A1 (de) * 1986-11-29 1988-06-01 Boehringer Mannheim Gmbh Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindung enthaltende arzneimittel
EP0317505A1 (de) * 1987-11-13 1989-05-24 Ciba-Geigy Ag Neue Azacycloalkylalkandiphosphonsäuren

Also Published As

Publication number Publication date
CN1040590A (zh) 1990-03-21
KR900003186A (ko) 1990-03-26
DE68924681T2 (de) 1996-04-04
CN1027167C (zh) 1994-12-28
DK394789D0 (da) 1989-08-11
CA1332058C (en) 1994-09-20
GR3018086T3 (en) 1996-02-29
DK170257B1 (da) 1995-07-17
IE71185B1 (en) 1997-01-29
PH26376A (en) 1992-06-01
EP0354806B1 (de) 1995-11-02
EP0354806A2 (de) 1990-02-14
EP0354806A3 (de) 1991-05-02
HU205766B (en) 1992-06-29
DK394789A (da) 1990-02-13
KR0156239B1 (ko) 1998-12-01
IE892601L (en) 1990-02-12
US5039669A (en) 1991-08-13
US4990503A (en) 1991-02-05
HU211949A9 (en) 1996-01-29
AU3941989A (en) 1990-02-15
DE68924681D1 (de) 1995-12-07
AU624405B2 (en) 1992-06-11
HUT51637A (en) 1990-05-28
ES2082780T3 (es) 1996-04-01

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Legal Events

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UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee