DK394789A - Heterocyclisk biphosphonsyrederivat, fremgangsmaade til fremstilling deraf og farmaceutisk praeparat indeholdende en saadan forbindelse - Google Patents

Heterocyclisk biphosphonsyrederivat, fremgangsmaade til fremstilling deraf og farmaceutisk praeparat indeholdende en saadan forbindelse Download PDF

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Publication number
DK394789A
DK394789A DK394789A DK394789A DK394789A DK 394789 A DK394789 A DK 394789A DK 394789 A DK394789 A DK 394789A DK 394789 A DK394789 A DK 394789A DK 394789 A DK394789 A DK 394789A
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DK
Denmark
Prior art keywords
chem
heterocyclic
procedures
preparing
hydrogen atom
Prior art date
Application number
DK394789A
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English (en)
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DK394789D0 (da
DK170257B1 (da
Inventor
Yasuo Isomura
Makoto Takeuchi
Tetsushi Abe
Original Assignee
Yamanouchi Pharma Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Yamanouchi Pharma Co Ltd filed Critical Yamanouchi Pharma Co Ltd
Publication of DK394789D0 publication Critical patent/DK394789D0/da
Publication of DK394789A publication Critical patent/DK394789A/da
Application granted granted Critical
Publication of DK170257B1 publication Critical patent/DK170257B1/da

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Adhesives Or Adhesive Processes (AREA)
  • Detergent Compositions (AREA)
DK394789A 1988-08-12 1989-08-11 Heterocyclisk biphosphonsyrederivat, fremgangsmåde til fremstilling deraf og farmaceutisk præparat indeholdende et sådant derivat DK170257B1 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP20153688 1988-08-12
JP20153588 1988-08-12
JP20153688 1988-08-12
JP20153588 1988-08-12

Publications (3)

Publication Number Publication Date
DK394789D0 DK394789D0 (da) 1989-08-11
DK394789A true DK394789A (da) 1990-02-13
DK170257B1 DK170257B1 (da) 1995-07-17

Family

ID=26512843

Family Applications (1)

Application Number Title Priority Date Filing Date
DK394789A DK170257B1 (da) 1988-08-12 1989-08-11 Heterocyclisk biphosphonsyrederivat, fremgangsmåde til fremstilling deraf og farmaceutisk præparat indeholdende et sådant derivat

Country Status (14)

Country Link
US (2) US4990503A (da)
EP (1) EP0354806B1 (da)
KR (1) KR0156239B1 (da)
CN (1) CN1027167C (da)
AT (1) ATE129714T1 (da)
AU (1) AU624405B2 (da)
CA (1) CA1332058C (da)
DE (1) DE68924681T2 (da)
DK (1) DK170257B1 (da)
ES (1) ES2082780T3 (da)
GR (1) GR3018086T3 (da)
HU (2) HU205766B (da)
IE (1) IE71185B1 (da)
PH (1) PH26376A (da)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0521622B1 (en) * 1991-07-03 1997-08-13 PHARMACIA & UPJOHN COMPANY Pyrazolopyrimidine and pyrimidinyl bisphosphonic esters as anti-inflammatories
TW222637B (da) * 1991-12-12 1994-04-21 Hoechst Ag
US5270365A (en) * 1991-12-17 1993-12-14 Merck & Co., Inc. Prevention and treatment of periodontal disease with alendronate
JPH05345791A (ja) * 1992-03-18 1993-12-27 Hoechst Japan Ltd 環状アミノメチレンビスホスホン酸誘導体
DK0647649T3 (da) * 1992-06-23 1999-07-26 Yamanouchi Pharma Co Ltd Ny krystal af heterocyklisk bis(phosphonsyre)monohydratderivat
EP0663919A1 (en) * 1992-10-09 1995-07-26 PHARMACIA & UPJOHN COMPANY Pyrimidine bisphosphonate esters as anti-inflamatories
JPH06298779A (ja) * 1993-04-15 1994-10-25 Hoechst Japan Ltd ヘテロ環イミノビスメチレンビスホスホン酸誘導体
US5728650A (en) * 1993-10-07 1998-03-17 Zeneca Limited Herbicidal aza bisphosphonic acids and compositions containing the same
US5854227A (en) * 1994-03-04 1998-12-29 Hartmann; John F. Therapeutic derivatives of diphosphonates
US5880111A (en) * 1995-06-07 1999-03-09 Farcasiu; Dan Therapeutic derivations of diphosphonates
AU6691798A (en) * 1997-03-07 1998-09-22 Metabasis Therapeutics, Inc. Novel indole and azaindole inhibitors of fructose-1,6-bisphosphatase
US6284748B1 (en) 1997-03-07 2001-09-04 Metabasis Therapeutics, Inc. Purine inhibitors of fructose 1,6-bisphosphatase
US7008645B2 (en) * 1998-07-14 2006-03-07 Yissum Research Development Company Of The Hebrew University Of Jerusalem Method of inhibiting restenosis using bisphosphonates
US6727233B1 (en) * 1998-12-25 2004-04-27 Yamanouchi Pharmaceutical Co., Ltd. Medicinal compositions for treating osseous lesion in multiple myeloma
US20030036537A1 (en) * 2001-07-16 2003-02-20 Marc Lecouvey Bisphosphonate derivatives, their preparations and uses
BR0309691A (pt) 2002-12-20 2005-08-02 Hoffmann La Roche Formulação de ibandronato em alta dose
HUP0300227A2 (hu) * 2003-01-28 2004-09-28 Richter Gedeon Vegyészeti Gyár Rt. Eljárás nagy tisztaságú 2-szubsztituált -1-(hidroxi-etilidén)-1,1-biszfoszfonsavak és sóik előállítására
US20060051407A1 (en) * 2003-06-27 2006-03-09 Yoram Richter Method of treating ischemia-reperfusion injury
US10517883B2 (en) 2003-06-27 2019-12-31 Zuli Holdings Ltd. Method of treating acute myocardial infarction
EP1709968A1 (en) * 2004-01-30 2006-10-11 Astellas Pharma Inc. P2x receptor inhibitor
CN101531681B (zh) * 2008-03-10 2013-06-05 北京德众万全医药科技有限公司 一种高纯度的米诺膦酸及其制备方法
KR20110079813A (ko) * 2008-09-22 2011-07-08 아이시스 이노베이션 리미티드 이미다조〔1,2－α〕피리디닐 비스포스포네이트
WO2010033980A2 (en) * 2008-09-22 2010-03-25 Isis Innovation Ltd. 4-azaindole bisphosphonates
EP2493905B1 (en) * 2009-10-26 2016-11-30 Warner Chilcott Company, LLC Bisphosphonate compounds for treating bone metabolism disorders
CN101973993A (zh) * 2010-11-05 2011-02-16 天津药物研究院 一种制备2-[咪唑并(1,2-a)吡啶-3-基]乙酸的方法
CN102153585B (zh) * 2011-02-24 2013-04-17 北京欧克兰医药技术开发中心 一种米诺膦酸中间体的合成方法及米诺膦酸的合成
CN102268042B (zh) * 2011-06-01 2014-06-25 广东宏远集团药业有限公司 一种米诺膦酸晶型ii及其制备方法
US9993427B2 (en) 2013-03-14 2018-06-12 Biorest Ltd. Liposome formulation and manufacture
CN107033187A (zh) * 2017-04-28 2017-08-11 江苏笃诚医药科技股份有限公司 一种米诺膦酸的制备方法
KR20220115062A (ko) 2021-02-09 2022-08-17 (주)오스티오뉴로젠 크로몬 구조의 화합물을 포함하는 골다공증의 예방 및 치료용 약학적 조성물

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3203308A1 (de) * 1982-01-27 1983-07-28 Schering Ag, 1000 Berlin Und 4619 Bergkamen Diphosphonsaeure-derivate und diese enthaltende pharmazeutische praeparate
DE3428524A1 (de) * 1984-08-02 1986-02-13 Boehringer Mannheim Gmbh, 6800 Mannheim Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel
DE3626058A1 (de) * 1986-08-01 1988-02-11 Boehringer Mannheim Gmbh Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel
DE3770787D1 (en) * 1986-11-21 1991-07-18 Ciba Geigy Ag Aromatisch substituierte azacyclo-alkylalkandiphosphonsaeuren.
DE3640938A1 (de) * 1986-11-29 1988-06-01 Boehringer Mannheim Gmbh Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindung enthaltende arzneimittel
EP0317505A1 (de) * 1987-11-13 1989-05-24 Ciba-Geigy Ag Neue Azacycloalkylalkandiphosphonsäuren

Also Published As

Publication number Publication date
DK394789D0 (da) 1989-08-11
AU624405B2 (en) 1992-06-11
US4990503A (en) 1991-02-05
DE68924681D1 (de) 1995-12-07
HU211949A9 (en) 1996-01-29
HUT51637A (en) 1990-05-28
IE71185B1 (en) 1997-01-29
EP0354806A2 (en) 1990-02-14
GR3018086T3 (en) 1996-02-29
EP0354806A3 (en) 1991-05-02
AU3941989A (en) 1990-02-15
CA1332058C (en) 1994-09-20
CN1027167C (zh) 1994-12-28
ATE129714T1 (de) 1995-11-15
KR900003186A (ko) 1990-03-26
DE68924681T2 (de) 1996-04-04
US5039669A (en) 1991-08-13
DK170257B1 (da) 1995-07-17
ES2082780T3 (es) 1996-04-01
IE892601L (en) 1990-02-12
CN1040590A (zh) 1990-03-21
PH26376A (en) 1992-06-01
HU205766B (en) 1992-06-29
EP0354806B1 (en) 1995-11-02
KR0156239B1 (ko) 1998-12-01

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