ATE130838T1 - Derivate der 4-(2,4-difluorbiphenyl)-2-methyl-4- oxobutansäure. - Google Patents

Derivate der 4-(2,4-difluorbiphenyl)-2-methyl-4- oxobutansäure.

Info

Publication number
ATE130838T1
ATE130838T1 AT91109980T AT91109980T ATE130838T1 AT E130838 T1 ATE130838 T1 AT E130838T1 AT 91109980 T AT91109980 T AT 91109980T AT 91109980 T AT91109980 T AT 91109980T AT E130838 T1 ATE130838 T1 AT E130838T1
Authority
AT
Austria
Prior art keywords
methyl
cation
alkyl
carbon atoms
formula
Prior art date
Application number
AT91109980T
Other languages
English (en)
Inventor
Miroslav Kuchar
Marie Poppova
Jaroslava Dr Grimova
Eva Dr Maturova
Original Assignee
Vyzk Ustav Farm Biochem Sp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vyzk Ustav Farm Biochem Sp filed Critical Vyzk Ustav Farm Biochem Sp
Application granted granted Critical
Publication of ATE130838T1 publication Critical patent/ATE130838T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/70—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/72—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atoms of the carboxamide groups bound to acyclic carbon atoms
    • C07C235/76—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton
    • C07C235/78—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton the carbon skeleton containing rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/33—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C211/34—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of a saturated carbon skeleton
    • C07C211/35—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of a saturated carbon skeleton containing only non-condensed rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/26—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having more than one amino group bound to the carbon skeleton, e.g. lysine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/76—Unsaturated compounds containing keto groups
    • C07C59/88—Unsaturated compounds containing keto groups containing halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
    • C07C69/738—Esters of keto-carboxylic acids or aldehydo-carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
AT91109980T 1990-06-18 1991-06-18 Derivate der 4-(2,4-difluorbiphenyl)-2-methyl-4- oxobutansäure. ATE130838T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CS903027A CS276833B6 (en) 1990-06-18 1990-06-18 Functional derivatives of 4-(2,4-difluorobiphenylyl)-2-methyl -4- oxobutanoic acid

Publications (1)

Publication Number Publication Date
ATE130838T1 true ATE130838T1 (de) 1995-12-15

Family

ID=5369145

Family Applications (1)

Application Number Title Priority Date Filing Date
AT91109980T ATE130838T1 (de) 1990-06-18 1991-06-18 Derivate der 4-(2,4-difluorbiphenyl)-2-methyl-4- oxobutansäure.

Country Status (7)

Country Link
US (1) US5177204A (de)
EP (1) EP0465879B1 (de)
JP (1) JPH04253936A (de)
AT (1) ATE130838T1 (de)
CA (1) CA2044837A1 (de)
CS (1) CS276833B6 (de)
DE (1) DE69114927T2 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5789434A (en) * 1994-11-15 1998-08-04 Bayer Corporation Derivatives of substituted 4-biarylbutyric acid as matrix metalloprotease inhibitors
IL115995A0 (en) * 1994-11-15 1996-01-31 Bayer Ag Substituted 4-biarylbutyric or 5-biarylpentanoic acids and derivatives as matrix metalloprotease inhibitors
US5886022A (en) * 1995-06-05 1999-03-23 Bayer Corporation Substituted cycloalkanecarboxylic acid derivatives as matrix metalloprotease inhibitors
EP1031349A1 (de) * 1999-02-25 2000-08-30 Bayer Aktiengesellschaft Verwendung von substituierten 4-Biarylbuttersäuren und 5-Biarylpentansäuren zur Behandlung von zerebralen Krankheiten
KR100405914B1 (ko) * 2000-04-25 2003-11-15 삼성전자주식회사 메트릭스 메탈로프로테이나제의 저해제로서의 비페닐부티릭산 유도체
KR100405913B1 (ko) * 2000-04-25 2003-11-14 삼성전자주식회사 메트릭스 메탈로프로테이나제의 저해제로서의 비페닐부티릭산 유도체

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CS243570B1 (en) * 1984-08-31 1986-06-12 Miroslav Kuchar Omega-aryloxoalkane acids

Also Published As

Publication number Publication date
EP0465879B1 (de) 1995-11-29
DE69114927D1 (de) 1996-01-11
US5177204A (en) 1993-01-05
DE69114927T2 (de) 1996-04-18
JPH04253936A (ja) 1992-09-09
EP0465879A1 (de) 1992-01-15
CS302790A3 (en) 1992-03-18
CS276833B6 (en) 1992-08-12
CA2044837A1 (en) 1991-12-19

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee